Amino acid dipepetide frequency for Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.698AlaAla: 12.698 ± 0.15
1.3AlaCys: 1.3 ± 0.037
6.161AlaAsp: 6.161 ± 0.087
7.236AlaGlu: 7.236 ± 0.103
4.046AlaPhe: 4.046 ± 0.065
8.983AlaGly: 8.983 ± 0.102
2.755AlaHis: 2.755 ± 0.057
5.388AlaIle: 5.388 ± 0.084
2.668AlaLys: 2.668 ± 0.058
14.658AlaLeu: 14.658 ± 0.158
3.417AlaMet: 3.417 ± 0.06
2.616AlaAsn: 2.616 ± 0.056
5.429AlaPro: 5.429 ± 0.089
4.282AlaGln: 4.282 ± 0.064
8.737AlaArg: 8.737 ± 0.107
6.795AlaSer: 6.795 ± 0.089
5.95AlaThr: 5.95 ± 0.1
7.476AlaVal: 7.476 ± 0.089
2.011AlaTrp: 2.011 ± 0.053
2.511AlaTyr: 2.511 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.963CysAla: 0.963 ± 0.03
0.133CysCys: 0.133 ± 0.012
0.596CysAsp: 0.596 ± 0.027
0.559CysGlu: 0.559 ± 0.024
0.332CysPhe: 0.332 ± 0.015
0.942CysGly: 0.942 ± 0.033
0.343CysHis: 0.343 ± 0.016
0.367CysIle: 0.367 ± 0.017
0.186CysLys: 0.186 ± 0.013
1.139CysLeu: 1.139 ± 0.036
0.221CysMet: 0.221 ± 0.014
0.224CysAsn: 0.224 ± 0.014
0.51CysPro: 0.51 ± 0.023
0.34CysGln: 0.34 ± 0.018
0.783CysArg: 0.783 ± 0.028
0.446CysSer: 0.446 ± 0.019
0.393CysThr: 0.393 ± 0.019
0.667CysVal: 0.667 ± 0.029
0.135CysTrp: 0.135 ± 0.011
0.27CysTyr: 0.27 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
8.006AspAla: 8.006 ± 0.111
0.465AspCys: 0.465 ± 0.021
4.612AspAsp: 4.612 ± 0.089
4.18AspGlu: 4.18 ± 0.066
2.127AspPhe: 2.127 ± 0.046
4.882AspGly: 4.882 ± 0.109
1.317AspHis: 1.317 ± 0.035
3.122AspIle: 3.122 ± 0.058
1.646AspLys: 1.646 ± 0.041
5.535AspLeu: 5.535 ± 0.075
1.509AspMet: 1.509 ± 0.042
1.658AspAsn: 1.658 ± 0.047
3.007AspPro: 3.007 ± 0.049
1.875AspGln: 1.875 ± 0.043
3.564AspArg: 3.564 ± 0.057
2.723AspSer: 2.723 ± 0.06
3.488AspThr: 3.488 ± 0.072
4.505AspVal: 4.505 ± 0.078
1.068AspTrp: 1.068 ± 0.034
1.823AspTyr: 1.823 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
8.312GluAla: 8.312 ± 0.103
0.478GluCys: 0.478 ± 0.019
3.275GluAsp: 3.275 ± 0.055
3.498GluGlu: 3.498 ± 0.067
1.554GluPhe: 1.554 ± 0.04
4.687GluGly: 4.687 ± 0.066
1.823GluHis: 1.823 ± 0.045
2.805GluIle: 2.805 ± 0.053
1.72GluLys: 1.72 ± 0.051
6.129GluLeu: 6.129 ± 0.077
1.408GluMet: 1.408 ± 0.035
1.518GluAsn: 1.518 ± 0.042
2.514GluPro: 2.514 ± 0.048
2.742GluGln: 2.742 ± 0.054
6.234GluArg: 6.234 ± 0.085
3.151GluSer: 3.151 ± 0.053
3.733GluThr: 3.733 ± 0.055
4.271GluVal: 4.271 ± 0.063
0.923GluTrp: 0.923 ± 0.026
1.264GluTyr: 1.264 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
3.72PheAla: 3.72 ± 0.066
0.375PheCys: 0.375 ± 0.019
2.596PheAsp: 2.596 ± 0.046
2.227PheGlu: 2.227 ± 0.047
1.357PhePhe: 1.357 ± 0.047
3.093PheGly: 3.093 ± 0.056
0.786PheHis: 0.786 ± 0.027
1.674PheIle: 1.674 ± 0.04
0.905PheLys: 0.905 ± 0.033
3.213PheLeu: 3.213 ± 0.068
0.892PheMet: 0.892 ± 0.03
0.996PheAsn: 0.996 ± 0.029
1.434PhePro: 1.434 ± 0.038
1.148PheGln: 1.148 ± 0.035
1.898PheArg: 1.898 ± 0.046
2.177PheSer: 2.177 ± 0.046
1.953PheThr: 1.953 ± 0.05
2.53PheVal: 2.53 ± 0.06
0.487PheTrp: 0.487 ± 0.019
0.972PheTyr: 0.972 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
7.749GlyAla: 7.749 ± 0.086
0.918GlyCys: 0.918 ± 0.028
4.913GlyAsp: 4.913 ± 0.088
5.519GlyGlu: 5.519 ± 0.08
3.201GlyPhe: 3.201 ± 0.062
6.647GlyGly: 6.647 ± 0.107
2.163GlyHis: 2.163 ± 0.044
4.336GlyIle: 4.336 ± 0.066
2.597GlyLys: 2.597 ± 0.057
8.977GlyLeu: 8.977 ± 0.107
2.496GlyMet: 2.496 ± 0.055
2.15GlyAsn: 2.15 ± 0.058
2.773GlyPro: 2.773 ± 0.052
3.052GlyGln: 3.052 ± 0.057
5.514GlyArg: 5.514 ± 0.071
4.018GlySer: 4.018 ± 0.06
3.959GlyThr: 3.959 ± 0.075
6.511GlyVal: 6.511 ± 0.087
1.385GlyTrp: 1.385 ± 0.036
2.389GlyTyr: 2.389 ± 0.053
0.0GlyXaa: 0.0 ± 0.0
His
3.051HisAla: 3.051 ± 0.064
0.326HisCys: 0.326 ± 0.019
1.769HisAsp: 1.769 ± 0.04
1.418HisGlu: 1.418 ± 0.037
1.02HisPhe: 1.02 ± 0.027
2.329HisGly: 2.329 ± 0.049
0.846HisHis: 0.846 ± 0.028
0.961HisIle: 0.961 ± 0.029
0.523HisLys: 0.523 ± 0.022
2.65HisLeu: 2.65 ± 0.05
0.506HisMet: 0.506 ± 0.021
0.527HisAsn: 0.527 ± 0.024
1.591HisPro: 1.591 ± 0.038
0.924HisGln: 0.924 ± 0.031
1.956HisArg: 1.956 ± 0.047
1.053HisSer: 1.053 ± 0.031
1.013HisThr: 1.013 ± 0.03
1.771HisVal: 1.771 ± 0.038
0.453HisTrp: 0.453 ± 0.024
0.824HisTyr: 0.824 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
5.887IleAla: 5.887 ± 0.079
0.428IleCys: 0.428 ± 0.024
3.585IleAsp: 3.585 ± 0.067
3.377IleGlu: 3.377 ± 0.061
1.453IlePhe: 1.453 ± 0.037
4.411IleGly: 4.411 ± 0.086
0.972IleHis: 0.972 ± 0.03
1.867IleIle: 1.867 ± 0.047
1.213IleLys: 1.213 ± 0.032
3.857IleLeu: 3.857 ± 0.069
0.897IleMet: 0.897 ± 0.031
1.386IleAsn: 1.386 ± 0.039
2.153IlePro: 2.153 ± 0.053
1.367IleGln: 1.367 ± 0.033
2.883IleArg: 2.883 ± 0.057
2.47IleSer: 2.47 ± 0.055
2.448IleThr: 2.448 ± 0.06
3.644IleVal: 3.644 ± 0.065
0.453IleTrp: 0.453 ± 0.021
0.95IleTyr: 0.95 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
2.942LysAla: 2.942 ± 0.061
0.166LysCys: 0.166 ± 0.014
1.202LysAsp: 1.202 ± 0.044
1.364LysGlu: 1.364 ± 0.045
0.545LysPhe: 0.545 ± 0.025
1.992LysGly: 1.992 ± 0.046
0.59LysHis: 0.59 ± 0.028
1.115LysIle: 1.115 ± 0.039
0.912LysLys: 0.912 ± 0.037
2.644LysLeu: 2.644 ± 0.059
0.575LysMet: 0.575 ± 0.026
0.606LysAsn: 0.606 ± 0.025
1.368LysPro: 1.368 ± 0.039
1.054LysGln: 1.054 ± 0.037
2.402LysArg: 2.402 ± 0.05
1.433LysSer: 1.433 ± 0.042
1.369LysThr: 1.369 ± 0.04
1.932LysVal: 1.932 ± 0.048
0.306LysTrp: 0.306 ± 0.017
0.535LysTyr: 0.535 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
14.715LeuAla: 14.715 ± 0.147
1.137LeuCys: 1.137 ± 0.032
7.602LeuAsp: 7.602 ± 0.098
7.328LeuGlu: 7.328 ± 0.099
3.724LeuPhe: 3.724 ± 0.071
9.459LeuGly: 9.459 ± 0.11
2.494LeuHis: 2.494 ± 0.045
5.263LeuIle: 5.263 ± 0.069
3.147LeuLys: 3.147 ± 0.067
11.703LeuLeu: 11.703 ± 0.142
2.738LeuMet: 2.738 ± 0.054
2.719LeuAsn: 2.719 ± 0.048
5.975LeuPro: 5.975 ± 0.091
3.136LeuGln: 3.136 ± 0.056
7.011LeuArg: 7.011 ± 0.094
6.754LeuSer: 6.754 ± 0.076
6.042LeuThr: 6.042 ± 0.088
7.776LeuVal: 7.776 ± 0.095
1.498LeuTrp: 1.498 ± 0.043
2.366LeuTyr: 2.366 ± 0.044
0.0LeuXaa: 0.0 ± 0.0
Met
3.158MetAla: 3.158 ± 0.055
0.181MetCys: 0.181 ± 0.014
1.041MetAsp: 1.041 ± 0.03
1.128MetGlu: 1.128 ± 0.03
0.68MetPhe: 0.68 ± 0.023
1.842MetGly: 1.842 ± 0.042
0.584MetHis: 0.584 ± 0.026
1.179MetIle: 1.179 ± 0.037
0.739MetLys: 0.739 ± 0.027
2.882MetLeu: 2.882 ± 0.056
0.614MetMet: 0.614 ± 0.025
0.751MetAsn: 0.751 ± 0.024
1.51MetPro: 1.51 ± 0.041
1.109MetGln: 1.109 ± 0.033
1.843MetArg: 1.843 ± 0.043
1.831MetSer: 1.831 ± 0.041
1.857MetThr: 1.857 ± 0.041
1.644MetVal: 1.644 ± 0.044
0.214MetTrp: 0.214 ± 0.014
0.336MetTyr: 0.336 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.187AsnAla: 3.187 ± 0.056
0.201AsnCys: 0.201 ± 0.016
1.563AsnAsp: 1.563 ± 0.044
1.248AsnGlu: 1.248 ± 0.03
0.89AsnPhe: 0.89 ± 0.032
2.081AsnGly: 2.081 ± 0.06
0.514AsnHis: 0.514 ± 0.022
1.186AsnIle: 1.186 ± 0.036
0.548AsnLys: 0.548 ± 0.026
2.54AsnLeu: 2.54 ± 0.05
0.554AsnMet: 0.554 ± 0.023
0.659AsnAsn: 0.659 ± 0.027
1.47AsnPro: 1.47 ± 0.036
0.828AsnGln: 0.828 ± 0.032
1.763AsnArg: 1.763 ± 0.046
1.056AsnSer: 1.056 ± 0.037
1.254AsnThr: 1.254 ± 0.036
1.932AsnVal: 1.932 ± 0.042
0.337AsnTrp: 0.337 ± 0.019
0.6AsnTyr: 0.6 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
5.318ProAla: 5.318 ± 0.076
0.402ProCys: 0.402 ± 0.02
3.377ProAsp: 3.377 ± 0.052
3.784ProGlu: 3.784 ± 0.062
1.741ProPhe: 1.741 ± 0.037
4.163ProGly: 4.163 ± 0.067
1.25ProHis: 1.25 ± 0.035
1.866ProIle: 1.866 ± 0.04
1.011ProLys: 1.011 ± 0.03
5.582ProLeu: 5.582 ± 0.084
1.209ProMet: 1.209 ± 0.036
1.103ProAsn: 1.103 ± 0.038
2.194ProPro: 2.194 ± 0.049
1.761ProGln: 1.761 ± 0.038
3.441ProArg: 3.441 ± 0.065
2.783ProSer: 2.783 ± 0.058
2.374ProThr: 2.374 ± 0.042
3.692ProVal: 3.692 ± 0.057
0.835ProTrp: 0.835 ± 0.027
1.143ProTyr: 1.143 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
5.356GlnAla: 5.356 ± 0.079
0.335GlnCys: 0.335 ± 0.015
1.71GlnAsp: 1.71 ± 0.04
1.962GlnGlu: 1.962 ± 0.045
1.019GlnPhe: 1.019 ± 0.036
3.297GlnGly: 3.297 ± 0.064
0.964GlnHis: 0.964 ± 0.033
1.367GlnIle: 1.367 ± 0.039
0.839GlnLys: 0.839 ± 0.029
3.946GlnLeu: 3.946 ± 0.068
0.766GlnMet: 0.766 ± 0.027
0.744GlnAsn: 0.744 ± 0.027
1.781GlnPro: 1.781 ± 0.041
1.891GlnGln: 1.891 ± 0.059
3.78GlnArg: 3.78 ± 0.067
1.887GlnSer: 1.887 ± 0.043
1.688GlnThr: 1.688 ± 0.043
2.731GlnVal: 2.731 ± 0.052
0.66GlnTrp: 0.66 ± 0.026
0.775GlnTyr: 0.775 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
7.018ArgAla: 7.018 ± 0.087
0.647ArgCys: 0.647 ± 0.024
5.025ArgAsp: 5.025 ± 0.071
5.416ArgGlu: 5.416 ± 0.089
3.056ArgPhe: 3.056 ± 0.058
4.833ArgGly: 4.833 ± 0.068
2.644ArgHis: 2.644 ± 0.06
3.346ArgIle: 3.346 ± 0.058
1.672ArgLys: 1.672 ± 0.047
10.05ArgLeu: 10.05 ± 0.121
1.77ArgMet: 1.77 ± 0.04
1.624ArgAsn: 1.624 ± 0.038
3.083ArgPro: 3.083 ± 0.058
3.585ArgGln: 3.585 ± 0.07
6.467ArgArg: 6.467 ± 0.121
2.964ArgSer: 2.964 ± 0.052
2.937ArgThr: 2.937 ± 0.056
5.17ArgVal: 5.17 ± 0.076
1.159ArgTrp: 1.159 ± 0.033
2.233ArgTyr: 2.233 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
5.481SerAla: 5.481 ± 0.073
0.443SerCys: 0.443 ± 0.022
3.12SerAsp: 3.12 ± 0.061
2.983SerGlu: 2.983 ± 0.054
1.828SerPhe: 1.828 ± 0.044
4.891SerGly: 4.891 ± 0.077
1.371SerHis: 1.371 ± 0.033
2.329SerIle: 2.329 ± 0.045
1.126SerLys: 1.126 ± 0.03
6.529SerLeu: 6.529 ± 0.085
1.468SerMet: 1.468 ± 0.04
1.277SerAsn: 1.277 ± 0.038
2.931SerPro: 2.931 ± 0.054
2.173SerGln: 2.173 ± 0.051
4.3SerArg: 4.3 ± 0.069
3.006SerSer: 3.006 ± 0.067
2.632SerThr: 2.632 ± 0.051
3.911SerVal: 3.911 ± 0.056
0.702SerTrp: 0.702 ± 0.029
1.174SerTyr: 1.174 ± 0.035
0.0SerXaa: 0.0 ± 0.0
Thr
5.39ThrAla: 5.39 ± 0.086
0.449ThrCys: 0.449 ± 0.022
2.539ThrAsp: 2.539 ± 0.065
2.354ThrGlu: 2.354 ± 0.048
1.914ThrPhe: 1.914 ± 0.044
4.215ThrGly: 4.215 ± 0.07
1.402ThrHis: 1.402 ± 0.031
2.092ThrIle: 2.092 ± 0.053
0.847ThrLys: 0.847 ± 0.031
7.814ThrLeu: 7.814 ± 0.09
1.092ThrMet: 1.092 ± 0.033
1.061ThrAsn: 1.061 ± 0.036
3.829ThrPro: 3.829 ± 0.061
2.195ThrGln: 2.195 ± 0.043
3.926ThrArg: 3.926 ± 0.059
2.897ThrSer: 2.897 ± 0.057
2.77ThrThr: 2.77 ± 0.062
3.565ThrVal: 3.565 ± 0.068
0.714ThrTrp: 0.714 ± 0.026
1.145ThrTyr: 1.145 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
8.436ValAla: 8.436 ± 0.109
0.719ValCys: 0.719 ± 0.027
4.424ValAsp: 4.424 ± 0.068
4.631ValGlu: 4.631 ± 0.063
2.525ValPhe: 2.525 ± 0.051
5.568ValGly: 5.568 ± 0.086
1.56ValHis: 1.56 ± 0.036
3.874ValIle: 3.874 ± 0.057
1.914ValLys: 1.914 ± 0.052
7.426ValLeu: 7.426 ± 0.084
2.122ValMet: 2.122 ± 0.049
1.881ValAsn: 1.881 ± 0.044
3.424ValPro: 3.424 ± 0.053
2.008ValGln: 2.008 ± 0.044
4.562ValArg: 4.562 ± 0.07
4.325ValSer: 4.325 ± 0.072
4.439ValThr: 4.439 ± 0.068
5.761ValVal: 5.761 ± 0.094
0.926ValTrp: 0.926 ± 0.032
1.581ValTyr: 1.581 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.137TrpAla: 1.137 ± 0.032
0.187TrpCys: 0.187 ± 0.012
0.597TrpAsp: 0.597 ± 0.022
0.679TrpGlu: 0.679 ± 0.025
0.497TrpPhe: 0.497 ± 0.024
0.981TrpGly: 0.981 ± 0.03
0.464TrpHis: 0.464 ± 0.02
0.658TrpIle: 0.658 ± 0.028
0.343TrpLys: 0.343 ± 0.018
2.489TrpLeu: 2.489 ± 0.065
0.427TrpMet: 0.427 ± 0.021
0.352TrpAsn: 0.352 ± 0.019
0.791TrpPro: 0.791 ± 0.026
0.991TrpGln: 0.991 ± 0.028
1.372TrpArg: 1.372 ± 0.042
0.728TrpSer: 0.728 ± 0.028
0.666TrpThr: 0.666 ± 0.029
0.98TrpVal: 0.98 ± 0.034
0.299TrpTrp: 0.299 ± 0.019
0.314TrpTyr: 0.314 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.594TyrAla: 2.594 ± 0.05
0.259TyrCys: 0.259 ± 0.016
1.403TyrAsp: 1.403 ± 0.038
1.149TyrGlu: 1.149 ± 0.032
0.922TyrPhe: 0.922 ± 0.029
1.973TyrGly: 1.973 ± 0.042
0.67TyrHis: 0.67 ± 0.024
0.907TyrIle: 0.907 ± 0.029
0.493TyrLys: 0.493 ± 0.022
2.824TyrLeu: 2.824 ± 0.052
0.443TyrMet: 0.443 ± 0.022
0.56TyrAsn: 0.56 ± 0.02
1.261TyrPro: 1.261 ± 0.033
1.038TyrGln: 1.038 ± 0.035
2.26TyrArg: 2.26 ± 0.05
1.179TyrSer: 1.179 ± 0.028
1.246TyrThr: 1.246 ± 0.035
1.633TyrVal: 1.633 ± 0.038
0.389TyrTrp: 0.389 ± 0.02
0.738TyrTyr: 0.738 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3298 proteins (1099637 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski