Amino acid dipepetide frequency for Calothrix elsteri CCALA 953

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.501AlaAla: 6.501 ± 0.093
0.829AlaCys: 0.829 ± 0.021
3.737AlaAsp: 3.737 ± 0.054
4.875AlaGlu: 4.875 ± 0.062
2.926AlaPhe: 2.926 ± 0.041
5.02AlaGly: 5.02 ± 0.063
1.058AlaHis: 1.058 ± 0.026
7.053AlaIle: 7.053 ± 0.065
4.373AlaLys: 4.373 ± 0.06
7.671AlaLeu: 7.671 ± 0.083
1.621AlaMet: 1.621 ± 0.031
3.768AlaAsn: 3.768 ± 0.065
2.521AlaPro: 2.521 ± 0.038
3.374AlaGln: 3.374 ± 0.047
3.214AlaArg: 3.214 ± 0.045
5.017AlaSer: 5.017 ± 0.072
4.549AlaThr: 4.549 ± 0.068
5.138AlaVal: 5.138 ± 0.067
0.996AlaTrp: 0.996 ± 0.027
2.215AlaTyr: 2.215 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
0.608CysAla: 0.608 ± 0.019
0.165CysCys: 0.165 ± 0.012
0.753CysAsp: 0.753 ± 0.021
0.598CysGlu: 0.598 ± 0.022
0.417CysPhe: 0.417 ± 0.014
0.794CysGly: 0.794 ± 0.024
0.268CysHis: 0.268 ± 0.013
0.637CysIle: 0.637 ± 0.02
0.441CysLys: 0.441 ± 0.018
1.073CysLeu: 1.073 ± 0.027
0.17CysMet: 0.17 ± 0.01
0.439CysAsn: 0.439 ± 0.015
0.514CysPro: 0.514 ± 0.018
0.535CysGln: 0.535 ± 0.02
0.528CysArg: 0.528 ± 0.018
0.601CysSer: 0.601 ± 0.018
0.479CysThr: 0.479 ± 0.017
0.588CysVal: 0.588 ± 0.019
0.143CysTrp: 0.143 ± 0.009
0.354CysTyr: 0.354 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
3.74AspAla: 3.74 ± 0.052
0.527AspCys: 0.527 ± 0.019
2.323AspAsp: 2.323 ± 0.046
3.115AspGlu: 3.115 ± 0.045
2.521AspPhe: 2.521 ± 0.041
3.444AspGly: 3.444 ± 0.061
0.498AspHis: 0.498 ± 0.018
3.946AspIle: 3.946 ± 0.052
2.937AspLys: 2.937 ± 0.053
5.242AspLeu: 5.242 ± 0.055
0.839AspMet: 0.839 ± 0.024
2.413AspAsn: 2.413 ± 0.043
1.685AspPro: 1.685 ± 0.034
1.113AspGln: 1.113 ± 0.028
3.048AspArg: 3.048 ± 0.049
3.162AspSer: 3.162 ± 0.049
2.76AspThr: 2.76 ± 0.043
3.063AspVal: 3.063 ± 0.048
0.878AspTrp: 0.878 ± 0.023
1.854AspTyr: 1.854 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
4.977GluAla: 4.977 ± 0.055
0.526GluCys: 0.526 ± 0.02
2.794GluAsp: 2.794 ± 0.049
4.26GluGlu: 4.26 ± 0.058
2.547GluPhe: 2.547 ± 0.041
3.16GluGly: 3.16 ± 0.05
0.987GluHis: 0.987 ± 0.026
5.411GluIle: 5.411 ± 0.063
4.185GluLys: 4.185 ± 0.059
6.908GluLeu: 6.908 ± 0.082
1.419GluMet: 1.419 ± 0.034
3.41GluAsn: 3.41 ± 0.046
2.315GluPro: 2.315 ± 0.04
3.239GluGln: 3.239 ± 0.047
3.151GluArg: 3.151 ± 0.053
3.637GluSer: 3.637 ± 0.053
3.48GluThr: 3.48 ± 0.052
4.318GluVal: 4.318 ± 0.052
0.784GluTrp: 0.784 ± 0.022
2.041GluTyr: 2.041 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
3.36PheAla: 3.36 ± 0.046
0.559PheCys: 0.559 ± 0.019
2.319PheAsp: 2.319 ± 0.037
2.173PheGlu: 2.173 ± 0.036
1.706PhePhe: 1.706 ± 0.034
2.998PheGly: 2.998 ± 0.047
0.725PheHis: 0.725 ± 0.024
2.706PheIle: 2.706 ± 0.04
1.866PheLys: 1.866 ± 0.036
4.093PheLeu: 4.093 ± 0.058
0.699PheMet: 0.699 ± 0.019
1.964PheAsn: 1.964 ± 0.039
1.941PhePro: 1.941 ± 0.036
1.791PheGln: 1.791 ± 0.035
1.831PheArg: 1.831 ± 0.035
3.105PheSer: 3.105 ± 0.055
2.422PheThr: 2.422 ± 0.033
2.512PheVal: 2.512 ± 0.043
0.674PheTrp: 0.674 ± 0.02
1.333PheTyr: 1.333 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
4.313GlyAla: 4.313 ± 0.08
0.824GlyCys: 0.824 ± 0.027
3.315GlyAsp: 3.315 ± 0.048
4.288GlyGlu: 4.288 ± 0.051
3.123GlyPhe: 3.123 ± 0.049
4.46GlyGly: 4.46 ± 0.066
1.084GlyHis: 1.084 ± 0.031
5.505GlyIle: 5.505 ± 0.069
4.743GlyLys: 4.743 ± 0.059
6.549GlyLeu: 6.549 ± 0.063
1.571GlyMet: 1.571 ± 0.035
3.411GlyAsn: 3.411 ± 0.064
0.929GlyPro: 0.929 ± 0.029
2.435GlyGln: 2.435 ± 0.039
2.919GlyArg: 2.919 ± 0.043
4.1GlySer: 4.1 ± 0.059
3.722GlyThr: 3.722 ± 0.064
4.465GlyVal: 4.465 ± 0.059
1.036GlyTrp: 1.036 ± 0.023
2.366GlyTyr: 2.366 ± 0.042
0.0GlyXaa: 0.0 ± 0.0
His
1.008HisAla: 1.008 ± 0.026
0.216HisCys: 0.216 ± 0.01
0.742HisAsp: 0.742 ± 0.022
0.929HisGlu: 0.929 ± 0.023
0.732HisPhe: 0.732 ± 0.023
1.071HisGly: 1.071 ± 0.026
0.511HisHis: 0.511 ± 0.019
1.107HisIle: 1.107 ± 0.027
0.771HisLys: 0.771 ± 0.021
2.052HisLeu: 2.052 ± 0.039
0.238HisMet: 0.238 ± 0.012
0.783HisAsn: 0.783 ± 0.023
1.239HisPro: 1.239 ± 0.022
1.016HisGln: 1.016 ± 0.027
0.929HisArg: 0.929 ± 0.021
1.119HisSer: 1.119 ± 0.028
0.845HisThr: 0.845 ± 0.021
0.813HisVal: 0.813 ± 0.027
0.298HisTrp: 0.298 ± 0.012
0.619HisTyr: 0.619 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
7.321IleAla: 7.321 ± 0.077
0.812IleCys: 0.812 ± 0.022
3.962IleAsp: 3.962 ± 0.048
4.609IleGlu: 4.609 ± 0.057
2.982IlePhe: 2.982 ± 0.048
4.608IleGly: 4.608 ± 0.062
1.272IleHis: 1.272 ± 0.029
4.844IleIle: 4.844 ± 0.066
3.67IleLys: 3.67 ± 0.052
7.251IleLeu: 7.251 ± 0.091
0.984IleMet: 0.984 ± 0.028
3.739IleAsn: 3.739 ± 0.054
4.025IlePro: 4.025 ± 0.055
3.251IleGln: 3.251 ± 0.049
3.356IleArg: 3.356 ± 0.047
5.185IleSer: 5.185 ± 0.063
4.043IleThr: 4.043 ± 0.052
4.288IleVal: 4.288 ± 0.051
0.938IleTrp: 0.938 ± 0.027
2.145IleTyr: 2.145 ± 0.036
0.001IleXaa: 0.001 ± 0.001
Lys
4.094LysAla: 4.094 ± 0.054
0.404LysCys: 0.404 ± 0.016
2.474LysAsp: 2.474 ± 0.044
3.176LysGlu: 3.176 ± 0.05
2.165LysPhe: 2.165 ± 0.041
2.924LysGly: 2.924 ± 0.049
0.878LysHis: 0.878 ± 0.025
4.296LysIle: 4.296 ± 0.049
2.987LysLys: 2.987 ± 0.055
6.061LysLeu: 6.061 ± 0.074
1.165LysMet: 1.165 ± 0.024
2.749LysAsn: 2.749 ± 0.048
2.764LysPro: 2.764 ± 0.042
3.018LysGln: 3.018 ± 0.042
2.541LysArg: 2.541 ± 0.043
3.666LysSer: 3.666 ± 0.05
3.247LysThr: 3.247 ± 0.055
3.51LysVal: 3.51 ± 0.045
0.6LysTrp: 0.6 ± 0.021
1.809LysTyr: 1.809 ± 0.037
0.0LysXaa: 0.0 ± 0.0
Leu
8.618LeuAla: 8.618 ± 0.084
1.014LeuCys: 1.014 ± 0.026
5.112LeuAsp: 5.112 ± 0.049
7.25LeuGlu: 7.25 ± 0.081
3.852LeuPhe: 3.852 ± 0.052
7.228LeuGly: 7.228 ± 0.074
1.797LeuHis: 1.797 ± 0.038
6.976LeuIle: 6.976 ± 0.074
5.668LeuLys: 5.668 ± 0.062
10.627LeuLeu: 10.627 ± 0.106
2.032LeuMet: 2.032 ± 0.034
4.854LeuAsn: 4.854 ± 0.055
5.43LeuPro: 5.43 ± 0.063
5.494LeuGln: 5.494 ± 0.076
5.343LeuArg: 5.343 ± 0.066
7.123LeuSer: 7.123 ± 0.077
5.955LeuThr: 5.955 ± 0.06
6.859LeuVal: 6.859 ± 0.064
1.326LeuTrp: 1.326 ± 0.036
2.574LeuTyr: 2.574 ± 0.041
0.0LeuXaa: 0.0 ± 0.0
Met
1.606MetAla: 1.606 ± 0.035
0.134MetCys: 0.134 ± 0.008
0.76MetAsp: 0.76 ± 0.026
1.082MetGlu: 1.082 ± 0.025
0.603MetPhe: 0.603 ± 0.02
1.45MetGly: 1.45 ± 0.029
0.313MetHis: 0.313 ± 0.015
1.043MetIle: 1.043 ± 0.024
1.027MetLys: 1.027 ± 0.025
2.001MetLeu: 2.001 ± 0.033
0.487MetMet: 0.487 ± 0.019
0.929MetAsn: 0.929 ± 0.023
0.921MetPro: 0.921 ± 0.026
0.977MetGln: 0.977 ± 0.028
1.09MetArg: 1.09 ± 0.028
1.361MetSer: 1.361 ± 0.031
1.293MetThr: 1.293 ± 0.027
1.34MetVal: 1.34 ± 0.03
0.186MetTrp: 0.186 ± 0.011
0.422MetTyr: 0.422 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.25AsnAla: 3.25 ± 0.052
0.539AsnCys: 0.539 ± 0.02
1.908AsnAsp: 1.908 ± 0.045
2.15AsnGlu: 2.15 ± 0.042
2.161AsnPhe: 2.161 ± 0.039
2.947AsnGly: 2.947 ± 0.061
0.962AsnHis: 0.962 ± 0.024
3.601AsnIle: 3.601 ± 0.057
2.283AsnLys: 2.283 ± 0.038
5.966AsnLeu: 5.966 ± 0.083
0.76AsnMet: 0.76 ± 0.023
2.797AsnAsn: 2.797 ± 0.062
3.354AsnPro: 3.354 ± 0.053
3.106AsnGln: 3.106 ± 0.05
2.571AsnArg: 2.571 ± 0.04
3.824AsnSer: 3.824 ± 0.065
2.697AsnThr: 2.697 ± 0.047
2.484AsnVal: 2.484 ± 0.046
0.832AsnTrp: 0.832 ± 0.024
1.798AsnTyr: 1.798 ± 0.028
0.001AsnXaa: 0.001 ± 0.001
Pro
2.92ProAla: 2.92 ± 0.039
0.329ProCys: 0.329 ± 0.015
2.752ProAsp: 2.752 ± 0.047
3.709ProGlu: 3.709 ± 0.054
1.698ProPhe: 1.698 ± 0.032
2.91ProGly: 2.91 ± 0.046
0.765ProHis: 0.765 ± 0.024
3.173ProIle: 3.173 ± 0.044
2.355ProLys: 2.355 ± 0.041
4.224ProLeu: 4.224 ± 0.051
0.713ProMet: 0.713 ± 0.02
2.459ProAsn: 2.459 ± 0.041
1.933ProPro: 1.933 ± 0.046
2.404ProGln: 2.404 ± 0.049
1.6ProArg: 1.6 ± 0.03
2.945ProSer: 2.945 ± 0.045
2.676ProThr: 2.676 ± 0.048
3.042ProVal: 3.042 ± 0.046
0.559ProTrp: 0.559 ± 0.018
1.167ProTyr: 1.167 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
4.082GlnAla: 4.082 ± 0.055
0.328GlnCys: 0.328 ± 0.012
2.015GlnAsp: 2.015 ± 0.034
3.497GlnGlu: 3.497 ± 0.052
1.721GlnPhe: 1.721 ± 0.035
2.918GlnGly: 2.918 ± 0.048
0.815GlnHis: 0.815 ± 0.022
3.863GlnIle: 3.863 ± 0.054
2.98GlnLys: 2.98 ± 0.043
5.412GlnLeu: 5.412 ± 0.061
1.011GlnMet: 1.011 ± 0.022
2.452GlnAsn: 2.452 ± 0.049
2.33GlnPro: 2.33 ± 0.043
3.571GlnGln: 3.571 ± 0.056
2.692GlnArg: 2.692 ± 0.044
2.87GlnSer: 2.87 ± 0.039
2.842GlnThr: 2.842 ± 0.048
3.563GlnVal: 3.563 ± 0.051
0.581GlnTrp: 0.581 ± 0.018
1.222GlnTyr: 1.222 ± 0.024
0.001GlnXaa: 0.001 ± 0.001
Arg
2.882ArgAla: 2.882 ± 0.039
0.466ArgCys: 0.466 ± 0.017
2.749ArgAsp: 2.749 ± 0.045
3.363ArgGlu: 3.363 ± 0.042
2.126ArgPhe: 2.126 ± 0.037
2.947ArgGly: 2.947 ± 0.05
0.925ArgHis: 0.925 ± 0.023
3.525ArgIle: 3.525 ± 0.048
2.538ArgLys: 2.538 ± 0.039
5.357ArgLeu: 5.357 ± 0.067
0.999ArgMet: 0.999 ± 0.022
2.448ArgAsn: 2.448 ± 0.038
1.662ArgPro: 1.662 ± 0.037
2.89ArgGln: 2.89 ± 0.042
2.77ArgArg: 2.77 ± 0.059
3.128ArgSer: 3.128 ± 0.043
2.497ArgThr: 2.497 ± 0.043
3.224ArgVal: 3.224 ± 0.044
0.688ArgTrp: 0.688 ± 0.02
1.769ArgTyr: 1.769 ± 0.033
0.0ArgXaa: 0.0 ± 0.0
Ser
4.527SerAla: 4.527 ± 0.057
0.649SerCys: 0.649 ± 0.02
3.357SerAsp: 3.357 ± 0.055
3.962SerGlu: 3.962 ± 0.052
2.742SerPhe: 2.742 ± 0.042
4.684SerGly: 4.684 ± 0.054
1.344SerHis: 1.344 ± 0.027
4.323SerIle: 4.323 ± 0.057
3.247SerLys: 3.247 ± 0.043
7.312SerLeu: 7.312 ± 0.067
1.224SerMet: 1.224 ± 0.028
3.381SerAsn: 3.381 ± 0.06
3.286SerPro: 3.286 ± 0.053
4.02SerGln: 4.02 ± 0.058
3.315SerArg: 3.315 ± 0.05
4.828SerSer: 4.828 ± 0.067
3.734SerThr: 3.734 ± 0.05
3.972SerVal: 3.972 ± 0.048
0.917SerTrp: 0.917 ± 0.024
1.892SerTyr: 1.892 ± 0.029
0.0SerXaa: 0.0 ± 0.0
Thr
4.533ThrAla: 4.533 ± 0.07
0.49ThrCys: 0.49 ± 0.019
2.571ThrAsp: 2.571 ± 0.046
3.343ThrGlu: 3.343 ± 0.049
2.162ThrPhe: 2.162 ± 0.041
4.291ThrGly: 4.291 ± 0.058
0.93ThrHis: 0.93 ± 0.025
3.943ThrIle: 3.943 ± 0.06
2.706ThrLys: 2.706 ± 0.042
5.918ThrLeu: 5.918 ± 0.073
0.817ThrMet: 0.817 ± 0.026
2.845ThrAsn: 2.845 ± 0.047
3.196ThrPro: 3.196 ± 0.054
2.849ThrGln: 2.849 ± 0.04
2.325ThrArg: 2.325 ± 0.037
3.918ThrSer: 3.918 ± 0.051
3.479ThrThr: 3.479 ± 0.064
3.998ThrVal: 3.998 ± 0.06
0.733ThrTrp: 0.733 ± 0.023
1.608ThrTyr: 1.608 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
5.311ValAla: 5.311 ± 0.068
0.68ValCys: 0.68 ± 0.021
3.318ValAsp: 3.318 ± 0.048
4.483ValGlu: 4.483 ± 0.055
2.587ValPhe: 2.587 ± 0.041
4.367ValGly: 4.367 ± 0.055
0.939ValHis: 0.939 ± 0.024
4.589ValIle: 4.589 ± 0.058
3.564ValLys: 3.564 ± 0.054
6.138ValLeu: 6.138 ± 0.066
1.437ValMet: 1.437 ± 0.03
3.187ValAsn: 3.187 ± 0.049
2.627ValPro: 2.627 ± 0.042
2.598ValGln: 2.598 ± 0.044
3.11ValArg: 3.11 ± 0.044
4.28ValSer: 4.28 ± 0.05
3.853ValThr: 3.853 ± 0.052
4.574ValVal: 4.574 ± 0.06
0.807ValTrp: 0.807 ± 0.022
1.775ValTyr: 1.775 ± 0.033
0.0ValXaa: 0.0 ± 0.0
Trp
0.793TrpAla: 0.793 ± 0.025
0.196TrpCys: 0.196 ± 0.011
0.687TrpAsp: 0.687 ± 0.023
0.947TrpGlu: 0.947 ± 0.023
0.612TrpPhe: 0.612 ± 0.02
0.929TrpGly: 0.929 ± 0.024
0.322TrpHis: 0.322 ± 0.016
0.852TrpIle: 0.852 ± 0.022
0.735TrpLys: 0.735 ± 0.022
1.77TrpLeu: 1.77 ± 0.036
0.359TrpMet: 0.359 ± 0.014
0.674TrpAsn: 0.674 ± 0.022
0.073TrpPro: 0.073 ± 0.008
1.125TrpGln: 1.125 ± 0.03
0.724TrpArg: 0.724 ± 0.022
0.779TrpSer: 0.779 ± 0.023
0.558TrpThr: 0.558 ± 0.018
0.916TrpVal: 0.916 ± 0.027
0.234TrpTrp: 0.234 ± 0.014
0.432TrpTyr: 0.432 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.012TyrAla: 2.012 ± 0.034
0.418TyrCys: 0.418 ± 0.016
1.458TyrAsp: 1.458 ± 0.029
1.742TyrGlu: 1.742 ± 0.041
1.397TyrPhe: 1.397 ± 0.027
2.007TyrGly: 2.007 ± 0.037
0.643TyrHis: 0.643 ± 0.019
1.895TyrIle: 1.895 ± 0.033
1.451TyrLys: 1.451 ± 0.036
3.506TyrLeu: 3.506 ± 0.055
0.481TyrMet: 0.481 ± 0.015
1.289TyrAsn: 1.289 ± 0.03
1.587TyrPro: 1.587 ± 0.029
1.959TyrGln: 1.959 ± 0.038
1.896TyrArg: 1.896 ± 0.042
2.066TyrSer: 2.066 ± 0.035
1.526TyrThr: 1.526 ± 0.032
1.558TyrVal: 1.558 ± 0.034
0.508TyrTrp: 0.508 ± 0.017
1.09TyrTyr: 1.09 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.001XaaLeu: 0.001 ± 0.001
0.001XaaMet: 0.001 ± 0.001
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.001XaaTyr: 0.001 ± 0.001
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5667 proteins (1726011 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski