Amino acid dipepetide frequency for Wenzhou picorna-like virus 40

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.124AlaAla: 5.124 ± 0.34
0.788AlaCys: 0.788 ± 0.655
1.577AlaAsp: 1.577 ± 0.929
1.971AlaGlu: 1.971 ± 1.161
3.153AlaPhe: 3.153 ± 0.738
5.124AlaGly: 5.124 ± 0.34
1.577AlaHis: 1.577 ± 0.191
4.73AlaIle: 4.73 ± 0.012
3.153AlaLys: 3.153 ± 1.298
4.73AlaLeu: 4.73 ± 0.548
1.577AlaMet: 1.577 ± 0.929
1.971AlaAsn: 1.971 ± 0.042
3.153AlaPro: 3.153 ± 0.941
1.971AlaGln: 1.971 ± 0.518
1.577AlaArg: 1.577 ± 0.75
1.971AlaSer: 1.971 ± 0.601
7.489AlaThr: 7.489 ± 2.865
2.365AlaVal: 2.365 ± 0.274
0.0AlaTrp: 0.0 ± 0.0
2.365AlaTyr: 2.365 ± 1.405
0.0AlaXaa: 0.0 ± 0.0
Cys
1.577CysAla: 1.577 ± 0.369
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.788CysGlu: 0.788 ± 0.464
1.577CysPhe: 1.577 ± 0.191
0.394CysGly: 0.394 ± 0.232
0.394CysHis: 0.394 ± 0.232
1.182CysIle: 1.182 ± 0.137
1.182CysLys: 1.182 ± 0.137
1.182CysLeu: 1.182 ± 0.137
0.394CysMet: 0.394 ± 0.232
1.182CysAsn: 1.182 ± 0.137
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.788CysArg: 0.788 ± 0.095
0.0CysSer: 0.0 ± 0.0
0.788CysThr: 0.788 ± 0.464
1.971CysVal: 1.971 ± 0.601
0.0CysTrp: 0.0 ± 0.0
0.394CysTyr: 0.394 ± 0.328
0.0CysXaa: 0.0 ± 0.0
Asp
4.336AspAla: 4.336 ± 0.315
0.394AspCys: 0.394 ± 0.232
2.365AspAsp: 2.365 ± 0.834
5.518AspGlu: 5.518 ± 1.012
4.336AspPhe: 4.336 ± 0.875
1.577AspGly: 1.577 ± 0.369
1.577AspHis: 1.577 ± 0.929
4.336AspIle: 4.336 ± 0.244
3.942AspLys: 3.942 ± 1.203
5.124AspLeu: 5.124 ± 0.34
1.182AspMet: 1.182 ± 0.423
2.759AspAsn: 2.759 ± 0.506
2.365AspPro: 2.365 ± 1.405
0.0AspGln: 0.0 ± 0.0
0.394AspArg: 0.394 ± 0.328
3.153AspSer: 3.153 ± 1.501
4.336AspThr: 4.336 ± 0.244
5.124AspVal: 5.124 ± 1.34
0.394AspTrp: 0.394 ± 0.232
1.577AspTyr: 1.577 ± 0.369
0.0AspXaa: 0.0 ± 0.0
Glu
4.336GluAla: 4.336 ± 0.315
0.0GluCys: 0.0 ± 0.0
3.547GluAsp: 3.547 ± 0.411
2.365GluGlu: 2.365 ± 0.834
3.547GluPhe: 3.547 ± 0.411
1.182GluGly: 1.182 ± 0.697
1.577GluHis: 1.577 ± 0.191
4.336GluIle: 4.336 ± 0.315
3.153GluLys: 3.153 ± 0.178
3.547GluLeu: 3.547 ± 0.709
1.971GluMet: 1.971 ± 0.601
3.942GluAsn: 3.942 ± 2.322
2.759GluPro: 2.759 ± 0.613
1.971GluGln: 1.971 ± 0.042
0.788GluArg: 0.788 ± 0.655
4.336GluSer: 4.336 ± 1.435
2.365GluThr: 2.365 ± 0.286
3.942GluVal: 3.942 ± 0.083
1.577GluTrp: 1.577 ± 0.369
2.365GluTyr: 2.365 ± 0.834
0.0GluXaa: 0.0 ± 0.0
Phe
1.182PheAla: 1.182 ± 0.137
0.394PheCys: 0.394 ± 0.232
4.73PheAsp: 4.73 ± 1.107
3.153PheGlu: 3.153 ± 1.298
2.759PhePhe: 2.759 ± 0.506
3.942PheGly: 3.942 ± 0.083
0.788PheHis: 0.788 ± 0.095
3.547PheIle: 3.547 ± 0.97
3.942PheLys: 3.942 ± 0.083
4.73PheLeu: 4.73 ± 0.572
2.365PheMet: 2.365 ± 0.214
4.336PheAsn: 4.336 ± 0.244
1.182PhePro: 1.182 ± 0.423
2.365PheGln: 2.365 ± 0.286
1.577PheArg: 1.577 ± 0.369
4.336PheSer: 4.336 ± 0.875
3.547PheThr: 3.547 ± 0.709
8.277PheVal: 8.277 ± 0.721
0.0PheTrp: 0.0 ± 0.0
3.547PheTyr: 3.547 ± 0.149
0.0PheXaa: 0.0 ± 0.0
Gly
2.365GlyAla: 2.365 ± 0.274
2.365GlyCys: 2.365 ± 0.834
2.759GlyAsp: 2.759 ± 1.066
3.153GlyGlu: 3.153 ± 0.178
4.336GlyPhe: 4.336 ± 0.315
3.547GlyGly: 3.547 ± 0.709
0.788GlyHis: 0.788 ± 0.464
3.153GlyIle: 3.153 ± 0.381
6.701GlyLys: 6.701 ± 2.828
2.759GlyLeu: 2.759 ± 0.613
0.788GlyMet: 0.788 ± 0.464
2.365GlyAsn: 2.365 ± 0.286
1.577GlyPro: 1.577 ± 0.75
1.577GlyGln: 1.577 ± 0.191
2.365GlyArg: 2.365 ± 0.286
2.759GlySer: 2.759 ± 0.613
4.336GlyThr: 4.336 ± 0.804
2.365GlyVal: 2.365 ± 0.846
0.394GlyTrp: 0.394 ± 0.328
3.153GlyTyr: 3.153 ± 0.178
0.0GlyXaa: 0.0 ± 0.0
His
1.577HisAla: 1.577 ± 0.75
0.394HisCys: 0.394 ± 0.232
0.394HisAsp: 0.394 ± 0.328
3.153HisGlu: 3.153 ± 0.178
2.759HisPhe: 2.759 ± 0.506
0.788HisGly: 0.788 ± 0.095
0.0HisHis: 0.0 ± 0.0
1.182HisIle: 1.182 ± 0.697
1.577HisLys: 1.577 ± 0.369
1.577HisLeu: 1.577 ± 0.369
1.577HisMet: 1.577 ± 0.369
0.394HisAsn: 0.394 ± 0.328
0.788HisPro: 0.788 ± 0.464
0.0HisGln: 0.0 ± 0.0
0.394HisArg: 0.394 ± 0.328
2.759HisSer: 2.759 ± 0.506
1.182HisThr: 1.182 ± 0.423
2.365HisVal: 2.365 ± 0.274
0.0HisTrp: 0.0 ± 0.0
0.394HisTyr: 0.394 ± 0.232
0.0HisXaa: 0.0 ± 0.0
Ile
3.547IleAla: 3.547 ± 0.149
0.788IleCys: 0.788 ± 0.464
5.518IleAsp: 5.518 ± 0.452
5.518IleGlu: 5.518 ± 0.452
3.547IlePhe: 3.547 ± 0.97
2.759IleGly: 2.759 ± 0.506
0.788IleHis: 0.788 ± 0.464
5.912IleIle: 5.912 ± 0.684
5.912IleLys: 5.912 ± 1.804
3.547IleLeu: 3.547 ± 0.149
1.577IleMet: 1.577 ± 0.191
3.942IleAsn: 3.942 ± 1.203
2.365IlePro: 2.365 ± 0.286
1.182IleGln: 1.182 ± 0.423
1.971IleArg: 1.971 ± 0.601
3.153IleSer: 3.153 ± 0.941
5.124IleThr: 5.124 ± 2.019
2.365IleVal: 2.365 ± 0.846
0.788IleTrp: 0.788 ± 0.464
4.336IleTyr: 4.336 ± 0.315
0.0IleXaa: 0.0 ± 0.0
Lys
1.182LysAla: 1.182 ± 0.137
0.788LysCys: 0.788 ± 0.095
4.73LysAsp: 4.73 ± 1.667
5.124LysGlu: 5.124 ± 0.22
4.336LysPhe: 4.336 ± 0.244
1.577LysGly: 1.577 ± 0.929
1.577LysHis: 1.577 ± 0.929
4.336LysIle: 4.336 ± 0.875
4.73LysLys: 4.73 ± 0.012
6.307LysLeu: 6.307 ± 0.203
1.577LysMet: 1.577 ± 0.191
4.336LysAsn: 4.336 ± 0.315
1.182LysPro: 1.182 ± 0.137
1.971LysGln: 1.971 ± 0.518
3.547LysArg: 3.547 ± 1.53
4.73LysSer: 4.73 ± 0.572
4.336LysThr: 4.336 ± 0.875
5.912LysVal: 5.912 ± 1.244
1.577LysTrp: 1.577 ± 0.191
4.73LysTyr: 4.73 ± 1.667
0.0LysXaa: 0.0 ± 0.0
Leu
5.124LeuAla: 5.124 ± 0.34
0.788LeuCys: 0.788 ± 0.095
3.942LeuAsp: 3.942 ± 0.477
2.365LeuGlu: 2.365 ± 0.274
4.336LeuPhe: 4.336 ± 0.315
5.124LeuGly: 5.124 ± 1.899
1.971LeuHis: 1.971 ± 0.042
5.124LeuIle: 5.124 ± 1.34
3.942LeuLys: 3.942 ± 0.477
7.095LeuLeu: 7.095 ± 1.381
2.759LeuMet: 2.759 ± 0.37
4.73LeuAsn: 4.73 ± 0.012
5.518LeuPro: 5.518 ± 0.667
1.182LeuGln: 1.182 ± 0.423
5.124LeuArg: 5.124 ± 0.78
5.124LeuSer: 5.124 ± 0.78
6.307LeuThr: 6.307 ± 0.357
3.547LeuVal: 3.547 ± 1.828
0.394LeuTrp: 0.394 ± 0.328
2.365LeuTyr: 2.365 ± 0.834
0.0LeuXaa: 0.0 ± 0.0
Met
3.547MetAla: 3.547 ± 0.709
0.394MetCys: 0.394 ± 0.232
1.971MetAsp: 1.971 ± 0.518
1.182MetGlu: 1.182 ± 0.137
1.182MetPhe: 1.182 ± 0.137
1.182MetGly: 1.182 ± 0.137
0.788MetHis: 0.788 ± 0.095
1.577MetIle: 1.577 ± 0.369
1.971MetLys: 1.971 ± 0.042
2.365MetLeu: 2.365 ± 0.834
0.0MetMet: 0.0 ± 0.0
3.153MetAsn: 3.153 ± 0.178
0.788MetPro: 0.788 ± 0.095
1.182MetGln: 1.182 ± 0.697
0.788MetArg: 0.788 ± 0.464
0.788MetSer: 0.788 ± 0.464
2.365MetThr: 2.365 ± 1.405
1.182MetVal: 1.182 ± 0.697
0.0MetTrp: 0.0 ± 0.0
1.182MetTyr: 1.182 ± 0.983
0.0MetXaa: 0.0 ± 0.0
Asn
3.942AsnAla: 3.942 ± 0.477
0.788AsnCys: 0.788 ± 0.464
3.153AsnAsp: 3.153 ± 0.381
2.365AsnGlu: 2.365 ± 0.274
3.942AsnPhe: 3.942 ± 0.083
3.153AsnGly: 3.153 ± 0.381
1.577AsnHis: 1.577 ± 0.369
3.547AsnIle: 3.547 ± 0.149
7.095AsnLys: 7.095 ± 2.501
3.942AsnLeu: 3.942 ± 0.477
2.365AsnMet: 2.365 ± 0.846
3.942AsnAsn: 3.942 ± 1.036
4.336AsnPro: 4.336 ± 2.483
0.788AsnGln: 0.788 ± 0.464
1.182AsnArg: 1.182 ± 0.423
3.547AsnSer: 3.547 ± 0.97
5.124AsnThr: 5.124 ± 0.22
5.124AsnVal: 5.124 ± 0.899
0.788AsnTrp: 0.788 ± 0.095
3.153AsnTyr: 3.153 ± 0.381
0.0AsnXaa: 0.0 ± 0.0
Pro
2.759ProAla: 2.759 ± 0.054
1.577ProCys: 1.577 ± 0.369
2.759ProAsp: 2.759 ± 1.733
1.182ProGlu: 1.182 ± 0.137
5.124ProPhe: 5.124 ± 2.579
2.365ProGly: 2.365 ± 0.286
0.788ProHis: 0.788 ± 0.095
1.577ProIle: 1.577 ± 1.31
0.394ProLys: 0.394 ± 0.328
3.942ProLeu: 3.942 ± 0.477
0.394ProMet: 0.394 ± 0.328
3.547ProAsn: 3.547 ± 1.268
2.759ProPro: 2.759 ± 0.613
4.73ProGln: 4.73 ± 1.132
0.788ProArg: 0.788 ± 0.095
3.942ProSer: 3.942 ± 1.596
2.759ProThr: 2.759 ± 0.613
3.942ProVal: 3.942 ± 0.083
0.394ProTrp: 0.394 ± 0.328
1.971ProTyr: 1.971 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
1.182GlnAla: 1.182 ± 0.137
1.182GlnCys: 1.182 ± 0.137
1.577GlnAsp: 1.577 ± 0.369
2.759GlnGlu: 2.759 ± 0.613
1.577GlnPhe: 1.577 ± 0.191
3.153GlnGly: 3.153 ± 0.178
0.788GlnHis: 0.788 ± 0.464
1.577GlnIle: 1.577 ± 0.369
0.788GlnLys: 0.788 ± 0.464
3.547GlnLeu: 3.547 ± 1.53
0.0GlnMet: 0.0 ± 0.0
0.788GlnAsn: 0.788 ± 0.095
1.971GlnPro: 1.971 ± 1.078
0.788GlnGln: 0.788 ± 0.095
0.394GlnArg: 0.394 ± 0.328
3.153GlnSer: 3.153 ± 2.06
1.577GlnThr: 1.577 ± 0.369
1.971GlnVal: 1.971 ± 0.042
0.788GlnTrp: 0.788 ± 0.464
1.182GlnTyr: 1.182 ± 0.423
0.0GlnXaa: 0.0 ± 0.0
Arg
1.971ArgAla: 1.971 ± 0.601
0.0ArgCys: 0.0 ± 0.0
1.971ArgAsp: 1.971 ± 1.161
1.577ArgGlu: 1.577 ± 0.191
2.365ArgPhe: 2.365 ± 0.846
2.365ArgGly: 2.365 ± 0.846
1.182ArgHis: 1.182 ± 0.137
2.365ArgIle: 2.365 ± 0.274
1.182ArgLys: 1.182 ± 0.137
1.577ArgLeu: 1.577 ± 0.75
1.182ArgMet: 1.182 ± 0.423
3.547ArgAsn: 3.547 ± 0.411
1.577ArgPro: 1.577 ± 0.75
1.577ArgGln: 1.577 ± 0.929
1.182ArgArg: 1.182 ± 0.423
1.971ArgSer: 1.971 ± 0.042
1.971ArgThr: 1.971 ± 1.161
3.942ArgVal: 3.942 ± 1.596
0.0ArgTrp: 0.0 ± 0.0
1.971ArgTyr: 1.971 ± 0.601
0.0ArgXaa: 0.0 ± 0.0
Ser
2.365SerAla: 2.365 ± 0.286
1.182SerCys: 1.182 ± 0.137
3.942SerAsp: 3.942 ± 0.643
3.547SerGlu: 3.547 ± 0.97
5.124SerPhe: 5.124 ± 0.22
4.73SerGly: 4.73 ± 0.012
1.577SerHis: 1.577 ± 0.191
1.971SerIle: 1.971 ± 0.518
4.73SerLys: 4.73 ± 0.572
4.336SerLeu: 4.336 ± 0.244
1.577SerMet: 1.577 ± 0.369
3.942SerAsn: 3.942 ± 1.036
5.518SerPro: 5.518 ± 0.667
3.547SerGln: 3.547 ± 0.97
2.759SerArg: 2.759 ± 0.054
7.095SerSer: 7.095 ± 0.298
3.547SerThr: 3.547 ± 0.709
5.518SerVal: 5.518 ± 0.667
0.394SerTrp: 0.394 ± 0.328
1.182SerTyr: 1.182 ± 0.137
0.0SerXaa: 0.0 ± 0.0
Thr
3.942ThrAla: 3.942 ± 0.083
0.394ThrCys: 0.394 ± 0.328
3.153ThrAsp: 3.153 ± 0.941
1.577ThrGlu: 1.577 ± 0.191
2.759ThrPhe: 2.759 ± 0.054
3.547ThrGly: 3.547 ± 0.411
2.759ThrHis: 2.759 ± 0.613
7.095ThrIle: 7.095 ± 0.858
3.547ThrLys: 3.547 ± 0.97
5.124ThrLeu: 5.124 ± 0.22
1.182ThrMet: 1.182 ± 0.983
5.912ThrAsn: 5.912 ± 1.554
3.547ThrPro: 3.547 ± 0.709
2.759ThrGln: 2.759 ± 0.054
3.153ThrArg: 3.153 ± 1.501
7.095ThrSer: 7.095 ± 0.858
5.912ThrThr: 5.912 ± 2.114
5.124ThrVal: 5.124 ± 1.459
2.365ThrTrp: 2.365 ± 0.834
1.182ThrTyr: 1.182 ± 0.423
0.0ThrXaa: 0.0 ± 0.0
Val
3.547ValAla: 3.547 ± 0.149
1.182ValCys: 1.182 ± 0.697
4.336ValAsp: 4.336 ± 1.364
2.365ValGlu: 2.365 ± 0.274
1.971ValPhe: 1.971 ± 0.601
4.73ValGly: 4.73 ± 0.572
1.182ValHis: 1.182 ± 0.137
5.518ValIle: 5.518 ± 0.452
6.307ValLys: 6.307 ± 0.762
7.489ValLeu: 7.489 ± 2.173
3.942ValMet: 3.942 ± 0.083
4.73ValAsn: 4.73 ± 1.132
4.336ValPro: 4.336 ± 1.364
1.971ValGln: 1.971 ± 0.042
2.759ValArg: 2.759 ± 0.506
5.912ValSer: 5.912 ± 0.435
5.124ValThr: 5.124 ± 0.899
3.547ValVal: 3.547 ± 0.709
0.788ValTrp: 0.788 ± 0.464
2.759ValTyr: 2.759 ± 2.293
0.0ValXaa: 0.0 ± 0.0
Trp
0.788TrpAla: 0.788 ± 0.095
0.0TrpCys: 0.0 ± 0.0
0.394TrpAsp: 0.394 ± 0.232
1.182TrpGlu: 1.182 ± 0.137
0.394TrpPhe: 0.394 ± 0.232
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
1.182TrpIle: 1.182 ± 0.697
1.182TrpLys: 1.182 ± 0.137
1.182TrpLeu: 1.182 ± 0.697
0.0TrpMet: 0.0 ± 0.0
0.394TrpAsn: 0.394 ± 0.328
0.0TrpPro: 0.0 ± 0.0
0.394TrpGln: 0.394 ± 0.232
1.182TrpArg: 1.182 ± 0.137
0.394TrpSer: 0.394 ± 0.328
0.788TrpThr: 0.788 ± 0.095
0.788TrpVal: 0.788 ± 0.095
0.394TrpTrp: 0.394 ± 0.232
0.394TrpTyr: 0.394 ± 0.328
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.971TyrAla: 1.971 ± 0.518
0.394TyrCys: 0.394 ± 0.328
1.971TyrAsp: 1.971 ± 0.601
2.759TyrGlu: 2.759 ± 0.613
1.577TyrPhe: 1.577 ± 0.929
2.365TyrGly: 2.365 ± 1.405
1.577TyrHis: 1.577 ± 0.75
0.394TyrIle: 0.394 ± 0.328
3.153TyrLys: 3.153 ± 1.501
3.153TyrLeu: 3.153 ± 0.178
0.788TyrMet: 0.788 ± 0.464
3.942TyrAsn: 3.942 ± 0.477
1.971TyrPro: 1.971 ± 0.042
0.788TyrGln: 0.788 ± 0.095
2.759TyrArg: 2.759 ± 0.506
2.365TyrSer: 2.365 ± 1.393
3.153TyrThr: 3.153 ± 0.381
5.124TyrVal: 5.124 ± 0.78
0.0TyrTrp: 0.0 ± 0.0
1.971TyrTyr: 1.971 ± 0.518
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2538 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski