Amino acid dipepetide frequency for Endomicrobium trichonymphae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.179AlaAla: 6.179 ± 0.111	0.962AlaCys: 0.962 ± 0.04	4.06AlaAsp: 4.06 ± 0.075	4.929AlaGlu: 4.929 ± 0.096	2.994AlaPhe: 2.994 ± 0.07	5.792AlaGly: 5.792 ± 0.109	0.936AlaHis: 0.936 ± 0.038	4.862AlaIle: 4.862 ± 0.102	6.133AlaLys: 6.133 ± 0.102	6.646AlaLeu: 6.646 ± 0.093	1.721AlaMet: 1.721 ± 0.05	2.678AlaAsn: 2.678 ± 0.069	1.472AlaPro: 1.472 ± 0.051	1.845AlaGln: 1.845 ± 0.047	2.731AlaArg: 2.731 ± 0.069	4.03AlaSer: 4.03 ± 0.077	2.533AlaThr: 2.533 ± 0.061	6.805AlaVal: 6.805 ± 0.114	0.407AlaTrp: 0.407 ± 0.024	2.116AlaTyr: 2.116 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.969CysAla: 0.969 ± 0.043	0.22CysCys: 0.22 ± 0.018	0.722CysAsp: 0.722 ± 0.029	0.8CysGlu: 0.8 ± 0.038	0.655CysPhe: 0.655 ± 0.03	1.593CysGly: 1.593 ± 0.049	0.175CysHis: 0.175 ± 0.015	1.107CysIle: 1.107 ± 0.048	0.956CysLys: 0.956 ± 0.041	1.107CysLeu: 1.107 ± 0.038	0.256CysMet: 0.256 ± 0.019	0.504CysAsn: 0.504 ± 0.031	0.634CysPro: 0.634 ± 0.033	0.253CysGln: 0.253 ± 0.018	0.712CysArg: 0.712 ± 0.032	1.0CysSer: 1.0 ± 0.045	0.523CysThr: 0.523 ± 0.029	0.881CysVal: 0.881 ± 0.031	0.103CysTrp: 0.103 ± 0.012	0.429CysTyr: 0.429 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	3.105AspAla: 3.105 ± 0.078	0.686AspCys: 0.686 ± 0.028	2.176AspAsp: 2.176 ± 0.07	3.555AspGlu: 3.555 ± 0.083	3.048AspPhe: 3.048 ± 0.063	3.36AspGly: 3.36 ± 0.075	0.637AspHis: 0.637 ± 0.029	6.013AspIle: 6.013 ± 0.095	4.654AspLys: 4.654 ± 0.091	4.796AspLeu: 4.796 ± 0.085	1.327AspMet: 1.327 ± 0.044	2.563AspAsn: 2.563 ± 0.062	1.331AspPro: 1.331 ± 0.05	0.601AspGln: 0.601 ± 0.028	1.892AspArg: 1.892 ± 0.047	2.858AspSer: 2.858 ± 0.065	2.317AspThr: 2.317 ± 0.063	3.166AspVal: 3.166 ± 0.075	0.407AspTrp: 0.407 ± 0.027	2.007AspTyr: 2.007 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	4.289GluAla: 4.289 ± 0.081	0.715GluCys: 0.715 ± 0.037	3.037GluAsp: 3.037 ± 0.079	4.629GluGlu: 4.629 ± 0.095	2.874GluPhe: 2.874 ± 0.065	2.876GluGly: 2.876 ± 0.071	1.071GluHis: 1.071 ± 0.042	7.676GluIle: 7.676 ± 0.131	8.053GluLys: 8.053 ± 0.123	5.693GluLeu: 5.693 ± 0.099	1.711GluMet: 1.711 ± 0.057	4.754GluAsn: 4.754 ± 0.092	1.291GluPro: 1.291 ± 0.046	1.741GluGln: 1.741 ± 0.046	3.161GluArg: 3.161 ± 0.075	3.636GluSer: 3.636 ± 0.071	3.703GluThr: 3.703 ± 0.088	3.921GluVal: 3.921 ± 0.082	0.407GluTrp: 0.407 ± 0.025	2.575GluTyr: 2.575 ± 0.067	0.0GluXaa: 0.0 ± 0.0
Phe	3.467PheAla: 3.467 ± 0.09	0.809PheCys: 0.809 ± 0.042	2.731PheAsp: 2.731 ± 0.058	2.978PheGlu: 2.978 ± 0.069	2.577PhePhe: 2.577 ± 0.08	3.148PheGly: 3.148 ± 0.076	0.597PheHis: 0.597 ± 0.032	4.149PheIle: 4.149 ± 0.086	4.243PheLys: 4.243 ± 0.085	4.629PheLeu: 4.629 ± 0.09	1.169PheMet: 1.169 ± 0.043	2.379PheAsn: 2.379 ± 0.068	1.554PhePro: 1.554 ± 0.047	1.087PheGln: 1.087 ± 0.036	1.679PheArg: 1.679 ± 0.047	3.547PheSer: 3.547 ± 0.083	2.294PheThr: 2.294 ± 0.06	2.909PheVal: 2.909 ± 0.077	0.357PheTrp: 0.357 ± 0.024	1.793PheTyr: 1.793 ± 0.055	0.0PheXaa: 0.0 ± 0.0
Gly	4.362GlyAla: 4.362 ± 0.094	1.038GlyCys: 1.038 ± 0.047	2.919GlyAsp: 2.919 ± 0.064	3.453GlyGlu: 3.453 ± 0.074	3.35GlyPhe: 3.35 ± 0.085	4.455GlyGly: 4.455 ± 0.089	1.232GlyHis: 1.232 ± 0.052	6.61GlyIle: 6.61 ± 0.105	6.096GlyLys: 6.096 ± 0.102	5.276GlyLeu: 5.276 ± 0.089	1.593GlyMet: 1.593 ± 0.061	2.901GlyAsn: 2.901 ± 0.063	1.403GlyPro: 1.403 ± 0.048	1.661GlyGln: 1.661 ± 0.055	3.389GlyArg: 3.389 ± 0.087	3.951GlySer: 3.951 ± 0.09	3.247GlyThr: 3.247 ± 0.077	4.237GlyVal: 4.237 ± 0.085	0.549GlyTrp: 0.549 ± 0.032	2.342GlyTyr: 2.342 ± 0.059	0.001GlyXaa: 0.001 ± 0.002
His	0.775HisAla: 0.775 ± 0.033	0.284HisCys: 0.284 ± 0.02	0.637HisAsp: 0.637 ± 0.034	0.787HisGlu: 0.787 ± 0.036	0.817HisPhe: 0.817 ± 0.035	1.143HisGly: 1.143 ± 0.044	0.292HisHis: 0.292 ± 0.023	1.59HisIle: 1.59 ± 0.054	1.279HisLys: 1.279 ± 0.04	1.313HisLeu: 1.313 ± 0.042	0.289HisMet: 0.289 ± 0.017	0.758HisAsn: 0.758 ± 0.036	0.791HisPro: 0.791 ± 0.032	0.304HisGln: 0.304 ± 0.024	0.621HisArg: 0.621 ± 0.03	1.15HisSer: 1.15 ± 0.04	0.779HisThr: 0.779 ± 0.038	0.707HisVal: 0.707 ± 0.032	0.084HisTrp: 0.084 ± 0.01	0.597HisTyr: 0.597 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.688IleAla: 6.688 ± 0.12	1.347IleCys: 1.347 ± 0.042	4.896IleAsp: 4.896 ± 0.077	6.495IleGlu: 6.495 ± 0.105	4.421IlePhe: 4.421 ± 0.099	5.352IleGly: 5.352 ± 0.095	1.125IleHis: 1.125 ± 0.039	8.206IleIle: 8.206 ± 0.123	8.946IleLys: 8.946 ± 0.109	7.937IleLeu: 7.937 ± 0.103	2.127IleMet: 2.127 ± 0.062	4.579IleAsn: 4.579 ± 0.098	3.342IlePro: 3.342 ± 0.07	1.742IleGln: 1.742 ± 0.053	3.419IleArg: 3.419 ± 0.07	6.821IleSer: 6.821 ± 0.109	4.306IleThr: 4.306 ± 0.082	5.8IleVal: 5.8 ± 0.1	0.543IleTrp: 0.543 ± 0.033	2.948IleTyr: 2.948 ± 0.072	0.0IleXaa: 0.0 ± 0.0
Lys	6.097LysAla: 6.097 ± 0.087	1.002LysCys: 1.002 ± 0.038	5.167LysAsp: 5.167 ± 0.099	7.581LysGlu: 7.581 ± 0.126	3.839LysPhe: 3.839 ± 0.078	4.584LysGly: 4.584 ± 0.093	1.365LysHis: 1.365 ± 0.052	9.908LysIle: 9.908 ± 0.131	10.449LysLys: 10.449 ± 0.129	7.356LysLeu: 7.356 ± 0.108	2.647LysMet: 2.647 ± 0.065	6.58LysAsn: 6.58 ± 0.109	2.496LysPro: 2.496 ± 0.068	2.704LysGln: 2.704 ± 0.071	3.969LysArg: 3.969 ± 0.082	5.795LysSer: 5.795 ± 0.099	5.412LysThr: 5.412 ± 0.093	5.381LysVal: 5.381 ± 0.082	0.61LysTrp: 0.61 ± 0.032	3.852LysTyr: 3.852 ± 0.083	0.001LysXaa: 0.001 ± 0.002
Leu	6.015LeuAla: 6.015 ± 0.094	1.292LeuCys: 1.292 ± 0.045	4.234LeuAsp: 4.234 ± 0.089	5.826LeuGlu: 5.826 ± 0.106	3.927LeuPhe: 3.927 ± 0.085	5.299LeuGly: 5.299 ± 0.088	1.355LeuHis: 1.355 ± 0.045	7.15LeuIle: 7.15 ± 0.116	9.65LeuLys: 9.65 ± 0.122	7.609LeuLeu: 7.609 ± 0.128	2.019LeuMet: 2.019 ± 0.057	5.032LeuAsn: 5.032 ± 0.102	3.236LeuPro: 3.236 ± 0.08	2.207LeuGln: 2.207 ± 0.058	4.03LeuArg: 4.03 ± 0.08	7.297LeuSer: 7.297 ± 0.113	4.243LeuThr: 4.243 ± 0.074	4.611LeuVal: 4.611 ± 0.088	0.677LeuTrp: 0.677 ± 0.03	2.791LeuTyr: 2.791 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	1.754MetAla: 1.754 ± 0.052	0.298MetCys: 0.298 ± 0.024	1.044MetAsp: 1.044 ± 0.043	1.536MetGlu: 1.536 ± 0.056	1.119MetPhe: 1.119 ± 0.041	1.44MetGly: 1.44 ± 0.046	0.449MetHis: 0.449 ± 0.024	1.709MetIle: 1.709 ± 0.048	2.276MetLys: 2.276 ± 0.046	2.518MetLeu: 2.518 ± 0.064	0.473MetMet: 0.473 ± 0.026	1.161MetAsn: 1.161 ± 0.042	1.235MetPro: 1.235 ± 0.045	0.902MetGln: 0.902 ± 0.036	1.095MetArg: 1.095 ± 0.038	1.819MetSer: 1.819 ± 0.054	1.075MetThr: 1.075 ± 0.041	1.347MetVal: 1.347 ± 0.046	0.123MetTrp: 0.123 ± 0.013	0.597MetTyr: 0.597 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	3.49AsnAla: 3.49 ± 0.066	0.715AsnCys: 0.715 ± 0.032	2.159AsnAsp: 2.159 ± 0.057	3.185AsnGlu: 3.185 ± 0.076	2.672AsnPhe: 2.672 ± 0.07	3.009AsnGly: 3.009 ± 0.074	0.625AsnHis: 0.625 ± 0.029	6.052AsnIle: 6.052 ± 0.098	4.654AsnLys: 4.654 ± 0.091	4.703AsnLeu: 4.703 ± 0.094	1.319AsnMet: 1.319 ± 0.045	2.592AsnAsn: 2.592 ± 0.071	2.273AsnPro: 2.273 ± 0.056	1.026AsnGln: 1.026 ± 0.046	2.112AsnArg: 2.112 ± 0.059	3.241AsnSer: 3.241 ± 0.073	2.297AsnThr: 2.297 ± 0.054	3.342AsnVal: 3.342 ± 0.071	0.389AsnTrp: 0.389 ± 0.025	1.947AsnTyr: 1.947 ± 0.058	0.001AsnXaa: 0.001 ± 0.002
Pro	2.173ProAla: 2.173 ± 0.059	0.374ProCys: 0.374 ± 0.024	1.932ProAsp: 1.932 ± 0.048	2.826ProGlu: 2.826 ± 0.064	1.516ProPhe: 1.516 ± 0.048	2.237ProGly: 2.237 ± 0.063	0.634ProHis: 0.634 ± 0.036	1.875ProIle: 1.875 ± 0.052	2.409ProLys: 2.409 ± 0.054	2.779ProLeu: 2.779 ± 0.073	0.573ProMet: 0.573 ± 0.03	1.159ProAsn: 1.159 ± 0.04	0.921ProPro: 0.921 ± 0.043	1.279ProGln: 1.279 ± 0.043	1.017ProArg: 1.017 ± 0.041	2.008ProSer: 2.008 ± 0.056	1.303ProThr: 1.303 ± 0.045	3.013ProVal: 3.013 ± 0.074	0.199ProTrp: 0.199 ± 0.018	1.158ProTyr: 1.158 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	1.694GlnAla: 1.694 ± 0.049	0.277GlnCys: 0.277 ± 0.023	1.059GlnAsp: 1.059 ± 0.039	1.745GlnGlu: 1.745 ± 0.055	1.005GlnPhe: 1.005 ± 0.039	1.246GlnGly: 1.246 ± 0.045	0.401GlnHis: 0.401 ± 0.023	2.412GlnIle: 2.412 ± 0.065	2.738GlnLys: 2.738 ± 0.07	1.842GlnLeu: 1.842 ± 0.056	0.692GlnMet: 0.692 ± 0.039	1.573GlnAsn: 1.573 ± 0.046	0.642GlnPro: 0.642 ± 0.034	0.837GlnGln: 0.837 ± 0.044	1.159GlnArg: 1.159 ± 0.045	1.751GlnSer: 1.751 ± 0.06	1.389GlnThr: 1.389 ± 0.051	1.279GlnVal: 1.279 ± 0.041	0.2GlnTrp: 0.2 ± 0.018	0.936GlnTyr: 0.936 ± 0.042	0.001GlnXaa: 0.001 ± 0.002
Arg	2.339ArgAla: 2.339 ± 0.063	0.618ArgCys: 0.618 ± 0.03	2.02ArgAsp: 2.02 ± 0.057	2.96ArgGlu: 2.96 ± 0.079	1.92ArgPhe: 1.92 ± 0.056	2.441ArgGly: 2.441 ± 0.064	0.829ArgHis: 0.829 ± 0.038	3.899ArgIle: 3.899 ± 0.07	4.231ArgLys: 4.231 ± 0.076	3.731ArgLeu: 3.731 ± 0.072	1.051ArgMet: 1.051 ± 0.039	2.45ArgAsn: 2.45 ± 0.055	1.283ArgPro: 1.283 ± 0.048	1.401ArgGln: 1.401 ± 0.047	1.964ArgArg: 1.964 ± 0.055	2.435ArgSer: 2.435 ± 0.067	2.17ArgThr: 2.17 ± 0.053	2.351ArgVal: 2.351 ± 0.065	0.317ArgTrp: 0.317 ± 0.022	1.51ArgTyr: 1.51 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	5.15SerAla: 5.15 ± 0.08	0.918SerCys: 0.918 ± 0.043	3.698SerAsp: 3.698 ± 0.081	4.506SerGlu: 4.506 ± 0.097	3.648SerPhe: 3.648 ± 0.087	5.568SerGly: 5.568 ± 0.102	0.917SerHis: 0.917 ± 0.031	5.035SerIle: 5.035 ± 0.107	5.919SerLys: 5.919 ± 0.109	6.17SerLeu: 6.17 ± 0.111	1.37SerMet: 1.37 ± 0.048	2.674SerAsn: 2.674 ± 0.072	1.953SerPro: 1.953 ± 0.06	1.792SerGln: 1.792 ± 0.055	2.792SerArg: 2.792 ± 0.064	4.594SerSer: 4.594 ± 0.09	2.255SerThr: 2.255 ± 0.058	4.989SerVal: 4.989 ± 0.093	0.429SerTrp: 0.429 ± 0.024	2.276SerTyr: 2.276 ± 0.06	0.0SerXaa: 0.0 ± 0.0
Thr	4.31ThrAla: 4.31 ± 0.075	0.458ThrCys: 0.458 ± 0.028	2.672ThrAsp: 2.672 ± 0.058	2.835ThrGlu: 2.835 ± 0.063	1.983ThrPhe: 1.983 ± 0.053	4.056ThrGly: 4.056 ± 0.076	0.742ThrHis: 0.742 ± 0.034	3.438ThrIle: 3.438 ± 0.077	3.709ThrLys: 3.709 ± 0.076	4.149ThrLeu: 4.149 ± 0.079	1.039ThrMet: 1.039 ± 0.039	2.031ThrAsn: 2.031 ± 0.055	1.697ThrPro: 1.697 ± 0.054	1.092ThrGln: 1.092 ± 0.039	1.554ThrArg: 1.554 ± 0.046	2.753ThrSer: 2.753 ± 0.064	2.089ThrThr: 2.089 ± 0.063	4.28ThrVal: 4.28 ± 0.084	0.221ThrTrp: 0.221 ± 0.018	1.313ThrTyr: 1.313 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	4.282ValAla: 4.282 ± 0.062	0.965ValCys: 0.965 ± 0.038	3.118ValAsp: 3.118 ± 0.074	4.436ValGlu: 4.436 ± 0.091	3.477ValPhe: 3.477 ± 0.084	3.703ValGly: 3.703 ± 0.074	0.983ValHis: 0.983 ± 0.036	5.529ValIle: 5.529 ± 0.108	6.573ValLys: 6.573 ± 0.106	6.484ValLeu: 6.484 ± 0.103	1.642ValMet: 1.642 ± 0.054	3.124ValAsn: 3.124 ± 0.067	2.382ValPro: 2.382 ± 0.061	1.401ValGln: 1.401 ± 0.053	2.641ValArg: 2.641 ± 0.068	5.173ValSer: 5.173 ± 0.1	2.725ValThr: 2.725 ± 0.071	4.331ValVal: 4.331 ± 0.091	0.488ValTrp: 0.488 ± 0.026	2.297ValTyr: 2.297 ± 0.058	0.0ValXaa: 0.0 ± 0.0
Trp	0.36TrpAla: 0.36 ± 0.023	0.111TrpCys: 0.111 ± 0.016	0.356TrpAsp: 0.356 ± 0.025	0.502TrpGlu: 0.502 ± 0.028	0.393TrpPhe: 0.393 ± 0.028	0.384TrpGly: 0.384 ± 0.023	0.17TrpHis: 0.17 ± 0.016	0.664TrpIle: 0.664 ± 0.036	0.594TrpLys: 0.594 ± 0.031	0.577TrpLeu: 0.577 ± 0.035	0.206TrpMet: 0.206 ± 0.017	0.446TrpAsn: 0.446 ± 0.027	0.141TrpPro: 0.141 ± 0.014	0.254TrpGln: 0.254 ± 0.019	0.353TrpArg: 0.353 ± 0.023	0.351TrpSer: 0.351 ± 0.021	0.344TrpThr: 0.344 ± 0.023	0.416TrpVal: 0.416 ± 0.026	0.07TrpTrp: 0.07 ± 0.011	0.187TrpTyr: 0.187 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.333TyrAla: 2.333 ± 0.061	0.511TyrCys: 0.511 ± 0.029	1.859TyrAsp: 1.859 ± 0.051	2.249TyrGlu: 2.249 ± 0.058	1.86TyrPhe: 1.86 ± 0.057	2.379TyrGly: 2.379 ± 0.067	0.461TyrHis: 0.461 ± 0.024	3.154TyrIle: 3.154 ± 0.069	3.23TyrLys: 3.23 ± 0.064	3.184TyrLeu: 3.184 ± 0.069	0.743TyrMet: 0.743 ± 0.033	1.866TyrAsn: 1.866 ± 0.057	1.309TyrPro: 1.309 ± 0.043	0.751TyrGln: 0.751 ± 0.037	1.63TyrArg: 1.63 ± 0.045	2.444TyrSer: 2.444 ± 0.063	1.418TyrThr: 1.418 ± 0.043	1.988TyrVal: 1.988 ± 0.051	0.301TyrTrp: 0.301 ± 0.024	1.418TyrTyr: 1.418 ± 0.053	0.003TyrXaa: 0.003 ± 0.003
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.004XaaLys: 0.004 ± 0.005	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.002	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.002	0.001XaaXaa: 0.001 ± 0.002

Statistics based on 2732 proteins (668676 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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