Amino acid dipepetide frequency for Breznakibacter xylanolyticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.741AlaAla: 5.741 ± 0.085	0.803AlaCys: 0.803 ± 0.027	4.343AlaAsp: 4.343 ± 0.065	3.981AlaGlu: 3.981 ± 0.066	3.45AlaPhe: 3.45 ± 0.058	5.41AlaGly: 5.41 ± 0.076	1.609AlaHis: 1.609 ± 0.039	5.362AlaIle: 5.362 ± 0.071	3.663AlaLys: 3.663 ± 0.064	7.308AlaLeu: 7.308 ± 0.092	2.137AlaMet: 2.137 ± 0.045	3.548AlaAsn: 3.548 ± 0.072	2.614AlaPro: 2.614 ± 0.055	3.111AlaGln: 3.111 ± 0.057	3.385AlaArg: 3.385 ± 0.063	4.788AlaSer: 4.788 ± 0.089	4.173AlaThr: 4.173 ± 0.081	4.797AlaVal: 4.797 ± 0.069	0.911AlaTrp: 0.911 ± 0.028	2.548AlaTyr: 2.548 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.606CysAla: 0.606 ± 0.024	0.178CysCys: 0.178 ± 0.013	0.642CysAsp: 0.642 ± 0.028	0.575CysGlu: 0.575 ± 0.022	0.493CysPhe: 0.493 ± 0.019	0.828CysGly: 0.828 ± 0.026	0.333CysHis: 0.333 ± 0.017	0.652CysIle: 0.652 ± 0.024	0.53CysLys: 0.53 ± 0.02	0.874CysLeu: 0.874 ± 0.026	0.248CysMet: 0.248 ± 0.014	0.523CysAsn: 0.523 ± 0.019	0.465CysPro: 0.465 ± 0.019	0.353CysGln: 0.353 ± 0.017	0.561CysArg: 0.561 ± 0.023	0.655CysSer: 0.655 ± 0.025	0.521CysThr: 0.521 ± 0.022	0.682CysVal: 0.682 ± 0.025	0.119CysTrp: 0.119 ± 0.011	0.426CysTyr: 0.426 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	4.576AspAla: 4.576 ± 0.073	0.534AspCys: 0.534 ± 0.024	3.096AspAsp: 3.096 ± 0.059	3.887AspGlu: 3.887 ± 0.068	3.03AspPhe: 3.03 ± 0.052	4.223AspGly: 4.223 ± 0.082	1.162AspHis: 1.162 ± 0.03	3.81AspIle: 3.81 ± 0.06	3.262AspLys: 3.262 ± 0.058	5.018AspLeu: 5.018 ± 0.068	1.36AspMet: 1.36 ± 0.034	2.726AspAsn: 2.726 ± 0.054	1.83AspPro: 1.83 ± 0.044	1.685AspGln: 1.685 ± 0.038	2.36AspArg: 2.36 ± 0.044	2.975AspSer: 2.975 ± 0.061	2.541AspThr: 2.541 ± 0.057	4.063AspVal: 4.063 ± 0.066	0.765AspTrp: 0.765 ± 0.026	2.5AspTyr: 2.5 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	4.474GluAla: 4.474 ± 0.08	0.468GluCys: 0.468 ± 0.018	2.395GluAsp: 2.395 ± 0.054	3.278GluGlu: 3.278 ± 0.069	2.345GluPhe: 2.345 ± 0.046	3.629GluGly: 3.629 ± 0.069	1.14GluHis: 1.14 ± 0.031	4.059GluIle: 4.059 ± 0.063	4.313GluLys: 4.313 ± 0.085	5.971GluLeu: 5.971 ± 0.097	1.978GluMet: 1.978 ± 0.041	2.999GluAsn: 2.999 ± 0.054	1.828GluPro: 1.828 ± 0.045	2.554GluGln: 2.554 ± 0.059	2.898GluArg: 2.898 ± 0.053	3.224GluSer: 3.224 ± 0.052	3.032GluThr: 3.032 ± 0.053	4.144GluVal: 4.144 ± 0.065	0.75GluTrp: 0.75 ± 0.026	2.042GluTyr: 2.042 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.25PheAla: 3.25 ± 0.058	0.518PheCys: 0.518 ± 0.021	3.092PheAsp: 3.092 ± 0.049	2.783PheGlu: 2.783 ± 0.052	2.353PhePhe: 2.353 ± 0.051	3.064PheGly: 3.064 ± 0.058	0.949PheHis: 0.949 ± 0.031	3.03PheIle: 3.03 ± 0.06	2.642PheLys: 2.642 ± 0.046	3.675PheLeu: 3.675 ± 0.067	1.217PheMet: 1.217 ± 0.033	2.705PheAsn: 2.705 ± 0.047	1.689PhePro: 1.689 ± 0.04	1.382PheGln: 1.382 ± 0.033	2.078PheArg: 2.078 ± 0.046	3.344PheSer: 3.344 ± 0.057	2.762PheThr: 2.762 ± 0.054	3.234PheVal: 3.234 ± 0.062	0.576PheTrp: 0.576 ± 0.023	1.833PheTyr: 1.833 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	4.742GlyAla: 4.742 ± 0.09	0.885GlyCys: 0.885 ± 0.04	3.697GlyAsp: 3.697 ± 0.063	3.7GlyGlu: 3.7 ± 0.06	3.319GlyPhe: 3.319 ± 0.064	4.993GlyGly: 4.993 ± 0.086	1.549GlyHis: 1.549 ± 0.033	5.181GlyIle: 5.181 ± 0.078	4.382GlyLys: 4.382 ± 0.061	6.183GlyLeu: 6.183 ± 0.083	2.17GlyMet: 2.17 ± 0.043	3.602GlyAsn: 3.602 ± 0.077	1.256GlyPro: 1.256 ± 0.034	2.564GlyGln: 2.564 ± 0.049	3.075GlyArg: 3.075 ± 0.058	4.406GlySer: 4.406 ± 0.098	4.214GlyThr: 4.214 ± 0.11	5.228GlyVal: 5.228 ± 0.078	1.01GlyTrp: 1.01 ± 0.036	2.946GlyTyr: 2.946 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.499HisAla: 1.499 ± 0.039	0.31HisCys: 0.31 ± 0.018	1.192HisAsp: 1.192 ± 0.031	1.243HisGlu: 1.243 ± 0.035	1.224HisPhe: 1.224 ± 0.033	1.486HisGly: 1.486 ± 0.036	0.857HisHis: 0.857 ± 0.03	1.518HisIle: 1.518 ± 0.037	1.057HisLys: 1.057 ± 0.033	2.545HisLeu: 2.545 ± 0.056	0.459HisMet: 0.459 ± 0.019	1.008HisAsn: 1.008 ± 0.032	1.419HisPro: 1.419 ± 0.04	1.161HisGln: 1.161 ± 0.034	1.255HisArg: 1.255 ± 0.035	1.286HisSer: 1.286 ± 0.041	1.168HisThr: 1.168 ± 0.032	1.268HisVal: 1.268 ± 0.029	0.303HisTrp: 0.303 ± 0.014	0.969HisTyr: 0.969 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	4.997IleAla: 4.997 ± 0.072	0.665IleCys: 0.665 ± 0.024	4.709IleAsp: 4.709 ± 0.066	4.64IleGlu: 4.64 ± 0.07	2.571IlePhe: 2.571 ± 0.056	4.614IleGly: 4.614 ± 0.068	1.586IleHis: 1.586 ± 0.038	4.459IleIle: 4.459 ± 0.076	3.787IleLys: 3.787 ± 0.068	5.346IleLeu: 5.346 ± 0.087	1.337IleMet: 1.337 ± 0.037	3.78IleAsn: 3.78 ± 0.062	2.954IlePro: 2.954 ± 0.049	2.318IleGln: 2.318 ± 0.044	3.36IleArg: 3.36 ± 0.053	4.419IleSer: 4.419 ± 0.072	4.199IleThr: 4.199 ± 0.068	4.275IleVal: 4.275 ± 0.067	0.691IleTrp: 0.691 ± 0.027	2.384IleTyr: 2.384 ± 0.049	0.0IleXaa: 0.0 ± 0.0
Lys	4.447LysAla: 4.447 ± 0.078	0.462LysCys: 0.462 ± 0.019	2.862LysAsp: 2.862 ± 0.049	3.865LysGlu: 3.865 ± 0.072	2.009LysPhe: 2.009 ± 0.047	4.167LysGly: 4.167 ± 0.057	1.22LysHis: 1.22 ± 0.033	3.811LysIle: 3.811 ± 0.063	3.991LysLys: 3.991 ± 0.071	4.81LysLeu: 4.81 ± 0.071	1.863LysMet: 1.863 ± 0.042	3.161LysAsn: 3.161 ± 0.057	2.153LysPro: 2.153 ± 0.038	2.512LysGln: 2.512 ± 0.048	2.708LysArg: 2.708 ± 0.05	3.448LysSer: 3.448 ± 0.061	3.545LysThr: 3.545 ± 0.059	3.907LysVal: 3.907 ± 0.059	0.697LysTrp: 0.697 ± 0.027	2.27LysTyr: 2.27 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	6.729LeuAla: 6.729 ± 0.081	0.966LeuCys: 0.966 ± 0.031	4.576LeuAsp: 4.576 ± 0.058	4.849LeuGlu: 4.849 ± 0.076	4.588LeuPhe: 4.588 ± 0.079	5.493LeuGly: 5.493 ± 0.085	2.1LeuHis: 2.1 ± 0.049	5.814LeuIle: 5.814 ± 0.083	6.1LeuLys: 6.1 ± 0.082	9.146LeuLeu: 9.146 ± 0.125	3.04LeuMet: 3.04 ± 0.063	4.961LeuAsn: 4.961 ± 0.075	4.195LeuPro: 4.195 ± 0.064	3.398LeuGln: 3.398 ± 0.061	4.297LeuArg: 4.297 ± 0.067	6.997LeuSer: 6.997 ± 0.083	6.079LeuThr: 6.079 ± 0.088	6.106LeuVal: 6.106 ± 0.084	1.101LeuTrp: 1.101 ± 0.034	2.999LeuTyr: 2.999 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.553MetAla: 2.553 ± 0.051	0.211MetCys: 0.211 ± 0.014	1.451MetAsp: 1.451 ± 0.034	1.424MetGlu: 1.424 ± 0.033	0.957MetPhe: 0.957 ± 0.032	2.066MetGly: 2.066 ± 0.049	0.572MetHis: 0.572 ± 0.023	1.637MetIle: 1.637 ± 0.035	2.033MetLys: 2.033 ± 0.041	2.509MetLeu: 2.509 ± 0.052	0.966MetMet: 0.966 ± 0.032	1.529MetAsn: 1.529 ± 0.034	1.381MetPro: 1.381 ± 0.038	1.083MetGln: 1.083 ± 0.03	1.286MetArg: 1.286 ± 0.037	1.724MetSer: 1.724 ± 0.035	1.674MetThr: 1.674 ± 0.037	2.165MetVal: 2.165 ± 0.045	0.273MetTrp: 0.273 ± 0.017	0.682MetTyr: 0.682 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.821AsnAla: 3.821 ± 0.076	0.512AsnCys: 0.512 ± 0.024	3.138AsnAsp: 3.138 ± 0.06	2.846AsnGlu: 2.846 ± 0.05	2.096AsnPhe: 2.096 ± 0.045	4.072AsnGly: 4.072 ± 0.092	1.374AsnHis: 1.374 ± 0.035	3.649AsnIle: 3.649 ± 0.06	2.765AsnLys: 2.765 ± 0.051	4.553AsnLeu: 4.553 ± 0.068	1.18AsnMet: 1.18 ± 0.03	2.746AsnAsn: 2.746 ± 0.071	2.546AsnPro: 2.546 ± 0.05	2.099AsnGln: 2.099 ± 0.043	2.567AsnArg: 2.567 ± 0.05	2.865AsnSer: 2.865 ± 0.061	2.887AsnThr: 2.887 ± 0.062	3.21AsnVal: 3.21 ± 0.07	0.686AsnTrp: 0.686 ± 0.022	2.143AsnTyr: 2.143 ± 0.052	0.0AsnXaa: 0.0 ± 0.0
Pro	3.02ProAla: 3.02 ± 0.053	0.363ProCys: 0.363 ± 0.019	2.701ProAsp: 2.701 ± 0.054	2.729ProGlu: 2.729 ± 0.057	1.905ProPhe: 1.905 ± 0.04	2.842ProGly: 2.842 ± 0.048	0.947ProHis: 0.947 ± 0.031	2.283ProIle: 2.283 ± 0.046	1.745ProLys: 1.745 ± 0.042	3.577ProLeu: 3.577 ± 0.057	1.049ProMet: 1.049 ± 0.031	1.77ProAsn: 1.77 ± 0.036	1.126ProPro: 1.126 ± 0.036	1.62ProGln: 1.62 ± 0.044	1.417ProArg: 1.417 ± 0.035	2.512ProSer: 2.512 ± 0.049	1.97ProThr: 1.97 ± 0.045	3.439ProVal: 3.439 ± 0.061	0.453ProTrp: 0.453 ± 0.021	1.445ProTyr: 1.445 ± 0.042	0.001ProXaa: 0.001 ± 0.001
Gln	2.821GlnAla: 2.821 ± 0.056	0.343GlnCys: 0.343 ± 0.018	1.335GlnAsp: 1.335 ± 0.035	1.96GlnGlu: 1.96 ± 0.044	1.612GlnPhe: 1.612 ± 0.036	2.341GlnGly: 2.341 ± 0.046	0.97GlnHis: 0.97 ± 0.029	2.52GlnIle: 2.52 ± 0.043	2.449GlnLys: 2.449 ± 0.054	4.158GlnLeu: 4.158 ± 0.063	1.353GlnMet: 1.353 ± 0.037	1.987GlnAsn: 1.987 ± 0.048	1.594GlnPro: 1.594 ± 0.037	2.119GlnGln: 2.119 ± 0.054	1.903GlnArg: 1.903 ± 0.046	2.5GlnSer: 2.5 ± 0.047	2.366GlnThr: 2.366 ± 0.054	2.54GlnVal: 2.54 ± 0.047	0.607GlnTrp: 0.607 ± 0.025	1.555GlnTyr: 1.555 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.74ArgAla: 2.74 ± 0.049	0.473ArgCys: 0.473 ± 0.021	2.518ArgAsp: 2.518 ± 0.048	2.883ArgGlu: 2.883 ± 0.059	2.596ArgPhe: 2.596 ± 0.054	2.495ArgGly: 2.495 ± 0.044	1.331ArgHis: 1.331 ± 0.038	3.482ArgIle: 3.482 ± 0.057	2.69ArgLys: 2.69 ± 0.051	4.885ArgLeu: 4.885 ± 0.072	1.509ArgMet: 1.509 ± 0.04	2.342ArgAsn: 2.342 ± 0.045	1.607ArgPro: 1.607 ± 0.035	2.216ArgGln: 2.216 ± 0.053	2.208ArgArg: 2.208 ± 0.055	2.397ArgSer: 2.397 ± 0.044	2.268ArgThr: 2.268 ± 0.04	3.246ArgVal: 3.246 ± 0.057	0.686ArgTrp: 0.686 ± 0.027	2.023ArgTyr: 2.023 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	4.465SerAla: 4.465 ± 0.076	0.678SerCys: 0.678 ± 0.026	3.489SerAsp: 3.489 ± 0.06	3.444SerGlu: 3.444 ± 0.054	3.245SerPhe: 3.245 ± 0.061	5.207SerGly: 5.207 ± 0.105	1.553SerHis: 1.553 ± 0.035	4.213SerIle: 4.213 ± 0.063	3.202SerLys: 3.202 ± 0.055	6.109SerLeu: 6.109 ± 0.086	1.664SerMet: 1.664 ± 0.033	3.142SerAsn: 3.142 ± 0.066	2.557SerPro: 2.557 ± 0.053	2.392SerGln: 2.392 ± 0.051	2.844SerArg: 2.844 ± 0.055	4.215SerSer: 4.215 ± 0.076	3.396SerThr: 3.396 ± 0.07	4.581SerVal: 4.581 ± 0.089	0.773SerTrp: 0.773 ± 0.028	2.408SerTyr: 2.408 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	4.279ThrAla: 4.279 ± 0.069	0.5ThrCys: 0.5 ± 0.021	3.236ThrAsp: 3.236 ± 0.053	2.827ThrGlu: 2.827 ± 0.05	2.634ThrPhe: 2.634 ± 0.054	4.482ThrGly: 4.482 ± 0.091	1.362ThrHis: 1.362 ± 0.033	4.384ThrIle: 4.384 ± 0.091	2.497ThrLys: 2.497 ± 0.05	5.684ThrLeu: 5.684 ± 0.095	1.196ThrMet: 1.196 ± 0.031	2.764ThrAsn: 2.764 ± 0.057	3.077ThrPro: 3.077 ± 0.064	2.09ThrGln: 2.09 ± 0.044	2.487ThrArg: 2.487 ± 0.054	3.619ThrSer: 3.619 ± 0.085	3.507ThrThr: 3.507 ± 0.07	3.962ThrVal: 3.962 ± 0.088	0.661ThrTrp: 0.661 ± 0.027	2.116ThrTyr: 2.116 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	5.539ValAla: 5.539 ± 0.073	0.795ValCys: 0.795 ± 0.027	3.991ValAsp: 3.991 ± 0.065	3.913ValGlu: 3.913 ± 0.062	3.204ValPhe: 3.204 ± 0.056	4.225ValGly: 4.225 ± 0.075	1.269ValHis: 1.269 ± 0.028	4.505ValIle: 4.505 ± 0.06	4.176ValLys: 4.176 ± 0.068	6.035ValLeu: 6.035 ± 0.079	2.124ValMet: 2.124 ± 0.048	3.827ValAsn: 3.827 ± 0.075	2.666ValPro: 2.666 ± 0.051	2.134ValGln: 2.134 ± 0.039	3.06ValArg: 3.06 ± 0.051	4.989ValSer: 4.989 ± 0.095	4.325ValThr: 4.325 ± 0.103	5.86ValVal: 5.86 ± 0.1	0.843ValTrp: 0.843 ± 0.028	2.504ValTyr: 2.504 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.803TrpAla: 0.803 ± 0.028	0.152TrpCys: 0.152 ± 0.013	0.71TrpAsp: 0.71 ± 0.026	0.747TrpGlu: 0.747 ± 0.026	0.647TrpPhe: 0.647 ± 0.024	0.942TrpGly: 0.942 ± 0.03	0.323TrpHis: 0.323 ± 0.017	0.712TrpIle: 0.712 ± 0.027	0.617TrpLys: 0.617 ± 0.023	1.3TrpLeu: 1.3 ± 0.036	0.517TrpMet: 0.517 ± 0.023	0.644TrpAsn: 0.644 ± 0.026	0.352TrpPro: 0.352 ± 0.018	0.593TrpGln: 0.593 ± 0.024	0.598TrpArg: 0.598 ± 0.025	0.762TrpSer: 0.762 ± 0.029	0.617TrpThr: 0.617 ± 0.029	0.949TrpVal: 0.949 ± 0.032	0.215TrpTrp: 0.215 ± 0.014	0.447TrpTyr: 0.447 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.582TyrAla: 2.582 ± 0.051	0.448TyrCys: 0.448 ± 0.024	2.232TyrAsp: 2.232 ± 0.046	1.945TyrGlu: 1.945 ± 0.049	1.899TyrPhe: 1.899 ± 0.042	2.525TyrGly: 2.525 ± 0.054	1.024TyrHis: 1.024 ± 0.031	2.01TyrIle: 2.01 ± 0.046	2.006TyrLys: 2.006 ± 0.042	3.846TyrLeu: 3.846 ± 0.064	0.808TyrMet: 0.808 ± 0.024	1.989TyrAsn: 1.989 ± 0.048	1.605TyrPro: 1.605 ± 0.037	1.649TyrGln: 1.649 ± 0.041	2.248TyrArg: 2.248 ± 0.043	2.452TyrSer: 2.452 ± 0.047	2.119TyrThr: 2.119 ± 0.053	2.327TyrVal: 2.327 ± 0.047	0.526TyrTrp: 0.526 ± 0.021	1.808TyrTyr: 1.808 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 3475 proteins (1239837 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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