Amino acid dipepetide frequency for Acetonema longum DSM 6540

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.418AlaAla: 12.418 ± 0.129	1.158AlaCys: 1.158 ± 0.038	4.79AlaAsp: 4.79 ± 0.069	5.965AlaGlu: 5.965 ± 0.079	3.337AlaPhe: 3.337 ± 0.058	9.316AlaGly: 9.316 ± 0.111	1.423AlaHis: 1.423 ± 0.037	6.233AlaIle: 6.233 ± 0.081	5.071AlaLys: 5.071 ± 0.068	9.313AlaLeu: 9.313 ± 0.099	2.771AlaMet: 2.771 ± 0.061	3.126AlaAsn: 3.126 ± 0.061	2.801AlaPro: 2.801 ± 0.045	3.453AlaGln: 3.453 ± 0.058	4.595AlaArg: 4.595 ± 0.073	4.654AlaSer: 4.654 ± 0.068	4.151AlaThr: 4.151 ± 0.075	8.404AlaVal: 8.404 ± 0.097	0.883AlaTrp: 0.883 ± 0.026	2.74AlaTyr: 2.74 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.847CysAla: 0.847 ± 0.028	0.234CysCys: 0.234 ± 0.015	0.516CysAsp: 0.516 ± 0.022	0.528CysGlu: 0.528 ± 0.02	0.466CysPhe: 0.466 ± 0.017	1.252CysGly: 1.252 ± 0.035	0.291CysHis: 0.291 ± 0.016	0.768CysIle: 0.768 ± 0.023	0.444CysLys: 0.444 ± 0.017	1.16CysLeu: 1.16 ± 0.031	0.292CysMet: 0.292 ± 0.015	0.372CysAsn: 0.372 ± 0.018	0.687CysPro: 0.687 ± 0.029	0.496CysGln: 0.496 ± 0.024	0.869CysArg: 0.869 ± 0.028	0.777CysSer: 0.777 ± 0.028	0.496CysThr: 0.496 ± 0.024	0.688CysVal: 0.688 ± 0.023	0.131CysTrp: 0.131 ± 0.011	0.359CysTyr: 0.359 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	4.222AspAla: 4.222 ± 0.059	0.641AspCys: 0.641 ± 0.025	2.092AspAsp: 2.092 ± 0.051	3.074AspGlu: 3.074 ± 0.053	2.151AspPhe: 2.151 ± 0.036	3.396AspGly: 3.396 ± 0.056	0.969AspHis: 0.969 ± 0.023	4.052AspIle: 4.052 ± 0.071	2.718AspLys: 2.718 ± 0.048	4.913AspLeu: 4.913 ± 0.073	1.466AspMet: 1.466 ± 0.033	1.664AspAsn: 1.664 ± 0.039	2.265AspPro: 2.265 ± 0.049	1.818AspGln: 1.818 ± 0.046	2.874AspArg: 2.874 ± 0.055	2.647AspSer: 2.647 ± 0.048	2.552AspThr: 2.552 ± 0.053	3.505AspVal: 3.505 ± 0.053	0.668AspTrp: 0.668 ± 0.025	1.914AspTyr: 1.914 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	5.667GluAla: 5.667 ± 0.072	0.541GluCys: 0.541 ± 0.022	2.579GluAsp: 2.579 ± 0.048	4.029GluGlu: 4.029 ± 0.068	2.079GluPhe: 2.079 ± 0.037	3.456GluGly: 3.456 ± 0.058	1.164GluHis: 1.164 ± 0.029	4.668GluIle: 4.668 ± 0.066	4.341GluLys: 4.341 ± 0.066	6.082GluLeu: 6.082 ± 0.079	1.92GluMet: 1.92 ± 0.044	2.502GluAsn: 2.502 ± 0.048	2.001GluPro: 2.001 ± 0.042	3.078GluGln: 3.078 ± 0.053	3.472GluArg: 3.472 ± 0.057	2.718GluSer: 2.718 ± 0.044	3.474GluThr: 3.474 ± 0.055	4.026GluVal: 4.026 ± 0.064	0.627GluTrp: 0.627 ± 0.025	2.045GluTyr: 2.045 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.55PheAla: 3.55 ± 0.052	0.554PheCys: 0.554 ± 0.023	2.107PheAsp: 2.107 ± 0.044	1.776PheGlu: 1.776 ± 0.043	1.728PhePhe: 1.728 ± 0.048	3.122PheGly: 3.122 ± 0.057	0.796PheHis: 0.796 ± 0.028	2.719PheIle: 2.719 ± 0.049	1.526PheLys: 1.526 ± 0.037	3.815PheLeu: 3.815 ± 0.061	1.013PheMet: 1.013 ± 0.034	1.441PheAsn: 1.441 ± 0.036	1.567PhePro: 1.567 ± 0.037	1.319PheGln: 1.319 ± 0.031	1.897PheArg: 1.897 ± 0.044	2.705PheSer: 2.705 ± 0.041	2.162PheThr: 2.162 ± 0.049	2.542PheVal: 2.542 ± 0.049	0.473PheTrp: 0.473 ± 0.022	1.23PheTyr: 1.23 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	6.458GlyAla: 6.458 ± 0.105	1.128GlyCys: 1.128 ± 0.03	3.583GlyAsp: 3.583 ± 0.061	4.322GlyGlu: 4.322 ± 0.064	3.251GlyPhe: 3.251 ± 0.06	5.976GlyGly: 5.976 ± 0.089	1.46GlyHis: 1.46 ± 0.034	6.196GlyIle: 6.196 ± 0.075	4.823GlyLys: 4.823 ± 0.068	7.771GlyLeu: 7.771 ± 0.098	2.473GlyMet: 2.473 ± 0.046	2.774GlyAsn: 2.774 ± 0.052	2.193GlyPro: 2.193 ± 0.046	3.228GlyGln: 3.228 ± 0.062	4.138GlyArg: 4.138 ± 0.074	4.498GlySer: 4.498 ± 0.069	4.088GlyThr: 4.088 ± 0.065	5.805GlyVal: 5.805 ± 0.07	0.865GlyTrp: 0.865 ± 0.028	2.73GlyTyr: 2.73 ± 0.046	0.002GlyXaa: 0.002 ± 0.001
His	1.458HisAla: 1.458 ± 0.032	0.304HisCys: 0.304 ± 0.013	0.954HisAsp: 0.954 ± 0.027	0.96HisGlu: 0.96 ± 0.025	0.814HisPhe: 0.814 ± 0.025	1.446HisGly: 1.446 ± 0.034	0.491HisHis: 0.491 ± 0.02	1.442HisIle: 1.442 ± 0.032	0.858HisLys: 0.858 ± 0.027	1.927HisLeu: 1.927 ± 0.037	0.535HisMet: 0.535 ± 0.024	0.725HisAsn: 0.725 ± 0.024	1.062HisPro: 1.062 ± 0.029	0.789HisGln: 0.789 ± 0.025	1.051HisArg: 1.051 ± 0.03	1.176HisSer: 1.176 ± 0.034	1.047HisThr: 1.047 ± 0.031	1.113HisVal: 1.113 ± 0.034	0.267HisTrp: 0.267 ± 0.014	0.762HisTyr: 0.762 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	7.051IleAla: 7.051 ± 0.084	0.803IleCys: 0.803 ± 0.026	3.636IleAsp: 3.636 ± 0.06	3.868IleGlu: 3.868 ± 0.059	2.451IlePhe: 2.451 ± 0.053	5.623IleGly: 5.623 ± 0.074	1.422IleHis: 1.422 ± 0.033	4.754IleIle: 4.754 ± 0.08	3.424IleLys: 3.424 ± 0.062	6.962IleLeu: 6.962 ± 0.082	1.74IleMet: 1.74 ± 0.041	2.472IleAsn: 2.472 ± 0.049	3.348IlePro: 3.348 ± 0.052	2.484IleGln: 2.484 ± 0.046	3.765IleArg: 3.765 ± 0.054	4.32IleSer: 4.32 ± 0.064	3.974IleThr: 3.974 ± 0.057	4.994IleVal: 4.994 ± 0.066	0.59IleTrp: 0.59 ± 0.022	1.971IleTyr: 1.971 ± 0.037	0.001IleXaa: 0.001 ± 0.0
Lys	4.913LysAla: 4.913 ± 0.07	0.391LysCys: 0.391 ± 0.02	2.616LysAsp: 2.616 ± 0.047	3.717LysGlu: 3.717 ± 0.065	1.462LysPhe: 1.462 ± 0.034	3.504LysGly: 3.504 ± 0.054	0.898LysHis: 0.898 ± 0.028	3.862LysIle: 3.862 ± 0.058	3.338LysLys: 3.338 ± 0.062	4.898LysLeu: 4.898 ± 0.06	1.62LysMet: 1.62 ± 0.035	2.269LysAsn: 2.269 ± 0.041	2.257LysPro: 2.257 ± 0.049	2.278LysGln: 2.278 ± 0.046	2.563LysArg: 2.563 ± 0.049	2.645LysSer: 2.645 ± 0.047	3.146LysThr: 3.146 ± 0.051	3.722LysVal: 3.722 ± 0.058	0.525LysTrp: 0.525 ± 0.022	1.724LysTyr: 1.724 ± 0.041	0.001LysXaa: 0.001 ± 0.001
Leu	10.966LeuAla: 10.966 ± 0.115	1.129LeuCys: 1.129 ± 0.034	4.954LeuAsp: 4.954 ± 0.063	6.002LeuGlu: 6.002 ± 0.078	3.945LeuPhe: 3.945 ± 0.069	7.345LeuGly: 7.345 ± 0.092	1.842LeuHis: 1.842 ± 0.044	6.095LeuIle: 6.095 ± 0.079	5.001LeuLys: 5.001 ± 0.063	10.472LeuLeu: 10.472 ± 0.127	2.494LeuMet: 2.494 ± 0.045	3.673LeuAsn: 3.673 ± 0.057	4.781LeuPro: 4.781 ± 0.066	3.908LeuGln: 3.908 ± 0.056	5.062LeuArg: 5.062 ± 0.065	6.417LeuSer: 6.417 ± 0.074	6.115LeuThr: 6.115 ± 0.078	6.674LeuVal: 6.674 ± 0.081	0.949LeuTrp: 0.949 ± 0.029	2.759LeuTyr: 2.759 ± 0.044	0.001LeuXaa: 0.001 ± 0.001
Met	2.89MetAla: 2.89 ± 0.053	0.222MetCys: 0.222 ± 0.013	1.459MetAsp: 1.459 ± 0.038	1.662MetGlu: 1.662 ± 0.04	0.861MetPhe: 0.861 ± 0.029	2.078MetGly: 2.078 ± 0.047	0.434MetHis: 0.434 ± 0.017	1.998MetIle: 1.998 ± 0.036	1.602MetLys: 1.602 ± 0.039	2.775MetLeu: 2.775 ± 0.055	0.751MetMet: 0.751 ± 0.024	1.189MetAsn: 1.189 ± 0.028	1.304MetPro: 1.304 ± 0.031	1.157MetGln: 1.157 ± 0.027	1.364MetArg: 1.364 ± 0.032	1.539MetSer: 1.539 ± 0.033	1.663MetThr: 1.663 ± 0.036	1.948MetVal: 1.948 ± 0.042	0.181MetTrp: 0.181 ± 0.012	0.614MetTyr: 0.614 ± 0.024	0.001MetXaa: 0.001 ± 0.001
Asn	3.018AsnAla: 3.018 ± 0.052	0.429AsnCys: 0.429 ± 0.019	1.54AsnAsp: 1.54 ± 0.04	1.848AsnGlu: 1.848 ± 0.04	1.304AsnPhe: 1.304 ± 0.037	2.734AsnGly: 2.734 ± 0.05	0.747AsnHis: 0.747 ± 0.025	2.748AsnIle: 2.748 ± 0.05	1.812AsnLys: 1.812 ± 0.041	3.734AsnLeu: 3.734 ± 0.059	1.038AsnMet: 1.038 ± 0.03	1.36AsnAsn: 1.36 ± 0.044	2.184AsnPro: 2.184 ± 0.044	1.568AsnGln: 1.568 ± 0.041	2.112AsnArg: 2.112 ± 0.04	2.025AsnSer: 2.025 ± 0.042	1.945AsnThr: 1.945 ± 0.046	2.445AsnVal: 2.445 ± 0.042	0.432AsnTrp: 0.432 ± 0.019	1.135AsnTyr: 1.135 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	4.283ProAla: 4.283 ± 0.062	0.434ProCys: 0.434 ± 0.017	2.761ProAsp: 2.761 ± 0.047	3.277ProGlu: 3.277 ± 0.061	1.715ProPhe: 1.715 ± 0.039	3.583ProGly: 3.583 ± 0.06	0.874ProHis: 0.874 ± 0.025	2.216ProIle: 2.216 ± 0.046	1.712ProLys: 1.712 ± 0.044	4.031ProLeu: 4.031 ± 0.067	0.887ProMet: 0.887 ± 0.026	1.2ProAsn: 1.2 ± 0.035	1.565ProPro: 1.565 ± 0.042	1.691ProGln: 1.691 ± 0.046	1.743ProArg: 1.743 ± 0.039	2.038ProSer: 2.038 ± 0.044	1.783ProThr: 1.783 ± 0.04	3.945ProVal: 3.945 ± 0.067	0.513ProTrp: 0.513 ± 0.02	1.376ProTyr: 1.376 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	4.642GlnAla: 4.642 ± 0.07	0.381GlnCys: 0.381 ± 0.018	2.029GlnAsp: 2.029 ± 0.042	2.942GlnGlu: 2.942 ± 0.057	1.311GlnPhe: 1.311 ± 0.034	2.893GlnGly: 2.893 ± 0.048	0.713GlnHis: 0.713 ± 0.025	2.664GlnIle: 2.664 ± 0.049	2.345GlnLys: 2.345 ± 0.04	3.693GlnLeu: 3.693 ± 0.058	1.185GlnMet: 1.185 ± 0.032	1.585GlnAsn: 1.585 ± 0.033	1.776GlnPro: 1.776 ± 0.043	2.11GlnGln: 2.11 ± 0.053	2.017GlnArg: 2.017 ± 0.045	2.155GlnSer: 2.155 ± 0.046	2.279GlnThr: 2.279 ± 0.05	2.934GlnVal: 2.934 ± 0.045	0.396GlnTrp: 0.396 ± 0.017	1.413GlnTyr: 1.413 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	3.608ArgAla: 3.608 ± 0.057	0.597ArgCys: 0.597 ± 0.021	2.627ArgAsp: 2.627 ± 0.044	4.037ArgGlu: 4.037 ± 0.062	2.096ArgPhe: 2.096 ± 0.038	3.179ArgGly: 3.179 ± 0.051	1.23ArgHis: 1.23 ± 0.032	3.921ArgIle: 3.921 ± 0.057	2.767ArgLys: 2.767 ± 0.052	5.631ArgLeu: 5.631 ± 0.081	1.641ArgMet: 1.641 ± 0.042	1.955ArgAsn: 1.955 ± 0.042	2.079ArgPro: 2.079 ± 0.041	3.207ArgGln: 3.207 ± 0.059	3.216ArgArg: 3.216 ± 0.061	2.689ArgSer: 2.689 ± 0.048	2.536ArgThr: 2.536 ± 0.05	3.386ArgVal: 3.386 ± 0.055	0.577ArgTrp: 0.577 ± 0.021	1.849ArgTyr: 1.849 ± 0.037	0.001ArgXaa: 0.001 ± 0.001
Ser	4.719SerAla: 4.719 ± 0.071	0.67SerCys: 0.67 ± 0.024	2.725SerAsp: 2.725 ± 0.048	2.908SerGlu: 2.908 ± 0.045	2.414SerPhe: 2.414 ± 0.048	5.251SerGly: 5.251 ± 0.06	1.183SerHis: 1.183 ± 0.033	3.608SerIle: 3.608 ± 0.05	2.375SerLys: 2.375 ± 0.045	6.256SerLeu: 6.256 ± 0.08	1.51SerMet: 1.51 ± 0.036	1.762SerAsn: 1.762 ± 0.04	2.391SerPro: 2.391 ± 0.042	2.413SerGln: 2.413 ± 0.053	3.311SerArg: 3.311 ± 0.046	3.179SerSer: 3.179 ± 0.069	2.568SerThr: 2.568 ± 0.053	4.002SerVal: 4.002 ± 0.058	0.61SerTrp: 0.61 ± 0.023	1.854SerTyr: 1.854 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	5.746ThrAla: 5.746 ± 0.077	0.553ThrCys: 0.553 ± 0.022	2.653ThrAsp: 2.653 ± 0.05	2.907ThrGlu: 2.907 ± 0.054	1.911ThrPhe: 1.911 ± 0.036	5.356ThrGly: 5.356 ± 0.089	0.979ThrHis: 0.979 ± 0.026	3.602ThrIle: 3.602 ± 0.053	2.268ThrLys: 2.268 ± 0.049	5.229ThrLeu: 5.229 ± 0.074	1.278ThrMet: 1.278 ± 0.033	1.689ThrAsn: 1.689 ± 0.04	2.599ThrPro: 2.599 ± 0.052	1.776ThrGln: 1.776 ± 0.043	2.324ThrArg: 2.324 ± 0.041	2.567ThrSer: 2.567 ± 0.048	2.742ThrThr: 2.742 ± 0.055	4.969ThrVal: 4.969 ± 0.066	0.487ThrTrp: 0.487 ± 0.019	1.551ThrTyr: 1.551 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	6.837ValAla: 6.837 ± 0.081	0.944ValCys: 0.944 ± 0.028	3.719ValAsp: 3.719 ± 0.059	4.243ValGlu: 4.243 ± 0.055	2.848ValPhe: 2.848 ± 0.048	4.986ValGly: 4.986 ± 0.068	1.293ValHis: 1.293 ± 0.033	5.328ValIle: 5.328 ± 0.079	4.082ValLys: 4.082 ± 0.053	7.396ValLeu: 7.396 ± 0.082	2.082ValMet: 2.082 ± 0.043	2.837ValAsn: 2.837 ± 0.051	2.872ValPro: 2.872 ± 0.05	2.56ValGln: 2.56 ± 0.045	3.759ValArg: 3.759 ± 0.06	4.527ValSer: 4.527 ± 0.058	4.354ValThr: 4.354 ± 0.072	5.418ValVal: 5.418 ± 0.073	0.716ValTrp: 0.716 ± 0.027	2.298ValTyr: 2.298 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.791TrpAla: 0.791 ± 0.022	0.101TrpCys: 0.101 ± 0.009	0.52TrpAsp: 0.52 ± 0.022	0.597TrpGlu: 0.597 ± 0.022	0.462TrpPhe: 0.462 ± 0.02	0.773TrpGly: 0.773 ± 0.028	0.218TrpHis: 0.218 ± 0.012	0.637TrpIle: 0.637 ± 0.022	0.504TrpLys: 0.504 ± 0.023	1.268TrpLeu: 1.268 ± 0.032	0.295TrpMet: 0.295 ± 0.017	0.41TrpAsn: 0.41 ± 0.019	0.402TrpPro: 0.402 ± 0.017	0.642TrpGln: 0.642 ± 0.025	0.664TrpArg: 0.664 ± 0.024	0.547TrpSer: 0.547 ± 0.024	0.487TrpThr: 0.487 ± 0.02	0.654TrpVal: 0.654 ± 0.023	0.164TrpTrp: 0.164 ± 0.013	0.317TrpTyr: 0.317 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.52TyrAla: 2.52 ± 0.053	0.459TyrCys: 0.459 ± 0.02	1.743TyrAsp: 1.743 ± 0.044	1.805TyrGlu: 1.805 ± 0.043	1.433TyrPhe: 1.433 ± 0.033	2.491TyrGly: 2.491 ± 0.046	0.755TyrHis: 0.755 ± 0.023	2.139TyrIle: 2.139 ± 0.048	1.339TyrLys: 1.339 ± 0.035	3.26TyrLeu: 3.26 ± 0.058	0.701TyrMet: 0.701 ± 0.027	1.152TyrAsn: 1.152 ± 0.033	1.492TyrPro: 1.492 ± 0.036	1.486TyrGln: 1.486 ± 0.035	2.031TyrArg: 2.031 ± 0.041	1.888TyrSer: 1.888 ± 0.044	1.624TyrThr: 1.624 ± 0.037	1.927TyrVal: 1.927 ± 0.041	0.398TyrTrp: 0.398 ± 0.018	1.207TyrTyr: 1.207 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 4283 proteins (1245218 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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