Amino acid dipepetide frequency for Ranid herpesvirus 1 (strain McKinnell) (RaHV-1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.82AlaAla: 11.82 ± 0.483
2.688AlaCys: 2.688 ± 0.251
4.441AlaAsp: 4.441 ± 0.305
5.042AlaGlu: 5.042 ± 0.355
3.155AlaPhe: 3.155 ± 0.303
4.408AlaGly: 4.408 ± 0.288
3.957AlaHis: 3.957 ± 0.242
3.072AlaIle: 3.072 ± 0.267
2.22AlaLys: 2.22 ± 0.254
11.987AlaLeu: 11.987 ± 0.602
2.471AlaMet: 2.471 ± 0.242
2.454AlaAsn: 2.454 ± 0.219
6.929AlaPro: 6.929 ± 0.593
4.625AlaGln: 4.625 ± 0.351
7.73AlaArg: 7.73 ± 0.447
6.177AlaSer: 6.177 ± 0.513
5.326AlaThr: 5.326 ± 0.308
7.129AlaVal: 7.129 ± 0.423
1.386AlaTrp: 1.386 ± 0.166
3.189AlaTyr: 3.189 ± 0.24
0.0AlaXaa: 0.0 ± 0.0
Cys
3.907CysAla: 3.907 ± 0.31
1.102CysCys: 1.102 ± 0.185
1.686CysAsp: 1.686 ± 0.165
1.586CysGlu: 1.586 ± 0.175
1.219CysPhe: 1.219 ± 0.112
2.371CysGly: 2.371 ± 0.248
0.701CysHis: 0.701 ± 0.119
1.402CysIle: 1.402 ± 0.172
1.018CysLys: 1.018 ± 0.157
3.072CysLeu: 3.072 ± 0.267
1.069CysMet: 1.069 ± 0.168
1.152CysAsn: 1.152 ± 0.16
1.603CysPro: 1.603 ± 0.189
0.801CysGln: 0.801 ± 0.111
1.619CysArg: 1.619 ± 0.167
1.703CysSer: 1.703 ± 0.186
2.554CysThr: 2.554 ± 0.238
2.521CysVal: 2.521 ± 0.211
0.267CysTrp: 0.267 ± 0.086
1.219CysTyr: 1.219 ± 0.157
0.0CysXaa: 0.0 ± 0.0
Asp
5.075AspAla: 5.075 ± 0.307
1.052AspCys: 1.052 ± 0.149
1.92AspAsp: 1.92 ± 0.201
2.488AspGlu: 2.488 ± 0.177
0.902AspPhe: 0.902 ± 0.121
2.738AspGly: 2.738 ± 0.264
0.885AspHis: 0.885 ± 0.13
1.836AspIle: 1.836 ± 0.208
1.286AspLys: 1.286 ± 0.16
3.623AspLeu: 3.623 ± 0.287
1.302AspMet: 1.302 ± 0.177
1.185AspAsn: 1.185 ± 0.155
3.256AspPro: 3.256 ± 0.229
1.336AspGln: 1.336 ± 0.157
2.538AspArg: 2.538 ± 0.22
2.438AspSer: 2.438 ± 0.196
3.489AspThr: 3.489 ± 0.213
3.673AspVal: 3.673 ± 0.265
0.718AspTrp: 0.718 ± 0.1
1.085AspTyr: 1.085 ± 0.148
0.0AspXaa: 0.0 ± 0.0
Glu
4.625GluAla: 4.625 ± 0.385
1.369GluCys: 1.369 ± 0.137
2.788GluAsp: 2.788 ± 0.227
3.573GluGlu: 3.573 ± 0.369
0.985GluPhe: 0.985 ± 0.123
2.888GluGly: 2.888 ± 0.19
2.02GluHis: 2.02 ± 0.157
1.67GluIle: 1.67 ± 0.201
1.503GluLys: 1.503 ± 0.191
5.66GluLeu: 5.66 ± 0.546
1.436GluMet: 1.436 ± 0.16
1.486GluAsn: 1.486 ± 0.139
3.122GluPro: 3.122 ± 0.181
2.621GluGln: 2.621 ± 0.358
4.14GluArg: 4.14 ± 0.343
3.606GluSer: 3.606 ± 0.39
3.005GluThr: 3.005 ± 0.215
2.822GluVal: 2.822 ± 0.246
0.785GluTrp: 0.785 ± 0.097
1.519GluTyr: 1.519 ± 0.144
0.0GluXaa: 0.0 ± 0.0
Phe
3.222PheAla: 3.222 ± 0.223
0.968PheCys: 0.968 ± 0.137
1.102PheAsp: 1.102 ± 0.188
1.269PheGlu: 1.269 ± 0.172
1.085PhePhe: 1.085 ± 0.161
1.436PheGly: 1.436 ± 0.172
1.069PheHis: 1.069 ± 0.156
1.085PheIle: 1.085 ± 0.152
1.085PheLys: 1.085 ± 0.158
2.972PheLeu: 2.972 ± 0.243
0.902PheMet: 0.902 ± 0.125
0.985PheAsn: 0.985 ± 0.157
1.503PhePro: 1.503 ± 0.146
0.768PheGln: 0.768 ± 0.124
1.653PheArg: 1.653 ± 0.188
1.386PheSer: 1.386 ± 0.153
2.07PheThr: 2.07 ± 0.198
2.471PheVal: 2.471 ± 0.235
0.351PheTrp: 0.351 ± 0.075
1.352PheTyr: 1.352 ± 0.184
0.0PheXaa: 0.0 ± 0.0
Gly
6.494GlyAla: 6.494 ± 0.421
1.553GlyCys: 1.553 ± 0.14
2.571GlyAsp: 2.571 ± 0.237
3.239GlyGlu: 3.239 ± 0.24
1.903GlyPhe: 1.903 ± 0.188
4.341GlyGly: 4.341 ± 0.401
1.77GlyHis: 1.77 ± 0.122
2.204GlyIle: 2.204 ± 0.173
1.436GlyLys: 1.436 ± 0.153
4.207GlyLeu: 4.207 ± 0.326
1.052GlyMet: 1.052 ± 0.152
1.887GlyAsn: 1.887 ± 0.19
2.655GlyPro: 2.655 ± 0.213
1.603GlyGln: 1.603 ± 0.148
4.524GlyArg: 4.524 ± 0.371
4.207GlySer: 4.207 ± 0.493
4.157GlyThr: 4.157 ± 0.282
4.808GlyVal: 4.808 ± 0.326
0.968GlyTrp: 0.968 ± 0.123
1.903GlyTyr: 1.903 ± 0.185
0.0GlyXaa: 0.0 ± 0.0
His
3.272HisAla: 3.272 ± 0.209
0.985HisCys: 0.985 ± 0.112
1.386HisAsp: 1.386 ± 0.161
1.553HisGlu: 1.553 ± 0.185
0.818HisPhe: 0.818 ± 0.142
2.237HisGly: 2.237 ± 0.191
1.235HisHis: 1.235 ± 0.161
1.736HisIle: 1.736 ± 0.19
1.235HisLys: 1.235 ± 0.14
3.356HisLeu: 3.356 ± 0.27
1.352HisMet: 1.352 ± 0.157
1.469HisAsn: 1.469 ± 0.174
2.254HisPro: 2.254 ± 0.277
1.018HisGln: 1.018 ± 0.123
2.521HisArg: 2.521 ± 0.225
2.488HisSer: 2.488 ± 0.234
3.222HisThr: 3.222 ± 0.271
2.671HisVal: 2.671 ± 0.223
0.317HisTrp: 0.317 ± 0.069
1.419HisTyr: 1.419 ± 0.19
0.0HisXaa: 0.0 ± 0.0
Ile
3.589IleAla: 3.589 ± 0.244
1.302IleCys: 1.302 ± 0.154
1.603IleAsp: 1.603 ± 0.181
1.72IleGlu: 1.72 ± 0.157
1.419IlePhe: 1.419 ± 0.202
2.07IleGly: 2.07 ± 0.197
1.152IleHis: 1.152 ± 0.124
1.352IleIle: 1.352 ± 0.154
1.185IleLys: 1.185 ± 0.123
3.589IleLeu: 3.589 ± 0.347
1.119IleMet: 1.119 ± 0.144
1.369IleAsn: 1.369 ± 0.147
2.638IlePro: 2.638 ± 0.228
1.336IleGln: 1.336 ± 0.212
2.421IleArg: 2.421 ± 0.216
2.438IleSer: 2.438 ± 0.212
2.588IleThr: 2.588 ± 0.283
2.421IleVal: 2.421 ± 0.232
0.401IleTrp: 0.401 ± 0.078
1.352IleTyr: 1.352 ± 0.146
0.0IleXaa: 0.0 ± 0.0
Lys
2.888LysAla: 2.888 ± 0.257
1.052LysCys: 1.052 ± 0.144
1.302LysAsp: 1.302 ± 0.125
1.72LysGlu: 1.72 ± 0.198
0.401LysPhe: 0.401 ± 0.072
1.185LysGly: 1.185 ± 0.177
1.636LysHis: 1.636 ± 0.198
0.985LysIle: 0.985 ± 0.162
0.718LysLys: 0.718 ± 0.151
2.955LysLeu: 2.955 ± 0.258
0.701LysMet: 0.701 ± 0.102
0.835LysAsn: 0.835 ± 0.124
1.953LysPro: 1.953 ± 0.268
1.603LysGln: 1.603 ± 0.228
2.504LysArg: 2.504 ± 0.237
1.72LysSer: 1.72 ± 0.184
1.452LysThr: 1.452 ± 0.177
1.503LysVal: 1.503 ± 0.165
0.367LysTrp: 0.367 ± 0.078
0.935LysTyr: 0.935 ± 0.135
0.0LysXaa: 0.0 ± 0.0
Leu
7.48LeuAla: 7.48 ± 0.527
4.374LeuCys: 4.374 ± 0.346
3.923LeuAsp: 3.923 ± 0.292
5.209LeuGlu: 5.209 ± 0.462
2.972LeuPhe: 2.972 ± 0.243
4.491LeuGly: 4.491 ± 0.293
3.589LeuHis: 3.589 ± 0.323
3.306LeuIle: 3.306 ± 0.244
2.805LeuLys: 2.805 ± 0.23
9.399LeuLeu: 9.399 ± 0.566
2.521LeuMet: 2.521 ± 0.208
3.072LeuAsn: 3.072 ± 0.253
5.509LeuPro: 5.509 ± 0.367
4.491LeuGln: 4.491 ± 0.402
8.197LeuArg: 8.197 ± 0.503
7.129LeuSer: 7.129 ± 0.39
6.01LeuThr: 6.01 ± 0.324
5.209LeuVal: 5.209 ± 0.395
1.286LeuTrp: 1.286 ± 0.132
4.875LeuTyr: 4.875 ± 0.359
0.0LeuXaa: 0.0 ± 0.0
Met
2.304MetAla: 2.304 ± 0.229
1.219MetCys: 1.219 ± 0.159
0.885MetAsp: 0.885 ± 0.119
1.436MetGlu: 1.436 ± 0.15
0.735MetPhe: 0.735 ± 0.122
1.67MetGly: 1.67 ± 0.2
1.235MetHis: 1.235 ± 0.148
0.818MetIle: 0.818 ± 0.104
0.634MetLys: 0.634 ± 0.106
2.621MetLeu: 2.621 ± 0.246
0.434MetMet: 0.434 ± 0.104
0.618MetAsn: 0.618 ± 0.094
1.419MetPro: 1.419 ± 0.213
1.252MetGln: 1.252 ± 0.157
2.488MetArg: 2.488 ± 0.204
1.352MetSer: 1.352 ± 0.181
1.085MetThr: 1.085 ± 0.145
1.836MetVal: 1.836 ± 0.19
0.384MetTrp: 0.384 ± 0.092
0.801MetTyr: 0.801 ± 0.106
0.0MetXaa: 0.0 ± 0.0
Asn
3.973AsnAla: 3.973 ± 0.276
0.651AsnCys: 0.651 ± 0.118
1.235AsnAsp: 1.235 ± 0.174
1.619AsnGlu: 1.619 ± 0.186
0.835AsnPhe: 0.835 ± 0.121
2.054AsnGly: 2.054 ± 0.211
1.052AsnHis: 1.052 ± 0.119
1.586AsnIle: 1.586 ± 0.178
1.102AsnLys: 1.102 ± 0.17
2.504AsnLeu: 2.504 ± 0.2
1.035AsnMet: 1.035 ± 0.135
1.069AsnAsn: 1.069 ± 0.149
2.137AsnPro: 2.137 ± 0.232
0.735AsnGln: 0.735 ± 0.119
2.054AsnArg: 2.054 ± 0.193
2.254AsnSer: 2.254 ± 0.203
3.039AsnThr: 3.039 ± 0.216
2.404AsnVal: 2.404 ± 0.212
0.284AsnTrp: 0.284 ± 0.065
0.885AsnTyr: 0.885 ± 0.117
0.0AsnXaa: 0.0 ± 0.0
Pro
5.543ProAla: 5.543 ± 0.523
1.97ProCys: 1.97 ± 0.218
2.721ProAsp: 2.721 ± 0.204
2.738ProGlu: 2.738 ± 0.225
1.469ProPhe: 1.469 ± 0.156
3.673ProGly: 3.673 ± 0.288
3.439ProHis: 3.439 ± 0.336
2.354ProIle: 2.354 ± 0.196
1.402ProLys: 1.402 ± 0.196
6.361ProLeu: 6.361 ± 0.462
1.252ProMet: 1.252 ± 0.16
2.17ProAsn: 2.17 ± 0.199
7.58ProPro: 7.58 ± 1.428
2.888ProGln: 2.888 ± 0.334
4.708ProArg: 4.708 ± 0.394
4.408ProSer: 4.408 ± 0.563
4.558ProThr: 4.558 ± 0.531
4.307ProVal: 4.307 ± 0.314
0.918ProTrp: 0.918 ± 0.113
1.786ProTyr: 1.786 ± 0.191
0.0ProXaa: 0.0 ± 0.0
Gln
3.172GlnAla: 3.172 ± 0.269
1.803GlnCys: 1.803 ± 0.188
1.903GlnAsp: 1.903 ± 0.179
2.037GlnGlu: 2.037 ± 0.232
0.902GlnPhe: 0.902 ± 0.115
1.92GlnGly: 1.92 ± 0.149
1.569GlnHis: 1.569 ± 0.189
1.319GlnIle: 1.319 ± 0.137
1.135GlnLys: 1.135 ± 0.149
3.372GlnLeu: 3.372 ± 0.271
0.985GlnMet: 0.985 ± 0.142
1.569GlnAsn: 1.569 ± 0.2
2.17GlnPro: 2.17 ± 0.211
1.686GlnGln: 1.686 ± 0.244
3.389GlnArg: 3.389 ± 0.288
2.621GlnSer: 2.621 ± 0.302
2.204GlnThr: 2.204 ± 0.212
1.603GlnVal: 1.603 ± 0.15
0.618GlnTrp: 0.618 ± 0.095
1.82GlnTyr: 1.82 ± 0.2
0.0GlnXaa: 0.0 ± 0.0
Arg
7.93ArgAla: 7.93 ± 0.516
2.488ArgCys: 2.488 ± 0.23
3.589ArgAsp: 3.589 ± 0.3
3.807ArgGlu: 3.807 ± 0.465
2.07ArgPhe: 2.07 ± 0.152
5.125ArgGly: 5.125 ± 0.279
2.371ArgHis: 2.371 ± 0.207
3.189ArgIle: 3.189 ± 0.247
2.287ArgLys: 2.287 ± 0.219
6.494ArgLeu: 6.494 ± 0.403
1.92ArgMet: 1.92 ± 0.175
2.237ArgAsn: 2.237 ± 0.22
3.74ArgPro: 3.74 ± 0.345
2.003ArgGln: 2.003 ± 0.183
6.06ArgArg: 6.06 ± 0.403
4.975ArgSer: 4.975 ± 0.724
4.858ArgThr: 4.858 ± 0.252
5.593ArgVal: 5.593 ± 0.324
1.052ArgTrp: 1.052 ± 0.127
2.538ArgTyr: 2.538 ± 0.199
0.0ArgXaa: 0.0 ± 0.0
Ser
7.463SerAla: 7.463 ± 0.458
1.586SerCys: 1.586 ± 0.165
2.554SerAsp: 2.554 ± 0.233
2.788SerGlu: 2.788 ± 0.233
2.321SerPhe: 2.321 ± 0.225
4.191SerGly: 4.191 ± 0.574
1.97SerHis: 1.97 ± 0.178
2.237SerIle: 2.237 ± 0.202
2.003SerLys: 2.003 ± 0.207
5.726SerLeu: 5.726 ± 0.247
1.503SerMet: 1.503 ± 0.184
2.237SerAsn: 2.237 ± 0.215
4.775SerPro: 4.775 ± 1.158
1.82SerGln: 1.82 ± 0.261
4.09SerArg: 4.09 ± 0.528
5.576SerSer: 5.576 ± 1.225
5.426SerThr: 5.426 ± 0.434
4.725SerVal: 4.725 ± 0.251
0.785SerTrp: 0.785 ± 0.118
2.337SerTyr: 2.337 ± 0.215
0.0SerXaa: 0.0 ± 0.0
Thr
6.912ThrAla: 6.912 ± 0.303
2.254ThrCys: 2.254 ± 0.24
2.22ThrAsp: 2.22 ± 0.192
3.089ThrGlu: 3.089 ± 0.257
2.12ThrPhe: 2.12 ± 0.187
3.539ThrGly: 3.539 ± 0.275
2.738ThrHis: 2.738 ± 0.197
2.538ThrIle: 2.538 ± 0.243
1.836ThrLys: 1.836 ± 0.211
6.745ThrLeu: 6.745 ± 0.359
1.369ThrMet: 1.369 ± 0.172
2.404ThrAsn: 2.404 ± 0.254
6.561ThrPro: 6.561 ± 0.607
2.872ThrGln: 2.872 ± 0.286
4.892ThrArg: 4.892 ± 0.287
4.191ThrSer: 4.191 ± 0.402
5.125ThrThr: 5.125 ± 0.37
4.274ThrVal: 4.274 ± 0.223
0.735ThrTrp: 0.735 ± 0.135
1.987ThrTyr: 1.987 ± 0.213
0.0ThrXaa: 0.0 ± 0.0
Val
5.893ValAla: 5.893 ± 0.384
2.655ValCys: 2.655 ± 0.236
2.771ValAsp: 2.771 ± 0.241
4.424ValGlu: 4.424 ± 0.279
2.137ValPhe: 2.137 ± 0.187
3.873ValGly: 3.873 ± 0.267
2.521ValHis: 2.521 ± 0.202
2.187ValIle: 2.187 ± 0.181
1.77ValLys: 1.77 ± 0.165
7.363ValLeu: 7.363 ± 0.503
1.402ValMet: 1.402 ± 0.148
1.92ValAsn: 1.92 ± 0.232
4.408ValPro: 4.408 ± 0.351
3.055ValGln: 3.055 ± 0.209
5.543ValArg: 5.543 ± 0.398
4.257ValSer: 4.257 ± 0.282
4.291ValThr: 4.291 ± 0.272
5.242ValVal: 5.242 ± 0.409
1.135ValTrp: 1.135 ± 0.152
2.354ValTyr: 2.354 ± 0.206
0.0ValXaa: 0.0 ± 0.0
Trp
1.018TrpAla: 1.018 ± 0.129
0.401TrpCys: 0.401 ± 0.082
0.701TrpAsp: 0.701 ± 0.121
0.618TrpGlu: 0.618 ± 0.099
0.401TrpPhe: 0.401 ± 0.081
0.952TrpGly: 0.952 ± 0.107
0.618TrpHis: 0.618 ± 0.123
0.551TrpIle: 0.551 ± 0.095
0.484TrpLys: 0.484 ± 0.092
1.135TrpLeu: 1.135 ± 0.152
0.301TrpMet: 0.301 ± 0.078
0.718TrpAsn: 0.718 ± 0.109
0.584TrpPro: 0.584 ± 0.097
0.384TrpGln: 0.384 ± 0.091
1.219TrpArg: 1.219 ± 0.136
0.851TrpSer: 0.851 ± 0.133
0.751TrpThr: 0.751 ± 0.119
0.835TrpVal: 0.835 ± 0.131
0.451TrpTrp: 0.451 ± 0.103
0.651TrpTyr: 0.651 ± 0.098
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.623TyrAla: 3.623 ± 0.251
1.102TyrCys: 1.102 ± 0.152
1.519TyrAsp: 1.519 ± 0.182
1.686TyrGlu: 1.686 ± 0.181
0.885TyrPhe: 0.885 ± 0.112
2.321TyrGly: 2.321 ± 0.191
1.018TyrHis: 1.018 ± 0.112
1.636TyrIle: 1.636 ± 0.188
1.269TyrLys: 1.269 ± 0.133
2.705TyrLeu: 2.705 ± 0.251
1.085TyrMet: 1.085 ± 0.14
1.67TyrAsn: 1.67 ± 0.156
1.452TyrPro: 1.452 ± 0.171
0.902TyrGln: 0.902 ± 0.146
2.037TyrArg: 2.037 ± 0.196
2.337TyrSer: 2.337 ± 0.199
3.189TyrThr: 3.189 ± 0.215
3.155TyrVal: 3.155 ± 0.266
0.417TyrTrp: 0.417 ± 0.086
1.235TyrTyr: 1.235 ± 0.155
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 132 proteins (59898 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski