Amino acid dipepetide frequency for Arthrobacter echini

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.255AlaAla: 18.255 ± 0.213	0.738AlaCys: 0.738 ± 0.037	7.512AlaAsp: 7.512 ± 0.088	7.81AlaGlu: 7.81 ± 0.1	3.616AlaPhe: 3.616 ± 0.067	12.322AlaGly: 12.322 ± 0.133	2.31AlaHis: 2.31 ± 0.051	4.586AlaIle: 4.586 ± 0.081	2.298AlaLys: 2.298 ± 0.064	13.38AlaLeu: 13.38 ± 0.151	2.524AlaMet: 2.524 ± 0.054	2.085AlaAsn: 2.085 ± 0.049	6.066AlaPro: 6.066 ± 0.112	3.912AlaGln: 3.912 ± 0.059	8.592AlaArg: 8.592 ± 0.117	6.904AlaSer: 6.904 ± 0.083	6.626AlaThr: 6.626 ± 0.094	11.453AlaVal: 11.453 ± 0.13	1.611AlaTrp: 1.611 ± 0.048	2.254AlaTyr: 2.254 ± 0.059	0.001AlaXaa: 0.001 ± 0.001
Cys	0.661CysAla: 0.661 ± 0.026	0.057CysCys: 0.057 ± 0.01	0.309CysAsp: 0.309 ± 0.019	0.284CysGlu: 0.284 ± 0.019	0.172CysPhe: 0.172 ± 0.013	0.616CysGly: 0.616 ± 0.028	0.114CysHis: 0.114 ± 0.012	0.244CysIle: 0.244 ± 0.016	0.08CysLys: 0.08 ± 0.009	0.542CysLeu: 0.542 ± 0.024	0.091CysMet: 0.091 ± 0.01	0.106CysAsn: 0.106 ± 0.01	0.35CysPro: 0.35 ± 0.021	0.147CysGln: 0.147 ± 0.012	0.429CysArg: 0.429 ± 0.023	0.436CysSer: 0.436 ± 0.022	0.38CysThr: 0.38 ± 0.021	0.437CysVal: 0.437 ± 0.024	0.087CysTrp: 0.087 ± 0.011	0.12CysTyr: 0.12 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.123AspAla: 8.123 ± 0.108	0.282AspCys: 0.282 ± 0.018	4.32AspAsp: 4.32 ± 0.074	4.02AspGlu: 4.02 ± 0.074	1.838AspPhe: 1.838 ± 0.047	6.024AspGly: 6.024 ± 0.079	1.349AspHis: 1.349 ± 0.044	2.359AspIle: 2.359 ± 0.051	1.0AspLys: 1.0 ± 0.038	6.347AspLeu: 6.347 ± 0.088	0.907AspMet: 0.907 ± 0.029	0.971AspAsn: 0.971 ± 0.04	4.14AspPro: 4.14 ± 0.08	1.928AspGln: 1.928 ± 0.051	4.448AspArg: 4.448 ± 0.067	3.027AspSer: 3.027 ± 0.064	3.178AspThr: 3.178 ± 0.066	5.455AspVal: 5.455 ± 0.087	0.848AspTrp: 0.848 ± 0.032	1.282AspTyr: 1.282 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	7.014GluAla: 7.014 ± 0.109	0.305GluCys: 0.305 ± 0.02	3.651GluAsp: 3.651 ± 0.071	3.61GluGlu: 3.61 ± 0.078	1.641GluPhe: 1.641 ± 0.046	4.447GluGly: 4.447 ± 0.076	1.511GluHis: 1.511 ± 0.041	2.619GluIle: 2.619 ± 0.054	1.488GluLys: 1.488 ± 0.042	6.87GluLeu: 6.87 ± 0.091	0.906GluMet: 0.906 ± 0.033	1.495GluAsn: 1.495 ± 0.04	3.19GluPro: 3.19 ± 0.07	2.624GluGln: 2.624 ± 0.063	4.907GluArg: 4.907 ± 0.081	3.073GluSer: 3.073 ± 0.064	3.013GluThr: 3.013 ± 0.06	4.607GluVal: 4.607 ± 0.068	0.7GluTrp: 0.7 ± 0.028	1.121GluTyr: 1.121 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.665PheAla: 3.665 ± 0.06	0.222PheCys: 0.222 ± 0.017	2.355PheAsp: 2.355 ± 0.05	1.756PheGlu: 1.756 ± 0.045	1.088PhePhe: 1.088 ± 0.043	3.112PheGly: 3.112 ± 0.063	0.586PheHis: 0.586 ± 0.026	1.248PheIle: 1.248 ± 0.045	0.523PheLys: 0.523 ± 0.025	3.088PheLeu: 3.088 ± 0.069	0.499PheMet: 0.499 ± 0.025	0.735PheAsn: 0.735 ± 0.026	1.367PhePro: 1.367 ± 0.044	0.736PheGln: 0.736 ± 0.026	1.816PheArg: 1.816 ± 0.045	2.092PheSer: 2.092 ± 0.045	2.106PheThr: 2.106 ± 0.051	2.632PheVal: 2.632 ± 0.054	0.439PheTrp: 0.439 ± 0.025	0.629PheTyr: 0.629 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	10.24GlyAla: 10.24 ± 0.122	0.594GlyCys: 0.594 ± 0.028	4.622GlyAsp: 4.622 ± 0.083	4.821GlyGlu: 4.821 ± 0.079	3.205GlyPhe: 3.205 ± 0.061	7.526GlyGly: 7.526 ± 0.126	1.861GlyHis: 1.861 ± 0.052	4.519GlyIle: 4.519 ± 0.073	2.15GlyLys: 2.15 ± 0.056	8.986GlyLeu: 8.986 ± 0.116	1.956GlyMet: 1.956 ± 0.045	1.834GlyAsn: 1.834 ± 0.046	4.171GlyPro: 4.171 ± 0.072	2.688GlyGln: 2.688 ± 0.056	6.741GlyArg: 6.741 ± 0.099	6.394GlySer: 6.394 ± 0.094	6.241GlyThr: 6.241 ± 0.088	7.701GlyVal: 7.701 ± 0.098	1.498GlyTrp: 1.498 ± 0.04	2.154GlyTyr: 2.154 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.341HisAla: 2.341 ± 0.051	0.16HisCys: 0.16 ± 0.013	1.276HisAsp: 1.276 ± 0.04	1.23HisGlu: 1.23 ± 0.038	0.583HisPhe: 0.583 ± 0.024	2.018HisGly: 2.018 ± 0.056	0.648HisHis: 0.648 ± 0.028	0.713HisIle: 0.713 ± 0.032	0.318HisLys: 0.318 ± 0.02	2.228HisLeu: 2.228 ± 0.054	0.322HisMet: 0.322 ± 0.019	0.379HisAsn: 0.379 ± 0.022	1.439HisPro: 1.439 ± 0.044	0.603HisGln: 0.603 ± 0.022	1.764HisArg: 1.764 ± 0.048	1.156HisSer: 1.156 ± 0.04	1.129HisThr: 1.129 ± 0.035	1.638HisVal: 1.638 ± 0.044	0.287HisTrp: 0.287 ± 0.019	0.44HisTyr: 0.44 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.614IleAla: 5.614 ± 0.083	0.276IleCys: 0.276 ± 0.017	3.175IleAsp: 3.175 ± 0.07	2.6IleGlu: 2.6 ± 0.053	1.279IlePhe: 1.279 ± 0.045	4.406IleGly: 4.406 ± 0.077	0.73IleHis: 0.73 ± 0.029	1.884IleIle: 1.884 ± 0.067	0.799IleLys: 0.799 ± 0.033	4.063IleLeu: 4.063 ± 0.073	0.713IleMet: 0.713 ± 0.028	1.03IleAsn: 1.03 ± 0.034	2.165IlePro: 2.165 ± 0.052	0.982IleGln: 0.982 ± 0.033	2.851IleArg: 2.851 ± 0.052	2.589IleSer: 2.589 ± 0.054	2.963IleThr: 2.963 ± 0.069	3.617IleVal: 3.617 ± 0.073	0.457IleTrp: 0.457 ± 0.028	0.746IleTyr: 0.746 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	2.475LysAla: 2.475 ± 0.064	0.065LysCys: 0.065 ± 0.008	1.302LysAsp: 1.302 ± 0.047	1.086LysGlu: 1.086 ± 0.036	0.473LysPhe: 0.473 ± 0.024	1.589LysGly: 1.589 ± 0.047	0.459LysHis: 0.459 ± 0.024	0.997LysIle: 0.997 ± 0.032	0.73LysLys: 0.73 ± 0.035	1.968LysLeu: 1.968 ± 0.047	0.37LysMet: 0.37 ± 0.019	0.571LysAsn: 0.571 ± 0.027	1.148LysPro: 1.148 ± 0.038	0.72LysGln: 0.72 ± 0.03	1.484LysArg: 1.484 ± 0.046	1.121LysSer: 1.121 ± 0.033	1.232LysThr: 1.232 ± 0.046	1.557LysVal: 1.557 ± 0.043	0.229LysTrp: 0.229 ± 0.017	0.483LysTyr: 0.483 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.648LeuAla: 13.648 ± 0.143	0.552LeuCys: 0.552 ± 0.026	6.704LeuAsp: 6.704 ± 0.079	5.925LeuGlu: 5.925 ± 0.101	2.91LeuPhe: 2.91 ± 0.073	9.459LeuGly: 9.459 ± 0.107	2.14LeuHis: 2.14 ± 0.052	4.411LeuIle: 4.411 ± 0.075	1.951LeuLys: 1.951 ± 0.049	11.179LeuLeu: 11.179 ± 0.149	1.824LeuMet: 1.824 ± 0.043	2.016LeuAsn: 2.016 ± 0.05	5.865LeuPro: 5.865 ± 0.085	2.876LeuGln: 2.876 ± 0.059	7.751LeuArg: 7.751 ± 0.108	6.129LeuSer: 6.129 ± 0.081	6.689LeuThr: 6.689 ± 0.088	9.228LeuVal: 9.228 ± 0.111	1.196LeuTrp: 1.196 ± 0.041	1.793LeuTyr: 1.793 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.296MetAla: 2.296 ± 0.051	0.104MetCys: 0.104 ± 0.011	1.018MetAsp: 1.018 ± 0.036	0.886MetGlu: 0.886 ± 0.039	0.509MetPhe: 0.509 ± 0.024	1.464MetGly: 1.464 ± 0.041	0.341MetHis: 0.341 ± 0.019	0.94MetIle: 0.94 ± 0.031	0.505MetLys: 0.505 ± 0.023	1.868MetLeu: 1.868 ± 0.048	0.344MetMet: 0.344 ± 0.02	0.536MetAsn: 0.536 ± 0.021	1.02MetPro: 1.02 ± 0.033	0.523MetGln: 0.523 ± 0.026	1.297MetArg: 1.297 ± 0.033	1.5MetSer: 1.5 ± 0.036	1.564MetThr: 1.564 ± 0.041	1.465MetVal: 1.465 ± 0.042	0.163MetTrp: 0.163 ± 0.014	0.294MetTyr: 0.294 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.438AsnAla: 2.438 ± 0.055	0.131AsnCys: 0.131 ± 0.011	1.172AsnAsp: 1.172 ± 0.035	1.126AsnGlu: 1.126 ± 0.037	0.646AsnPhe: 0.646 ± 0.027	1.848AsnGly: 1.848 ± 0.049	0.48AsnHis: 0.48 ± 0.02	0.903AsnIle: 0.903 ± 0.033	0.397AsnLys: 0.397 ± 0.022	2.155AsnLeu: 2.155 ± 0.041	0.346AsnMet: 0.346 ± 0.021	0.543AsnAsn: 0.543 ± 0.024	1.589AsnPro: 1.589 ± 0.039	0.638AsnGln: 0.638 ± 0.03	1.557AsnArg: 1.557 ± 0.046	1.178AsnSer: 1.178 ± 0.04	1.242AsnThr: 1.242 ± 0.039	1.541AsnVal: 1.541 ± 0.048	0.29AsnTrp: 0.29 ± 0.019	0.469AsnTyr: 0.469 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	7.129ProAla: 7.129 ± 0.106	0.217ProCys: 0.217 ± 0.016	3.965ProAsp: 3.965 ± 0.078	4.079ProGlu: 4.079 ± 0.065	1.651ProPhe: 1.651 ± 0.039	5.538ProGly: 5.538 ± 0.072	1.074ProHis: 1.074 ± 0.031	1.749ProIle: 1.749 ± 0.045	0.982ProLys: 0.982 ± 0.04	4.837ProLeu: 4.837 ± 0.068	0.985ProMet: 0.985 ± 0.034	0.934ProAsn: 0.934 ± 0.033	2.473ProPro: 2.473 ± 0.066	1.571ProGln: 1.571 ± 0.04	3.279ProArg: 3.279 ± 0.067	3.373ProSer: 3.373 ± 0.068	3.301ProThr: 3.301 ± 0.065	5.067ProVal: 5.067 ± 0.082	0.769ProTrp: 0.769 ± 0.028	1.027ProTyr: 1.027 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.544GlnAla: 3.544 ± 0.064	0.146GlnCys: 0.146 ± 0.015	1.848GlnAsp: 1.848 ± 0.051	1.865GlnGlu: 1.865 ± 0.048	0.867GlnPhe: 0.867 ± 0.029	2.396GlnGly: 2.396 ± 0.048	0.719GlnHis: 0.719 ± 0.03	1.358GlnIle: 1.358 ± 0.038	0.68GlnLys: 0.68 ± 0.032	3.501GlnLeu: 3.501 ± 0.063	0.56GlnMet: 0.56 ± 0.023	0.68GlnAsn: 0.68 ± 0.028	1.519GlnPro: 1.519 ± 0.044	1.5GlnGln: 1.5 ± 0.044	2.608GlnArg: 2.608 ± 0.054	1.601GlnSer: 1.601 ± 0.045	1.431GlnThr: 1.431 ± 0.041	2.521GlnVal: 2.521 ± 0.048	0.546GlnTrp: 0.546 ± 0.022	0.698GlnTyr: 0.698 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	8.161ArgAla: 8.161 ± 0.108	0.397ArgCys: 0.397 ± 0.026	4.016ArgAsp: 4.016 ± 0.071	4.31ArgGlu: 4.31 ± 0.064	2.371ArgPhe: 2.371 ± 0.051	5.216ArgGly: 5.216 ± 0.081	1.567ArgHis: 1.567 ± 0.046	3.74ArgIle: 3.74 ± 0.064	1.668ArgLys: 1.668 ± 0.045	7.479ArgLeu: 7.479 ± 0.102	1.711ArgMet: 1.711 ± 0.046	1.661ArgAsn: 1.661 ± 0.046	3.717ArgPro: 3.717 ± 0.073	2.393ArgGln: 2.393 ± 0.051	6.803ArgArg: 6.803 ± 0.122	5.042ArgSer: 5.042 ± 0.078	4.86ArgThr: 4.86 ± 0.086	5.556ArgVal: 5.556 ± 0.078	1.201ArgTrp: 1.201 ± 0.034	1.616ArgTyr: 1.616 ± 0.045	0.001ArgXaa: 0.001 ± 0.001
Ser	7.656SerAla: 7.656 ± 0.118	0.362SerCys: 0.362 ± 0.022	3.296SerAsp: 3.296 ± 0.07	3.132SerGlu: 3.132 ± 0.071	2.066SerPhe: 2.066 ± 0.053	6.178SerGly: 6.178 ± 0.093	1.143SerHis: 1.143 ± 0.037	2.623SerIle: 2.623 ± 0.059	1.168SerLys: 1.168 ± 0.043	5.838SerLeu: 5.838 ± 0.094	1.362SerMet: 1.362 ± 0.045	1.248SerAsn: 1.248 ± 0.035	3.29SerPro: 3.29 ± 0.058	1.525SerGln: 1.525 ± 0.038	4.285SerArg: 4.285 ± 0.076	4.301SerSer: 4.301 ± 0.085	4.167SerThr: 4.167 ± 0.069	5.106SerVal: 5.106 ± 0.072	0.995SerTrp: 0.995 ± 0.034	1.406SerTyr: 1.406 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	7.937ThrAla: 7.937 ± 0.103	0.32ThrCys: 0.32 ± 0.02	3.762ThrAsp: 3.762 ± 0.061	3.372ThrGlu: 3.372 ± 0.071	1.816ThrPhe: 1.816 ± 0.048	5.988ThrGly: 5.988 ± 0.075	1.166ThrHis: 1.166 ± 0.038	2.7ThrIle: 2.7 ± 0.055	1.16ThrLys: 1.16 ± 0.036	5.934ThrLeu: 5.934 ± 0.086	1.103ThrMet: 1.103 ± 0.034	1.22ThrAsn: 1.22 ± 0.035	3.921ThrPro: 3.921 ± 0.071	1.617ThrGln: 1.617 ± 0.041	3.925ThrArg: 3.925 ± 0.071	3.783ThrSer: 3.783 ± 0.072	4.185ThrThr: 4.185 ± 0.084	5.579ThrVal: 5.579 ± 0.08	0.769ThrTrp: 0.769 ± 0.026	1.284ThrTyr: 1.284 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	9.991ValAla: 9.991 ± 0.118	0.487ValCys: 0.487 ± 0.024	5.473ValAsp: 5.473 ± 0.082	5.077ValGlu: 5.077 ± 0.081	2.694ValPhe: 2.694 ± 0.054	6.966ValGly: 6.966 ± 0.09	1.838ValHis: 1.838 ± 0.041	4.081ValIle: 4.081 ± 0.069	1.53ValLys: 1.53 ± 0.047	10.088ValLeu: 10.088 ± 0.119	1.572ValMet: 1.572 ± 0.044	1.782ValAsn: 1.782 ± 0.044	4.876ValPro: 4.876 ± 0.074	2.434ValGln: 2.434 ± 0.052	6.14ValArg: 6.14 ± 0.095	5.29ValSer: 5.29 ± 0.079	5.166ValThr: 5.166 ± 0.083	8.751ValVal: 8.751 ± 0.12	0.95ValTrp: 0.95 ± 0.029	1.397ValTyr: 1.397 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.376TrpAla: 1.376 ± 0.043	0.094TrpCys: 0.094 ± 0.01	0.782TrpAsp: 0.782 ± 0.028	0.635TrpGlu: 0.635 ± 0.028	0.54TrpPhe: 0.54 ± 0.028	0.892TrpGly: 0.892 ± 0.035	0.307TrpHis: 0.307 ± 0.017	0.63TrpIle: 0.63 ± 0.028	0.321TrpLys: 0.321 ± 0.019	1.675TrpLeu: 1.675 ± 0.048	0.291TrpMet: 0.291 ± 0.019	0.422TrpAsn: 0.422 ± 0.021	0.622TrpPro: 0.622 ± 0.027	0.531TrpGln: 0.531 ± 0.026	1.084TrpArg: 1.084 ± 0.037	0.911TrpSer: 0.911 ± 0.036	0.871TrpThr: 0.871 ± 0.035	1.071TrpVal: 1.071 ± 0.04	0.321TrpTrp: 0.321 ± 0.018	0.287TrpTyr: 0.287 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.292TyrAla: 2.292 ± 0.044	0.154TyrCys: 0.154 ± 0.013	1.286TyrAsp: 1.286 ± 0.036	1.168TyrGlu: 1.168 ± 0.039	0.73TyrPhe: 0.73 ± 0.032	1.897TyrGly: 1.897 ± 0.054	0.33TyrHis: 0.33 ± 0.021	0.634TyrIle: 0.634 ± 0.028	0.31TyrLys: 0.31 ± 0.019	2.22TyrLeu: 2.22 ± 0.051	0.249TyrMet: 0.249 ± 0.017	0.44TyrAsn: 0.44 ± 0.025	1.072TyrPro: 1.072 ± 0.036	0.64TyrGln: 0.64 ± 0.027	1.727TyrArg: 1.727 ± 0.048	1.246TyrSer: 1.246 ± 0.038	1.199TyrThr: 1.199 ± 0.038	1.603TyrVal: 1.603 ± 0.037	0.305TyrTrp: 0.305 ± 0.019	0.494TyrTyr: 0.494 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.001XaaCys: 0.001 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.001

Statistics based on 2848 proteins (924687 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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