Amino acid dipepetide frequency for Streptococcus intermedius B196

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.557AlaAla: 5.557 ± 0.123
0.466AlaCys: 0.466 ± 0.032
3.871AlaAsp: 3.871 ± 0.085
4.858AlaGlu: 4.858 ± 0.117
3.272AlaPhe: 3.272 ± 0.077
5.33AlaGly: 5.33 ± 0.103
1.32AlaHis: 1.32 ± 0.051
5.578AlaIle: 5.578 ± 0.114
5.369AlaLys: 5.369 ± 0.112
7.09AlaLeu: 7.09 ± 0.146
1.784AlaMet: 1.784 ± 0.06
3.223AlaAsn: 3.223 ± 0.081
1.877AlaPro: 1.877 ± 0.065
2.929AlaGln: 2.929 ± 0.082
2.813AlaArg: 2.813 ± 0.085
4.226AlaSer: 4.226 ± 0.097
4.193AlaThr: 4.193 ± 0.108
5.027AlaVal: 5.027 ± 0.095
0.595AlaTrp: 0.595 ± 0.034
2.629AlaTyr: 2.629 ± 0.058
0.0AlaXaa: 0.0 ± 0.0
Cys
0.326CysAla: 0.326 ± 0.024
0.063CysCys: 0.063 ± 0.009
0.304CysAsp: 0.304 ± 0.023
0.29CysGlu: 0.29 ± 0.022
0.281CysPhe: 0.281 ± 0.024
0.467CysGly: 0.467 ± 0.028
0.192CysHis: 0.192 ± 0.02
0.398CysIle: 0.398 ± 0.032
0.31CysLys: 0.31 ± 0.028
0.694CysLeu: 0.694 ± 0.038
0.147CysMet: 0.147 ± 0.017
0.216CysAsn: 0.216 ± 0.022
0.239CysPro: 0.239 ± 0.019
0.277CysGln: 0.277 ± 0.023
0.222CysArg: 0.222 ± 0.02
0.45CysSer: 0.45 ± 0.029
0.253CysThr: 0.253 ± 0.021
0.349CysVal: 0.349 ± 0.026
0.061CysTrp: 0.061 ± 0.01
0.249CysTyr: 0.249 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
3.237AspAla: 3.237 ± 0.077
0.298AspCys: 0.298 ± 0.023
2.735AspAsp: 2.735 ± 0.081
4.256AspGlu: 4.256 ± 0.099
3.236AspPhe: 3.236 ± 0.079
3.543AspGly: 3.543 ± 0.089
0.853AspHis: 0.853 ± 0.038
4.202AspIle: 4.202 ± 0.096
4.228AspLys: 4.228 ± 0.085
5.549AspLeu: 5.549 ± 0.102
1.381AspMet: 1.381 ± 0.051
2.37AspAsn: 2.37 ± 0.064
1.42AspPro: 1.42 ± 0.062
1.692AspGln: 1.692 ± 0.056
2.004AspArg: 2.004 ± 0.061
2.855AspSer: 2.855 ± 0.071
2.777AspThr: 2.777 ± 0.075
3.698AspVal: 3.698 ± 0.082
0.654AspTrp: 0.654 ± 0.036
2.74AspTyr: 2.74 ± 0.076
0.0AspXaa: 0.0 ± 0.0
Glu
5.13GluAla: 5.13 ± 0.118
0.277GluCys: 0.277 ± 0.026
3.424GluAsp: 3.424 ± 0.101
5.894GluGlu: 5.894 ± 0.119
2.915GluPhe: 2.915 ± 0.077
3.342GluGly: 3.342 ± 0.089
1.369GluHis: 1.369 ± 0.056
5.538GluIle: 5.538 ± 0.107
6.564GluLys: 6.564 ± 0.112
6.963GluLeu: 6.963 ± 0.121
1.922GluMet: 1.922 ± 0.059
4.178GluAsn: 4.178 ± 0.09
1.476GluPro: 1.476 ± 0.061
3.068GluGln: 3.068 ± 0.094
3.295GluArg: 3.295 ± 0.09
3.19GluSer: 3.19 ± 0.079
3.659GluThr: 3.659 ± 0.086
4.778GluVal: 4.778 ± 0.103
0.537GluTrp: 0.537 ± 0.03
2.193GluTyr: 2.193 ± 0.071
0.0GluXaa: 0.0 ± 0.0
Phe
3.311PheAla: 3.311 ± 0.086
0.326PheCys: 0.326 ± 0.029
2.972PheAsp: 2.972 ± 0.077
3.14PheGlu: 3.14 ± 0.081
2.369PhePhe: 2.369 ± 0.079
3.127PheGly: 3.127 ± 0.088
0.874PheHis: 0.874 ± 0.04
3.454PheIle: 3.454 ± 0.09
2.632PheLys: 2.632 ± 0.056
4.779PheLeu: 4.779 ± 0.127
1.074PheMet: 1.074 ± 0.043
2.069PheAsn: 2.069 ± 0.062
1.558PhePro: 1.558 ± 0.062
1.634PheGln: 1.634 ± 0.05
1.641PheArg: 1.641 ± 0.048
3.49PheSer: 3.49 ± 0.086
2.568PheThr: 2.568 ± 0.067
3.251PheVal: 3.251 ± 0.081
0.466PheTrp: 0.466 ± 0.034
2.02PheTyr: 2.02 ± 0.063
0.0PheXaa: 0.0 ± 0.0
Gly
4.371GlyAla: 4.371 ± 0.105
0.385GlyCys: 0.385 ± 0.029
3.136GlyAsp: 3.136 ± 0.079
3.832GlyGlu: 3.832 ± 0.084
3.173GlyPhe: 3.173 ± 0.081
4.076GlyGly: 4.076 ± 0.117
1.24GlyHis: 1.24 ± 0.048
5.367GlyIle: 5.367 ± 0.101
5.053GlyLys: 5.053 ± 0.115
6.469GlyLeu: 6.469 ± 0.126
1.68GlyMet: 1.68 ± 0.061
2.873GlyAsn: 2.873 ± 0.081
1.228GlyPro: 1.228 ± 0.048
2.824GlyGln: 2.824 ± 0.073
2.738GlyArg: 2.738 ± 0.078
3.64GlySer: 3.64 ± 0.081
3.804GlyThr: 3.804 ± 0.096
4.675GlyVal: 4.675 ± 0.099
0.624GlyTrp: 0.624 ± 0.034
2.686GlyTyr: 2.686 ± 0.085
0.0GlyXaa: 0.0 ± 0.0
His
1.183HisAla: 1.183 ± 0.042
0.134HisCys: 0.134 ± 0.016
0.999HisAsp: 0.999 ± 0.042
1.156HisGlu: 1.156 ± 0.046
1.148HisPhe: 1.148 ± 0.048
1.226HisGly: 1.226 ± 0.047
0.584HisHis: 0.584 ± 0.029
1.423HisIle: 1.423 ± 0.053
1.043HisLys: 1.043 ± 0.042
2.175HisLeu: 2.175 ± 0.059
0.412HisMet: 0.412 ± 0.025
0.815HisAsn: 0.815 ± 0.04
0.923HisPro: 0.923 ± 0.043
0.973HisGln: 0.973 ± 0.042
0.818HisArg: 0.818 ± 0.045
1.167HisSer: 1.167 ± 0.05
0.961HisThr: 0.961 ± 0.045
1.125HisVal: 1.125 ± 0.042
0.173HisTrp: 0.173 ± 0.019
1.047HisTyr: 1.047 ± 0.046
0.0HisXaa: 0.0 ± 0.0
Ile
5.993IleAla: 5.993 ± 0.103
0.595IleCys: 0.595 ± 0.034
4.148IleAsp: 4.148 ± 0.092
5.046IleGlu: 5.046 ± 0.12
3.789IlePhe: 3.789 ± 0.099
4.976IleGly: 4.976 ± 0.112
1.498IleHis: 1.498 ± 0.052
5.439IleIle: 5.439 ± 0.128
4.778IleLys: 4.778 ± 0.103
7.978IleLeu: 7.978 ± 0.152
1.612IleMet: 1.612 ± 0.054
3.284IleAsn: 3.284 ± 0.076
2.915IlePro: 2.915 ± 0.069
2.901IleGln: 2.901 ± 0.074
3.03IleArg: 3.03 ± 0.074
5.149IleSer: 5.149 ± 0.106
3.947IleThr: 3.947 ± 0.094
5.163IleVal: 5.163 ± 0.095
0.696IleTrp: 0.696 ± 0.039
2.936IleTyr: 2.936 ± 0.074
0.0IleXaa: 0.0 ± 0.0
Lys
4.971LysAla: 4.971 ± 0.107
0.258LysCys: 0.258 ± 0.024
4.083LysAsp: 4.083 ± 0.087
6.632LysGlu: 6.632 ± 0.138
2.4LysPhe: 2.4 ± 0.067
4.087LysGly: 4.087 ± 0.091
1.312LysHis: 1.312 ± 0.049
5.425LysIle: 5.425 ± 0.097
6.387LysLys: 6.387 ± 0.13
6.278LysLeu: 6.278 ± 0.106
2.227LysMet: 2.227 ± 0.056
4.27LysAsn: 4.27 ± 0.101
1.978LysPro: 1.978 ± 0.058
3.035LysGln: 3.035 ± 0.081
3.302LysArg: 3.302 ± 0.078
4.01LysSer: 4.01 ± 0.104
4.115LysThr: 4.115 ± 0.092
4.957LysVal: 4.957 ± 0.108
0.624LysTrp: 0.624 ± 0.032
2.677LysTyr: 2.677 ± 0.081
0.0LysXaa: 0.0 ± 0.0
Leu
8.257LeuAla: 8.257 ± 0.141
0.598LeuCys: 0.598 ± 0.034
5.463LeuAsp: 5.463 ± 0.105
6.881LeuGlu: 6.881 ± 0.127
4.589LeuPhe: 4.589 ± 0.129
6.143LeuGly: 6.143 ± 0.131
1.723LeuHis: 1.723 ± 0.055
6.818LeuIle: 6.818 ± 0.156
6.923LeuLys: 6.923 ± 0.104
10.268LeuLeu: 10.268 ± 0.199
2.493LeuMet: 2.493 ± 0.071
4.458LeuAsn: 4.458 ± 0.086
3.968LeuPro: 3.968 ± 0.076
3.649LeuGln: 3.649 ± 0.082
3.708LeuArg: 3.708 ± 0.09
7.092LeuSer: 7.092 ± 0.157
6.459LeuThr: 6.459 ± 0.113
6.593LeuVal: 6.593 ± 0.116
0.703LeuTrp: 0.703 ± 0.034
3.407LeuTyr: 3.407 ± 0.08
0.0LeuXaa: 0.0 ± 0.0
Met
1.879MetAla: 1.879 ± 0.062
0.136MetCys: 0.136 ± 0.017
1.289MetAsp: 1.289 ± 0.053
1.538MetGlu: 1.538 ± 0.058
0.856MetPhe: 0.856 ± 0.04
1.629MetGly: 1.629 ± 0.06
0.361MetHis: 0.361 ± 0.023
2.027MetIle: 2.027 ± 0.061
2.138MetLys: 2.138 ± 0.063
2.337MetLeu: 2.337 ± 0.073
0.752MetMet: 0.752 ± 0.035
1.366MetAsn: 1.366 ± 0.044
0.767MetPro: 0.767 ± 0.036
0.907MetGln: 0.907 ± 0.035
1.02MetArg: 1.02 ± 0.039
1.552MetSer: 1.552 ± 0.063
1.8MetThr: 1.8 ± 0.056
1.556MetVal: 1.556 ± 0.049
0.19MetTrp: 0.19 ± 0.017
0.642MetTyr: 0.642 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
2.977AsnAla: 2.977 ± 0.073
0.295AsnCys: 0.295 ± 0.024
2.356AsnAsp: 2.356 ± 0.065
2.737AsnGlu: 2.737 ± 0.072
2.189AsnPhe: 2.189 ± 0.063
3.745AsnGly: 3.745 ± 0.095
1.167AsnHis: 1.167 ± 0.043
3.797AsnIle: 3.797 ± 0.081
3.3AsnLys: 3.3 ± 0.095
4.886AsnLeu: 4.886 ± 0.097
1.136AsnMet: 1.136 ± 0.046
2.336AsnAsn: 2.336 ± 0.086
2.229AsnPro: 2.229 ± 0.068
2.259AsnGln: 2.259 ± 0.068
2.17AsnArg: 2.17 ± 0.067
2.725AsnSer: 2.725 ± 0.082
2.383AsnThr: 2.383 ± 0.069
3.028AsnVal: 3.028 ± 0.075
0.541AsnTrp: 0.541 ± 0.033
2.027AsnTyr: 2.027 ± 0.073
0.0AsnXaa: 0.0 ± 0.0
Pro
2.28ProAla: 2.28 ± 0.066
0.14ProCys: 0.14 ± 0.017
1.94ProAsp: 1.94 ± 0.06
2.555ProGlu: 2.555 ± 0.07
1.608ProPhe: 1.608 ± 0.061
1.615ProGly: 1.615 ± 0.055
0.687ProHis: 0.687 ± 0.037
2.545ProIle: 2.545 ± 0.069
2.123ProLys: 2.123 ± 0.072
2.786ProLeu: 2.786 ± 0.065
0.684ProMet: 0.684 ± 0.032
1.72ProAsn: 1.72 ± 0.063
0.523ProPro: 0.523 ± 0.031
1.217ProGln: 1.217 ± 0.051
0.942ProArg: 0.942 ± 0.043
2.032ProSer: 2.032 ± 0.064
2.006ProThr: 2.006 ± 0.061
2.247ProVal: 2.247 ± 0.073
0.281ProTrp: 0.281 ± 0.023
1.352ProTyr: 1.352 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
3.382GlnAla: 3.382 ± 0.085
0.157GlnCys: 0.157 ± 0.016
1.995GlnAsp: 1.995 ± 0.059
3.054GlnGlu: 3.054 ± 0.088
1.674GlnPhe: 1.674 ± 0.061
2.299GlnGly: 2.299 ± 0.061
0.827GlnHis: 0.827 ± 0.036
3.136GlnIle: 3.136 ± 0.087
3.136GlnLys: 3.136 ± 0.076
4.092GlnLeu: 4.092 ± 0.109
1.01GlnMet: 1.01 ± 0.041
1.933GlnAsn: 1.933 ± 0.069
1.109GlnPro: 1.109 ± 0.046
1.661GlnGln: 1.661 ± 0.062
1.519GlnArg: 1.519 ± 0.049
2.186GlnSer: 2.186 ± 0.069
2.432GlnThr: 2.432 ± 0.067
3.052GlnVal: 3.052 ± 0.074
0.297GlnTrp: 0.297 ± 0.024
1.453GlnTyr: 1.453 ± 0.052
0.0GlnXaa: 0.0 ± 0.0
Arg
2.601ArgAla: 2.601 ± 0.08
0.23ArgCys: 0.23 ± 0.022
2.105ArgAsp: 2.105 ± 0.065
3.061ArgGlu: 3.061 ± 0.092
1.99ArgPhe: 1.99 ± 0.063
2.269ArgGly: 2.269 ± 0.062
0.879ArgHis: 0.879 ± 0.043
3.091ArgIle: 3.091 ± 0.073
3.101ArgLys: 3.101 ± 0.075
4.141ArgLeu: 4.141 ± 0.094
1.158ArgMet: 1.158 ± 0.047
1.999ArgAsn: 1.999 ± 0.064
1.209ArgPro: 1.209 ± 0.048
1.854ArgGln: 1.854 ± 0.052
1.924ArgArg: 1.924 ± 0.068
2.222ArgSer: 2.222 ± 0.072
2.02ArgThr: 2.02 ± 0.061
2.648ArgVal: 2.648 ± 0.072
0.314ArgTrp: 0.314 ± 0.024
1.681ArgTyr: 1.681 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
3.715SerAla: 3.715 ± 0.085
0.37SerCys: 0.37 ± 0.026
3.284SerAsp: 3.284 ± 0.08
3.574SerGlu: 3.574 ± 0.086
3.07SerPhe: 3.07 ± 0.078
4.366SerGly: 4.366 ± 0.089
1.279SerHis: 1.279 ± 0.052
4.551SerIle: 4.551 ± 0.105
4.361SerLys: 4.361 ± 0.101
6.253SerLeu: 6.253 ± 0.118
1.504SerMet: 1.504 ± 0.054
2.944SerAsn: 2.944 ± 0.084
1.77SerPro: 1.77 ± 0.054
2.789SerGln: 2.789 ± 0.087
2.498SerArg: 2.498 ± 0.071
4.273SerSer: 4.273 ± 0.121
3.328SerThr: 3.328 ± 0.08
3.972SerVal: 3.972 ± 0.093
0.595SerTrp: 0.595 ± 0.033
2.623SerTyr: 2.623 ± 0.075
0.0SerXaa: 0.0 ± 0.0
Thr
4.233ThrAla: 4.233 ± 0.095
0.319ThrCys: 0.319 ± 0.026
3.15ThrAsp: 3.15 ± 0.078
3.433ThrGlu: 3.433 ± 0.084
2.733ThrPhe: 2.733 ± 0.073
4.136ThrGly: 4.136 ± 0.094
1.069ThrHis: 1.069 ± 0.043
4.776ThrIle: 4.776 ± 0.11
3.659ThrLys: 3.659 ± 0.104
5.432ThrLeu: 5.432 ± 0.104
1.146ThrMet: 1.146 ± 0.042
2.669ThrAsn: 2.669 ± 0.074
2.254ThrPro: 2.254 ± 0.068
1.784ThrGln: 1.784 ± 0.062
2.006ThrArg: 2.006 ± 0.067
3.677ThrSer: 3.677 ± 0.083
3.325ThrThr: 3.325 ± 0.097
4.423ThrVal: 4.423 ± 0.114
0.541ThrTrp: 0.541 ± 0.03
2.281ThrTyr: 2.281 ± 0.074
0.0ThrXaa: 0.0 ± 0.0
Val
5.489ValAla: 5.489 ± 0.114
0.44ValCys: 0.44 ± 0.026
3.67ValAsp: 3.67 ± 0.081
4.69ValGlu: 4.69 ± 0.099
2.929ValPhe: 2.929 ± 0.073
4.382ValGly: 4.382 ± 0.104
1.146ValHis: 1.146 ± 0.046
4.99ValIle: 4.99 ± 0.091
4.84ValLys: 4.84 ± 0.089
6.783ValLeu: 6.783 ± 0.108
1.579ValMet: 1.579 ± 0.053
3.15ValAsn: 3.15 ± 0.073
2.252ValPro: 2.252 ± 0.058
2.292ValGln: 2.292 ± 0.063
2.815ValArg: 2.815 ± 0.077
4.383ValSer: 4.383 ± 0.091
4.401ValThr: 4.401 ± 0.11
4.847ValVal: 4.847 ± 0.101
0.529ValTrp: 0.529 ± 0.033
2.421ValTyr: 2.421 ± 0.07
0.0ValXaa: 0.0 ± 0.0
Trp
0.53TrpAla: 0.53 ± 0.034
0.061TrpCys: 0.061 ± 0.01
0.466TrpAsp: 0.466 ± 0.03
0.572TrpGlu: 0.572 ± 0.039
0.445TrpPhe: 0.445 ± 0.029
0.619TrpGly: 0.619 ± 0.037
0.176TrpHis: 0.176 ± 0.018
0.666TrpIle: 0.666 ± 0.036
0.605TrpLys: 0.605 ± 0.036
1.02TrpLeu: 1.02 ± 0.045
0.23TrpMet: 0.23 ± 0.022
0.532TrpAsn: 0.532 ± 0.033
0.181TrpPro: 0.181 ± 0.016
0.422TrpGln: 0.422 ± 0.025
0.394TrpArg: 0.394 ± 0.03
0.558TrpSer: 0.558 ± 0.04
0.474TrpThr: 0.474 ± 0.029
0.457TrpVal: 0.457 ± 0.031
0.129TrpTrp: 0.129 ± 0.014
0.419TrpTyr: 0.419 ± 0.032
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.585TyrAla: 2.585 ± 0.063
0.239TyrCys: 0.239 ± 0.02
2.337TyrAsp: 2.337 ± 0.068
2.512TyrGlu: 2.512 ± 0.066
2.09TyrPhe: 2.09 ± 0.059
2.498TyrGly: 2.498 ± 0.078
0.928TyrHis: 0.928 ± 0.048
2.651TyrIle: 2.651 ± 0.071
2.477TyrLys: 2.477 ± 0.066
4.221TyrLeu: 4.221 ± 0.081
0.813TyrMet: 0.813 ± 0.038
1.877TyrAsn: 1.877 ± 0.067
1.406TyrPro: 1.406 ± 0.053
2.236TyrGln: 2.236 ± 0.063
1.64TyrArg: 1.64 ± 0.058
2.24TyrSer: 2.24 ± 0.068
2.142TyrThr: 2.142 ± 0.072
2.182TyrVal: 2.182 ± 0.057
0.41TyrTrp: 0.41 ± 0.027
1.708TyrTyr: 1.708 ± 0.06
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1812 proteins (573309 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski