Amino acid dipepetide frequency for Sphingobium czechense LL01

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.945AlaAla: 18.945 ± 0.202
1.161AlaCys: 1.161 ± 0.031
8.266AlaAsp: 8.266 ± 0.094
6.589AlaGlu: 6.589 ± 0.091
4.32AlaPhe: 4.32 ± 0.066
11.201AlaGly: 11.201 ± 0.091
2.443AlaHis: 2.443 ± 0.052
7.342AlaIle: 7.342 ± 0.087
4.202AlaLys: 4.202 ± 0.065
14.338AlaLeu: 14.338 ± 0.128
4.42AlaMet: 4.42 ± 0.062
3.104AlaAsn: 3.104 ± 0.051
6.442AlaPro: 6.442 ± 0.084
5.282AlaGln: 5.282 ± 0.072
9.616AlaArg: 9.616 ± 0.102
6.527AlaSer: 6.527 ± 0.079
6.732AlaThr: 6.732 ± 0.073
8.289AlaVal: 8.289 ± 0.085
1.584AlaTrp: 1.584 ± 0.033
2.712AlaTyr: 2.712 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
1.101CysAla: 1.101 ± 0.027
0.094CysCys: 0.094 ± 0.009
0.531CysAsp: 0.531 ± 0.019
0.376CysGlu: 0.376 ± 0.017
0.295CysPhe: 0.295 ± 0.016
0.895CysGly: 0.895 ± 0.025
0.225CysHis: 0.225 ± 0.013
0.386CysIle: 0.386 ± 0.019
0.167CysLys: 0.167 ± 0.013
0.707CysLeu: 0.707 ± 0.023
0.165CysMet: 0.165 ± 0.011
0.211CysAsn: 0.211 ± 0.013
0.454CysPro: 0.454 ± 0.022
0.214CysGln: 0.214 ± 0.012
0.556CysArg: 0.556 ± 0.022
0.409CysSer: 0.409 ± 0.017
0.385CysThr: 0.385 ± 0.017
0.57CysVal: 0.57 ± 0.021
0.128CysTrp: 0.128 ± 0.009
0.178CysTyr: 0.178 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
8.214AspAla: 8.214 ± 0.08
0.451AspCys: 0.451 ± 0.021
3.559AspAsp: 3.559 ± 0.064
3.187AspGlu: 3.187 ± 0.063
2.195AspPhe: 2.195 ± 0.041
5.98AspGly: 5.98 ± 0.073
1.542AspHis: 1.542 ± 0.035
3.357AspIle: 3.357 ± 0.056
1.924AspLys: 1.924 ± 0.042
5.945AspLeu: 5.945 ± 0.071
1.766AspMet: 1.766 ± 0.035
1.462AspAsn: 1.462 ± 0.033
3.698AspPro: 3.698 ± 0.055
1.977AspGln: 1.977 ± 0.035
5.159AspArg: 5.159 ± 0.069
2.444AspSer: 2.444 ± 0.039
2.545AspThr: 2.545 ± 0.041
4.227AspVal: 4.227 ± 0.051
1.15AspTrp: 1.15 ± 0.031
1.805AspTyr: 1.805 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
7.131GluAla: 7.131 ± 0.086
0.283GluCys: 0.283 ± 0.016
2.638GluAsp: 2.638 ± 0.045
2.766GluGlu: 2.766 ± 0.06
1.33GluPhe: 1.33 ± 0.032
4.255GluGly: 4.255 ± 0.069
0.964GluHis: 0.964 ± 0.028
2.842GluIle: 2.842 ± 0.054
2.046GluLys: 2.046 ± 0.045
4.398GluLeu: 4.398 ± 0.066
1.397GluMet: 1.397 ± 0.036
1.244GluAsn: 1.244 ± 0.027
2.254GluPro: 2.254 ± 0.047
2.091GluGln: 2.091 ± 0.043
4.447GluArg: 4.447 ± 0.076
2.254GluSer: 2.254 ± 0.042
2.903GluThr: 2.903 ± 0.036
3.037GluVal: 3.037 ± 0.054
0.676GluTrp: 0.676 ± 0.023
0.887GluTyr: 0.887 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
4.821PheAla: 4.821 ± 0.058
0.345PheCys: 0.345 ± 0.016
2.743PheAsp: 2.743 ± 0.051
1.806PheGlu: 1.806 ± 0.042
1.284PhePhe: 1.284 ± 0.034
3.535PheGly: 3.535 ± 0.054
0.741PheHis: 0.741 ± 0.024
1.485PheIle: 1.485 ± 0.034
0.889PheLys: 0.889 ± 0.032
3.079PheLeu: 3.079 ± 0.058
0.786PheMet: 0.786 ± 0.022
1.003PheAsn: 1.003 ± 0.034
1.538PhePro: 1.538 ± 0.029
0.903PheGln: 0.903 ± 0.027
2.193PheArg: 2.193 ± 0.049
2.018PheSer: 2.018 ± 0.045
1.997PheThr: 1.997 ± 0.043
2.458PheVal: 2.458 ± 0.043
0.486PheTrp: 0.486 ± 0.02
0.876PheTyr: 0.876 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
10.374GlyAla: 10.374 ± 0.101
0.837GlyCys: 0.837 ± 0.02
5.229GlyAsp: 5.229 ± 0.069
4.512GlyGlu: 4.512 ± 0.06
3.653GlyPhe: 3.653 ± 0.054
8.193GlyGly: 8.193 ± 0.123
1.942GlyHis: 1.942 ± 0.041
4.49GlyIle: 4.49 ± 0.063
3.459GlyLys: 3.459 ± 0.057
8.808GlyLeu: 8.808 ± 0.076
2.508GlyMet: 2.508 ± 0.048
2.131GlyAsn: 2.131 ± 0.048
3.575GlyPro: 3.575 ± 0.056
3.237GlyGln: 3.237 ± 0.053
6.458GlyArg: 6.458 ± 0.071
4.541GlySer: 4.541 ± 0.063
4.366GlyThr: 4.366 ± 0.068
6.455GlyVal: 6.455 ± 0.063
1.708GlyTrp: 1.708 ± 0.038
2.411GlyTyr: 2.411 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
2.361HisAla: 2.361 ± 0.041
0.217HisCys: 0.217 ± 0.014
1.354HisAsp: 1.354 ± 0.035
0.954HisGlu: 0.954 ± 0.029
0.852HisPhe: 0.852 ± 0.026
2.15HisGly: 2.15 ± 0.048
0.617HisHis: 0.617 ± 0.024
1.057HisIle: 1.057 ± 0.03
0.532HisLys: 0.532 ± 0.022
1.909HisLeu: 1.909 ± 0.034
0.543HisMet: 0.543 ± 0.021
0.47HisAsn: 0.47 ± 0.018
1.23HisPro: 1.23 ± 0.03
0.577HisGln: 0.577 ± 0.024
1.458HisArg: 1.458 ± 0.041
0.94HisSer: 0.94 ± 0.025
0.604HisThr: 0.604 ± 0.021
1.637HisVal: 1.637 ± 0.043
0.404HisTrp: 0.404 ± 0.019
0.626HisTyr: 0.626 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
8.325IleAla: 8.325 ± 0.082
0.459IleCys: 0.459 ± 0.02
4.222IleAsp: 4.222 ± 0.059
3.274IleGlu: 3.274 ± 0.058
1.761IlePhe: 1.761 ± 0.041
5.293IleGly: 5.293 ± 0.064
0.954IleHis: 0.954 ± 0.03
2.344IleIle: 2.344 ± 0.047
1.348IleLys: 1.348 ± 0.033
4.45IleLeu: 4.45 ± 0.067
1.077IleMet: 1.077 ± 0.03
1.42IleAsn: 1.42 ± 0.035
2.312IlePro: 2.312 ± 0.042
1.169IleGln: 1.169 ± 0.031
3.257IleArg: 3.257 ± 0.045
2.608IleSer: 2.608 ± 0.047
2.517IleThr: 2.517 ± 0.042
4.258IleVal: 4.258 ± 0.058
0.67IleTrp: 0.67 ± 0.023
1.038IleTyr: 1.038 ± 0.027
0.0IleXaa: 0.0 ± 0.0
Lys
4.521LysAla: 4.521 ± 0.062
0.165LysCys: 0.165 ± 0.012
1.766LysAsp: 1.766 ± 0.046
1.296LysGlu: 1.296 ± 0.037
0.868LysPhe: 0.868 ± 0.027
2.951LysGly: 2.951 ± 0.047
0.529LysHis: 0.529 ± 0.022
1.607LysIle: 1.607 ± 0.039
1.136LysLys: 1.136 ± 0.035
3.091LysLeu: 3.091 ± 0.052
0.836LysMet: 0.836 ± 0.025
0.806LysAsn: 0.806 ± 0.028
2.035LysPro: 2.035 ± 0.039
0.948LysGln: 0.948 ± 0.029
2.236LysArg: 2.236 ± 0.044
1.606LysSer: 1.606 ± 0.035
1.743LysThr: 1.743 ± 0.037
2.271LysVal: 2.271 ± 0.045
0.391LysTrp: 0.391 ± 0.015
0.604LysTyr: 0.604 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
13.563LeuAla: 13.563 ± 0.113
0.894LeuCys: 0.894 ± 0.024
6.24LeuAsp: 6.24 ± 0.076
4.424LeuGlu: 4.424 ± 0.061
3.748LeuPhe: 3.748 ± 0.06
8.116LeuGly: 8.116 ± 0.087
1.85LeuHis: 1.85 ± 0.042
5.071LeuIle: 5.071 ± 0.07
3.008LeuLys: 3.008 ± 0.05
9.755LeuLeu: 9.755 ± 0.117
2.385LeuMet: 2.385 ± 0.039
2.498LeuAsn: 2.498 ± 0.042
5.603LeuPro: 5.603 ± 0.067
2.452LeuGln: 2.452 ± 0.045
6.735LeuArg: 6.735 ± 0.076
6.178LeuSer: 6.178 ± 0.081
5.627LeuThr: 5.627 ± 0.078
6.748LeuVal: 6.748 ± 0.071
1.306LeuTrp: 1.306 ± 0.034
2.051LeuTyr: 2.051 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
3.73MetAla: 3.73 ± 0.059
0.141MetCys: 0.141 ± 0.01
1.42MetAsp: 1.42 ± 0.033
1.216MetGlu: 1.216 ± 0.03
0.745MetPhe: 0.745 ± 0.026
2.167MetGly: 2.167 ± 0.042
0.449MetHis: 0.449 ± 0.019
1.469MetIle: 1.469 ± 0.032
1.014MetLys: 1.014 ± 0.028
2.823MetLeu: 2.823 ± 0.051
0.785MetMet: 0.785 ± 0.027
0.726MetAsn: 0.726 ± 0.024
1.553MetPro: 1.553 ± 0.033
0.879MetGln: 0.879 ± 0.024
1.87MetArg: 1.87 ± 0.041
1.514MetSer: 1.514 ± 0.037
2.007MetThr: 2.007 ± 0.04
1.796MetVal: 1.796 ± 0.035
0.22MetTrp: 0.22 ± 0.013
0.251MetTyr: 0.251 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
3.273AsnAla: 3.273 ± 0.054
0.232AsnCys: 0.232 ± 0.012
1.443AsnAsp: 1.443 ± 0.033
1.075AsnGlu: 1.075 ± 0.032
0.941AsnPhe: 0.941 ± 0.028
2.474AsnGly: 2.474 ± 0.044
0.473AsnHis: 0.473 ± 0.019
1.406AsnIle: 1.406 ± 0.036
0.703AsnLys: 0.703 ± 0.025
2.369AsnLeu: 2.369 ± 0.048
0.598AsnMet: 0.598 ± 0.02
0.659AsnAsn: 0.659 ± 0.022
1.701AsnPro: 1.701 ± 0.033
0.794AsnGln: 0.794 ± 0.023
1.818AsnArg: 1.818 ± 0.035
1.24AsnSer: 1.24 ± 0.027
0.959AsnThr: 0.959 ± 0.034
1.835AsnVal: 1.835 ± 0.036
0.453AsnTrp: 0.453 ± 0.017
0.69AsnTyr: 0.69 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
6.896ProAla: 6.896 ± 0.087
0.338ProCys: 0.338 ± 0.015
4.016ProAsp: 4.016 ± 0.052
2.94ProGlu: 2.94 ± 0.049
1.899ProPhe: 1.899 ± 0.035
4.622ProGly: 4.622 ± 0.058
1.08ProHis: 1.08 ± 0.026
2.659ProIle: 2.659 ± 0.042
1.52ProLys: 1.52 ± 0.035
4.842ProLeu: 4.842 ± 0.06
1.398ProMet: 1.398 ± 0.034
1.246ProAsn: 1.246 ± 0.032
2.719ProPro: 2.719 ± 0.066
1.811ProGln: 1.811 ± 0.039
2.923ProArg: 2.923 ± 0.051
2.723ProSer: 2.723 ± 0.048
2.735ProThr: 2.735 ± 0.049
4.26ProVal: 4.26 ± 0.055
0.66ProTrp: 0.66 ± 0.021
1.122ProTyr: 1.122 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
4.62GlnAla: 4.62 ± 0.07
0.252GlnCys: 0.252 ± 0.013
1.658GlnAsp: 1.658 ± 0.032
1.412GlnGlu: 1.412 ± 0.032
1.072GlnPhe: 1.072 ± 0.031
2.767GlnGly: 2.767 ± 0.047
0.608GlnHis: 0.608 ± 0.02
1.923GlnIle: 1.923 ± 0.033
1.035GlnLys: 1.035 ± 0.027
3.093GlnLeu: 3.093 ± 0.06
0.969GlnMet: 0.969 ± 0.029
0.801GlnAsn: 0.801 ± 0.024
1.875GlnPro: 1.875 ± 0.036
1.256GlnGln: 1.256 ± 0.038
2.608GlnArg: 2.608 ± 0.043
1.819GlnSer: 1.819 ± 0.042
1.723GlnThr: 1.723 ± 0.038
2.403GlnVal: 2.403 ± 0.045
0.451GlnTrp: 0.451 ± 0.018
0.666GlnTyr: 0.666 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
8.853ArgAla: 8.853 ± 0.111
0.527ArgCys: 0.527 ± 0.019
4.477ArgAsp: 4.477 ± 0.068
3.646ArgGlu: 3.646 ± 0.06
2.957ArgPhe: 2.957 ± 0.05
4.946ArgGly: 4.946 ± 0.063
1.795ArgHis: 1.795 ± 0.038
4.163ArgIle: 4.163 ± 0.062
2.182ArgLys: 2.182 ± 0.046
7.94ArgLeu: 7.94 ± 0.085
2.001ArgMet: 2.001 ± 0.035
1.858ArgAsn: 1.858 ± 0.036
3.645ArgPro: 3.645 ± 0.055
2.681ArgGln: 2.681 ± 0.048
5.507ArgArg: 5.507 ± 0.085
3.549ArgSer: 3.549 ± 0.048
3.558ArgThr: 3.558 ± 0.05
4.426ArgVal: 4.426 ± 0.06
1.235ArgTrp: 1.235 ± 0.034
2.004ArgTyr: 2.004 ± 0.041
0.001ArgXaa: 0.001 ± 0.001
Ser
6.519SerAla: 6.519 ± 0.075
0.423SerCys: 0.423 ± 0.02
3.15SerAsp: 3.15 ± 0.052
2.308SerGlu: 2.308 ± 0.044
2.149SerPhe: 2.149 ± 0.046
5.252SerGly: 5.252 ± 0.071
1.015SerHis: 1.015 ± 0.03
2.753SerIle: 2.753 ± 0.045
1.484SerLys: 1.484 ± 0.041
5.089SerLeu: 5.089 ± 0.062
1.249SerMet: 1.249 ± 0.031
1.29SerAsn: 1.29 ± 0.034
2.817SerPro: 2.817 ± 0.043
1.637SerGln: 1.637 ± 0.037
3.389SerArg: 3.389 ± 0.044
2.682SerSer: 2.682 ± 0.053
2.465SerThr: 2.465 ± 0.054
3.587SerVal: 3.587 ± 0.053
0.778SerTrp: 0.778 ± 0.019
1.398SerTyr: 1.398 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
6.201ThrAla: 6.201 ± 0.072
0.385ThrCys: 0.385 ± 0.018
3.024ThrAsp: 3.024 ± 0.055
2.053ThrGlu: 2.053 ± 0.043
1.693ThrPhe: 1.693 ± 0.044
5.268ThrGly: 5.268 ± 0.075
0.991ThrHis: 0.991 ± 0.028
3.061ThrIle: 3.061 ± 0.051
1.363ThrLys: 1.363 ± 0.038
5.869ThrLeu: 5.869 ± 0.067
1.225ThrMet: 1.225 ± 0.029
1.211ThrAsn: 1.211 ± 0.037
3.523ThrPro: 3.523 ± 0.056
1.605ThrGln: 1.605 ± 0.033
3.422ThrArg: 3.422 ± 0.052
2.535ThrSer: 2.535 ± 0.049
2.563ThrThr: 2.563 ± 0.047
4.015ThrVal: 4.015 ± 0.059
0.568ThrTrp: 0.568 ± 0.022
1.097ThrTyr: 1.097 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
9.888ValAla: 9.888 ± 0.099
0.492ValCys: 0.492 ± 0.019
4.453ValAsp: 4.453 ± 0.061
4.336ValGlu: 4.336 ± 0.059
1.869ValPhe: 1.869 ± 0.034
5.647ValGly: 5.647 ± 0.069
1.387ValHis: 1.387 ± 0.034
3.704ValIle: 3.704 ± 0.061
2.226ValLys: 2.226 ± 0.044
5.845ValLeu: 5.845 ± 0.073
1.8ValMet: 1.8 ± 0.036
1.948ValAsn: 1.948 ± 0.038
3.654ValPro: 3.654 ± 0.048
2.195ValGln: 2.195 ± 0.043
5.032ValArg: 5.032 ± 0.061
3.78ValSer: 3.78 ± 0.054
4.364ValThr: 4.364 ± 0.064
5.074ValVal: 5.074 ± 0.072
0.782ValTrp: 0.782 ± 0.028
1.357ValTyr: 1.357 ± 0.032
0.0ValXaa: 0.0 ± 0.0
Trp
1.38TrpAla: 1.38 ± 0.034
0.119TrpCys: 0.119 ± 0.01
0.782TrpAsp: 0.782 ± 0.027
0.587TrpGlu: 0.587 ± 0.02
0.496TrpPhe: 0.496 ± 0.021
0.981TrpGly: 0.981 ± 0.029
0.341TrpHis: 0.341 ± 0.016
0.718TrpIle: 0.718 ± 0.024
0.5TrpLys: 0.5 ± 0.019
1.716TrpLeu: 1.716 ± 0.037
0.386TrpMet: 0.386 ± 0.02
0.454TrpAsn: 0.454 ± 0.02
0.727TrpPro: 0.727 ± 0.024
0.555TrpGln: 0.555 ± 0.021
1.355TrpArg: 1.355 ± 0.036
0.889TrpSer: 0.889 ± 0.03
0.889TrpThr: 0.889 ± 0.027
0.846TrpVal: 0.846 ± 0.026
0.271TrpTrp: 0.271 ± 0.016
0.278TrpTyr: 0.278 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.8TyrAla: 2.8 ± 0.048
0.232TyrCys: 0.232 ± 0.015
1.615TyrAsp: 1.615 ± 0.04
1.086TyrGlu: 1.086 ± 0.028
0.861TyrPhe: 0.861 ± 0.028
2.195TyrGly: 2.195 ± 0.039
0.544TyrHis: 0.544 ± 0.02
0.92TyrIle: 0.92 ± 0.026
0.67TyrLys: 0.67 ± 0.027
2.184TyrLeu: 2.184 ± 0.042
0.48TyrMet: 0.48 ± 0.018
0.594TyrAsn: 0.594 ± 0.024
1.054TyrPro: 1.054 ± 0.03
0.746TyrGln: 0.746 ± 0.024
1.914TyrArg: 1.914 ± 0.038
1.175TyrSer: 1.175 ± 0.033
0.988TyrThr: 0.988 ± 0.032
1.642TyrVal: 1.642 ± 0.031
0.351TyrTrp: 0.351 ± 0.018
0.676TyrTyr: 0.676 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.001XaaGlu: 0.001 ± 0.001
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4505 proteins (1355987 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski