Amino acid dipepetide frequency for Candidatus Brocadiaceae bacterium S225

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.547AlaAla: 4.547 ± 0.093	0.835AlaCys: 0.835 ± 0.03	3.425AlaAsp: 3.425 ± 0.069	4.417AlaGlu: 4.417 ± 0.09	2.844AlaPhe: 2.844 ± 0.068	4.883AlaGly: 4.883 ± 0.086	1.234AlaHis: 1.234 ± 0.044	5.699AlaIle: 5.699 ± 0.102	4.368AlaLys: 4.368 ± 0.085	6.335AlaLeu: 6.335 ± 0.101	1.768AlaMet: 1.768 ± 0.049	2.631AlaAsn: 2.631 ± 0.066	1.793AlaPro: 1.793 ± 0.045	1.747AlaGln: 1.747 ± 0.042	3.013AlaArg: 3.013 ± 0.058	3.806AlaSer: 3.806 ± 0.075	3.144AlaThr: 3.144 ± 0.074	4.624AlaVal: 4.624 ± 0.087	0.557AlaTrp: 0.557 ± 0.027	2.136AlaTyr: 2.136 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.756CysAla: 0.756 ± 0.032	0.228CysCys: 0.228 ± 0.018	0.71CysAsp: 0.71 ± 0.029	0.714CysGlu: 0.714 ± 0.032	0.683CysPhe: 0.683 ± 0.029	1.083CysGly: 1.083 ± 0.039	0.468CysHis: 0.468 ± 0.039	0.934CysIle: 0.934 ± 0.036	0.8CysLys: 0.8 ± 0.029	1.178CysLeu: 1.178 ± 0.039	0.314CysMet: 0.314 ± 0.019	0.651CysAsn: 0.651 ± 0.027	0.641CysPro: 0.641 ± 0.036	0.325CysGln: 0.325 ± 0.021	0.631CysArg: 0.631 ± 0.03	0.867CysSer: 0.867 ± 0.035	0.584CysThr: 0.584 ± 0.031	0.847CysVal: 0.847 ± 0.037	0.09CysTrp: 0.09 ± 0.009	0.453CysTyr: 0.453 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.596AspAla: 3.596 ± 0.076	0.74AspCys: 0.74 ± 0.035	3.102AspAsp: 3.102 ± 0.064	4.024AspGlu: 4.024 ± 0.078	2.707AspPhe: 2.707 ± 0.066	3.709AspGly: 3.709 ± 0.077	0.902AspHis: 0.902 ± 0.034	5.254AspIle: 5.254 ± 0.076	4.238AspLys: 4.238 ± 0.075	5.126AspLeu: 5.126 ± 0.086	1.359AspMet: 1.359 ± 0.041	2.778AspAsn: 2.778 ± 0.062	2.035AspPro: 2.035 ± 0.054	1.238AspGln: 1.238 ± 0.038	2.466AspArg: 2.466 ± 0.06	3.354AspSer: 3.354 ± 0.069	2.918AspThr: 2.918 ± 0.065	3.879AspVal: 3.879 ± 0.075	0.677AspTrp: 0.677 ± 0.03	2.293AspTyr: 2.293 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	4.363GluAla: 4.363 ± 0.092	0.707GluCys: 0.707 ± 0.032	3.708GluAsp: 3.708 ± 0.078	5.6GluGlu: 5.6 ± 0.094	2.583GluPhe: 2.583 ± 0.064	3.987GluGly: 3.987 ± 0.088	1.35GluHis: 1.35 ± 0.047	6.382GluIle: 6.382 ± 0.095	6.567GluLys: 6.567 ± 0.12	6.523GluLeu: 6.523 ± 0.093	1.952GluMet: 1.952 ± 0.056	3.49GluAsn: 3.49 ± 0.058	1.832GluPro: 1.832 ± 0.051	2.146GluGln: 2.146 ± 0.053	3.49GluArg: 3.49 ± 0.067	3.962GluSer: 3.962 ± 0.075	3.727GluThr: 3.727 ± 0.066	4.074GluVal: 4.074 ± 0.073	0.717GluTrp: 0.717 ± 0.035	2.363GluTyr: 2.363 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	2.853PheAla: 2.853 ± 0.059	0.722PheCys: 0.722 ± 0.028	2.659PheAsp: 2.659 ± 0.061	2.713PheGlu: 2.713 ± 0.055	2.394PhePhe: 2.394 ± 0.062	3.141PheGly: 3.141 ± 0.066	0.938PheHis: 0.938 ± 0.034	3.511PheIle: 3.511 ± 0.07	2.916PheLys: 2.916 ± 0.067	4.387PheLeu: 4.387 ± 0.084	1.013PheMet: 1.013 ± 0.03	2.162PheAsn: 2.162 ± 0.052	1.654PhePro: 1.654 ± 0.05	1.239PheGln: 1.239 ± 0.038	1.869PheArg: 1.869 ± 0.053	3.36PheSer: 3.36 ± 0.067	2.412PheThr: 2.412 ± 0.056	2.951PheVal: 2.951 ± 0.063	0.527PheTrp: 0.527 ± 0.026	1.665PheTyr: 1.665 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	4.196GlyAla: 4.196 ± 0.082	0.999GlyCys: 0.999 ± 0.037	3.487GlyAsp: 3.487 ± 0.082	4.168GlyGlu: 4.168 ± 0.071	3.364GlyPhe: 3.364 ± 0.063	4.588GlyGly: 4.588 ± 0.091	1.407GlyHis: 1.407 ± 0.044	6.185GlyIle: 6.185 ± 0.097	5.494GlyLys: 5.494 ± 0.079	6.013GlyLeu: 6.013 ± 0.094	1.847GlyMet: 1.847 ± 0.057	3.31GlyAsn: 3.31 ± 0.063	1.626GlyPro: 1.626 ± 0.053	1.857GlyGln: 1.857 ± 0.052	3.127GlyArg: 3.127 ± 0.064	4.371GlySer: 4.371 ± 0.093	3.811GlyThr: 3.811 ± 0.095	4.684GlyVal: 4.684 ± 0.087	0.789GlyTrp: 0.789 ± 0.034	2.571GlyTyr: 2.571 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.247HisAla: 1.247 ± 0.038	0.317HisCys: 0.317 ± 0.018	1.042HisAsp: 1.042 ± 0.038	1.261HisGlu: 1.261 ± 0.045	0.99HisPhe: 0.99 ± 0.035	1.463HisGly: 1.463 ± 0.046	0.491HisHis: 0.491 ± 0.027	1.608HisIle: 1.608 ± 0.042	1.29HisLys: 1.29 ± 0.043	1.865HisLeu: 1.865 ± 0.05	0.459HisMet: 0.459 ± 0.024	0.981HisAsn: 0.981 ± 0.032	1.038HisPro: 1.038 ± 0.035	0.519HisGln: 0.519 ± 0.024	0.853HisArg: 0.853 ± 0.032	1.269HisSer: 1.269 ± 0.039	1.019HisThr: 1.019 ± 0.033	1.146HisVal: 1.146 ± 0.036	0.216HisTrp: 0.216 ± 0.016	0.746HisTyr: 0.746 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.712IleAla: 5.712 ± 0.093	1.122IleCys: 1.122 ± 0.036	5.093IleAsp: 5.093 ± 0.084	5.88IleGlu: 5.88 ± 0.098	3.571IlePhe: 3.571 ± 0.073	5.471IleGly: 5.471 ± 0.088	1.532IleHis: 1.532 ± 0.044	7.076IleIle: 7.076 ± 0.101	6.36IleLys: 6.36 ± 0.102	7.441IleLeu: 7.441 ± 0.116	1.859IleMet: 1.859 ± 0.053	4.035IleAsn: 4.035 ± 0.081	3.484IlePro: 3.484 ± 0.074	2.181IleGln: 2.181 ± 0.048	3.745IleArg: 3.745 ± 0.062	5.974IleSer: 5.974 ± 0.082	4.962IleThr: 4.962 ± 0.075	5.529IleVal: 5.529 ± 0.095	0.667IleTrp: 0.667 ± 0.03	2.468IleTyr: 2.468 ± 0.059	0.0IleXaa: 0.0 ± 0.0
Lys	4.739LysAla: 4.739 ± 0.094	0.742LysCys: 0.742 ± 0.038	4.425LysAsp: 4.425 ± 0.081	6.439LysGlu: 6.439 ± 0.104	2.413LysPhe: 2.413 ± 0.057	4.618LysGly: 4.618 ± 0.073	1.459LysHis: 1.459 ± 0.041	6.417LysIle: 6.417 ± 0.097	7.049LysLys: 7.049 ± 0.126	6.316LysLeu: 6.316 ± 0.09	1.98LysMet: 1.98 ± 0.046	4.001LysAsn: 4.001 ± 0.071	2.528LysPro: 2.528 ± 0.061	2.42LysGln: 2.42 ± 0.059	3.809LysArg: 3.809 ± 0.077	4.584LysSer: 4.584 ± 0.086	4.078LysThr: 4.078 ± 0.074	4.502LysVal: 4.502 ± 0.084	0.672LysTrp: 0.672 ± 0.03	2.718LysTyr: 2.718 ± 0.063	0.0LysXaa: 0.0 ± 0.0
Leu	6.154LeuAla: 6.154 ± 0.102	1.216LeuCys: 1.216 ± 0.042	5.111LeuAsp: 5.111 ± 0.08	6.187LeuGlu: 6.187 ± 0.097	4.425LeuPhe: 4.425 ± 0.089	6.09LeuGly: 6.09 ± 0.101	1.754LeuHis: 1.754 ± 0.045	7.244LeuIle: 7.244 ± 0.117	7.378LeuLys: 7.378 ± 0.092	8.984LeuLeu: 8.984 ± 0.145	2.117LeuMet: 2.117 ± 0.049	4.627LeuAsn: 4.627 ± 0.08	3.784LeuPro: 3.784 ± 0.08	2.886LeuGln: 2.886 ± 0.066	4.457LeuArg: 4.457 ± 0.074	7.007LeuSer: 7.007 ± 0.099	4.802LeuThr: 4.802 ± 0.083	5.594LeuVal: 5.594 ± 0.094	0.843LeuTrp: 0.843 ± 0.035	2.845LeuTyr: 2.845 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	1.932MetAla: 1.932 ± 0.049	0.277MetCys: 0.277 ± 0.017	1.335MetAsp: 1.335 ± 0.042	1.665MetGlu: 1.665 ± 0.044	0.928MetPhe: 0.928 ± 0.032	1.72MetGly: 1.72 ± 0.043	0.4MetHis: 0.4 ± 0.021	1.927MetIle: 1.927 ± 0.05	2.189MetLys: 2.189 ± 0.056	2.169MetLeu: 2.169 ± 0.06	0.582MetMet: 0.582 ± 0.03	1.2MetAsn: 1.2 ± 0.035	1.024MetPro: 1.024 ± 0.036	0.753MetGln: 0.753 ± 0.03	1.108MetArg: 1.108 ± 0.037	1.685MetSer: 1.685 ± 0.047	1.242MetThr: 1.242 ± 0.037	1.675MetVal: 1.675 ± 0.043	0.196MetTrp: 0.196 ± 0.014	0.636MetTyr: 0.636 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.881AsnAla: 2.881 ± 0.06	0.6AsnCys: 0.6 ± 0.027	2.517AsnAsp: 2.517 ± 0.058	2.989AsnGlu: 2.989 ± 0.068	1.922AsnPhe: 1.922 ± 0.05	2.992AsnGly: 2.992 ± 0.08	0.921AsnHis: 0.921 ± 0.034	4.594AsnIle: 4.594 ± 0.078	3.372AsnLys: 3.372 ± 0.073	4.655AsnLeu: 4.655 ± 0.086	1.275AsnMet: 1.275 ± 0.039	2.586AsnAsn: 2.586 ± 0.063	2.206AsnPro: 2.206 ± 0.055	1.284AsnGln: 1.284 ± 0.045	2.271AsnArg: 2.271 ± 0.047	2.83AsnSer: 2.83 ± 0.066	2.521AsnThr: 2.521 ± 0.063	3.298AsnVal: 3.298 ± 0.063	0.465AsnTrp: 0.465 ± 0.022	1.723AsnTyr: 1.723 ± 0.048	0.0AsnXaa: 0.0 ± 0.0
Pro	2.145ProAla: 2.145 ± 0.054	0.422ProCys: 0.422 ± 0.022	2.783ProAsp: 2.783 ± 0.069	3.177ProGlu: 3.177 ± 0.064	1.911ProPhe: 1.911 ± 0.049	2.775ProGly: 2.775 ± 0.065	0.777ProHis: 0.777 ± 0.036	2.455ProIle: 2.455 ± 0.065	1.922ProLys: 1.922 ± 0.048	3.278ProLeu: 3.278 ± 0.076	0.77ProMet: 0.77 ± 0.032	1.317ProAsn: 1.317 ± 0.04	1.243ProPro: 1.243 ± 0.038	1.001ProGln: 1.001 ± 0.037	1.395ProArg: 1.395 ± 0.04	2.129ProSer: 2.129 ± 0.05	1.689ProThr: 1.689 ± 0.046	2.957ProVal: 2.957 ± 0.058	0.392ProTrp: 0.392 ± 0.025	1.299ProTyr: 1.299 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	1.88GlnAla: 1.88 ± 0.057	0.311GlnCys: 0.311 ± 0.024	1.445GlnAsp: 1.445 ± 0.045	2.092GlnGlu: 2.092 ± 0.061	1.208GlnPhe: 1.208 ± 0.037	1.781GlnGly: 1.781 ± 0.052	0.559GlnHis: 0.559 ± 0.026	2.429GlnIle: 2.429 ± 0.062	2.421GlnLys: 2.421 ± 0.057	2.631GlnLeu: 2.631 ± 0.062	0.745GlnMet: 0.745 ± 0.031	1.422GlnAsn: 1.422 ± 0.043	0.903GlnPro: 0.903 ± 0.033	0.964GlnGln: 0.964 ± 0.034	1.384GlnArg: 1.384 ± 0.04	1.746GlnSer: 1.746 ± 0.05	1.577GlnThr: 1.577 ± 0.039	1.729GlnVal: 1.729 ± 0.047	0.284GlnTrp: 0.284 ± 0.019	1.0GlnTyr: 1.0 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	2.564ArgAla: 2.564 ± 0.058	0.568ArgCys: 0.568 ± 0.028	2.505ArgAsp: 2.505 ± 0.051	3.577ArgGlu: 3.577 ± 0.072	2.241ArgPhe: 2.241 ± 0.05	2.71ArgGly: 2.71 ± 0.067	1.026ArgHis: 1.026 ± 0.036	3.874ArgIle: 3.874 ± 0.07	3.854ArgLys: 3.854 ± 0.076	4.627ArgLeu: 4.627 ± 0.07	1.251ArgMet: 1.251 ± 0.043	2.291ArgAsn: 2.291 ± 0.054	1.507ArgPro: 1.507 ± 0.043	1.477ArgGln: 1.477 ± 0.042	2.265ArgArg: 2.265 ± 0.061	2.593ArgSer: 2.593 ± 0.061	2.207ArgThr: 2.207 ± 0.054	3.041ArgVal: 3.041 ± 0.064	0.495ArgTrp: 0.495 ± 0.026	1.699ArgTyr: 1.699 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	3.956SerAla: 3.956 ± 0.079	0.886SerCys: 0.886 ± 0.034	3.546SerAsp: 3.546 ± 0.071	4.229SerGlu: 4.229 ± 0.076	3.201SerPhe: 3.201 ± 0.069	5.147SerGly: 5.147 ± 0.091	1.285SerHis: 1.285 ± 0.038	5.273SerIle: 5.273 ± 0.081	4.386SerLys: 4.386 ± 0.073	6.362SerLeu: 6.362 ± 0.093	1.636SerMet: 1.636 ± 0.046	2.861SerAsn: 2.861 ± 0.06	2.28SerPro: 2.28 ± 0.053	1.845SerGln: 1.845 ± 0.053	2.948SerArg: 2.948 ± 0.061	4.279SerSer: 4.279 ± 0.081	3.404SerThr: 3.404 ± 0.058	4.346SerVal: 4.346 ± 0.078	0.684SerTrp: 0.684 ± 0.032	2.081SerTyr: 2.081 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	3.471ThrAla: 3.471 ± 0.078	0.606ThrCys: 0.606 ± 0.029	3.077ThrAsp: 3.077 ± 0.065	3.29ThrGlu: 3.29 ± 0.067	2.334ThrPhe: 2.334 ± 0.058	4.443ThrGly: 4.443 ± 0.083	1.08ThrHis: 1.08 ± 0.037	4.491ThrIle: 4.491 ± 0.08	3.285ThrLys: 3.285 ± 0.064	5.096ThrLeu: 5.096 ± 0.087	1.225ThrMet: 1.225 ± 0.04	2.346ThrAsn: 2.346 ± 0.053	2.301ThrPro: 2.301 ± 0.056	1.425ThrGln: 1.425 ± 0.041	2.316ThrArg: 2.316 ± 0.064	3.23ThrSer: 3.23 ± 0.064	2.851ThrThr: 2.851 ± 0.069	3.905ThrVal: 3.905 ± 0.074	0.525ThrTrp: 0.525 ± 0.027	1.58ThrTyr: 1.58 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	4.253ValAla: 4.253 ± 0.086	1.008ValCys: 1.008 ± 0.032	3.861ValAsp: 3.861 ± 0.072	4.354ValGlu: 4.354 ± 0.078	3.23ValPhe: 3.23 ± 0.067	4.224ValGly: 4.224 ± 0.076	1.256ValHis: 1.256 ± 0.038	5.508ValIle: 5.508 ± 0.088	4.742ValLys: 4.742 ± 0.085	6.152ValLeu: 6.152 ± 0.09	1.531ValMet: 1.531 ± 0.041	2.969ValAsn: 2.969 ± 0.061	2.411ValPro: 2.411 ± 0.053	1.738ValGln: 1.738 ± 0.048	2.968ValArg: 2.968 ± 0.064	4.739ValSer: 4.739 ± 0.073	3.71ValThr: 3.71 ± 0.088	4.807ValVal: 4.807 ± 0.088	0.629ValTrp: 0.629 ± 0.028	2.027ValTyr: 2.027 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.569TrpAla: 0.569 ± 0.026	0.146TrpCys: 0.146 ± 0.012	0.557TrpAsp: 0.557 ± 0.024	0.612TrpGlu: 0.612 ± 0.031	0.481TrpPhe: 0.481 ± 0.027	0.648TrpGly: 0.648 ± 0.027	0.211TrpHis: 0.211 ± 0.016	0.796TrpIle: 0.796 ± 0.036	0.802TrpLys: 0.802 ± 0.036	1.025TrpLeu: 1.025 ± 0.037	0.26TrpMet: 0.26 ± 0.018	0.522TrpAsn: 0.522 ± 0.027	0.311TrpPro: 0.311 ± 0.019	0.399TrpGln: 0.399 ± 0.023	0.533TrpArg: 0.533 ± 0.026	0.64TrpSer: 0.64 ± 0.028	0.435TrpThr: 0.435 ± 0.021	0.57TrpVal: 0.57 ± 0.028	0.16TrpTrp: 0.16 ± 0.015	0.341TrpTyr: 0.341 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.993TyrAla: 1.993 ± 0.053	0.504TyrCys: 0.504 ± 0.023	2.006TyrAsp: 2.006 ± 0.053	2.135TyrGlu: 2.135 ± 0.054	1.654TyrPhe: 1.654 ± 0.048	2.425TyrGly: 2.425 ± 0.06	0.77TyrHis: 0.77 ± 0.032	2.503TyrIle: 2.503 ± 0.052	2.474TyrLys: 2.474 ± 0.05	3.346TyrLeu: 3.346 ± 0.078	0.699TyrMet: 0.699 ± 0.033	1.722TyrAsn: 1.722 ± 0.048	1.237TyrPro: 1.237 ± 0.041	1.068TyrGln: 1.068 ± 0.033	1.723TyrArg: 1.723 ± 0.05	2.21TyrSer: 2.21 ± 0.054	1.783TyrThr: 1.783 ± 0.05	1.958TyrVal: 1.958 ± 0.046	0.436TyrTrp: 0.436 ± 0.026	1.388TyrTyr: 1.388 ± 0.045	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2768 proteins (835022 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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