Amino acid dipepetide frequency for Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.847AlaAla: 21.847 ± 0.208	0.989AlaCys: 0.989 ± 0.03	8.623AlaAsp: 8.623 ± 0.093	8.463AlaGlu: 8.463 ± 0.083	3.195AlaPhe: 3.195 ± 0.058	13.984AlaGly: 13.984 ± 0.116	2.581AlaHis: 2.581 ± 0.042	4.025AlaIle: 4.025 ± 0.052	2.125AlaLys: 2.125 ± 0.05	13.882AlaLeu: 13.882 ± 0.151	2.331AlaMet: 2.331 ± 0.042	2.236AlaAsn: 2.236 ± 0.042	6.663AlaPro: 6.663 ± 0.11	3.818AlaGln: 3.818 ± 0.052	9.908AlaArg: 9.908 ± 0.103	5.643AlaSer: 5.643 ± 0.124	8.207AlaThr: 8.207 ± 0.09	12.827AlaVal: 12.827 ± 0.126	1.806AlaTrp: 1.806 ± 0.035	2.706AlaTyr: 2.706 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.0CysAla: 1.0 ± 0.031	0.098CysCys: 0.098 ± 0.009	0.528CysAsp: 0.528 ± 0.018	0.347CysGlu: 0.347 ± 0.014	0.211CysPhe: 0.211 ± 0.012	0.917CysGly: 0.917 ± 0.025	0.2CysHis: 0.2 ± 0.012	0.162CysIle: 0.162 ± 0.011	0.096CysLys: 0.096 ± 0.008	0.73CysLeu: 0.73 ± 0.023	0.101CysMet: 0.101 ± 0.008	0.125CysAsn: 0.125 ± 0.009	0.563CysPro: 0.563 ± 0.024	0.227CysGln: 0.227 ± 0.013	0.719CysArg: 0.719 ± 0.024	0.424CysSer: 0.424 ± 0.02	0.482CysThr: 0.482 ± 0.018	0.679CysVal: 0.679 ± 0.021	0.134CysTrp: 0.134 ± 0.01	0.159CysTyr: 0.159 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.106AspAla: 7.106 ± 0.085	0.418AspCys: 0.418 ± 0.018	3.58AspAsp: 3.58 ± 0.055	3.726AspGlu: 3.726 ± 0.058	1.464AspPhe: 1.464 ± 0.03	6.064AspGly: 6.064 ± 0.075	1.314AspHis: 1.314 ± 0.038	1.79AspIle: 1.79 ± 0.035	0.799AspLys: 0.799 ± 0.024	6.755AspLeu: 6.755 ± 0.069	0.7AspMet: 0.7 ± 0.023	1.042AspAsn: 1.042 ± 0.03	4.683AspPro: 4.683 ± 0.065	2.03AspGln: 2.03 ± 0.038	5.566AspArg: 5.566 ± 0.079	2.62AspSer: 2.62 ± 0.047	2.981AspThr: 2.981 ± 0.053	4.766AspVal: 4.766 ± 0.055	0.985AspTrp: 0.985 ± 0.03	1.132AspTyr: 1.132 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	6.533GluAla: 6.533 ± 0.082	0.38GluCys: 0.38 ± 0.018	2.005GluAsp: 2.005 ± 0.043	2.649GluGlu: 2.649 ± 0.048	1.509GluPhe: 1.509 ± 0.029	3.377GluGly: 3.377 ± 0.042	1.391GluHis: 1.391 ± 0.027	2.202GluIle: 2.202 ± 0.046	1.0GluLys: 1.0 ± 0.032	6.789GluLeu: 6.789 ± 0.079	0.882GluMet: 0.882 ± 0.026	0.873GluAsn: 0.873 ± 0.022	3.376GluPro: 3.376 ± 0.054	2.366GluGln: 2.366 ± 0.046	5.079GluArg: 5.079 ± 0.077	2.445GluSer: 2.445 ± 0.042	2.724GluThr: 2.724 ± 0.041	4.942GluVal: 4.942 ± 0.067	0.745GluTrp: 0.745 ± 0.024	1.056GluTyr: 1.056 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.68PheAla: 3.68 ± 0.045	0.267PheCys: 0.267 ± 0.013	1.951PheAsp: 1.951 ± 0.037	1.113PheGlu: 1.113 ± 0.03	0.822PhePhe: 0.822 ± 0.027	3.042PheGly: 3.042 ± 0.047	0.585PheHis: 0.585 ± 0.019	0.705PheIle: 0.705 ± 0.026	0.337PheLys: 0.337 ± 0.016	2.446PheLeu: 2.446 ± 0.049	0.293PheMet: 0.293 ± 0.013	0.546PheAsn: 0.546 ± 0.021	1.335PhePro: 1.335 ± 0.027	0.623PheGln: 0.623 ± 0.022	1.868PheArg: 1.868 ± 0.036	1.345PheSer: 1.345 ± 0.034	1.864PheThr: 1.864 ± 0.041	2.456PheVal: 2.456 ± 0.046	0.382PheTrp: 0.382 ± 0.016	0.581PheTyr: 0.581 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	10.559GlyAla: 10.559 ± 0.096	0.912GlyCys: 0.912 ± 0.028	5.169GlyAsp: 5.169 ± 0.069	4.798GlyGlu: 4.798 ± 0.058	2.716GlyPhe: 2.716 ± 0.044	9.051GlyGly: 9.051 ± 0.12	2.218GlyHis: 2.218 ± 0.041	3.295GlyIle: 3.295 ± 0.06	1.808GlyLys: 1.808 ± 0.045	9.639GlyLeu: 9.639 ± 0.116	1.929GlyMet: 1.929 ± 0.039	1.661GlyAsn: 1.661 ± 0.038	5.135GlyPro: 5.135 ± 0.065	3.007GlyGln: 3.007 ± 0.047	7.979GlyArg: 7.979 ± 0.084	5.067GlySer: 5.067 ± 0.07	5.775GlyThr: 5.775 ± 0.083	8.182GlyVal: 8.182 ± 0.093	1.922GlyTrp: 1.922 ± 0.041	2.458GlyTyr: 2.458 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.448HisAla: 2.448 ± 0.045	0.208HisCys: 0.208 ± 0.012	1.39HisAsp: 1.39 ± 0.037	1.083HisGlu: 1.083 ± 0.026	0.551HisPhe: 0.551 ± 0.019	2.169HisGly: 2.169 ± 0.043	0.666HisHis: 0.666 ± 0.025	0.553HisIle: 0.553 ± 0.021	0.253HisLys: 0.253 ± 0.014	2.517HisLeu: 2.517 ± 0.042	0.262HisMet: 0.262 ± 0.014	0.384HisAsn: 0.384 ± 0.016	1.804HisPro: 1.804 ± 0.038	0.744HisGln: 0.744 ± 0.022	2.317HisArg: 2.317 ± 0.047	1.044HisSer: 1.044 ± 0.035	1.196HisThr: 1.196 ± 0.025	1.684HisVal: 1.684 ± 0.036	0.351HisTrp: 0.351 ± 0.015	0.459HisTyr: 0.459 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.809IleAla: 4.809 ± 0.064	0.331IleCys: 0.331 ± 0.017	2.395IleAsp: 2.395 ± 0.044	2.021IleGlu: 2.021 ± 0.041	0.9IlePhe: 0.9 ± 0.029	3.542IleGly: 3.542 ± 0.053	0.599IleHis: 0.599 ± 0.02	0.957IleIle: 0.957 ± 0.032	0.599IleLys: 0.599 ± 0.023	2.555IleLeu: 2.555 ± 0.051	0.469IleMet: 0.469 ± 0.016	0.765IleAsn: 0.765 ± 0.022	1.702IlePro: 1.702 ± 0.037	0.77IleGln: 0.77 ± 0.024	2.592IleArg: 2.592 ± 0.043	1.795IleSer: 1.795 ± 0.035	2.272IleThr: 2.272 ± 0.045	2.845IleVal: 2.845 ± 0.05	0.397IleTrp: 0.397 ± 0.017	0.597IleTyr: 0.597 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	1.935LysAla: 1.935 ± 0.049	0.089LysCys: 0.089 ± 0.009	0.758LysAsp: 0.758 ± 0.031	0.807LysGlu: 0.807 ± 0.026	0.324LysPhe: 0.324 ± 0.016	1.199LysGly: 1.199 ± 0.036	0.324LysHis: 0.324 ± 0.014	0.768LysIle: 0.768 ± 0.027	0.424LysLys: 0.424 ± 0.022	1.591LysLeu: 1.591 ± 0.038	0.274LysMet: 0.274 ± 0.013	0.372LysAsn: 0.372 ± 0.02	1.062LysPro: 1.062 ± 0.029	0.54LysGln: 0.54 ± 0.021	1.217LysArg: 1.217 ± 0.031	0.857LysSer: 0.857 ± 0.028	0.946LysThr: 0.946 ± 0.031	1.479LysVal: 1.479 ± 0.032	0.191LysTrp: 0.191 ± 0.011	0.297LysTyr: 0.297 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	16.479LeuAla: 16.479 ± 0.159	0.739LeuCys: 0.739 ± 0.022	6.757LeuAsp: 6.757 ± 0.073	4.042LeuGlu: 4.042 ± 0.062	2.579LeuPhe: 2.579 ± 0.05	9.319LeuGly: 9.319 ± 0.093	2.367LeuHis: 2.367 ± 0.043	3.444LeuIle: 3.444 ± 0.058	1.303LeuLys: 1.303 ± 0.037	11.953LeuLeu: 11.953 ± 0.144	1.379LeuMet: 1.379 ± 0.031	1.746LeuAsn: 1.746 ± 0.038	6.754LeuPro: 6.754 ± 0.084	1.958LeuGln: 1.958 ± 0.034	9.37LeuArg: 9.37 ± 0.095	4.98LeuSer: 4.98 ± 0.06	7.253LeuThr: 7.253 ± 0.075	9.895LeuVal: 9.895 ± 0.102	1.307LeuTrp: 1.307 ± 0.032	1.643LeuTyr: 1.643 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.032MetAla: 2.032 ± 0.039	0.119MetCys: 0.119 ± 0.009	0.714MetAsp: 0.714 ± 0.02	0.596MetGlu: 0.596 ± 0.022	0.44MetPhe: 0.44 ± 0.015	1.179MetGly: 1.179 ± 0.032	0.304MetHis: 0.304 ± 0.015	0.665MetIle: 0.665 ± 0.023	0.3MetLys: 0.3 ± 0.015	1.728MetLeu: 1.728 ± 0.038	0.278MetMet: 0.278 ± 0.013	0.38MetAsn: 0.38 ± 0.016	1.126MetPro: 1.126 ± 0.029	0.416MetGln: 0.416 ± 0.015	1.339MetArg: 1.339 ± 0.031	1.256MetSer: 1.256 ± 0.032	1.552MetThr: 1.552 ± 0.032	1.403MetVal: 1.403 ± 0.03	0.196MetTrp: 0.196 ± 0.012	0.267MetTyr: 0.267 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.182AsnAla: 2.182 ± 0.04	0.193AsnCys: 0.193 ± 0.011	0.954AsnAsp: 0.954 ± 0.03	0.853AsnGlu: 0.853 ± 0.026	0.464AsnPhe: 0.464 ± 0.016	1.846AsnGly: 1.846 ± 0.04	0.416AsnHis: 0.416 ± 0.017	0.646AsnIle: 0.646 ± 0.021	0.293AsnLys: 0.293 ± 0.017	1.887AsnLeu: 1.887 ± 0.038	0.257AsnMet: 0.257 ± 0.014	0.494AsnAsn: 0.494 ± 0.022	1.498AsnPro: 1.498 ± 0.034	0.648AsnGln: 0.648 ± 0.021	1.454AsnArg: 1.454 ± 0.031	0.959AsnSer: 0.959 ± 0.033	1.197AsnThr: 1.197 ± 0.039	1.421AsnVal: 1.421 ± 0.033	0.301AsnTrp: 0.301 ± 0.014	0.405AsnTyr: 0.405 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	9.101ProAla: 9.101 ± 0.106	0.336ProCys: 0.336 ± 0.017	4.439ProAsp: 4.439 ± 0.066	4.006ProGlu: 4.006 ± 0.059	1.399ProPhe: 1.399 ± 0.032	6.321ProGly: 6.321 ± 0.079	1.263ProHis: 1.263 ± 0.033	1.777ProIle: 1.777 ± 0.035	0.899ProLys: 0.899 ± 0.031	5.204ProLeu: 5.204 ± 0.063	1.029ProMet: 1.029 ± 0.024	1.113ProAsn: 1.113 ± 0.025	4.157ProPro: 4.157 ± 0.086	1.666ProGln: 1.666 ± 0.035	4.089ProArg: 4.089 ± 0.063	3.151ProSer: 3.151 ± 0.056	4.335ProThr: 4.335 ± 0.069	5.827ProVal: 5.827 ± 0.073	0.929ProTrp: 0.929 ± 0.024	1.23ProTyr: 1.23 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.825GlnAla: 3.825 ± 0.061	0.161GlnCys: 0.161 ± 0.01	1.176GlnAsp: 1.176 ± 0.028	1.346GlnGlu: 1.346 ± 0.036	0.716GlnPhe: 0.716 ± 0.021	1.983GlnGly: 1.983 ± 0.04	0.729GlnHis: 0.729 ± 0.019	1.133GlnIle: 1.133 ± 0.027	0.388GlnLys: 0.388 ± 0.015	3.634GlnLeu: 3.634 ± 0.054	0.472GlnMet: 0.472 ± 0.017	0.476GlnAsn: 0.476 ± 0.018	2.076GlnPro: 2.076 ± 0.037	1.283GlnGln: 1.283 ± 0.039	2.917GlnArg: 2.917 ± 0.051	1.197GlnSer: 1.197 ± 0.029	1.492GlnThr: 1.492 ± 0.033	3.027GlnVal: 3.027 ± 0.047	0.514GlnTrp: 0.514 ± 0.019	0.537GlnTyr: 0.537 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	9.94ArgAla: 9.94 ± 0.095	0.705ArgCys: 0.705 ± 0.023	4.534ArgAsp: 4.534 ± 0.067	4.248ArgGlu: 4.248 ± 0.065	2.46ArgPhe: 2.46 ± 0.043	6.031ArgGly: 6.031 ± 0.073	2.237ArgHis: 2.237 ± 0.042	3.149ArgIle: 3.149 ± 0.048	1.307ArgLys: 1.307 ± 0.033	9.419ArgLeu: 9.419 ± 0.11	1.879ArgMet: 1.879 ± 0.037	1.472ArgAsn: 1.472 ± 0.035	5.406ArgPro: 5.406 ± 0.074	2.838ArgGln: 2.838 ± 0.044	8.971ArgArg: 8.971 ± 0.12	4.501ArgSer: 4.501 ± 0.062	4.924ArgThr: 4.924 ± 0.053	6.604ArgVal: 6.604 ± 0.066	1.69ArgTrp: 1.69 ± 0.033	1.993ArgTyr: 1.993 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.596SerAla: 6.596 ± 0.104	0.412SerCys: 0.412 ± 0.015	2.571SerAsp: 2.571 ± 0.048	2.2SerGlu: 2.2 ± 0.042	1.438SerPhe: 1.438 ± 0.034	5.641SerGly: 5.641 ± 0.068	0.968SerHis: 0.968 ± 0.027	1.65SerIle: 1.65 ± 0.035	0.776SerLys: 0.776 ± 0.024	4.476SerLeu: 4.476 ± 0.066	1.046SerMet: 1.046 ± 0.029	0.899SerAsn: 0.899 ± 0.027	3.254SerPro: 3.254 ± 0.051	1.265SerGln: 1.265 ± 0.029	3.932SerArg: 3.932 ± 0.053	2.803SerSer: 2.803 ± 0.053	3.465SerThr: 3.465 ± 0.101	4.157SerVal: 4.157 ± 0.059	0.955SerTrp: 0.955 ± 0.028	1.161SerTyr: 1.161 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	8.766ThrAla: 8.766 ± 0.086	0.453ThrCys: 0.453 ± 0.018	3.914ThrAsp: 3.914 ± 0.051	3.263ThrGlu: 3.263 ± 0.049	1.651ThrPhe: 1.651 ± 0.037	6.691ThrGly: 6.691 ± 0.078	1.186ThrHis: 1.186 ± 0.03	2.176ThrIle: 2.176 ± 0.05	0.944ThrLys: 0.944 ± 0.028	5.93ThrLeu: 5.93 ± 0.075	1.058ThrMet: 1.058 ± 0.027	1.161ThrAsn: 1.161 ± 0.031	4.243ThrPro: 4.243 ± 0.073	1.365ThrGln: 1.365 ± 0.032	4.25ThrArg: 4.25 ± 0.06	3.224ThrSer: 3.224 ± 0.092	4.143ThrThr: 4.143 ± 0.082	6.383ThrVal: 6.383 ± 0.08	0.929ThrTrp: 0.929 ± 0.027	1.284ThrTyr: 1.284 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	12.696ValAla: 12.696 ± 0.12	0.749ValCys: 0.749 ± 0.022	5.897ValAsp: 5.897 ± 0.074	5.04ValGlu: 5.04 ± 0.067	2.289ValPhe: 2.289 ± 0.046	7.873ValGly: 7.873 ± 0.086	1.858ValHis: 1.858 ± 0.034	2.862ValIle: 2.862 ± 0.045	1.303ValLys: 1.303 ± 0.029	9.789ValLeu: 9.789 ± 0.116	1.189ValMet: 1.189 ± 0.029	1.916ValAsn: 1.916 ± 0.046	5.36ValPro: 5.36 ± 0.065	2.107ValGln: 2.107 ± 0.036	7.235ValArg: 7.235 ± 0.069	4.424ValSer: 4.424 ± 0.064	6.176ValThr: 6.176 ± 0.08	9.127ValVal: 9.127 ± 0.113	1.11ValTrp: 1.11 ± 0.028	1.424ValTyr: 1.424 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.662TrpAla: 1.662 ± 0.033	0.165TrpCys: 0.165 ± 0.009	0.73TrpAsp: 0.73 ± 0.023	0.678TrpGlu: 0.678 ± 0.021	0.51TrpPhe: 0.51 ± 0.022	1.035TrpGly: 1.035 ± 0.031	0.395TrpHis: 0.395 ± 0.017	0.54TrpIle: 0.54 ± 0.019	0.242TrpLys: 0.242 ± 0.015	1.983TrpLeu: 1.983 ± 0.038	0.277TrpMet: 0.277 ± 0.014	0.355TrpAsn: 0.355 ± 0.016	0.889TrpPro: 0.889 ± 0.025	0.692TrpGln: 0.692 ± 0.022	1.605TrpArg: 1.605 ± 0.037	1.023TrpSer: 1.023 ± 0.03	0.975TrpThr: 0.975 ± 0.025	1.079TrpVal: 1.079 ± 0.025	0.385TrpTrp: 0.385 ± 0.016	0.356TrpTyr: 0.356 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.664TyrAla: 2.664 ± 0.043	0.176TyrCys: 0.176 ± 0.012	1.435TyrAsp: 1.435 ± 0.045	1.044TyrGlu: 1.044 ± 0.025	0.605TyrPhe: 0.605 ± 0.023	2.014TyrGly: 2.014 ± 0.036	0.48TyrHis: 0.48 ± 0.021	0.414TyrIle: 0.414 ± 0.018	0.26TyrLys: 0.26 ± 0.014	2.36TyrLeu: 2.36 ± 0.045	0.181TyrMet: 0.181 ± 0.012	0.355TyrAsn: 0.355 ± 0.02	1.182TyrPro: 1.182 ± 0.029	0.722TyrGln: 0.722 ± 0.023	1.9TyrArg: 1.9 ± 0.044	0.909TyrSer: 0.909 ± 0.025	1.056TyrThr: 1.056 ± 0.031	1.639TyrVal: 1.639 ± 0.033	0.349TyrTrp: 0.349 ± 0.015	0.415TyrTyr: 0.415 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4522 proteins (1517537 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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