Amino acid dipepetide frequency for Corynebacterium timonense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.507AlaAla: 18.507 ± 0.287	1.01AlaCys: 1.01 ± 0.045	7.259AlaAsp: 7.259 ± 0.115	8.355AlaGlu: 8.355 ± 0.12	3.783AlaPhe: 3.783 ± 0.08	11.173AlaGly: 11.173 ± 0.145	2.672AlaHis: 2.672 ± 0.066	5.043AlaIle: 5.043 ± 0.082	2.909AlaLys: 2.909 ± 0.076	13.019AlaLeu: 13.019 ± 0.151	2.627AlaMet: 2.627 ± 0.065	2.746AlaAsn: 2.746 ± 0.069	6.437AlaPro: 6.437 ± 0.122	4.216AlaGln: 4.216 ± 0.079	8.811AlaArg: 8.811 ± 0.129	6.643AlaSer: 6.643 ± 0.095	7.416AlaThr: 7.416 ± 0.112	10.536AlaVal: 10.536 ± 0.133	1.718AlaTrp: 1.718 ± 0.06	2.472AlaTyr: 2.472 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.974CysAla: 0.974 ± 0.041	0.064CysCys: 0.064 ± 0.009	0.346CysAsp: 0.346 ± 0.021	0.384CysGlu: 0.384 ± 0.024	0.213CysPhe: 0.213 ± 0.018	0.715CysGly: 0.715 ± 0.032	0.148CysHis: 0.148 ± 0.015	0.278CysIle: 0.278 ± 0.02	0.107CysLys: 0.107 ± 0.012	0.566CysLeu: 0.566 ± 0.028	0.093CysMet: 0.093 ± 0.009	0.145CysAsn: 0.145 ± 0.015	0.358CysPro: 0.358 ± 0.022	0.183CysGln: 0.183 ± 0.016	0.424CysArg: 0.424 ± 0.027	0.452CysSer: 0.452 ± 0.03	0.442CysThr: 0.442 ± 0.028	0.551CysVal: 0.551 ± 0.029	0.075CysTrp: 0.075 ± 0.009	0.163CysTyr: 0.163 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.874AspAla: 7.874 ± 0.099	0.324AspCys: 0.324 ± 0.022	3.645AspAsp: 3.645 ± 0.085	4.32AspGlu: 4.32 ± 0.083	1.962AspPhe: 1.962 ± 0.053	5.047AspGly: 5.047 ± 0.089	1.195AspHis: 1.195 ± 0.038	2.871AspIle: 2.871 ± 0.069	1.64AspLys: 1.64 ± 0.047	5.458AspLeu: 5.458 ± 0.084	1.126AspMet: 1.126 ± 0.036	1.748AspAsn: 1.748 ± 0.055	3.907AspPro: 3.907 ± 0.069	1.455AspGln: 1.455 ± 0.047	3.321AspArg: 3.321 ± 0.071	3.041AspSer: 3.041 ± 0.068	3.569AspThr: 3.569 ± 0.076	5.287AspVal: 5.287 ± 0.094	0.81AspTrp: 0.81 ± 0.039	1.58AspTyr: 1.58 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	7.509GluAla: 7.509 ± 0.099	0.356GluCys: 0.356 ± 0.024	3.579GluAsp: 3.579 ± 0.071	4.44GluGlu: 4.44 ± 0.092	2.004GluPhe: 2.004 ± 0.05	4.926GluGly: 4.926 ± 0.094	1.569GluHis: 1.569 ± 0.05	3.027GluIle: 3.027 ± 0.074	2.193GluLys: 2.193 ± 0.068	6.785GluLeu: 6.785 ± 0.104	1.352GluMet: 1.352 ± 0.05	1.673GluAsn: 1.673 ± 0.052	3.079GluPro: 3.079 ± 0.064	2.514GluGln: 2.514 ± 0.059	4.901GluArg: 4.901 ± 0.082	2.891GluSer: 2.891 ± 0.053	3.328GluThr: 3.328 ± 0.069	5.114GluVal: 5.114 ± 0.074	0.907GluTrp: 0.907 ± 0.034	1.356GluTyr: 1.356 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	3.83PheAla: 3.83 ± 0.076	0.242PheCys: 0.242 ± 0.019	2.325PheAsp: 2.325 ± 0.061	1.804PheGlu: 1.804 ± 0.056	1.128PhePhe: 1.128 ± 0.044	3.254PheGly: 3.254 ± 0.071	0.643PheHis: 0.643 ± 0.033	1.312PheIle: 1.312 ± 0.05	0.555PheLys: 0.555 ± 0.03	2.959PheLeu: 2.959 ± 0.069	0.609PheMet: 0.609 ± 0.028	0.936PheAsn: 0.936 ± 0.033	1.413PhePro: 1.413 ± 0.046	0.765PheGln: 0.765 ± 0.034	1.774PheArg: 1.774 ± 0.05	1.986PheSer: 1.986 ± 0.057	2.23PheThr: 2.23 ± 0.065	2.591PheVal: 2.591 ± 0.064	0.434PheTrp: 0.434 ± 0.024	0.755PheTyr: 0.755 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	10.28GlyAla: 10.28 ± 0.151	0.63GlyCys: 0.63 ± 0.031	4.67GlyAsp: 4.67 ± 0.094	5.708GlyGlu: 5.708 ± 0.084	3.037GlyPhe: 3.037 ± 0.057	7.171GlyGly: 7.171 ± 0.138	1.848GlyHis: 1.848 ± 0.05	4.083GlyIle: 4.083 ± 0.079	2.414GlyLys: 2.414 ± 0.068	8.066GlyLeu: 8.066 ± 0.119	2.023GlyMet: 2.023 ± 0.053	2.069GlyAsn: 2.069 ± 0.06	3.833GlyPro: 3.833 ± 0.085	2.582GlyGln: 2.582 ± 0.062	5.683GlyArg: 5.683 ± 0.084	4.957GlySer: 4.957 ± 0.093	5.636GlyThr: 5.636 ± 0.107	7.67GlyVal: 7.67 ± 0.105	1.435GlyTrp: 1.435 ± 0.046	2.179GlyTyr: 2.179 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.347HisAla: 2.347 ± 0.062	0.163HisCys: 0.163 ± 0.015	1.367HisAsp: 1.367 ± 0.042	1.23HisGlu: 1.23 ± 0.042	0.611HisPhe: 0.611 ± 0.025	1.884HisGly: 1.884 ± 0.052	0.577HisHis: 0.577 ± 0.032	0.942HisIle: 0.942 ± 0.036	0.4HisLys: 0.4 ± 0.021	1.986HisLeu: 1.986 ± 0.062	0.425HisMet: 0.425 ± 0.026	0.603HisAsn: 0.603 ± 0.024	1.511HisPro: 1.511 ± 0.045	0.609HisGln: 0.609 ± 0.028	1.4HisArg: 1.4 ± 0.042	1.179HisSer: 1.179 ± 0.041	1.264HisThr: 1.264 ± 0.042	1.728HisVal: 1.728 ± 0.05	0.246HisTrp: 0.246 ± 0.018	0.47HisTyr: 0.47 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.228IleAla: 6.228 ± 0.099	0.325IleCys: 0.325 ± 0.02	3.418IleAsp: 3.418 ± 0.058	2.883IleGlu: 2.883 ± 0.078	1.304IlePhe: 1.304 ± 0.047	4.071IleGly: 4.071 ± 0.077	0.827IleHis: 0.827 ± 0.033	2.155IleIle: 2.155 ± 0.066	0.994IleLys: 0.994 ± 0.037	3.638IleLeu: 3.638 ± 0.071	0.805IleMet: 0.805 ± 0.038	1.311IleAsn: 1.311 ± 0.051	2.302IlePro: 2.302 ± 0.055	1.111IleGln: 1.111 ± 0.038	2.483IleArg: 2.483 ± 0.061	2.427IleSer: 2.427 ± 0.067	3.033IleThr: 3.033 ± 0.056	4.032IleVal: 4.032 ± 0.088	0.429IleTrp: 0.429 ± 0.024	0.919IleTyr: 0.919 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	2.988LysAla: 2.988 ± 0.076	0.117LysCys: 0.117 ± 0.013	1.455LysAsp: 1.455 ± 0.051	1.616LysGlu: 1.616 ± 0.05	0.643LysPhe: 0.643 ± 0.031	1.898LysGly: 1.898 ± 0.057	0.532LysHis: 0.532 ± 0.028	1.198LysIle: 1.198 ± 0.042	1.279LysLys: 1.279 ± 0.064	2.327LysLeu: 2.327 ± 0.066	0.557LysMet: 0.557 ± 0.028	0.863LysAsn: 0.863 ± 0.037	1.236LysPro: 1.236 ± 0.043	0.905LysGln: 0.905 ± 0.035	1.885LysArg: 1.885 ± 0.052	1.196LysSer: 1.196 ± 0.046	1.435LysThr: 1.435 ± 0.043	2.071LysVal: 2.071 ± 0.061	0.273LysTrp: 0.273 ± 0.019	0.512LysTyr: 0.512 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	12.856LeuAla: 12.856 ± 0.167	0.625LeuCys: 0.625 ± 0.029	6.18LeuAsp: 6.18 ± 0.091	5.225LeuGlu: 5.225 ± 0.099	2.759LeuPhe: 2.759 ± 0.07	8.523LeuGly: 8.523 ± 0.133	1.889LeuHis: 1.889 ± 0.049	4.501LeuIle: 4.501 ± 0.097	2.113LeuLys: 2.113 ± 0.06	8.679LeuLeu: 8.679 ± 0.152	1.813LeuMet: 1.813 ± 0.051	2.407LeuAsn: 2.407 ± 0.063	5.205LeuPro: 5.205 ± 0.09	2.302LeuGln: 2.302 ± 0.062	6.972LeuArg: 6.972 ± 0.117	5.885LeuSer: 5.885 ± 0.101	6.061LeuThr: 6.061 ± 0.089	8.427LeuVal: 8.427 ± 0.137	1.138LeuTrp: 1.138 ± 0.038	1.806LeuTyr: 1.806 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.478MetAla: 2.478 ± 0.058	0.128MetCys: 0.128 ± 0.013	1.036MetAsp: 1.036 ± 0.041	0.98MetGlu: 0.98 ± 0.036	0.609MetPhe: 0.609 ± 0.03	1.588MetGly: 1.588 ± 0.049	0.414MetHis: 0.414 ± 0.025	1.002MetIle: 1.002 ± 0.036	0.605MetLys: 0.605 ± 0.029	2.021MetLeu: 2.021 ± 0.054	0.413MetMet: 0.413 ± 0.025	0.658MetAsn: 0.658 ± 0.028	1.084MetPro: 1.084 ± 0.034	0.593MetGln: 0.593 ± 0.031	1.488MetArg: 1.488 ± 0.046	1.531MetSer: 1.531 ± 0.048	1.56MetThr: 1.56 ± 0.048	1.549MetVal: 1.549 ± 0.044	0.308MetTrp: 0.308 ± 0.02	0.377MetTyr: 0.377 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.031AsnAla: 3.031 ± 0.06	0.167AsnCys: 0.167 ± 0.016	1.455AsnAsp: 1.455 ± 0.046	1.468AsnGlu: 1.468 ± 0.052	0.803AsnPhe: 0.803 ± 0.037	2.21AsnGly: 2.21 ± 0.059	0.544AsnHis: 0.544 ± 0.027	1.206AsnIle: 1.206 ± 0.037	0.713AsnLys: 0.713 ± 0.031	2.442AsnLeu: 2.442 ± 0.054	0.542AsnMet: 0.542 ± 0.026	0.802AsnAsn: 0.802 ± 0.037	1.924AsnPro: 1.924 ± 0.051	0.831AsnGln: 0.831 ± 0.037	1.693AsnArg: 1.693 ± 0.048	1.359AsnSer: 1.359 ± 0.044	1.465AsnThr: 1.465 ± 0.051	2.05AsnVal: 2.05 ± 0.055	0.38AsnTrp: 0.38 ± 0.023	0.703AsnTyr: 0.703 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	7.064ProAla: 7.064 ± 0.125	0.268ProCys: 0.268 ± 0.021	3.57ProAsp: 3.57 ± 0.068	4.3ProGlu: 4.3 ± 0.077	1.656ProPhe: 1.656 ± 0.048	5.101ProGly: 5.101 ± 0.097	1.196ProHis: 1.196 ± 0.039	1.83ProIle: 1.83 ± 0.053	1.202ProLys: 1.202 ± 0.04	4.669ProLeu: 4.669 ± 0.093	0.898ProMet: 0.898 ± 0.033	1.332ProAsn: 1.332 ± 0.037	2.191ProPro: 2.191 ± 0.064	1.713ProGln: 1.713 ± 0.053	3.408ProArg: 3.408 ± 0.069	3.007ProSer: 3.007 ± 0.074	3.436ProThr: 3.436 ± 0.07	4.621ProVal: 4.621 ± 0.086	0.747ProTrp: 0.747 ± 0.03	1.128ProTyr: 1.128 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	3.601GlnAla: 3.601 ± 0.083	0.144GlnCys: 0.144 ± 0.018	1.351GlnAsp: 1.351 ± 0.039	1.741GlnGlu: 1.741 ± 0.044	0.913GlnPhe: 0.913 ± 0.035	2.227GlnGly: 2.227 ± 0.056	0.586GlnHis: 0.586 ± 0.024	1.471GlnIle: 1.471 ± 0.043	0.829GlnLys: 0.829 ± 0.036	3.469GlnLeu: 3.469 ± 0.071	0.669GlnMet: 0.669 ± 0.026	0.726GlnAsn: 0.726 ± 0.033	1.669GlnPro: 1.669 ± 0.052	1.321GlnGln: 1.321 ± 0.052	2.643GlnArg: 2.643 ± 0.069	1.412GlnSer: 1.412 ± 0.041	1.391GlnThr: 1.391 ± 0.045	2.492GlnVal: 2.492 ± 0.062	0.485GlnTrp: 0.485 ± 0.024	0.635GlnTyr: 0.635 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	8.387ArgAla: 8.387 ± 0.144	0.4ArgCys: 0.4 ± 0.02	4.152ArgAsp: 4.152 ± 0.072	4.979ArgGlu: 4.979 ± 0.077	2.198ArgPhe: 2.198 ± 0.05	5.334ArgGly: 5.334 ± 0.084	1.439ArgHis: 1.439 ± 0.04	3.123ArgIle: 3.123 ± 0.068	1.709ArgLys: 1.709 ± 0.054	6.063ArgLeu: 6.063 ± 0.088	1.637ArgMet: 1.637 ± 0.049	1.666ArgAsn: 1.666 ± 0.053	3.527ArgPro: 3.527 ± 0.084	2.17ArgGln: 2.17 ± 0.053	5.891ArgArg: 5.891 ± 0.125	3.762ArgSer: 3.762 ± 0.086	4.1ArgThr: 4.1 ± 0.072	5.55ArgVal: 5.55 ± 0.088	0.938ArgTrp: 0.938 ± 0.037	1.792ArgTyr: 1.792 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	6.801SerAla: 6.801 ± 0.109	0.354SerCys: 0.354 ± 0.023	2.92SerAsp: 2.92 ± 0.06	3.189SerGlu: 3.189 ± 0.079	1.912SerPhe: 1.912 ± 0.054	5.322SerGly: 5.322 ± 0.082	1.114SerHis: 1.114 ± 0.042	2.424SerIle: 2.424 ± 0.06	1.24SerLys: 1.24 ± 0.049	5.295SerLeu: 5.295 ± 0.086	1.276SerMet: 1.276 ± 0.04	1.385SerAsn: 1.385 ± 0.045	3.146SerPro: 3.146 ± 0.071	1.662SerGln: 1.662 ± 0.045	3.757SerArg: 3.757 ± 0.077	3.541SerSer: 3.541 ± 0.083	3.93SerThr: 3.93 ± 0.069	4.6SerVal: 4.6 ± 0.085	0.871SerTrp: 0.871 ± 0.034	1.387SerTyr: 1.387 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	7.343ThrAla: 7.343 ± 0.115	0.405ThrCys: 0.405 ± 0.021	3.473ThrAsp: 3.473 ± 0.074	3.293ThrGlu: 3.293 ± 0.057	1.998ThrPhe: 1.998 ± 0.056	5.495ThrGly: 5.495 ± 0.08	1.389ThrHis: 1.389 ± 0.05	2.804ThrIle: 2.804 ± 0.068	1.459ThrLys: 1.459 ± 0.047	6.17ThrLeu: 6.17 ± 0.088	1.16ThrMet: 1.16 ± 0.04	1.492ThrAsn: 1.492 ± 0.049	4.232ThrPro: 4.232 ± 0.084	1.698ThrGln: 1.698 ± 0.044	4.03ThrArg: 4.03 ± 0.08	3.549ThrSer: 3.549 ± 0.075	4.267ThrThr: 4.267 ± 0.103	5.739ThrVal: 5.739 ± 0.098	0.913ThrTrp: 0.913 ± 0.034	1.532ThrTyr: 1.532 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	11.102ValAla: 11.102 ± 0.159	0.663ValCys: 0.663 ± 0.029	5.865ValAsp: 5.865 ± 0.098	5.486ValGlu: 5.486 ± 0.094	2.694ValPhe: 2.694 ± 0.069	6.964ValGly: 6.964 ± 0.105	1.657ValHis: 1.657 ± 0.051	3.919ValIle: 3.919 ± 0.086	1.805ValLys: 1.805 ± 0.055	8.051ValLeu: 8.051 ± 0.124	1.697ValMet: 1.697 ± 0.055	2.155ValAsn: 2.155 ± 0.052	4.405ValPro: 4.405 ± 0.083	1.938ValGln: 1.938 ± 0.055	5.562ValArg: 5.562 ± 0.094	5.111ValSer: 5.111 ± 0.089	5.752ValThr: 5.752 ± 0.093	8.312ValVal: 8.312 ± 0.133	1.094ValTrp: 1.094 ± 0.047	1.72ValTyr: 1.72 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.567TrpAla: 1.567 ± 0.046	0.131TrpCys: 0.131 ± 0.014	0.71TrpAsp: 0.71 ± 0.031	0.778TrpGlu: 0.778 ± 0.032	0.521TrpPhe: 0.521 ± 0.025	0.983TrpGly: 0.983 ± 0.04	0.288TrpHis: 0.288 ± 0.019	0.606TrpIle: 0.606 ± 0.031	0.34TrpLys: 0.34 ± 0.024	1.543TrpLeu: 1.543 ± 0.051	0.312TrpMet: 0.312 ± 0.021	0.386TrpAsn: 0.386 ± 0.022	0.667TrpPro: 0.667 ± 0.029	0.505TrpGln: 0.505 ± 0.027	1.082TrpArg: 1.082 ± 0.039	0.754TrpSer: 0.754 ± 0.032	0.705TrpThr: 0.705 ± 0.031	1.345TrpVal: 1.345 ± 0.044	0.298TrpTrp: 0.298 ± 0.021	0.274TrpTyr: 0.274 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.587TyrAla: 2.587 ± 0.056	0.167TyrCys: 0.167 ± 0.016	1.403TyrAsp: 1.403 ± 0.042	1.323TyrGlu: 1.323 ± 0.044	0.799TyrPhe: 0.799 ± 0.028	2.087TyrGly: 2.087 ± 0.054	0.414TyrHis: 0.414 ± 0.023	0.902TyrIle: 0.902 ± 0.035	0.482TyrLys: 0.482 ± 0.027	2.161TyrLeu: 2.161 ± 0.062	0.386TyrMet: 0.386 ± 0.02	0.681TyrAsn: 0.681 ± 0.031	1.21TyrPro: 1.21 ± 0.037	0.702TyrGln: 0.702 ± 0.031	1.611TyrArg: 1.611 ± 0.045	1.444TyrSer: 1.444 ± 0.043	1.421TyrThr: 1.421 ± 0.048	1.686TyrVal: 1.686 ± 0.05	0.296TyrTrp: 0.296 ± 0.02	0.566TyrTyr: 0.566 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2311 proteins (750681 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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