Amino acid dipepetide frequency for Pontibacter sp. SGAir0037

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.716AlaAla: 7.716 ± 0.104
0.708AlaCys: 0.708 ± 0.02
4.236AlaAsp: 4.236 ± 0.058
5.257AlaGlu: 5.257 ± 0.066
3.805AlaPhe: 3.805 ± 0.059
6.326AlaGly: 6.326 ± 0.082
1.347AlaHis: 1.347 ± 0.034
5.248AlaIle: 5.248 ± 0.067
4.437AlaLys: 4.437 ± 0.056
8.073AlaLeu: 8.073 ± 0.086
1.936AlaMet: 1.936 ± 0.041
3.516AlaAsn: 3.516 ± 0.051
2.968AlaPro: 2.968 ± 0.055
3.381AlaGln: 3.381 ± 0.066
3.355AlaArg: 3.355 ± 0.05
5.181AlaSer: 5.181 ± 0.065
4.701AlaThr: 4.701 ± 0.064
5.62AlaVal: 5.62 ± 0.062
0.841AlaTrp: 0.841 ± 0.025
3.16AlaTyr: 3.16 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
0.488CysAla: 0.488 ± 0.021
0.129CysCys: 0.129 ± 0.01
0.352CysAsp: 0.352 ± 0.016
0.406CysGlu: 0.406 ± 0.018
0.37CysPhe: 0.37 ± 0.018
0.586CysGly: 0.586 ± 0.021
0.218CysHis: 0.218 ± 0.013
0.491CysIle: 0.491 ± 0.018
0.358CysLys: 0.358 ± 0.016
0.746CysLeu: 0.746 ± 0.022
0.156CysMet: 0.156 ± 0.01
0.316CysAsn: 0.316 ± 0.014
0.336CysPro: 0.336 ± 0.017
0.274CysGln: 0.274 ± 0.014
0.338CysArg: 0.338 ± 0.017
0.538CysSer: 0.538 ± 0.019
0.402CysThr: 0.402 ± 0.019
0.411CysVal: 0.411 ± 0.017
0.079CysTrp: 0.079 ± 0.008
0.29CysTyr: 0.29 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
3.929AspAla: 3.929 ± 0.053
0.351AspCys: 0.351 ± 0.017
2.139AspAsp: 2.139 ± 0.037
3.251AspGlu: 3.251 ± 0.046
2.765AspPhe: 2.765 ± 0.049
3.238AspGly: 3.238 ± 0.053
0.882AspHis: 0.882 ± 0.026
3.463AspIle: 3.463 ± 0.047
3.446AspLys: 3.446 ± 0.049
4.782AspLeu: 4.782 ± 0.056
1.188AspMet: 1.188 ± 0.03
2.45AspAsn: 2.45 ± 0.044
1.993AspPro: 1.993 ± 0.039
1.779AspGln: 1.779 ± 0.038
2.313AspArg: 2.313 ± 0.047
2.504AspSer: 2.504 ± 0.042
2.496AspThr: 2.496 ± 0.039
3.421AspVal: 3.421 ± 0.051
0.732AspTrp: 0.732 ± 0.021
2.384AspTyr: 2.384 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
5.844GluAla: 5.844 ± 0.092
0.275GluCys: 0.275 ± 0.015
3.051GluAsp: 3.051 ± 0.052
5.226GluGlu: 5.226 ± 0.078
2.31GluPhe: 2.31 ± 0.041
4.068GluGly: 4.068 ± 0.063
1.33GluHis: 1.33 ± 0.033
3.943GluIle: 3.943 ± 0.046
4.577GluLys: 4.577 ± 0.063
6.661GluLeu: 6.661 ± 0.067
1.597GluMet: 1.597 ± 0.03
3.295GluAsn: 3.295 ± 0.044
2.035GluPro: 2.035 ± 0.037
3.499GluGln: 3.499 ± 0.059
3.241GluArg: 3.241 ± 0.059
3.094GluSer: 3.094 ± 0.048
3.111GluThr: 3.111 ± 0.046
4.757GluVal: 4.757 ± 0.061
0.745GluTrp: 0.745 ± 0.023
2.097GluTyr: 2.097 ± 0.045
0.0GluXaa: 0.0 ± 0.0
Phe
3.317PheAla: 3.317 ± 0.052
0.393PheCys: 0.393 ± 0.016
2.531PheAsp: 2.531 ± 0.049
2.775PheGlu: 2.775 ± 0.04
2.324PhePhe: 2.324 ± 0.043
3.318PheGly: 3.318 ± 0.052
0.836PheHis: 0.836 ± 0.022
2.972PheIle: 2.972 ± 0.054
2.585PheLys: 2.585 ± 0.048
4.401PheLeu: 4.401 ± 0.069
1.131PheMet: 1.131 ± 0.028
2.405PheAsn: 2.405 ± 0.038
1.606PhePro: 1.606 ± 0.03
1.463PheGln: 1.463 ± 0.028
2.131PheArg: 2.131 ± 0.035
3.51PheSer: 3.51 ± 0.049
2.933PheThr: 2.933 ± 0.052
2.931PheVal: 2.931 ± 0.044
0.575PheTrp: 0.575 ± 0.019
1.955PheTyr: 1.955 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
5.193GlyAla: 5.193 ± 0.073
0.575GlyCys: 0.575 ± 0.019
3.177GlyAsp: 3.177 ± 0.049
3.964GlyGlu: 3.964 ± 0.056
3.433GlyPhe: 3.433 ± 0.053
5.186GlyGly: 5.186 ± 0.094
1.301GlyHis: 1.301 ± 0.034
5.051GlyIle: 5.051 ± 0.054
4.678GlyLys: 4.678 ± 0.058
6.409GlyLeu: 6.409 ± 0.072
1.735GlyMet: 1.735 ± 0.036
3.47GlyAsn: 3.47 ± 0.056
1.741GlyPro: 1.741 ± 0.035
2.507GlyGln: 2.507 ± 0.042
3.038GlyArg: 3.038 ± 0.052
4.372GlySer: 4.372 ± 0.077
4.321GlyThr: 4.321 ± 0.072
4.63GlyVal: 4.63 ± 0.066
0.941GlyTrp: 0.941 ± 0.027
3.014GlyTyr: 3.014 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
1.384HisAla: 1.384 ± 0.034
0.169HisCys: 0.169 ± 0.011
0.938HisAsp: 0.938 ± 0.029
1.195HisGlu: 1.195 ± 0.031
1.079HisPhe: 1.079 ± 0.031
1.247HisGly: 1.247 ± 0.027
0.628HisHis: 0.628 ± 0.023
1.349HisIle: 1.349 ± 0.033
1.048HisLys: 1.048 ± 0.027
2.074HisLeu: 2.074 ± 0.036
0.441HisMet: 0.441 ± 0.017
0.952HisAsn: 0.952 ± 0.024
1.087HisPro: 1.087 ± 0.029
0.919HisGln: 0.919 ± 0.027
0.934HisArg: 0.934 ± 0.026
1.105HisSer: 1.105 ± 0.028
1.207HisThr: 1.207 ± 0.027
1.199HisVal: 1.199 ± 0.025
0.242HisTrp: 0.242 ± 0.013
0.946HisTyr: 0.946 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
5.323IleAla: 5.323 ± 0.073
0.586IleCys: 0.586 ± 0.021
3.337IleAsp: 3.337 ± 0.048
3.773IleGlu: 3.773 ± 0.057
2.571IlePhe: 2.571 ± 0.046
4.68IleGly: 4.68 ± 0.065
1.169IleHis: 1.169 ± 0.026
4.005IleIle: 4.005 ± 0.059
3.599IleLys: 3.599 ± 0.056
5.715IleLeu: 5.715 ± 0.084
1.307IleMet: 1.307 ± 0.028
3.186IleAsn: 3.186 ± 0.056
2.842IlePro: 2.842 ± 0.047
2.253IleGln: 2.253 ± 0.037
3.081IleArg: 3.081 ± 0.051
4.447IleSer: 4.447 ± 0.048
3.945IleThr: 3.945 ± 0.057
4.019IleVal: 4.019 ± 0.057
0.619IleTrp: 0.619 ± 0.021
2.274IleTyr: 2.274 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
5.354LysAla: 5.354 ± 0.064
0.259LysCys: 0.259 ± 0.015
3.153LysAsp: 3.153 ± 0.051
4.686LysGlu: 4.686 ± 0.066
2.122LysPhe: 2.122 ± 0.039
4.125LysGly: 4.125 ± 0.057
1.213LysHis: 1.213 ± 0.028
3.604LysIle: 3.604 ± 0.059
4.169LysLys: 4.169 ± 0.065
5.801LysLeu: 5.801 ± 0.066
1.482LysMet: 1.482 ± 0.031
2.896LysAsn: 2.896 ± 0.047
2.618LysPro: 2.618 ± 0.047
2.77LysGln: 2.77 ± 0.05
2.796LysArg: 2.796 ± 0.048
3.277LysSer: 3.277 ± 0.048
3.105LysThr: 3.105 ± 0.046
4.345LysVal: 4.345 ± 0.055
0.64LysTrp: 0.64 ± 0.018
2.259LysTyr: 2.259 ± 0.044
0.0LysXaa: 0.0 ± 0.0
Leu
7.851LeuAla: 7.851 ± 0.095
0.814LeuCys: 0.814 ± 0.026
4.654LeuAsp: 4.654 ± 0.058
6.262LeuGlu: 6.262 ± 0.08
4.552LeuPhe: 4.552 ± 0.073
6.016LeuGly: 6.016 ± 0.07
2.255LeuHis: 2.255 ± 0.042
5.631LeuIle: 5.631 ± 0.074
6.163LeuLys: 6.163 ± 0.075
11.123LeuLeu: 11.123 ± 0.138
2.325LeuMet: 2.325 ± 0.04
4.978LeuAsn: 4.978 ± 0.057
4.54LeuPro: 4.54 ± 0.053
5.043LeuGln: 5.043 ± 0.076
4.596LeuArg: 4.596 ± 0.058
6.726LeuSer: 6.726 ± 0.069
5.356LeuThr: 5.356 ± 0.067
6.44LeuVal: 6.44 ± 0.075
0.978LeuTrp: 0.978 ± 0.028
3.692LeuTyr: 3.692 ± 0.055
0.0LeuXaa: 0.0 ± 0.0
Met
2.144MetAla: 2.144 ± 0.041
0.109MetCys: 0.109 ± 0.008
1.061MetAsp: 1.061 ± 0.024
1.447MetGlu: 1.447 ± 0.032
0.838MetPhe: 0.838 ± 0.025
1.557MetGly: 1.557 ± 0.034
0.535MetHis: 0.535 ± 0.018
1.287MetIle: 1.287 ± 0.029
1.695MetLys: 1.695 ± 0.034
2.531MetLeu: 2.531 ± 0.041
0.6MetMet: 0.6 ± 0.021
1.149MetAsn: 1.149 ± 0.03
1.134MetPro: 1.134 ± 0.027
1.239MetGln: 1.239 ± 0.029
1.122MetArg: 1.122 ± 0.027
1.33MetSer: 1.33 ± 0.031
1.058MetThr: 1.058 ± 0.025
1.572MetVal: 1.572 ± 0.032
0.182MetTrp: 0.182 ± 0.011
0.671MetTyr: 0.671 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.634AsnAla: 3.634 ± 0.054
0.329AsnCys: 0.329 ± 0.014
2.14AsnAsp: 2.14 ± 0.039
2.641AsnGlu: 2.641 ± 0.048
2.346AsnPhe: 2.346 ± 0.041
3.505AsnGly: 3.505 ± 0.059
0.928AsnHis: 0.928 ± 0.024
3.403AsnIle: 3.403 ± 0.047
2.82AsnLys: 2.82 ± 0.044
4.851AsnLeu: 4.851 ± 0.061
1.141AsnMet: 1.141 ± 0.027
2.661AsnAsn: 2.661 ± 0.052
2.509AsnPro: 2.509 ± 0.044
2.001AsnGln: 2.001 ± 0.042
2.492AsnArg: 2.492 ± 0.043
3.016AsnSer: 3.016 ± 0.049
2.901AsnThr: 2.901 ± 0.051
2.819AsnVal: 2.819 ± 0.046
0.698AsnTrp: 0.698 ± 0.021
2.292AsnTyr: 2.292 ± 0.04
0.0AsnXaa: 0.0 ± 0.0
Pro
3.927ProAla: 3.927 ± 0.067
0.199ProCys: 0.199 ± 0.013
2.622ProAsp: 2.622 ± 0.044
3.348ProGlu: 3.348 ± 0.051
1.925ProPhe: 1.925 ± 0.034
2.817ProGly: 2.817 ± 0.045
0.814ProHis: 0.814 ± 0.025
2.138ProIle: 2.138 ± 0.041
2.043ProLys: 2.043 ± 0.044
3.626ProLeu: 3.626 ± 0.048
0.815ProMet: 0.815 ± 0.024
1.813ProAsn: 1.813 ± 0.039
1.123ProPro: 1.123 ± 0.03
1.554ProGln: 1.554 ± 0.031
1.38ProArg: 1.38 ± 0.031
2.231ProSer: 2.231 ± 0.036
1.993ProThr: 1.993 ± 0.038
3.484ProVal: 3.484 ± 0.051
0.428ProTrp: 0.428 ± 0.015
1.635ProTyr: 1.635 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
3.624GlnAla: 3.624 ± 0.051
0.195GlnCys: 0.195 ± 0.012
2.057GlnAsp: 2.057 ± 0.042
3.44GlnGlu: 3.44 ± 0.058
1.59GlnPhe: 1.59 ± 0.035
2.444GlnGly: 2.444 ± 0.042
1.092GlnHis: 1.092 ± 0.028
2.246GlnIle: 2.246 ± 0.037
2.673GlnLys: 2.673 ± 0.046
4.604GlnLeu: 4.604 ± 0.065
0.993GlnMet: 0.993 ± 0.024
2.054GlnAsn: 2.054 ± 0.046
1.695GlnPro: 1.695 ± 0.035
2.831GlnGln: 2.831 ± 0.072
1.983GlnArg: 1.983 ± 0.038
2.072GlnSer: 2.072 ± 0.042
2.043GlnThr: 2.043 ± 0.041
3.297GlnVal: 3.297 ± 0.055
0.436GlnTrp: 0.436 ± 0.017
1.648GlnTyr: 1.648 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
3.09ArgAla: 3.09 ± 0.053
0.27ArgCys: 0.27 ± 0.013
2.103ArgAsp: 2.103 ± 0.039
3.072ArgGlu: 3.072 ± 0.05
2.367ArgPhe: 2.367 ± 0.04
2.569ArgGly: 2.569 ± 0.048
0.99ArgHis: 0.99 ± 0.024
3.147ArgIle: 3.147 ± 0.048
2.964ArgLys: 2.964 ± 0.049
4.706ArgLeu: 4.706 ± 0.057
1.229ArgMet: 1.229 ± 0.031
2.497ArgAsn: 2.497 ± 0.037
1.62ArgPro: 1.62 ± 0.033
2.204ArgGln: 2.204 ± 0.039
2.13ArgArg: 2.13 ± 0.045
2.598ArgSer: 2.598 ± 0.036
2.477ArgThr: 2.477 ± 0.045
3.049ArgVal: 3.049 ± 0.053
0.597ArgTrp: 0.597 ± 0.021
1.989ArgTyr: 1.989 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
4.588SerAla: 4.588 ± 0.052
0.608SerCys: 0.608 ± 0.021
3.045SerAsp: 3.045 ± 0.049
3.554SerGlu: 3.554 ± 0.043
3.418SerPhe: 3.418 ± 0.052
4.748SerGly: 4.748 ± 0.075
1.173SerHis: 1.173 ± 0.029
3.966SerIle: 3.966 ± 0.05
3.422SerLys: 3.422 ± 0.049
6.203SerLeu: 6.203 ± 0.068
1.398SerMet: 1.398 ± 0.03
2.849SerAsn: 2.849 ± 0.053
2.486SerPro: 2.486 ± 0.043
2.182SerGln: 2.182 ± 0.046
2.848SerArg: 2.848 ± 0.046
4.243SerSer: 4.243 ± 0.07
3.372SerThr: 3.372 ± 0.048
3.962SerVal: 3.962 ± 0.052
0.749SerTrp: 0.749 ± 0.023
2.698SerTyr: 2.698 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
4.899ThrAla: 4.899 ± 0.066
0.374ThrCys: 0.374 ± 0.015
3.086ThrAsp: 3.086 ± 0.041
3.205ThrGlu: 3.205 ± 0.046
2.66ThrPhe: 2.66 ± 0.043
4.582ThrGly: 4.582 ± 0.071
1.01ThrHis: 1.01 ± 0.025
3.738ThrIle: 3.738 ± 0.047
2.702ThrLys: 2.702 ± 0.042
5.393ThrLeu: 5.393 ± 0.068
1.063ThrMet: 1.063 ± 0.026
2.507ThrAsn: 2.507 ± 0.048
2.678ThrPro: 2.678 ± 0.041
1.866ThrGln: 1.866 ± 0.038
2.172ThrArg: 2.172 ± 0.042
3.518ThrSer: 3.518 ± 0.056
3.515ThrThr: 3.515 ± 0.086
3.964ThrVal: 3.964 ± 0.06
0.669ThrTrp: 0.669 ± 0.019
2.35ThrTyr: 2.35 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
5.82ValAla: 5.82 ± 0.071
0.536ValCys: 0.536 ± 0.019
3.203ValAsp: 3.203 ± 0.048
4.287ValGlu: 4.287 ± 0.058
3.028ValPhe: 3.028 ± 0.057
4.178ValGly: 4.178 ± 0.059
1.273ValHis: 1.273 ± 0.027
4.06ValIle: 4.06 ± 0.058
4.154ValLys: 4.154 ± 0.05
7.066ValLeu: 7.066 ± 0.074
1.559ValMet: 1.559 ± 0.035
3.209ValAsn: 3.209 ± 0.051
2.901ValPro: 2.901 ± 0.044
2.912ValGln: 2.912 ± 0.046
3.018ValArg: 3.018 ± 0.044
4.427ValSer: 4.427 ± 0.056
3.858ValThr: 3.858 ± 0.06
5.089ValVal: 5.089 ± 0.075
0.757ValTrp: 0.757 ± 0.026
2.626ValTyr: 2.626 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
0.809TrpAla: 0.809 ± 0.022
0.095TrpCys: 0.095 ± 0.008
0.559TrpAsp: 0.559 ± 0.02
0.71TrpGlu: 0.71 ± 0.022
0.544TrpPhe: 0.544 ± 0.022
0.803TrpGly: 0.803 ± 0.026
0.288TrpHis: 0.288 ± 0.014
0.621TrpIle: 0.621 ± 0.022
0.675TrpLys: 0.675 ± 0.024
1.28TrpLeu: 1.28 ± 0.032
0.322TrpMet: 0.322 ± 0.014
0.627TrpAsn: 0.627 ± 0.023
0.366TrpPro: 0.366 ± 0.014
0.615TrpGln: 0.615 ± 0.021
0.598TrpArg: 0.598 ± 0.019
0.678TrpSer: 0.678 ± 0.022
0.56TrpThr: 0.56 ± 0.019
0.778TrpVal: 0.778 ± 0.024
0.181TrpTrp: 0.181 ± 0.011
0.462TrpTyr: 0.462 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.874TyrAla: 2.874 ± 0.041
0.309TyrCys: 0.309 ± 0.017
2.061TyrAsp: 2.061 ± 0.042
2.256TyrGlu: 2.256 ± 0.043
2.045TyrPhe: 2.045 ± 0.037
2.748TyrGly: 2.748 ± 0.051
0.859TyrHis: 0.859 ± 0.029
2.369TyrIle: 2.369 ± 0.034
2.466TyrLys: 2.466 ± 0.044
3.951TyrLeu: 3.951 ± 0.056
0.841TyrMet: 0.841 ± 0.025
2.298TyrAsn: 2.298 ± 0.046
1.639TyrPro: 1.639 ± 0.035
1.726TyrGln: 1.726 ± 0.037
2.105TyrArg: 2.105 ± 0.041
2.644TyrSer: 2.644 ± 0.047
2.595TyrThr: 2.595 ± 0.045
2.172TyrVal: 2.172 ± 0.04
0.484TyrTrp: 0.484 ± 0.015
1.853TyrTyr: 1.853 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4435 proteins (1540259 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski