Amino acid dipepetide frequency for Aurantiacibacter spongiae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.327AlaAla: 17.327 ± 0.22	1.173AlaCys: 1.173 ± 0.041	8.032AlaAsp: 8.032 ± 0.11	7.887AlaGlu: 7.887 ± 0.096	4.298AlaPhe: 4.298 ± 0.077	11.664AlaGly: 11.664 ± 0.142	2.145AlaHis: 2.145 ± 0.055	6.738AlaIle: 6.738 ± 0.106	3.386AlaLys: 3.386 ± 0.081	13.647AlaLeu: 13.647 ± 0.158	4.087AlaMet: 4.087 ± 0.073	3.212AlaAsn: 3.212 ± 0.072	5.778AlaPro: 5.778 ± 0.1	4.453AlaGln: 4.453 ± 0.073	10.804AlaArg: 10.804 ± 0.152	6.452AlaSer: 6.452 ± 0.102	6.139AlaThr: 6.139 ± 0.086	8.297AlaVal: 8.297 ± 0.118	1.65AlaTrp: 1.65 ± 0.05	2.476AlaTyr: 2.476 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	1.11CysAla: 1.11 ± 0.038	0.1CysCys: 0.1 ± 0.011	0.653CysAsp: 0.653 ± 0.029	0.566CysGlu: 0.566 ± 0.03	0.271CysPhe: 0.271 ± 0.021	0.929CysGly: 0.929 ± 0.037	0.201CysHis: 0.201 ± 0.015	0.347CysIle: 0.347 ± 0.021	0.145CysLys: 0.145 ± 0.013	0.709CysLeu: 0.709 ± 0.033	0.144CysMet: 0.144 ± 0.013	0.207CysAsn: 0.207 ± 0.016	0.426CysPro: 0.426 ± 0.024	0.228CysGln: 0.228 ± 0.017	0.605CysArg: 0.605 ± 0.023	0.462CysSer: 0.462 ± 0.023	0.395CysThr: 0.395 ± 0.02	0.604CysVal: 0.604 ± 0.026	0.103CysTrp: 0.103 ± 0.011	0.159CysTyr: 0.159 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.307AspAla: 8.307 ± 0.12	0.577AspCys: 0.577 ± 0.029	4.142AspAsp: 4.142 ± 0.085	4.409AspGlu: 4.409 ± 0.069	2.433AspPhe: 2.433 ± 0.059	6.076AspGly: 6.076 ± 0.093	1.368AspHis: 1.368 ± 0.041	3.149AspIle: 3.149 ± 0.059	1.492AspLys: 1.492 ± 0.049	6.417AspLeu: 6.417 ± 0.111	1.647AspMet: 1.647 ± 0.041	1.606AspAsn: 1.606 ± 0.043	4.052AspPro: 4.052 ± 0.075	1.704AspGln: 1.704 ± 0.049	5.46AspArg: 5.46 ± 0.081	2.567AspSer: 2.567 ± 0.057	3.242AspThr: 3.242 ± 0.068	4.021AspVal: 4.021 ± 0.075	1.256AspTrp: 1.256 ± 0.039	1.732AspTyr: 1.732 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	8.11GluAla: 8.11 ± 0.094	0.408GluCys: 0.408 ± 0.027	3.849GluAsp: 3.849 ± 0.07	3.968GluGlu: 3.968 ± 0.081	1.727GluPhe: 1.727 ± 0.045	5.322GluGly: 5.322 ± 0.096	1.215GluHis: 1.215 ± 0.038	3.036GluIle: 3.036 ± 0.057	1.996GluLys: 1.996 ± 0.053	5.406GluLeu: 5.406 ± 0.075	1.602GluMet: 1.602 ± 0.048	1.665GluAsn: 1.665 ± 0.043	2.997GluPro: 2.997 ± 0.054	2.262GluGln: 2.262 ± 0.056	5.943GluArg: 5.943 ± 0.093	2.531GluSer: 2.531 ± 0.053	3.488GluThr: 3.488 ± 0.06	3.834GluVal: 3.834 ± 0.064	0.931GluTrp: 0.931 ± 0.034	1.154GluTyr: 1.154 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	5.213PheAla: 5.213 ± 0.087	0.348PheCys: 0.348 ± 0.021	2.872PheAsp: 2.872 ± 0.066	2.12PheGlu: 2.12 ± 0.054	1.194PhePhe: 1.194 ± 0.04	3.5PheGly: 3.5 ± 0.066	0.664PheHis: 0.664 ± 0.03	1.392PheIle: 1.392 ± 0.045	0.603PheLys: 0.603 ± 0.028	3.047PheLeu: 3.047 ± 0.069	0.695PheMet: 0.695 ± 0.029	0.893PheAsn: 0.893 ± 0.034	1.563PhePro: 1.563 ± 0.044	0.82PheGln: 0.82 ± 0.029	2.199PheArg: 2.199 ± 0.051	1.952PheSer: 1.952 ± 0.052	2.004PheThr: 2.004 ± 0.061	2.82PheVal: 2.82 ± 0.057	0.536PheTrp: 0.536 ± 0.031	0.893PheTyr: 0.893 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	9.782GlyAla: 9.782 ± 0.133	0.884GlyCys: 0.884 ± 0.033	5.662GlyAsp: 5.662 ± 0.089	6.076GlyGlu: 6.076 ± 0.09	3.588GlyPhe: 3.588 ± 0.078	8.231GlyGly: 8.231 ± 0.129	1.822GlyHis: 1.822 ± 0.043	4.373GlyIle: 4.373 ± 0.066	2.843GlyLys: 2.843 ± 0.079	8.39GlyLeu: 8.39 ± 0.101	2.441GlyMet: 2.441 ± 0.051	2.452GlyAsn: 2.452 ± 0.064	3.742GlyPro: 3.742 ± 0.072	2.891GlyGln: 2.891 ± 0.058	6.764GlyArg: 6.764 ± 0.091	4.992GlySer: 4.992 ± 0.072	4.826GlyThr: 4.826 ± 0.086	5.89GlyVal: 5.89 ± 0.091	1.662GlyTrp: 1.662 ± 0.046	2.316GlyTyr: 2.316 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.298HisAla: 2.298 ± 0.056	0.247HisCys: 0.247 ± 0.016	1.328HisAsp: 1.328 ± 0.041	1.077HisGlu: 1.077 ± 0.04	0.784HisPhe: 0.784 ± 0.031	1.83HisGly: 1.83 ± 0.044	0.525HisHis: 0.525 ± 0.028	0.837HisIle: 0.837 ± 0.031	0.363HisLys: 0.363 ± 0.02	1.835HisLeu: 1.835 ± 0.046	0.423HisMet: 0.423 ± 0.023	0.4HisAsn: 0.4 ± 0.019	1.213HisPro: 1.213 ± 0.039	0.451HisGln: 0.451 ± 0.021	1.567HisArg: 1.567 ± 0.04	0.962HisSer: 0.962 ± 0.036	0.724HisThr: 0.724 ± 0.027	1.427HisVal: 1.427 ± 0.037	0.33HisTrp: 0.33 ± 0.019	0.538HisTyr: 0.538 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	7.798IleAla: 7.798 ± 0.111	0.43IleCys: 0.43 ± 0.024	3.633IleAsp: 3.633 ± 0.079	3.519IleGlu: 3.519 ± 0.072	1.454IlePhe: 1.454 ± 0.04	4.909IleGly: 4.909 ± 0.089	0.81IleHis: 0.81 ± 0.029	1.739IleIle: 1.739 ± 0.052	0.936IleLys: 0.936 ± 0.035	3.659IleLeu: 3.659 ± 0.072	0.9IleMet: 0.9 ± 0.033	1.1IleAsn: 1.1 ± 0.037	2.221IlePro: 2.221 ± 0.054	0.969IleGln: 0.969 ± 0.039	3.086IleArg: 3.086 ± 0.065	2.316IleSer: 2.316 ± 0.053	2.255IleThr: 2.255 ± 0.05	4.144IleVal: 4.144 ± 0.074	0.583IleTrp: 0.583 ± 0.029	0.966IleTyr: 0.966 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.193LysAla: 3.193 ± 0.079	0.135LysCys: 0.135 ± 0.012	1.468LysAsp: 1.468 ± 0.046	1.196LysGlu: 1.196 ± 0.041	0.704LysPhe: 0.704 ± 0.026	2.237LysGly: 2.237 ± 0.066	0.456LysHis: 0.456 ± 0.024	1.233LysIle: 1.233 ± 0.043	0.982LysLys: 0.982 ± 0.054	2.569LysLeu: 2.569 ± 0.062	0.593LysMet: 0.593 ± 0.028	0.614LysAsn: 0.614 ± 0.029	1.535LysPro: 1.535 ± 0.047	0.733LysGln: 0.733 ± 0.032	2.116LysArg: 2.116 ± 0.052	1.334LysSer: 1.334 ± 0.047	1.39LysThr: 1.39 ± 0.045	1.838LysVal: 1.838 ± 0.052	0.304LysTrp: 0.304 ± 0.016	0.507LysTyr: 0.507 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	14.774LeuAla: 14.774 ± 0.174	0.773LeuCys: 0.773 ± 0.03	6.49LeuAsp: 6.49 ± 0.082	5.394LeuGlu: 5.394 ± 0.093	3.478LeuPhe: 3.478 ± 0.069	8.299LeuGly: 8.299 ± 0.103	1.663LeuHis: 1.663 ± 0.05	4.1LeuIle: 4.1 ± 0.08	2.421LeuLys: 2.421 ± 0.06	9.391LeuLeu: 9.391 ± 0.132	1.969LeuMet: 1.969 ± 0.044	2.098LeuAsn: 2.098 ± 0.051	5.441LeuPro: 5.441 ± 0.079	2.373LeuGln: 2.373 ± 0.062	7.016LeuArg: 7.016 ± 0.101	5.747LeuSer: 5.747 ± 0.082	5.572LeuThr: 5.572 ± 0.08	7.592LeuVal: 7.592 ± 0.114	1.134LeuTrp: 1.134 ± 0.041	1.853LeuTyr: 1.853 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	3.305MetAla: 3.305 ± 0.062	0.168MetCys: 0.168 ± 0.014	1.341MetAsp: 1.341 ± 0.041	1.3MetGlu: 1.3 ± 0.041	0.673MetPhe: 0.673 ± 0.028	2.005MetGly: 2.005 ± 0.05	0.468MetHis: 0.468 ± 0.024	1.181MetIle: 1.181 ± 0.038	0.86MetLys: 0.86 ± 0.032	2.58MetLeu: 2.58 ± 0.052	0.637MetMet: 0.637 ± 0.03	0.693MetAsn: 0.693 ± 0.032	1.422MetPro: 1.422 ± 0.038	0.86MetGln: 0.86 ± 0.037	2.006MetArg: 2.006 ± 0.044	1.401MetSer: 1.401 ± 0.035	1.753MetThr: 1.753 ± 0.044	1.612MetVal: 1.612 ± 0.041	0.227MetTrp: 0.227 ± 0.017	0.255MetTyr: 0.255 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.155AsnAla: 3.155 ± 0.062	0.24AsnCys: 0.24 ± 0.018	1.584AsnAsp: 1.584 ± 0.047	1.292AsnGlu: 1.292 ± 0.04	0.872AsnPhe: 0.872 ± 0.034	2.259AsnGly: 2.259 ± 0.066	0.469AsnHis: 0.469 ± 0.025	1.155AsnIle: 1.155 ± 0.043	0.481AsnLys: 0.481 ± 0.026	2.428AsnLeu: 2.428 ± 0.06	0.519AsnMet: 0.519 ± 0.026	0.584AsnAsn: 0.584 ± 0.029	1.754AsnPro: 1.754 ± 0.049	0.705AsnGln: 0.705 ± 0.03	2.058AsnArg: 2.058 ± 0.05	1.271AsnSer: 1.271 ± 0.042	1.17AsnThr: 1.17 ± 0.044	1.795AsnVal: 1.795 ± 0.046	0.393AsnTrp: 0.393 ± 0.024	0.606AsnTyr: 0.606 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	6.745ProAla: 6.745 ± 0.107	0.349ProCys: 0.349 ± 0.021	4.21ProAsp: 4.21 ± 0.079	3.761ProGlu: 3.761 ± 0.061	1.89ProPhe: 1.89 ± 0.052	4.88ProGly: 4.88 ± 0.076	1.035ProHis: 1.035 ± 0.036	2.104ProIle: 2.104 ± 0.046	1.077ProLys: 1.077 ± 0.038	4.782ProLeu: 4.782 ± 0.08	1.139ProMet: 1.139 ± 0.037	1.091ProAsn: 1.091 ± 0.037	2.905ProPro: 2.905 ± 0.094	1.673ProGln: 1.673 ± 0.04	3.446ProArg: 3.446 ± 0.077	2.513ProSer: 2.513 ± 0.056	2.267ProThr: 2.267 ± 0.057	4.437ProVal: 4.437 ± 0.071	0.617ProTrp: 0.617 ± 0.026	1.099ProTyr: 1.099 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.866GlnAla: 3.866 ± 0.083	0.209GlnCys: 0.209 ± 0.015	1.718GlnAsp: 1.718 ± 0.044	1.489GlnGlu: 1.489 ± 0.047	1.117GlnPhe: 1.117 ± 0.032	2.391GlnGly: 2.391 ± 0.054	0.558GlnHis: 0.558 ± 0.027	1.557GlnIle: 1.557 ± 0.041	0.746GlnLys: 0.746 ± 0.032	2.966GlnLeu: 2.966 ± 0.054	0.841GlnMet: 0.841 ± 0.033	0.763GlnAsn: 0.763 ± 0.03	1.662GlnPro: 1.662 ± 0.048	1.127GlnGln: 1.127 ± 0.044	2.554GlnArg: 2.554 ± 0.058	1.739GlnSer: 1.739 ± 0.046	1.61GlnThr: 1.61 ± 0.047	2.369GlnVal: 2.369 ± 0.05	0.389GlnTrp: 0.389 ± 0.02	0.658GlnTyr: 0.658 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	9.226ArgAla: 9.226 ± 0.124	0.514ArgCys: 0.514 ± 0.025	5.068ArgAsp: 5.068 ± 0.093	5.416ArgGlu: 5.416 ± 0.096	3.25ArgPhe: 3.25 ± 0.069	5.612ArgGly: 5.612 ± 0.086	1.723ArgHis: 1.723 ± 0.046	4.24ArgIle: 4.24 ± 0.079	2.025ArgLys: 2.025 ± 0.055	8.214ArgLeu: 8.214 ± 0.109	2.176ArgMet: 2.176 ± 0.055	1.929ArgAsn: 1.929 ± 0.046	3.777ArgPro: 3.777 ± 0.063	2.725ArgGln: 2.725 ± 0.064	6.547ArgArg: 6.547 ± 0.116	4.001ArgSer: 4.001 ± 0.07	3.758ArgThr: 3.758 ± 0.069	5.083ArgVal: 5.083 ± 0.068	1.217ArgTrp: 1.217 ± 0.035	1.908ArgTyr: 1.908 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	6.124SerAla: 6.124 ± 0.094	0.418SerCys: 0.418 ± 0.022	3.414SerAsp: 3.414 ± 0.065	2.925SerGlu: 2.925 ± 0.057	1.977SerPhe: 1.977 ± 0.049	5.452SerGly: 5.452 ± 0.085	0.94SerHis: 0.94 ± 0.035	2.385SerIle: 2.385 ± 0.051	1.171SerLys: 1.171 ± 0.04	5.035SerLeu: 5.035 ± 0.088	1.177SerMet: 1.177 ± 0.032	1.286SerAsn: 1.286 ± 0.04	2.736SerPro: 2.736 ± 0.06	1.647SerGln: 1.647 ± 0.05	3.872SerArg: 3.872 ± 0.064	2.722SerSer: 2.722 ± 0.069	2.567SerThr: 2.567 ± 0.057	3.511SerVal: 3.511 ± 0.066	0.793SerTrp: 0.793 ± 0.039	1.217SerTyr: 1.217 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	6.088ThrAla: 6.088 ± 0.1	0.44ThrCys: 0.44 ± 0.024	3.221ThrAsp: 3.221 ± 0.064	2.46ThrGlu: 2.46 ± 0.052	1.868ThrPhe: 1.868 ± 0.053	5.505ThrGly: 5.505 ± 0.084	0.94ThrHis: 0.94 ± 0.035	2.818ThrIle: 2.818 ± 0.06	1.062ThrLys: 1.062 ± 0.041	5.512ThrLeu: 5.512 ± 0.088	1.275ThrMet: 1.275 ± 0.036	1.232ThrAsn: 1.232 ± 0.037	3.063ThrPro: 3.063 ± 0.057	1.492ThrGln: 1.492 ± 0.052	3.758ThrArg: 3.758 ± 0.061	2.513ThrSer: 2.513 ± 0.056	2.625ThrThr: 2.625 ± 0.067	4.201ThrVal: 4.201 ± 0.066	0.6ThrTrp: 0.6 ± 0.027	1.235ThrTyr: 1.235 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	9.268ValAla: 9.268 ± 0.112	0.568ValCys: 0.568 ± 0.028	4.553ValAsp: 4.553 ± 0.08	4.685ValGlu: 4.685 ± 0.071	2.321ValPhe: 2.321 ± 0.047	5.481ValGly: 5.481 ± 0.082	1.318ValHis: 1.318 ± 0.037	3.605ValIle: 3.605 ± 0.067	1.729ValLys: 1.729 ± 0.049	7.02ValLeu: 7.02 ± 0.108	1.702ValMet: 1.702 ± 0.048	1.918ValAsn: 1.918 ± 0.051	3.94ValPro: 3.94 ± 0.076	1.987ValGln: 1.987 ± 0.052	5.194ValArg: 5.194 ± 0.09	3.858ValSer: 3.858 ± 0.071	4.333ValThr: 4.333 ± 0.09	5.21ValVal: 5.21 ± 0.094	0.912ValTrp: 0.912 ± 0.033	1.344ValTyr: 1.344 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.306TrpAla: 1.306 ± 0.047	0.129TrpCys: 0.129 ± 0.012	0.74TrpAsp: 0.74 ± 0.032	0.64TrpGlu: 0.64 ± 0.031	0.607TrpPhe: 0.607 ± 0.031	0.946TrpGly: 0.946 ± 0.035	0.373TrpHis: 0.373 ± 0.019	0.65TrpIle: 0.65 ± 0.029	0.391TrpLys: 0.391 ± 0.019	1.848TrpLeu: 1.848 ± 0.049	0.376TrpMet: 0.376 ± 0.019	0.471TrpAsn: 0.471 ± 0.021	0.757TrpPro: 0.757 ± 0.034	0.651TrpGln: 0.651 ± 0.029	1.396TrpArg: 1.396 ± 0.042	0.862TrpSer: 0.862 ± 0.034	0.782TrpThr: 0.782 ± 0.028	0.786TrpVal: 0.786 ± 0.036	0.295TrpTrp: 0.295 ± 0.021	0.296TrpTyr: 0.296 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.65TyrAla: 2.65 ± 0.053	0.254TyrCys: 0.254 ± 0.018	1.68TyrAsp: 1.68 ± 0.048	1.262TyrGlu: 1.262 ± 0.04	0.82TyrPhe: 0.82 ± 0.036	2.101TyrGly: 2.101 ± 0.053	0.464TyrHis: 0.464 ± 0.024	0.789TyrIle: 0.789 ± 0.031	0.431TyrLys: 0.431 ± 0.023	2.124TyrLeu: 2.124 ± 0.047	0.404TyrMet: 0.404 ± 0.02	0.574TyrAsn: 0.574 ± 0.026	1.036TyrPro: 1.036 ± 0.036	0.576TyrGln: 0.576 ± 0.027	2.019TyrArg: 2.019 ± 0.058	1.172TyrSer: 1.172 ± 0.037	1.011TyrThr: 1.011 ± 0.04	1.474TyrVal: 1.474 ± 0.046	0.371TyrTrp: 0.371 ± 0.02	0.611TyrTyr: 0.611 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2690 proteins (867789 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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