Amino acid dipepetide frequency for Edwardsiella phage Edno5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.888AlaAla: 9.888 ± 1.109
0.628AlaCys: 0.628 ± 0.259
4.865AlaAsp: 4.865 ± 0.637
7.612AlaGlu: 7.612 ± 0.897
2.825AlaPhe: 2.825 ± 0.455
6.121AlaGly: 6.121 ± 0.713
1.334AlaHis: 1.334 ± 0.368
6.356AlaIle: 6.356 ± 0.662
4.865AlaLys: 4.865 ± 0.603
7.69AlaLeu: 7.69 ± 0.88
2.904AlaMet: 2.904 ± 0.571
3.217AlaAsn: 3.217 ± 0.619
3.845AlaPro: 3.845 ± 0.504
3.688AlaGln: 3.688 ± 0.598
3.688AlaArg: 3.688 ± 0.55
5.886AlaSer: 5.886 ± 0.585
4.944AlaThr: 4.944 ± 0.658
5.572AlaVal: 5.572 ± 0.706
1.491AlaTrp: 1.491 ± 0.344
3.139AlaTyr: 3.139 ± 0.455
0.0AlaXaa: 0.0 ± 0.0
Cys
1.177CysAla: 1.177 ± 0.278
0.157CysCys: 0.157 ± 0.113
0.549CysAsp: 0.549 ± 0.237
0.785CysGlu: 0.785 ± 0.219
0.314CysPhe: 0.314 ± 0.134
1.256CysGly: 1.256 ± 0.329
0.157CysHis: 0.157 ± 0.102
0.706CysIle: 0.706 ± 0.226
0.549CysLys: 0.549 ± 0.29
0.942CysLeu: 0.942 ± 0.36
0.157CysMet: 0.157 ± 0.112
0.785CysAsn: 0.785 ± 0.24
0.706CysPro: 0.706 ± 0.234
0.471CysGln: 0.471 ± 0.172
1.413CysArg: 1.413 ± 0.48
1.334CysSer: 1.334 ± 0.339
0.628CysThr: 0.628 ± 0.25
0.471CysVal: 0.471 ± 0.165
0.235CysTrp: 0.235 ± 0.129
1.256CysTyr: 1.256 ± 0.337
0.0CysXaa: 0.0 ± 0.0
Asp
4.944AspAla: 4.944 ± 0.653
0.471AspCys: 0.471 ± 0.221
3.845AspAsp: 3.845 ± 0.597
4.002AspGlu: 4.002 ± 0.579
2.511AspPhe: 2.511 ± 0.454
5.258AspGly: 5.258 ± 0.717
0.628AspHis: 0.628 ± 0.255
3.453AspIle: 3.453 ± 0.442
3.688AspLys: 3.688 ± 0.544
5.022AspLeu: 5.022 ± 0.596
2.59AspMet: 2.59 ± 0.384
2.276AspAsn: 2.276 ± 0.404
1.962AspPro: 1.962 ± 0.441
2.119AspGln: 2.119 ± 0.397
1.883AspArg: 1.883 ± 0.376
3.767AspSer: 3.767 ± 0.661
2.119AspThr: 2.119 ± 0.442
3.688AspVal: 3.688 ± 0.652
1.02AspTrp: 1.02 ± 0.278
1.805AspTyr: 1.805 ± 0.395
0.0AspXaa: 0.0 ± 0.0
Glu
4.787GluAla: 4.787 ± 0.604
1.099GluCys: 1.099 ± 0.346
3.139GluAsp: 3.139 ± 0.496
3.531GluGlu: 3.531 ± 0.543
2.668GluPhe: 2.668 ± 0.42
2.904GluGly: 2.904 ± 0.596
1.099GluHis: 1.099 ± 0.27
4.63GluIle: 4.63 ± 0.632
5.022GluLys: 5.022 ± 0.666
5.493GluLeu: 5.493 ± 0.67
1.883GluMet: 1.883 ± 0.371
3.139GluAsn: 3.139 ± 0.401
1.726GluPro: 1.726 ± 0.321
2.119GluGln: 2.119 ± 0.424
4.63GluArg: 4.63 ± 0.688
3.531GluSer: 3.531 ± 0.462
2.668GluThr: 2.668 ± 0.409
3.767GluVal: 3.767 ± 0.496
1.099GluTrp: 1.099 ± 0.268
2.119GluTyr: 2.119 ± 0.314
0.0GluXaa: 0.0 ± 0.0
Phe
2.904PheAla: 2.904 ± 0.439
0.471PheCys: 0.471 ± 0.205
2.04PheAsp: 2.04 ± 0.454
2.04PheGlu: 2.04 ± 0.314
1.726PhePhe: 1.726 ± 0.473
3.296PheGly: 3.296 ± 0.56
0.628PheHis: 0.628 ± 0.238
2.197PheIle: 2.197 ± 0.424
1.962PheLys: 1.962 ± 0.375
2.119PheLeu: 2.119 ± 0.382
1.099PheMet: 1.099 ± 0.267
2.747PheAsn: 2.747 ± 0.531
1.491PhePro: 1.491 ± 0.383
0.863PheGln: 0.863 ± 0.321
2.197PheArg: 2.197 ± 0.44
2.747PheSer: 2.747 ± 0.45
2.982PheThr: 2.982 ± 0.507
1.648PheVal: 1.648 ± 0.362
0.471PheTrp: 0.471 ± 0.186
1.256PheTyr: 1.256 ± 0.315
0.0PheXaa: 0.0 ± 0.0
Gly
5.179GlyAla: 5.179 ± 0.761
1.02GlyCys: 1.02 ± 0.268
4.708GlyAsp: 4.708 ± 0.809
4.081GlyGlu: 4.081 ± 0.595
3.139GlyPhe: 3.139 ± 0.505
5.493GlyGly: 5.493 ± 0.684
0.863GlyHis: 0.863 ± 0.245
5.101GlyIle: 5.101 ± 0.769
3.688GlyLys: 3.688 ± 0.463
5.807GlyLeu: 5.807 ± 0.626
2.354GlyMet: 2.354 ± 0.428
4.002GlyAsn: 4.002 ± 0.618
1.02GlyPro: 1.02 ± 0.262
2.904GlyGln: 2.904 ± 0.51
3.374GlyArg: 3.374 ± 0.448
5.807GlySer: 5.807 ± 0.931
4.159GlyThr: 4.159 ± 0.675
6.435GlyVal: 6.435 ± 0.624
0.942GlyTrp: 0.942 ± 0.247
2.511GlyTyr: 2.511 ± 0.47
0.0GlyXaa: 0.0 ± 0.0
His
1.569HisAla: 1.569 ± 0.351
0.235HisCys: 0.235 ± 0.132
0.706HisAsp: 0.706 ± 0.224
0.863HisGlu: 0.863 ± 0.258
0.471HisPhe: 0.471 ± 0.21
1.02HisGly: 1.02 ± 0.309
0.392HisHis: 0.392 ± 0.177
0.863HisIle: 0.863 ± 0.252
0.235HisLys: 0.235 ± 0.115
1.099HisLeu: 1.099 ± 0.305
0.392HisMet: 0.392 ± 0.173
0.314HisAsn: 0.314 ± 0.166
0.706HisPro: 0.706 ± 0.205
0.706HisGln: 0.706 ± 0.213
0.471HisArg: 0.471 ± 0.229
0.706HisSer: 0.706 ± 0.267
0.785HisThr: 0.785 ± 0.294
1.099HisVal: 1.099 ± 0.304
0.314HisTrp: 0.314 ± 0.139
0.628HisTyr: 0.628 ± 0.193
0.0HisXaa: 0.0 ± 0.0
Ile
6.435IleAla: 6.435 ± 0.69
0.863IleCys: 0.863 ± 0.251
3.453IleAsp: 3.453 ± 0.513
3.531IleGlu: 3.531 ± 0.58
1.491IlePhe: 1.491 ± 0.262
3.845IleGly: 3.845 ± 0.54
0.942IleHis: 0.942 ± 0.296
3.688IleIle: 3.688 ± 0.63
4.708IleLys: 4.708 ± 0.573
2.825IleLeu: 2.825 ± 0.445
1.256IleMet: 1.256 ± 0.304
3.767IleAsn: 3.767 ± 0.543
3.139IlePro: 3.139 ± 0.552
2.982IleGln: 2.982 ± 0.563
3.61IleArg: 3.61 ± 0.485
5.022IleSer: 5.022 ± 0.486
5.336IleThr: 5.336 ± 0.881
3.374IleVal: 3.374 ± 0.447
0.785IleTrp: 0.785 ± 0.272
2.276IleTyr: 2.276 ± 0.523
0.0IleXaa: 0.0 ± 0.0
Lys
5.022LysAla: 5.022 ± 0.669
1.02LysCys: 1.02 ± 0.365
2.904LysAsp: 2.904 ± 0.601
4.081LysGlu: 4.081 ± 0.634
2.433LysPhe: 2.433 ± 0.381
3.688LysGly: 3.688 ± 0.593
0.942LysHis: 0.942 ± 0.197
3.374LysIle: 3.374 ± 0.566
3.217LysLys: 3.217 ± 0.536
5.336LysLeu: 5.336 ± 0.542
1.334LysMet: 1.334 ± 0.302
1.726LysAsn: 1.726 ± 0.361
2.119LysPro: 2.119 ± 0.48
2.511LysGln: 2.511 ± 0.415
3.924LysArg: 3.924 ± 0.638
4.316LysSer: 4.316 ± 0.525
2.982LysThr: 2.982 ± 0.533
3.845LysVal: 3.845 ± 0.508
0.942LysTrp: 0.942 ± 0.369
2.354LysTyr: 2.354 ± 0.493
0.0LysXaa: 0.0 ± 0.0
Leu
6.356LeuAla: 6.356 ± 0.64
1.413LeuCys: 1.413 ± 0.31
4.944LeuAsp: 4.944 ± 0.731
4.473LeuGlu: 4.473 ± 0.639
2.276LeuPhe: 2.276 ± 0.333
4.865LeuGly: 4.865 ± 0.541
0.235LeuHis: 0.235 ± 0.122
4.238LeuIle: 4.238 ± 0.537
4.473LeuLys: 4.473 ± 0.678
5.65LeuLeu: 5.65 ± 0.642
2.511LeuMet: 2.511 ± 0.458
4.552LeuAsn: 4.552 ± 0.611
3.61LeuPro: 3.61 ± 0.733
3.139LeuGln: 3.139 ± 0.498
4.944LeuArg: 4.944 ± 0.893
6.984LeuSer: 6.984 ± 0.813
4.316LeuThr: 4.316 ± 0.523
5.179LeuVal: 5.179 ± 0.62
0.863LeuTrp: 0.863 ± 0.256
2.04LeuTyr: 2.04 ± 0.462
0.0LeuXaa: 0.0 ± 0.0
Met
2.433MetAla: 2.433 ± 0.459
0.157MetCys: 0.157 ± 0.116
1.02MetAsp: 1.02 ± 0.271
1.491MetGlu: 1.491 ± 0.36
0.785MetPhe: 0.785 ± 0.252
2.276MetGly: 2.276 ± 0.495
0.392MetHis: 0.392 ± 0.151
1.962MetIle: 1.962 ± 0.495
2.119MetLys: 2.119 ± 0.34
2.197MetLeu: 2.197 ± 0.385
0.785MetMet: 0.785 ± 0.241
2.276MetAsn: 2.276 ± 0.409
1.962MetPro: 1.962 ± 0.444
1.413MetGln: 1.413 ± 0.272
1.648MetArg: 1.648 ± 0.344
2.04MetSer: 2.04 ± 0.367
2.904MetThr: 2.904 ± 0.434
1.177MetVal: 1.177 ± 0.279
0.392MetTrp: 0.392 ± 0.176
0.785MetTyr: 0.785 ± 0.272
0.0MetXaa: 0.0 ± 0.0
Asn
4.63AsnAla: 4.63 ± 0.566
0.471AsnCys: 0.471 ± 0.209
2.119AsnAsp: 2.119 ± 0.543
2.354AsnGlu: 2.354 ± 0.406
1.334AsnPhe: 1.334 ± 0.263
5.022AsnGly: 5.022 ± 0.601
0.785AsnHis: 0.785 ± 0.218
2.668AsnIle: 2.668 ± 0.43
2.747AsnLys: 2.747 ± 0.324
3.061AsnLeu: 3.061 ± 0.52
1.02AsnMet: 1.02 ± 0.36
2.04AsnAsn: 2.04 ± 0.43
2.825AsnPro: 2.825 ± 0.445
2.747AsnGln: 2.747 ± 0.465
2.825AsnArg: 2.825 ± 0.447
3.374AsnSer: 3.374 ± 0.507
2.433AsnThr: 2.433 ± 0.357
2.433AsnVal: 2.433 ± 0.484
0.471AsnTrp: 0.471 ± 0.221
1.805AsnTyr: 1.805 ± 0.324
0.0AsnXaa: 0.0 ± 0.0
Pro
3.139ProAla: 3.139 ± 0.428
0.628ProCys: 0.628 ± 0.219
3.374ProAsp: 3.374 ± 0.69
2.747ProGlu: 2.747 ± 0.394
1.883ProPhe: 1.883 ± 0.368
3.453ProGly: 3.453 ± 0.632
0.392ProHis: 0.392 ± 0.183
2.276ProIle: 2.276 ± 0.408
2.354ProLys: 2.354 ± 0.514
3.296ProLeu: 3.296 ± 0.539
1.334ProMet: 1.334 ± 0.365
1.648ProAsn: 1.648 ± 0.33
1.883ProPro: 1.883 ± 0.373
1.177ProGln: 1.177 ± 0.231
2.04ProArg: 2.04 ± 0.433
3.453ProSer: 3.453 ± 0.536
1.805ProThr: 1.805 ± 0.441
3.531ProVal: 3.531 ± 0.484
0.628ProTrp: 0.628 ± 0.187
1.256ProTyr: 1.256 ± 0.304
0.0ProXaa: 0.0 ± 0.0
Gln
4.159GlnAla: 4.159 ± 0.713
0.706GlnCys: 0.706 ± 0.202
1.962GlnAsp: 1.962 ± 0.399
2.747GlnGlu: 2.747 ± 0.553
1.177GlnPhe: 1.177 ± 0.281
1.648GlnGly: 1.648 ± 0.268
0.785GlnHis: 0.785 ± 0.262
2.197GlnIle: 2.197 ± 0.396
2.119GlnLys: 2.119 ± 0.484
3.296GlnLeu: 3.296 ± 0.596
1.491GlnMet: 1.491 ± 0.351
1.962GlnAsn: 1.962 ± 0.385
2.119GlnPro: 2.119 ± 0.375
1.962GlnGln: 1.962 ± 0.308
2.197GlnArg: 2.197 ± 0.503
3.61GlnSer: 3.61 ± 0.504
1.648GlnThr: 1.648 ± 0.333
2.433GlnVal: 2.433 ± 0.509
0.706GlnTrp: 0.706 ± 0.214
1.02GlnTyr: 1.02 ± 0.29
0.0GlnXaa: 0.0 ± 0.0
Arg
3.924ArgAla: 3.924 ± 0.569
1.099ArgCys: 1.099 ± 0.311
3.61ArgAsp: 3.61 ± 0.519
3.688ArgGlu: 3.688 ± 0.644
2.668ArgPhe: 2.668 ± 0.523
2.747ArgGly: 2.747 ± 0.508
0.471ArgHis: 0.471 ± 0.23
3.217ArgIle: 3.217 ± 0.552
5.336ArgLys: 5.336 ± 0.869
3.61ArgLeu: 3.61 ± 0.557
1.962ArgMet: 1.962 ± 0.476
1.805ArgAsn: 1.805 ± 0.372
1.962ArgPro: 1.962 ± 0.388
1.726ArgGln: 1.726 ± 0.36
3.217ArgArg: 3.217 ± 0.505
4.081ArgSer: 4.081 ± 0.673
2.433ArgThr: 2.433 ± 0.314
3.845ArgVal: 3.845 ± 0.525
1.413ArgTrp: 1.413 ± 0.407
1.569ArgTyr: 1.569 ± 0.392
0.0ArgXaa: 0.0 ± 0.0
Ser
7.926SerAla: 7.926 ± 0.81
0.863SerCys: 0.863 ± 0.245
4.316SerAsp: 4.316 ± 0.509
4.708SerGlu: 4.708 ± 0.672
2.433SerPhe: 2.433 ± 0.38
5.493SerGly: 5.493 ± 0.733
0.863SerHis: 0.863 ± 0.315
5.336SerIle: 5.336 ± 0.638
3.296SerLys: 3.296 ± 0.495
6.67SerLeu: 6.67 ± 0.74
2.276SerMet: 2.276 ± 0.338
3.453SerAsn: 3.453 ± 0.48
3.139SerPro: 3.139 ± 0.43
3.061SerGln: 3.061 ± 0.403
3.453SerArg: 3.453 ± 0.417
4.473SerSer: 4.473 ± 0.637
3.531SerThr: 3.531 ± 0.522
5.022SerVal: 5.022 ± 0.663
0.942SerTrp: 0.942 ± 0.254
1.883SerTyr: 1.883 ± 0.47
0.0SerXaa: 0.0 ± 0.0
Thr
5.886ThrAla: 5.886 ± 0.702
0.785ThrCys: 0.785 ± 0.247
2.825ThrAsp: 2.825 ± 0.446
2.04ThrGlu: 2.04 ± 0.474
1.726ThrPhe: 1.726 ± 0.345
5.258ThrGly: 5.258 ± 0.788
0.706ThrHis: 0.706 ± 0.257
4.002ThrIle: 4.002 ± 0.555
2.511ThrLys: 2.511 ± 0.471
4.316ThrLeu: 4.316 ± 0.51
1.805ThrMet: 1.805 ± 0.438
2.04ThrAsn: 2.04 ± 0.424
3.139ThrPro: 3.139 ± 0.425
1.883ThrGln: 1.883 ± 0.343
2.511ThrArg: 2.511 ± 0.437
4.081ThrSer: 4.081 ± 0.504
3.139ThrThr: 3.139 ± 0.536
3.924ThrVal: 3.924 ± 0.597
1.02ThrTrp: 1.02 ± 0.267
1.805ThrTyr: 1.805 ± 0.37
0.0ThrXaa: 0.0 ± 0.0
Val
5.886ValAla: 5.886 ± 0.665
0.706ValCys: 0.706 ± 0.262
3.688ValAsp: 3.688 ± 0.387
3.374ValGlu: 3.374 ± 0.47
2.511ValPhe: 2.511 ± 0.468
5.336ValGly: 5.336 ± 0.76
0.863ValHis: 0.863 ± 0.265
4.787ValIle: 4.787 ± 0.651
3.139ValLys: 3.139 ± 0.462
3.767ValLeu: 3.767 ± 0.436
1.883ValMet: 1.883 ± 0.383
4.002ValAsn: 4.002 ± 0.498
2.668ValPro: 2.668 ± 0.423
2.197ValGln: 2.197 ± 0.52
3.296ValArg: 3.296 ± 0.525
5.022ValSer: 5.022 ± 0.587
4.316ValThr: 4.316 ± 0.687
5.179ValVal: 5.179 ± 0.831
0.706ValTrp: 0.706 ± 0.18
1.805ValTyr: 1.805 ± 0.485
0.0ValXaa: 0.0 ± 0.0
Trp
1.569TrpAla: 1.569 ± 0.342
0.706TrpCys: 0.706 ± 0.213
1.02TrpAsp: 1.02 ± 0.263
1.099TrpGlu: 1.099 ± 0.284
0.628TrpPhe: 0.628 ± 0.193
1.02TrpGly: 1.02 ± 0.308
0.235TrpHis: 0.235 ± 0.133
0.785TrpIle: 0.785 ± 0.226
0.628TrpLys: 0.628 ± 0.219
1.883TrpLeu: 1.883 ± 0.504
0.785TrpMet: 0.785 ± 0.206
0.706TrpAsn: 0.706 ± 0.284
0.392TrpPro: 0.392 ± 0.181
0.785TrpGln: 0.785 ± 0.249
0.392TrpArg: 0.392 ± 0.208
0.549TrpSer: 0.549 ± 0.19
0.863TrpThr: 0.863 ± 0.279
0.863TrpVal: 0.863 ± 0.249
0.471TrpTrp: 0.471 ± 0.231
0.157TrpTyr: 0.157 ± 0.107
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.747TyrAla: 2.747 ± 0.46
0.549TyrCys: 0.549 ± 0.193
1.962TyrAsp: 1.962 ± 0.425
1.805TyrGlu: 1.805 ± 0.323
1.883TyrPhe: 1.883 ± 0.32
2.59TyrGly: 2.59 ± 0.391
0.942TyrHis: 0.942 ± 0.305
1.491TyrIle: 1.491 ± 0.363
1.413TyrLys: 1.413 ± 0.328
2.982TyrLeu: 2.982 ± 0.63
0.314TyrMet: 0.314 ± 0.156
0.706TyrAsn: 0.706 ± 0.247
1.883TyrPro: 1.883 ± 0.349
1.491TyrGln: 1.491 ± 0.363
2.668TyrArg: 2.668 ± 0.477
2.354TyrSer: 2.354 ± 0.391
1.413TyrThr: 1.413 ± 0.377
1.648TyrVal: 1.648 ± 0.415
0.628TyrTrp: 0.628 ± 0.219
1.099TyrTyr: 1.099 ± 0.261
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 76 proteins (12744 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski