Amino acid dipepetide frequency for Mycobacterium phage ArcusAngelus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.672AlaAla: 15.672 ± 1.569
0.813AlaCys: 0.813 ± 0.229
7.267AlaAsp: 7.267 ± 0.677
7.701AlaGlu: 7.701 ± 0.709
2.495AlaPhe: 2.495 ± 0.334
9.924AlaGly: 9.924 ± 1.288
2.115AlaHis: 2.115 ± 0.36
4.013AlaIle: 4.013 ± 0.489
3.471AlaLys: 3.471 ± 0.414
7.918AlaLeu: 7.918 ± 0.712
2.711AlaMet: 2.711 ± 0.393
2.766AlaAsn: 2.766 ± 0.453
5.206AlaPro: 5.206 ± 0.444
3.905AlaGln: 3.905 ± 0.466
6.887AlaArg: 6.887 ± 0.651
5.369AlaSer: 5.369 ± 0.498
6.182AlaThr: 6.182 ± 0.546
7.43AlaVal: 7.43 ± 0.705
2.874AlaTrp: 2.874 ± 0.421
2.223AlaTyr: 2.223 ± 0.341
0.0AlaXaa: 0.0 ± 0.0
Cys
1.085CysAla: 1.085 ± 0.273
0.108CysCys: 0.108 ± 0.081
1.302CysAsp: 1.302 ± 0.316
0.868CysGlu: 0.868 ± 0.247
0.163CysPhe: 0.163 ± 0.079
1.681CysGly: 1.681 ± 0.36
0.163CysHis: 0.163 ± 0.098
0.054CysIle: 0.054 ± 0.059
0.597CysLys: 0.597 ± 0.204
0.759CysLeu: 0.759 ± 0.24
0.163CysMet: 0.163 ± 0.095
0.488CysAsn: 0.488 ± 0.156
1.193CysPro: 1.193 ± 0.314
0.325CysGln: 0.325 ± 0.123
0.705CysArg: 0.705 ± 0.205
0.597CysSer: 0.597 ± 0.175
0.651CysThr: 0.651 ± 0.215
0.597CysVal: 0.597 ± 0.157
0.434CysTrp: 0.434 ± 0.156
0.38CysTyr: 0.38 ± 0.16
0.0CysXaa: 0.0 ± 0.0
Asp
7.375AspAla: 7.375 ± 0.656
0.705AspCys: 0.705 ± 0.216
4.664AspAsp: 4.664 ± 0.624
3.633AspGlu: 3.633 ± 0.489
2.007AspPhe: 2.007 ± 0.266
6.67AspGly: 6.67 ± 0.71
1.41AspHis: 1.41 ± 0.255
2.657AspIle: 2.657 ± 0.449
1.681AspLys: 1.681 ± 0.303
5.857AspLeu: 5.857 ± 0.584
0.976AspMet: 0.976 ± 0.273
1.627AspAsn: 1.627 ± 0.363
4.826AspPro: 4.826 ± 0.565
2.44AspGln: 2.44 ± 0.348
5.477AspArg: 5.477 ± 0.658
3.037AspSer: 3.037 ± 0.504
4.067AspThr: 4.067 ± 0.449
4.61AspVal: 4.61 ± 0.566
1.41AspTrp: 1.41 ± 0.317
2.061AspTyr: 2.061 ± 0.346
0.0AspXaa: 0.0 ± 0.0
Glu
5.586GluAla: 5.586 ± 0.572
0.868GluCys: 0.868 ± 0.205
3.416GluAsp: 3.416 ± 0.353
2.766GluGlu: 2.766 ± 0.494
2.115GluPhe: 2.115 ± 0.362
3.091GluGly: 3.091 ± 0.394
1.573GluHis: 1.573 ± 0.458
2.549GluIle: 2.549 ± 0.339
1.844GluLys: 1.844 ± 0.306
5.803GluLeu: 5.803 ± 0.759
1.573GluMet: 1.573 ± 0.302
2.223GluAsn: 2.223 ± 0.297
3.091GluPro: 3.091 ± 0.47
2.928GluGln: 2.928 ± 0.4
4.881GluArg: 4.881 ± 0.597
3.254GluSer: 3.254 ± 0.525
3.796GluThr: 3.796 ± 0.562
4.176GluVal: 4.176 ± 0.57
1.41GluTrp: 1.41 ± 0.293
2.007GluTyr: 2.007 ± 0.381
0.0GluXaa: 0.0 ± 0.0
Phe
2.495PheAla: 2.495 ± 0.398
0.325PheCys: 0.325 ± 0.116
2.278PheAsp: 2.278 ± 0.467
1.573PheGlu: 1.573 ± 0.265
0.922PhePhe: 0.922 ± 0.257
2.928PheGly: 2.928 ± 0.573
0.325PheHis: 0.325 ± 0.118
1.356PheIle: 1.356 ± 0.318
0.976PheLys: 0.976 ± 0.251
1.898PheLeu: 1.898 ± 0.287
0.434PheMet: 0.434 ± 0.166
1.302PheAsn: 1.302 ± 0.329
2.061PhePro: 2.061 ± 0.331
1.139PheGln: 1.139 ± 0.296
1.681PheArg: 1.681 ± 0.257
1.735PheSer: 1.735 ± 0.245
2.386PheThr: 2.386 ± 0.388
1.898PheVal: 1.898 ± 0.295
0.759PheTrp: 0.759 ± 0.184
0.813PheTyr: 0.813 ± 0.255
0.0PheXaa: 0.0 ± 0.0
Gly
8.514GlyAla: 8.514 ± 1.14
0.922GlyCys: 0.922 ± 0.277
6.453GlyAsp: 6.453 ± 0.502
3.525GlyGlu: 3.525 ± 0.494
2.766GlyPhe: 2.766 ± 0.398
9.87GlyGly: 9.87 ± 1.778
1.464GlyHis: 1.464 ± 0.26
4.393GlyIle: 4.393 ± 0.56
2.711GlyLys: 2.711 ± 0.467
5.911GlyLeu: 5.911 ± 0.525
2.223GlyMet: 2.223 ± 0.458
3.145GlyAsn: 3.145 ± 0.401
4.013GlyPro: 4.013 ± 0.503
2.169GlyGln: 2.169 ± 0.501
5.043GlyArg: 5.043 ± 0.652
6.291GlySer: 6.291 ± 0.815
6.074GlyThr: 6.074 ± 0.768
5.965GlyVal: 5.965 ± 0.554
2.386GlyTrp: 2.386 ± 0.35
1.898GlyTyr: 1.898 ± 0.339
0.0GlyXaa: 0.0 ± 0.0
His
2.115HisAla: 2.115 ± 0.408
0.325HisCys: 0.325 ± 0.126
1.085HisAsp: 1.085 ± 0.233
0.813HisGlu: 0.813 ± 0.225
0.434HisPhe: 0.434 ± 0.134
1.627HisGly: 1.627 ± 0.259
0.976HisHis: 0.976 ± 0.304
1.302HisIle: 1.302 ± 0.326
0.597HisLys: 0.597 ± 0.199
1.518HisLeu: 1.518 ± 0.292
0.434HisMet: 0.434 ± 0.125
0.813HisAsn: 0.813 ± 0.218
1.518HisPro: 1.518 ± 0.272
0.651HisGln: 0.651 ± 0.189
2.44HisArg: 2.44 ± 0.457
0.922HisSer: 0.922 ± 0.203
1.302HisThr: 1.302 ± 0.295
1.41HisVal: 1.41 ± 0.286
0.542HisTrp: 0.542 ± 0.182
0.705HisTyr: 0.705 ± 0.155
0.0HisXaa: 0.0 ± 0.0
Ile
5.586IleAla: 5.586 ± 0.54
0.759IleCys: 0.759 ± 0.238
3.959IleAsp: 3.959 ± 0.537
3.145IleGlu: 3.145 ± 0.352
0.651IlePhe: 0.651 ± 0.236
4.013IleGly: 4.013 ± 0.498
1.735IleHis: 1.735 ± 0.381
1.247IleIle: 1.247 ± 0.247
0.759IleLys: 0.759 ± 0.225
2.169IleLeu: 2.169 ± 0.334
0.271IleMet: 0.271 ± 0.112
1.735IleAsn: 1.735 ± 0.238
3.037IlePro: 3.037 ± 0.33
1.302IleGln: 1.302 ± 0.238
2.82IleArg: 2.82 ± 0.454
2.115IleSer: 2.115 ± 0.41
3.416IleThr: 3.416 ± 0.451
3.037IleVal: 3.037 ± 0.412
0.813IleTrp: 0.813 ± 0.237
0.868IleTyr: 0.868 ± 0.189
0.0IleXaa: 0.0 ± 0.0
Lys
3.362LysAla: 3.362 ± 0.499
0.434LysCys: 0.434 ± 0.184
1.681LysAsp: 1.681 ± 0.391
1.518LysGlu: 1.518 ± 0.276
1.302LysPhe: 1.302 ± 0.222
2.278LysGly: 2.278 ± 0.391
0.922LysHis: 0.922 ± 0.24
0.922LysIle: 0.922 ± 0.223
1.464LysLys: 1.464 ± 0.38
2.603LysLeu: 2.603 ± 0.405
1.193LysMet: 1.193 ± 0.258
0.759LysAsn: 0.759 ± 0.204
2.169LysPro: 2.169 ± 0.372
1.464LysGln: 1.464 ± 0.227
2.278LysArg: 2.278 ± 0.364
2.223LysSer: 2.223 ± 0.311
1.79LysThr: 1.79 ± 0.265
2.169LysVal: 2.169 ± 0.373
0.759LysTrp: 0.759 ± 0.206
0.759LysTyr: 0.759 ± 0.23
0.0LysXaa: 0.0 ± 0.0
Leu
7.592LeuAla: 7.592 ± 0.75
0.651LeuCys: 0.651 ± 0.228
4.447LeuAsp: 4.447 ± 0.455
4.121LeuGlu: 4.121 ± 0.489
2.603LeuPhe: 2.603 ± 0.35
4.881LeuGly: 4.881 ± 0.482
0.976LeuHis: 0.976 ± 0.22
3.145LeuIle: 3.145 ± 0.449
2.169LeuLys: 2.169 ± 0.316
5.586LeuLeu: 5.586 ± 0.649
1.627LeuMet: 1.627 ± 0.312
2.711LeuAsn: 2.711 ± 0.406
4.989LeuPro: 4.989 ± 0.6
2.766LeuGln: 2.766 ± 0.37
5.803LeuArg: 5.803 ± 0.653
5.152LeuSer: 5.152 ± 0.497
5.694LeuThr: 5.694 ± 0.531
4.555LeuVal: 4.555 ± 0.502
1.356LeuTrp: 1.356 ± 0.269
1.952LeuTyr: 1.952 ± 0.325
0.0LeuXaa: 0.0 ± 0.0
Met
2.169MetAla: 2.169 ± 0.384
0.271MetCys: 0.271 ± 0.186
1.41MetAsp: 1.41 ± 0.293
0.868MetGlu: 0.868 ± 0.179
0.759MetPhe: 0.759 ± 0.22
1.681MetGly: 1.681 ± 0.274
0.163MetHis: 0.163 ± 0.086
0.651MetIle: 0.651 ± 0.198
0.759MetLys: 0.759 ± 0.2
1.735MetLeu: 1.735 ± 0.247
0.597MetMet: 0.597 ± 0.224
0.922MetAsn: 0.922 ± 0.224
1.302MetPro: 1.302 ± 0.245
0.597MetGln: 0.597 ± 0.172
1.41MetArg: 1.41 ± 0.23
2.495MetSer: 2.495 ± 0.406
2.278MetThr: 2.278 ± 0.365
1.356MetVal: 1.356 ± 0.307
0.434MetTrp: 0.434 ± 0.15
0.542MetTyr: 0.542 ± 0.166
0.0MetXaa: 0.0 ± 0.0
Asn
3.416AsnAla: 3.416 ± 0.497
0.217AsnCys: 0.217 ± 0.099
1.952AsnAsp: 1.952 ± 0.317
1.79AsnGlu: 1.79 ± 0.338
0.813AsnPhe: 0.813 ± 0.296
4.23AsnGly: 4.23 ± 0.508
0.976AsnHis: 0.976 ± 0.234
1.79AsnIle: 1.79 ± 0.432
1.085AsnLys: 1.085 ± 0.233
2.169AsnLeu: 2.169 ± 0.351
0.597AsnMet: 0.597 ± 0.154
1.735AsnAsn: 1.735 ± 0.303
2.386AsnPro: 2.386 ± 0.308
1.085AsnGln: 1.085 ± 0.342
2.169AsnArg: 2.169 ± 0.398
1.735AsnSer: 1.735 ± 0.275
2.332AsnThr: 2.332 ± 0.357
2.386AsnVal: 2.386 ± 0.372
0.597AsnTrp: 0.597 ± 0.154
0.651AsnTyr: 0.651 ± 0.17
0.0AsnXaa: 0.0 ± 0.0
Pro
5.748ProAla: 5.748 ± 0.733
0.976ProCys: 0.976 ± 0.306
4.61ProAsp: 4.61 ± 0.531
4.067ProGlu: 4.067 ± 0.45
1.464ProPhe: 1.464 ± 0.299
5.965ProGly: 5.965 ± 0.574
1.627ProHis: 1.627 ± 0.292
2.169ProIle: 2.169 ± 0.312
1.952ProLys: 1.952 ± 0.344
4.338ProLeu: 4.338 ± 0.506
1.302ProMet: 1.302 ± 0.312
2.82ProAsn: 2.82 ± 0.383
3.688ProPro: 3.688 ± 0.598
2.061ProGln: 2.061 ± 0.38
2.874ProArg: 2.874 ± 0.498
3.416ProSer: 3.416 ± 0.409
3.2ProThr: 3.2 ± 0.442
5.26ProVal: 5.26 ± 0.528
1.247ProTrp: 1.247 ± 0.208
1.518ProTyr: 1.518 ± 0.286
0.0ProXaa: 0.0 ± 0.0
Gln
4.338GlnAla: 4.338 ± 0.653
0.271GlnCys: 0.271 ± 0.126
1.464GlnAsp: 1.464 ± 0.254
1.681GlnGlu: 1.681 ± 0.274
1.03GlnPhe: 1.03 ± 0.227
2.82GlnGly: 2.82 ± 0.496
0.868GlnHis: 0.868 ± 0.249
2.061GlnIle: 2.061 ± 0.333
1.41GlnLys: 1.41 ± 0.255
3.145GlnLeu: 3.145 ± 0.341
0.597GlnMet: 0.597 ± 0.2
0.868GlnAsn: 0.868 ± 0.274
2.332GlnPro: 2.332 ± 0.389
1.085GlnGln: 1.085 ± 0.273
2.278GlnArg: 2.278 ± 0.346
2.278GlnSer: 2.278 ± 0.337
1.898GlnThr: 1.898 ± 0.351
2.44GlnVal: 2.44 ± 0.332
0.651GlnTrp: 0.651 ± 0.202
0.813GlnTyr: 0.813 ± 0.288
0.0GlnXaa: 0.0 ± 0.0
Arg
7.701ArgAla: 7.701 ± 0.692
1.247ArgCys: 1.247 ± 0.343
4.338ArgAsp: 4.338 ± 0.543
5.531ArgGlu: 5.531 ± 0.673
2.169ArgPhe: 2.169 ± 0.368
3.362ArgGly: 3.362 ± 0.495
1.302ArgHis: 1.302 ± 0.265
3.742ArgIle: 3.742 ± 0.509
1.898ArgLys: 1.898 ± 0.361
4.393ArgLeu: 4.393 ± 0.574
2.44ArgMet: 2.44 ± 0.355
3.091ArgAsn: 3.091 ± 0.475
3.85ArgPro: 3.85 ± 0.411
2.007ArgGln: 2.007 ± 0.363
6.128ArgArg: 6.128 ± 0.904
3.688ArgSer: 3.688 ± 0.405
4.121ArgThr: 4.121 ± 0.682
5.098ArgVal: 5.098 ± 0.517
2.061ArgTrp: 2.061 ± 0.376
2.115ArgTyr: 2.115 ± 0.406
0.0ArgXaa: 0.0 ± 0.0
Ser
5.64SerAla: 5.64 ± 0.84
0.651SerCys: 0.651 ± 0.217
4.338SerAsp: 4.338 ± 0.511
3.037SerGlu: 3.037 ± 0.393
1.952SerPhe: 1.952 ± 0.361
6.562SerGly: 6.562 ± 0.841
1.085SerHis: 1.085 ± 0.261
3.2SerIle: 3.2 ± 0.401
2.44SerLys: 2.44 ± 0.428
3.362SerLeu: 3.362 ± 0.439
1.518SerMet: 1.518 ± 0.261
1.844SerAsn: 1.844 ± 0.337
3.579SerPro: 3.579 ± 0.34
1.681SerGln: 1.681 ± 0.255
3.742SerArg: 3.742 ± 0.493
3.254SerSer: 3.254 ± 0.554
3.633SerThr: 3.633 ± 0.445
4.393SerVal: 4.393 ± 0.474
1.41SerTrp: 1.41 ± 0.279
1.247SerTyr: 1.247 ± 0.227
0.0SerXaa: 0.0 ± 0.0
Thr
6.236ThrAla: 6.236 ± 0.554
0.922ThrCys: 0.922 ± 0.234
3.796ThrAsp: 3.796 ± 0.567
3.742ThrGlu: 3.742 ± 0.395
2.007ThrPhe: 2.007 ± 0.355
5.857ThrGly: 5.857 ± 0.646
1.464ThrHis: 1.464 ± 0.312
3.579ThrIle: 3.579 ± 0.533
2.278ThrLys: 2.278 ± 0.381
4.61ThrLeu: 4.61 ± 0.493
1.356ThrMet: 1.356 ± 0.247
2.061ThrAsn: 2.061 ± 0.351
4.393ThrPro: 4.393 ± 0.496
2.007ThrGln: 2.007 ± 0.298
4.284ThrArg: 4.284 ± 0.457
3.905ThrSer: 3.905 ± 0.441
4.881ThrThr: 4.881 ± 0.682
6.291ThrVal: 6.291 ± 0.714
1.356ThrTrp: 1.356 ± 0.266
1.573ThrTyr: 1.573 ± 0.348
0.0ThrXaa: 0.0 ± 0.0
Val
8.026ValAla: 8.026 ± 0.572
1.085ValCys: 1.085 ± 0.205
5.423ValAsp: 5.423 ± 0.494
5.64ValGlu: 5.64 ± 0.676
2.169ValPhe: 2.169 ± 0.378
5.531ValGly: 5.531 ± 0.572
1.302ValHis: 1.302 ± 0.276
2.332ValIle: 2.332 ± 0.358
2.386ValLys: 2.386 ± 0.371
5.26ValLeu: 5.26 ± 0.615
1.139ValMet: 1.139 ± 0.247
2.061ValAsn: 2.061 ± 0.319
3.796ValPro: 3.796 ± 0.42
2.711ValGln: 2.711 ± 0.373
4.935ValArg: 4.935 ± 0.624
4.664ValSer: 4.664 ± 0.519
5.206ValThr: 5.206 ± 0.424
6.725ValVal: 6.725 ± 0.669
2.007ValTrp: 2.007 ± 0.381
1.464ValTyr: 1.464 ± 0.24
0.0ValXaa: 0.0 ± 0.0
Trp
1.898TrpAla: 1.898 ± 0.27
0.325TrpCys: 0.325 ± 0.146
1.464TrpAsp: 1.464 ± 0.261
1.193TrpGlu: 1.193 ± 0.379
0.759TrpPhe: 0.759 ± 0.199
1.03TrpGly: 1.03 ± 0.253
0.651TrpHis: 0.651 ± 0.18
1.139TrpIle: 1.139 ± 0.208
0.976TrpLys: 0.976 ± 0.235
1.952TrpLeu: 1.952 ± 0.352
0.922TrpMet: 0.922 ± 0.244
0.597TrpAsn: 0.597 ± 0.213
1.573TrpPro: 1.573 ± 0.31
1.03TrpGln: 1.03 ± 0.269
2.386TrpArg: 2.386 ± 0.482
1.247TrpSer: 1.247 ± 0.281
1.898TrpThr: 1.898 ± 0.263
1.79TrpVal: 1.79 ± 0.405
1.085TrpTrp: 1.085 ± 0.212
0.597TrpTyr: 0.597 ± 0.168
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.386TyrAla: 2.386 ± 0.342
0.434TyrCys: 0.434 ± 0.165
1.844TyrAsp: 1.844 ± 0.33
1.735TyrGlu: 1.735 ± 0.315
0.705TyrPhe: 0.705 ± 0.182
1.735TyrGly: 1.735 ± 0.334
0.434TyrHis: 0.434 ± 0.138
1.139TyrIle: 1.139 ± 0.222
0.597TyrLys: 0.597 ± 0.173
1.79TyrLeu: 1.79 ± 0.246
0.271TyrMet: 0.271 ± 0.128
0.542TyrAsn: 0.542 ± 0.15
1.356TyrPro: 1.356 ± 0.311
0.976TyrGln: 0.976 ± 0.226
2.061TyrArg: 2.061 ± 0.331
1.193TyrSer: 1.193 ± 0.246
1.79TyrThr: 1.79 ± 0.352
2.278TyrVal: 2.278 ± 0.343
0.922TyrTrp: 0.922 ± 0.222
0.651TyrTyr: 0.651 ± 0.186
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 103 proteins (18441 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski