Amino acid dipepetide frequency for Lampropedia aestuarii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.908AlaAla: 15.908 ± 0.178	1.266AlaCys: 1.266 ± 0.035	5.665AlaAsp: 5.665 ± 0.078	6.114AlaGlu: 6.114 ± 0.083	3.87AlaPhe: 3.87 ± 0.066	9.226AlaGly: 9.226 ± 0.095	2.861AlaHis: 2.861 ± 0.059	6.095AlaIle: 6.095 ± 0.073	4.501AlaLys: 4.501 ± 0.073	14.235AlaLeu: 14.235 ± 0.125	3.628AlaMet: 3.628 ± 0.057	3.538AlaAsn: 3.538 ± 0.064	5.542AlaPro: 5.542 ± 0.088	7.839AlaGln: 7.839 ± 0.115	6.613AlaArg: 6.613 ± 0.08	7.355AlaSer: 7.355 ± 0.078	5.801AlaThr: 5.801 ± 0.076	8.286AlaVal: 8.286 ± 0.108	1.925AlaTrp: 1.925 ± 0.053	2.641AlaTyr: 2.641 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.097CysAla: 1.097 ± 0.034	0.117CysCys: 0.117 ± 0.01	0.432CysAsp: 0.432 ± 0.018	0.465CysGlu: 0.465 ± 0.021	0.321CysPhe: 0.321 ± 0.017	0.805CysGly: 0.805 ± 0.03	0.234CysHis: 0.234 ± 0.016	0.498CysIle: 0.498 ± 0.021	0.273CysLys: 0.273 ± 0.015	0.917CysLeu: 0.917 ± 0.028	0.275CysMet: 0.275 ± 0.017	0.286CysAsn: 0.286 ± 0.015	0.429CysPro: 0.429 ± 0.024	0.368CysGln: 0.368 ± 0.02	0.419CysArg: 0.419 ± 0.021	0.574CysSer: 0.574 ± 0.021	0.5CysThr: 0.5 ± 0.028	0.723CysVal: 0.723 ± 0.025	0.128CysTrp: 0.128 ± 0.012	0.187CysTyr: 0.187 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.502AspAla: 6.502 ± 0.088	0.436AspCys: 0.436 ± 0.02	2.328AspAsp: 2.328 ± 0.051	2.763AspGlu: 2.763 ± 0.047	1.998AspPhe: 1.998 ± 0.045	4.144AspGly: 4.144 ± 0.068	0.996AspHis: 0.996 ± 0.032	2.471AspIle: 2.471 ± 0.043	1.933AspLys: 1.933 ± 0.046	5.024AspLeu: 5.024 ± 0.079	1.282AspMet: 1.282 ± 0.035	1.4AspAsn: 1.4 ± 0.038	2.341AspPro: 2.341 ± 0.048	1.844AspGln: 1.844 ± 0.044	2.464AspArg: 2.464 ± 0.046	2.71AspSer: 2.71 ± 0.048	2.403AspThr: 2.403 ± 0.054	3.679AspVal: 3.679 ± 0.063	1.084AspTrp: 1.084 ± 0.031	1.436AspTyr: 1.436 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	6.328GluAla: 6.328 ± 0.081	0.369GluCys: 0.369 ± 0.017	2.214GluAsp: 2.214 ± 0.045	2.557GluGlu: 2.557 ± 0.051	1.795GluPhe: 1.795 ± 0.038	3.415GluGly: 3.415 ± 0.067	1.42GluHis: 1.42 ± 0.039	2.747GluIle: 2.747 ± 0.053	1.927GluLys: 1.927 ± 0.05	5.73GluLeu: 5.73 ± 0.09	1.259GluMet: 1.259 ± 0.031	1.39GluAsn: 1.39 ± 0.036	2.491GluPro: 2.491 ± 0.048	3.594GluGln: 3.594 ± 0.071	4.187GluArg: 4.187 ± 0.071	2.673GluSer: 2.673 ± 0.049	2.374GluThr: 2.374 ± 0.048	3.925GluVal: 3.925 ± 0.07	0.737GluTrp: 0.737 ± 0.027	1.184GluTyr: 1.184 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.031PheAla: 4.031 ± 0.056	0.375PheCys: 0.375 ± 0.018	2.363PheAsp: 2.363 ± 0.042	2.12PheGlu: 2.12 ± 0.046	1.409PhePhe: 1.409 ± 0.04	3.184PheGly: 3.184 ± 0.054	0.714PheHis: 0.714 ± 0.027	1.679PheIle: 1.679 ± 0.043	1.311PheLys: 1.311 ± 0.033	3.031PheLeu: 3.031 ± 0.055	0.838PheMet: 0.838 ± 0.027	1.261PheAsn: 1.261 ± 0.033	1.383PhePro: 1.383 ± 0.038	1.165PheGln: 1.165 ± 0.032	1.507PheArg: 1.507 ± 0.039	2.341PheSer: 2.341 ± 0.051	1.861PheThr: 1.861 ± 0.044	2.596PheVal: 2.596 ± 0.054	0.542PheTrp: 0.542 ± 0.024	0.926PheTyr: 0.926 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	8.063GlyAla: 8.063 ± 0.087	0.79GlyCys: 0.79 ± 0.029	3.497GlyAsp: 3.497 ± 0.06	3.786GlyGlu: 3.786 ± 0.067	3.208GlyPhe: 3.208 ± 0.053	5.91GlyGly: 5.91 ± 0.096	1.87GlyHis: 1.87 ± 0.046	4.281GlyIle: 4.281 ± 0.068	3.302GlyLys: 3.302 ± 0.062	8.627GlyLeu: 8.627 ± 0.109	2.303GlyMet: 2.303 ± 0.046	2.41GlyAsn: 2.41 ± 0.054	2.662GlyPro: 2.662 ± 0.053	4.274GlyGln: 4.274 ± 0.064	4.292GlyArg: 4.292 ± 0.062	4.601GlySer: 4.601 ± 0.088	3.816GlyThr: 3.816 ± 0.069	6.066GlyVal: 6.066 ± 0.08	1.279GlyTrp: 1.279 ± 0.042	2.314GlyTyr: 2.314 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.872HisAla: 2.872 ± 0.052	0.304HisCys: 0.304 ± 0.018	1.123HisAsp: 1.123 ± 0.033	1.125HisGlu: 1.125 ± 0.033	0.961HisPhe: 0.961 ± 0.031	1.924HisGly: 1.924 ± 0.046	0.628HisHis: 0.628 ± 0.029	1.275HisIle: 1.275 ± 0.034	0.719HisLys: 0.719 ± 0.024	2.228HisLeu: 2.228 ± 0.047	0.639HisMet: 0.639 ± 0.027	0.767HisAsn: 0.767 ± 0.022	1.286HisPro: 1.286 ± 0.035	1.088HisGln: 1.088 ± 0.036	1.249HisArg: 1.249 ± 0.034	1.457HisSer: 1.457 ± 0.042	1.338HisThr: 1.338 ± 0.037	1.55HisVal: 1.55 ± 0.044	0.512HisTrp: 0.512 ± 0.019	0.764HisTyr: 0.764 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.863IleAla: 6.863 ± 0.091	0.432IleCys: 0.432 ± 0.019	3.066IleAsp: 3.066 ± 0.051	3.438IleGlu: 3.438 ± 0.066	1.503IlePhe: 1.503 ± 0.042	4.405IleGly: 4.405 ± 0.066	0.982IleHis: 0.982 ± 0.034	1.933IleIle: 1.933 ± 0.052	1.705IleLys: 1.705 ± 0.039	3.754IleLeu: 3.754 ± 0.07	0.934IleMet: 0.934 ± 0.031	1.735IleAsn: 1.735 ± 0.041	2.154IlePro: 2.154 ± 0.044	1.782IleGln: 1.782 ± 0.042	2.54IleArg: 2.54 ± 0.055	2.893IleSer: 2.893 ± 0.057	2.79IleThr: 2.79 ± 0.056	3.735IleVal: 3.735 ± 0.064	0.621IleTrp: 0.621 ± 0.026	1.106IleTyr: 1.106 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.334LysAla: 4.334 ± 0.076	0.15LysCys: 0.15 ± 0.012	1.847LysAsp: 1.847 ± 0.042	1.908LysGlu: 1.908 ± 0.045	0.815LysPhe: 0.815 ± 0.028	2.504LysGly: 2.504 ± 0.049	0.882LysHis: 0.882 ± 0.028	1.603LysIle: 1.603 ± 0.041	1.569LysLys: 1.569 ± 0.057	3.396LysLeu: 3.396 ± 0.056	0.785LysMet: 0.785 ± 0.028	1.2LysAsn: 1.2 ± 0.035	2.179LysPro: 2.179 ± 0.042	1.676LysGln: 1.676 ± 0.042	2.315LysArg: 2.315 ± 0.045	1.893LysSer: 1.893 ± 0.048	2.144LysThr: 2.144 ± 0.05	2.375LysVal: 2.375 ± 0.045	0.359LysTrp: 0.359 ± 0.018	0.697LysTyr: 0.697 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	13.607LeuAla: 13.607 ± 0.141	1.073LeuCys: 1.073 ± 0.03	5.441LeuAsp: 5.441 ± 0.08	5.387LeuGlu: 5.387 ± 0.081	3.338LeuPhe: 3.338 ± 0.061	8.282LeuGly: 8.282 ± 0.099	2.62LeuHis: 2.62 ± 0.062	4.594LeuIle: 4.594 ± 0.073	3.487LeuLys: 3.487 ± 0.057	11.427LeuLeu: 11.427 ± 0.141	2.595LeuMet: 2.595 ± 0.058	3.327LeuAsn: 3.327 ± 0.05	5.871LeuPro: 5.871 ± 0.07	6.088LeuGln: 6.088 ± 0.088	6.731LeuArg: 6.731 ± 0.084	6.707LeuSer: 6.707 ± 0.077	5.139LeuThr: 5.139 ± 0.063	7.585LeuVal: 7.585 ± 0.1	1.379LeuTrp: 1.379 ± 0.045	2.191LeuTyr: 2.191 ± 0.05	0.001LeuXaa: 0.001 ± 0.001
Met	3.237MetAla: 3.237 ± 0.06	0.16MetCys: 0.16 ± 0.014	1.099MetAsp: 1.099 ± 0.029	1.113MetGlu: 1.113 ± 0.032	0.707MetPhe: 0.707 ± 0.023	2.049MetGly: 2.049 ± 0.042	0.644MetHis: 0.644 ± 0.024	0.955MetIle: 0.955 ± 0.03	0.828MetLys: 0.828 ± 0.028	2.852MetLeu: 2.852 ± 0.05	0.579MetMet: 0.579 ± 0.025	0.863MetAsn: 0.863 ± 0.028	1.566MetPro: 1.566 ± 0.037	1.568MetGln: 1.568 ± 0.041	1.711MetArg: 1.711 ± 0.037	1.587MetSer: 1.587 ± 0.032	1.502MetThr: 1.502 ± 0.032	1.891MetVal: 1.891 ± 0.045	0.221MetTrp: 0.221 ± 0.015	0.415MetTyr: 0.415 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.907AsnAla: 3.907 ± 0.069	0.296AsnCys: 0.296 ± 0.017	1.468AsnAsp: 1.468 ± 0.039	1.487AsnGlu: 1.487 ± 0.035	1.023AsnPhe: 1.023 ± 0.028	2.585AsnGly: 2.585 ± 0.06	0.683AsnHis: 0.683 ± 0.025	1.498AsnIle: 1.498 ± 0.04	1.044AsnLys: 1.044 ± 0.028	2.88AsnLeu: 2.88 ± 0.048	0.71AsnMet: 0.71 ± 0.024	1.083AsnAsn: 1.083 ± 0.04	2.073AsnPro: 2.073 ± 0.046	1.358AsnGln: 1.358 ± 0.035	1.713AsnArg: 1.713 ± 0.042	1.775AsnSer: 1.775 ± 0.044	1.949AsnThr: 1.949 ± 0.045	1.986AsnVal: 1.986 ± 0.041	0.487AsnTrp: 0.487 ± 0.02	0.846AsnTyr: 0.846 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	6.221ProAla: 6.221 ± 0.105	0.32ProCys: 0.32 ± 0.014	2.638ProAsp: 2.638 ± 0.05	3.275ProGlu: 3.275 ± 0.053	1.691ProPhe: 1.691 ± 0.036	3.709ProGly: 3.709 ± 0.06	1.157ProHis: 1.157 ± 0.032	2.257ProIle: 2.257 ± 0.047	1.566ProLys: 1.566 ± 0.041	5.055ProLeu: 5.055 ± 0.077	1.256ProMet: 1.256 ± 0.039	1.504ProAsn: 1.504 ± 0.035	2.065ProPro: 2.065 ± 0.063	2.513ProGln: 2.513 ± 0.047	2.16ProArg: 2.16 ± 0.054	3.156ProSer: 3.156 ± 0.055	2.57ProThr: 2.57 ± 0.052	3.932ProVal: 3.932 ± 0.069	0.751ProTrp: 0.751 ± 0.027	1.171ProTyr: 1.171 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	8.013GlnAla: 8.013 ± 0.11	0.384GlnCys: 0.384 ± 0.02	2.22GlnAsp: 2.22 ± 0.048	2.611GlnGlu: 2.611 ± 0.052	1.562GlnPhe: 1.562 ± 0.032	3.724GlnGly: 3.724 ± 0.063	1.369GlnHis: 1.369 ± 0.039	2.15GlnIle: 2.15 ± 0.041	1.367GlnLys: 1.367 ± 0.041	5.874GlnLeu: 5.874 ± 0.092	1.182GlnMet: 1.182 ± 0.033	1.214GlnAsn: 1.214 ± 0.033	2.519GlnPro: 2.519 ± 0.053	3.417GlnGln: 3.417 ± 0.073	3.809GlnArg: 3.809 ± 0.068	3.038GlnSer: 3.038 ± 0.054	2.749GlnThr: 2.749 ± 0.05	3.656GlnVal: 3.656 ± 0.064	1.167GlnTrp: 1.167 ± 0.037	1.179GlnTyr: 1.179 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	6.021ArgAla: 6.021 ± 0.086	0.46ArgCys: 0.46 ± 0.022	2.867ArgAsp: 2.867 ± 0.05	3.305ArgGlu: 3.305 ± 0.058	2.377ArgPhe: 2.377 ± 0.047	3.479ArgGly: 3.479 ± 0.065	1.487ArgHis: 1.487 ± 0.043	3.45ArgIle: 3.45 ± 0.058	2.159ArgLys: 2.159 ± 0.047	6.703ArgLeu: 6.703 ± 0.086	1.684ArgMet: 1.684 ± 0.04	1.947ArgAsn: 1.947 ± 0.043	2.328ArgPro: 2.328 ± 0.045	3.221ArgGln: 3.221 ± 0.054	3.374ArgArg: 3.374 ± 0.065	3.59ArgSer: 3.59 ± 0.061	2.798ArgThr: 2.798 ± 0.047	4.012ArgVal: 4.012 ± 0.055	1.013ArgTrp: 1.013 ± 0.035	1.804ArgTyr: 1.804 ± 0.047	0.001ArgXaa: 0.001 ± 0.001
Ser	7.048SerAla: 7.048 ± 0.076	0.474SerCys: 0.474 ± 0.022	2.886SerAsp: 2.886 ± 0.052	2.795SerGlu: 2.795 ± 0.05	2.127SerPhe: 2.127 ± 0.046	5.225SerGly: 5.225 ± 0.068	1.437SerHis: 1.437 ± 0.037	3.05SerIle: 3.05 ± 0.054	2.011SerLys: 2.011 ± 0.046	6.383SerLeu: 6.383 ± 0.088	1.555SerMet: 1.555 ± 0.035	2.017SerAsn: 2.017 ± 0.045	2.946SerPro: 2.946 ± 0.055	2.86SerGln: 2.86 ± 0.048	3.266SerArg: 3.266 ± 0.056	3.972SerSer: 3.972 ± 0.063	3.338SerThr: 3.338 ± 0.058	4.061SerVal: 4.061 ± 0.071	0.895SerTrp: 0.895 ± 0.029	1.578SerTyr: 1.578 ± 0.04	0.001SerXaa: 0.001 ± 0.001
Thr	6.182ThrAla: 6.182 ± 0.076	0.402ThrCys: 0.402 ± 0.022	2.41ThrAsp: 2.41 ± 0.05	2.495ThrGlu: 2.495 ± 0.051	1.626ThrPhe: 1.626 ± 0.037	4.462ThrGly: 4.462 ± 0.074	1.246ThrHis: 1.246 ± 0.037	2.577ThrIle: 2.577 ± 0.051	1.467ThrLys: 1.467 ± 0.041	5.618ThrLeu: 5.618 ± 0.074	1.205ThrMet: 1.205 ± 0.029	1.561ThrAsn: 1.561 ± 0.041	3.481ThrPro: 3.481 ± 0.05	2.535ThrGln: 2.535 ± 0.05	2.674ThrArg: 2.674 ± 0.054	3.114ThrSer: 3.114 ± 0.059	3.047ThrThr: 3.047 ± 0.069	3.888ThrVal: 3.888 ± 0.067	0.693ThrTrp: 0.693 ± 0.024	1.092ThrTyr: 1.092 ± 0.036	0.001ThrXaa: 0.001 ± 0.001
Val	8.459ValAla: 8.459 ± 0.099	0.795ValCys: 0.795 ± 0.025	3.643ValAsp: 3.643 ± 0.061	3.72ValGlu: 3.72 ± 0.064	2.79ValPhe: 2.79 ± 0.053	5.152ValGly: 5.152 ± 0.079	1.655ValHis: 1.655 ± 0.038	3.513ValIle: 3.513 ± 0.053	2.331ValLys: 2.331 ± 0.051	8.403ValLeu: 8.403 ± 0.103	1.981ValMet: 1.981 ± 0.046	2.217ValAsn: 2.217 ± 0.049	3.663ValPro: 3.663 ± 0.06	3.657ValGln: 3.657 ± 0.061	4.302ValArg: 4.302 ± 0.061	4.038ValSer: 4.038 ± 0.065	3.665ValThr: 3.665 ± 0.065	6.2ValVal: 6.2 ± 0.087	0.991ValTrp: 0.991 ± 0.027	1.6ValTyr: 1.6 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.408TrpAla: 1.408 ± 0.041	0.168TrpCys: 0.168 ± 0.013	0.689TrpAsp: 0.689 ± 0.027	0.558TrpGlu: 0.558 ± 0.019	0.551TrpPhe: 0.551 ± 0.022	1.081TrpGly: 1.081 ± 0.033	0.441TrpHis: 0.441 ± 0.018	0.752TrpIle: 0.752 ± 0.025	0.38TrpLys: 0.38 ± 0.019	2.259TrpLeu: 2.259 ± 0.065	0.388TrpMet: 0.388 ± 0.019	0.451TrpAsn: 0.451 ± 0.023	0.822TrpPro: 0.822 ± 0.03	1.144TrpGln: 1.144 ± 0.04	1.209TrpArg: 1.209 ± 0.038	0.944TrpSer: 0.944 ± 0.033	0.7TrpThr: 0.7 ± 0.025	0.988TrpVal: 0.988 ± 0.032	0.299TrpTrp: 0.299 ± 0.019	0.321TrpTyr: 0.321 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.809TyrAla: 2.809 ± 0.053	0.276TyrCys: 0.276 ± 0.016	1.344TyrAsp: 1.344 ± 0.046	1.297TyrGlu: 1.297 ± 0.04	0.966TyrPhe: 0.966 ± 0.028	2.087TyrGly: 2.087 ± 0.047	0.483TyrHis: 0.483 ± 0.024	0.994TyrIle: 0.994 ± 0.033	0.751TyrLys: 0.751 ± 0.032	2.47TyrLeu: 2.47 ± 0.05	0.467TyrMet: 0.467 ± 0.025	0.682TyrAsn: 0.682 ± 0.028	1.164TyrPro: 1.164 ± 0.033	1.213TyrGln: 1.213 ± 0.028	1.545TyrArg: 1.545 ± 0.039	1.506TyrSer: 1.506 ± 0.035	1.288TyrThr: 1.288 ± 0.039	1.643TyrVal: 1.643 ± 0.039	0.468TyrTrp: 0.468 ± 0.022	0.69TyrTyr: 0.69 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 3452 proteins (1160369 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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