Amino acid dipepetide frequency for Thalassoglobus neptunius

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.754AlaAla: 7.754 ± 0.074	1.01AlaCys: 1.01 ± 0.026	4.848AlaAsp: 4.848 ± 0.047	6.134AlaGlu: 6.134 ± 0.055	3.114AlaPhe: 3.114 ± 0.048	6.023AlaGly: 6.023 ± 0.059	1.519AlaHis: 1.519 ± 0.031	5.113AlaIle: 5.113 ± 0.051	3.325AlaLys: 3.325 ± 0.049	7.178AlaLeu: 7.178 ± 0.065	2.098AlaMet: 2.098 ± 0.034	2.828AlaAsn: 2.828 ± 0.037	3.372AlaPro: 3.372 ± 0.044	2.988AlaGln: 2.988 ± 0.045	4.547AlaArg: 4.547 ± 0.048	5.685AlaSer: 5.685 ± 0.053	4.689AlaThr: 4.689 ± 0.049	5.975AlaVal: 5.975 ± 0.06	1.05AlaTrp: 1.05 ± 0.023	1.837AlaTyr: 1.837 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	0.802CysAla: 0.802 ± 0.024	0.267CysCys: 0.267 ± 0.015	0.71CysAsp: 0.71 ± 0.021	0.752CysGlu: 0.752 ± 0.022	0.537CysPhe: 0.537 ± 0.016	1.064CysGly: 1.064 ± 0.028	0.459CysHis: 0.459 ± 0.019	0.475CysIle: 0.475 ± 0.015	0.313CysLys: 0.313 ± 0.013	1.232CysLeu: 1.232 ± 0.028	0.191CysMet: 0.191 ± 0.01	0.321CysAsn: 0.321 ± 0.013	0.628CysPro: 0.628 ± 0.02	0.485CysGln: 0.485 ± 0.016	0.844CysArg: 0.844 ± 0.024	0.792CysSer: 0.792 ± 0.021	0.528CysThr: 0.528 ± 0.017	0.823CysVal: 0.823 ± 0.022	0.193CysTrp: 0.193 ± 0.009	0.316CysTyr: 0.316 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.802AspAla: 4.802 ± 0.057	0.638AspCys: 0.638 ± 0.019	4.05AspAsp: 4.05 ± 0.064	4.745AspGlu: 4.745 ± 0.059	2.572AspPhe: 2.572 ± 0.037	5.053AspGly: 5.053 ± 0.076	1.512AspHis: 1.512 ± 0.031	2.516AspIle: 2.516 ± 0.037	1.541AspLys: 1.541 ± 0.032	5.988AspLeu: 5.988 ± 0.059	0.993AspMet: 0.993 ± 0.022	1.646AspAsn: 1.646 ± 0.039	3.566AspPro: 3.566 ± 0.052	2.847AspGln: 2.847 ± 0.035	4.295AspArg: 4.295 ± 0.06	4.348AspSer: 4.348 ± 0.053	2.173AspThr: 2.173 ± 0.032	4.374AspVal: 4.374 ± 0.058	1.174AspTrp: 1.174 ± 0.027	1.58AspTyr: 1.58 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	5.678GluAla: 5.678 ± 0.059	0.656GluCys: 0.656 ± 0.018	3.601GluAsp: 3.601 ± 0.049	5.279GluGlu: 5.279 ± 0.068	3.203GluPhe: 3.203 ± 0.04	3.964GluGly: 3.964 ± 0.055	1.49GluHis: 1.49 ± 0.029	4.35GluIle: 4.35 ± 0.057	3.058GluLys: 3.058 ± 0.051	7.48GluLeu: 7.48 ± 0.081	1.873GluMet: 1.873 ± 0.028	2.726GluAsn: 2.726 ± 0.035	2.727GluPro: 2.727 ± 0.038	3.427GluGln: 3.427 ± 0.048	4.494GluArg: 4.494 ± 0.051	5.393GluSer: 5.393 ± 0.056	4.348GluThr: 4.348 ± 0.046	4.729GluVal: 4.729 ± 0.053	0.986GluTrp: 0.986 ± 0.022	1.629GluTyr: 1.629 ± 0.029	0.001GluXaa: 0.001 ± 0.0
Phe	3.489PheAla: 3.489 ± 0.046	0.55PheCys: 0.55 ± 0.018	3.012PheAsp: 3.012 ± 0.042	2.856PheGlu: 2.856 ± 0.042	1.576PhePhe: 1.576 ± 0.03	3.48PheGly: 3.48 ± 0.039	0.978PheHis: 0.978 ± 0.028	1.693PheIle: 1.693 ± 0.032	1.012PheLys: 1.012 ± 0.022	4.066PheLeu: 4.066 ± 0.045	0.703PheMet: 0.703 ± 0.022	1.299PheAsn: 1.299 ± 0.031	2.012PhePro: 2.012 ± 0.034	1.736PheGln: 1.736 ± 0.03	2.732PheArg: 2.732 ± 0.042	2.807PheSer: 2.807 ± 0.042	1.981PheThr: 1.981 ± 0.034	3.075PheVal: 3.075 ± 0.046	0.613PheTrp: 0.613 ± 0.019	1.009PheTyr: 1.009 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	5.057GlyAla: 5.057 ± 0.059	0.974GlyCys: 0.974 ± 0.029	4.23GlyAsp: 4.23 ± 0.054	5.059GlyGlu: 5.059 ± 0.055	3.225GlyPhe: 3.225 ± 0.039	5.81GlyGly: 5.81 ± 0.093	1.655GlyHis: 1.655 ± 0.031	4.233GlyIle: 4.233 ± 0.056	3.348GlyLys: 3.348 ± 0.047	6.769GlyLeu: 6.769 ± 0.065	1.823GlyMet: 1.823 ± 0.035	2.722GlyAsn: 2.722 ± 0.058	2.901GlyPro: 2.901 ± 0.045	2.918GlyGln: 2.918 ± 0.041	4.663GlyArg: 4.663 ± 0.051	4.748GlySer: 4.748 ± 0.059	4.449GlyThr: 4.449 ± 0.058	5.28GlyVal: 5.28 ± 0.063	1.276GlyTrp: 1.276 ± 0.028	2.023GlyTyr: 2.023 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	1.705HisAla: 1.705 ± 0.033	0.344HisCys: 0.344 ± 0.014	1.325HisAsp: 1.325 ± 0.026	1.4HisGlu: 1.4 ± 0.028	1.027HisPhe: 1.027 ± 0.026	1.763HisGly: 1.763 ± 0.033	0.723HisHis: 0.723 ± 0.022	0.902HisIle: 0.902 ± 0.022	0.653HisLys: 0.653 ± 0.02	2.304HisLeu: 2.304 ± 0.039	0.365HisMet: 0.365 ± 0.013	0.657HisAsn: 0.657 ± 0.022	1.528HisPro: 1.528 ± 0.029	1.012HisGln: 1.012 ± 0.026	1.605HisArg: 1.605 ± 0.032	1.565HisSer: 1.565 ± 0.03	0.965HisThr: 0.965 ± 0.022	1.472HisVal: 1.472 ± 0.032	0.438HisTrp: 0.438 ± 0.014	0.596HisTyr: 0.596 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	5.253IleAla: 5.253 ± 0.049	0.697IleCys: 0.697 ± 0.02	4.154IleAsp: 4.154 ± 0.053	4.262IleGlu: 4.262 ± 0.051	1.763IlePhe: 1.763 ± 0.03	4.227IleGly: 4.227 ± 0.05	1.259IleHis: 1.259 ± 0.027	2.072IleIle: 2.072 ± 0.033	1.502IleLys: 1.502 ± 0.03	4.91IleLeu: 4.91 ± 0.062	0.727IleMet: 0.727 ± 0.022	1.592IleAsn: 1.592 ± 0.033	3.124IlePro: 3.124 ± 0.045	2.185IleGln: 2.185 ± 0.037	3.748IleArg: 3.748 ± 0.041	3.686IleSer: 3.686 ± 0.042	2.506IleThr: 2.506 ± 0.043	4.315IleVal: 4.315 ± 0.056	0.699IleTrp: 0.699 ± 0.021	1.22IleTyr: 1.22 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	2.918LysAla: 2.918 ± 0.042	0.36LysCys: 0.36 ± 0.017	1.897LysAsp: 1.897 ± 0.03	2.453LysGlu: 2.453 ± 0.039	1.438LysPhe: 1.438 ± 0.031	2.064LysGly: 2.064 ± 0.039	0.844LysHis: 0.844 ± 0.021	2.096LysIle: 2.096 ± 0.034	1.973LysLys: 1.973 ± 0.046	3.925LysLeu: 3.925 ± 0.054	0.966LysMet: 0.966 ± 0.022	1.392LysAsn: 1.392 ± 0.029	2.044LysPro: 2.044 ± 0.035	1.749LysGln: 1.749 ± 0.032	2.539LysArg: 2.539 ± 0.037	2.912LysSer: 2.912 ± 0.042	2.379LysThr: 2.379 ± 0.043	2.446LysVal: 2.446 ± 0.042	0.621LysTrp: 0.621 ± 0.018	0.985LysTyr: 0.985 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	8.769LeuAla: 8.769 ± 0.077	1.152LeuCys: 1.152 ± 0.026	5.691LeuAsp: 5.691 ± 0.055	6.295LeuGlu: 6.295 ± 0.064	3.783LeuPhe: 3.783 ± 0.051	6.582LeuGly: 6.582 ± 0.065	1.969LeuHis: 1.969 ± 0.039	5.51LeuIle: 5.51 ± 0.061	4.392LeuLys: 4.392 ± 0.055	9.19LeuLeu: 9.19 ± 0.091	2.083LeuMet: 2.083 ± 0.037	3.706LeuAsn: 3.706 ± 0.043	5.025LeuPro: 5.025 ± 0.057	3.783LeuGln: 3.783 ± 0.048	5.966LeuArg: 5.966 ± 0.066	7.042LeuSer: 7.042 ± 0.066	5.873LeuThr: 5.873 ± 0.059	6.581LeuVal: 6.581 ± 0.072	1.266LeuTrp: 1.266 ± 0.029	2.06LeuTyr: 2.06 ± 0.039	0.001LeuXaa: 0.001 ± 0.001
Met	1.833MetAla: 1.833 ± 0.031	0.22MetCys: 0.22 ± 0.011	1.0MetAsp: 1.0 ± 0.024	1.182MetGlu: 1.182 ± 0.027	0.824MetPhe: 0.824 ± 0.02	1.395MetGly: 1.395 ± 0.03	0.445MetHis: 0.445 ± 0.015	1.353MetIle: 1.353 ± 0.028	1.088MetLys: 1.088 ± 0.022	2.12MetLeu: 2.12 ± 0.031	0.566MetMet: 0.566 ± 0.017	0.969MetAsn: 0.969 ± 0.022	1.076MetPro: 1.076 ± 0.028	0.852MetGln: 0.852 ± 0.022	1.309MetArg: 1.309 ± 0.028	1.671MetSer: 1.671 ± 0.03	1.587MetThr: 1.587 ± 0.031	1.413MetVal: 1.413 ± 0.028	0.254MetTrp: 0.254 ± 0.013	0.36MetTyr: 0.36 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.774AsnAla: 2.774 ± 0.045	0.451AsnCys: 0.451 ± 0.018	2.146AsnAsp: 2.146 ± 0.038	2.297AsnGlu: 2.297 ± 0.034	1.333AsnPhe: 1.333 ± 0.029	3.074AsnGly: 3.074 ± 0.065	0.805AsnHis: 0.805 ± 0.023	1.498AsnIle: 1.498 ± 0.036	0.926AsnLys: 0.926 ± 0.019	3.38AsnLeu: 3.38 ± 0.053	0.635AsnMet: 0.635 ± 0.019	1.114AsnAsn: 1.114 ± 0.041	2.195AsnPro: 2.195 ± 0.036	1.509AsnGln: 1.509 ± 0.03	2.596AsnArg: 2.596 ± 0.042	2.696AsnSer: 2.696 ± 0.046	1.638AsnThr: 1.638 ± 0.036	2.476AsnVal: 2.476 ± 0.042	0.678AsnTrp: 0.678 ± 0.02	0.862AsnTyr: 0.862 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	3.873ProAla: 3.873 ± 0.049	0.37ProCys: 0.37 ± 0.015	3.437ProAsp: 3.437 ± 0.043	4.808ProGlu: 4.808 ± 0.064	2.06ProPhe: 2.06 ± 0.035	3.805ProGly: 3.805 ± 0.05	1.151ProHis: 1.151 ± 0.027	2.666ProIle: 2.666 ± 0.042	2.05ProLys: 2.05 ± 0.036	4.112ProLeu: 4.112 ± 0.051	1.009ProMet: 1.009 ± 0.022	2.016ProAsn: 2.016 ± 0.04	2.61ProPro: 2.61 ± 0.047	2.018ProGln: 2.018 ± 0.032	2.422ProArg: 2.422 ± 0.036	3.58ProSer: 3.58 ± 0.048	2.924ProThr: 2.924 ± 0.049	3.98ProVal: 3.98 ± 0.048	0.67ProTrp: 0.67 ± 0.019	1.125ProTyr: 1.125 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.383GlnAla: 3.383 ± 0.045	0.422GlnCys: 0.422 ± 0.014	1.822GlnAsp: 1.822 ± 0.031	2.652GlnGlu: 2.652 ± 0.043	1.844GlnPhe: 1.844 ± 0.034	2.375GlnGly: 2.375 ± 0.039	0.946GlnHis: 0.946 ± 0.022	2.499GlnIle: 2.499 ± 0.035	1.76GlnLys: 1.76 ± 0.031	4.665GlnLeu: 4.665 ± 0.055	0.961GlnMet: 0.961 ± 0.022	1.455GlnAsn: 1.455 ± 0.032	2.147GlnPro: 2.147 ± 0.04	2.295GlnGln: 2.295 ± 0.051	2.866GlnArg: 2.866 ± 0.05	3.249GlnSer: 3.249 ± 0.05	2.383GlnThr: 2.383 ± 0.032	2.807GlnVal: 2.807 ± 0.041	0.606GlnTrp: 0.606 ± 0.019	0.91GlnTyr: 0.91 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	4.043ArgAla: 4.043 ± 0.051	0.712ArgCys: 0.712 ± 0.018	3.678ArgAsp: 3.678 ± 0.05	4.518ArgGlu: 4.518 ± 0.058	3.002ArgPhe: 3.002 ± 0.038	3.872ArgGly: 3.872 ± 0.05	1.408ArgHis: 1.408 ± 0.028	3.932ArgIle: 3.932 ± 0.048	2.815ArgLys: 2.815 ± 0.05	6.386ArgLeu: 6.386 ± 0.066	1.585ArgMet: 1.585 ± 0.029	2.429ArgAsn: 2.429 ± 0.035	2.971ArgPro: 2.971 ± 0.052	2.774ArgGln: 2.774 ± 0.041	4.564ArgArg: 4.564 ± 0.06	4.522ArgSer: 4.522 ± 0.056	3.467ArgThr: 3.467 ± 0.049	4.465ArgVal: 4.465 ± 0.045	1.086ArgTrp: 1.086 ± 0.026	1.727ArgTyr: 1.727 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	5.55SerAla: 5.55 ± 0.057	0.781SerCys: 0.781 ± 0.021	4.433SerAsp: 4.433 ± 0.047	5.268SerGlu: 5.268 ± 0.057	2.655SerPhe: 2.655 ± 0.037	6.17SerGly: 6.17 ± 0.066	1.575SerHis: 1.575 ± 0.032	3.705SerIle: 3.705 ± 0.041	2.582SerLys: 2.582 ± 0.038	6.894SerLeu: 6.894 ± 0.064	1.65SerMet: 1.65 ± 0.032	2.475SerAsn: 2.475 ± 0.039	3.97SerPro: 3.97 ± 0.05	3.092SerGln: 3.092 ± 0.041	4.41SerArg: 4.41 ± 0.057	5.476SerSer: 5.476 ± 0.067	3.891SerThr: 3.891 ± 0.05	4.876SerVal: 4.876 ± 0.064	0.996SerTrp: 0.996 ± 0.025	1.47SerTyr: 1.47 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	4.462ThrAla: 4.462 ± 0.052	0.604ThrCys: 0.604 ± 0.02	3.339ThrAsp: 3.339 ± 0.044	3.496ThrGlu: 3.496 ± 0.046	2.201ThrPhe: 2.201 ± 0.038	4.576ThrGly: 4.576 ± 0.061	1.132ThrHis: 1.132 ± 0.027	3.349ThrIle: 3.349 ± 0.041	1.79ThrLys: 1.79 ± 0.031	5.442ThrLeu: 5.442 ± 0.055	1.067ThrMet: 1.067 ± 0.025	1.85ThrAsn: 1.85 ± 0.038	3.419ThrPro: 3.419 ± 0.045	2.042ThrGln: 2.042 ± 0.026	3.097ThrArg: 3.097 ± 0.044	3.855ThrSer: 3.855 ± 0.051	3.275ThrThr: 3.275 ± 0.058	4.225ThrVal: 4.225 ± 0.054	0.757ThrTrp: 0.757 ± 0.021	1.31ThrTyr: 1.31 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	6.179ValAla: 6.179 ± 0.063	0.971ValCys: 0.971 ± 0.026	4.645ValAsp: 4.645 ± 0.055	5.119ValGlu: 5.119 ± 0.051	2.807ValPhe: 2.807 ± 0.031	4.888ValGly: 4.888 ± 0.054	1.491ValHis: 1.491 ± 0.031	4.071ValIle: 4.071 ± 0.054	2.374ValLys: 2.374 ± 0.039	6.742ValLeu: 6.742 ± 0.065	1.426ValMet: 1.426 ± 0.029	2.435ValAsn: 2.435 ± 0.046	3.504ValPro: 3.504 ± 0.044	2.604ValGln: 2.604 ± 0.037	4.454ValArg: 4.454 ± 0.058	5.139ValSer: 5.139 ± 0.055	4.252ValThr: 4.252 ± 0.057	5.72ValVal: 5.72 ± 0.067	1.027ValTrp: 1.027 ± 0.027	1.658ValTyr: 1.658 ± 0.035	0.001ValXaa: 0.001 ± 0.0
Trp	0.979TrpAla: 0.979 ± 0.024	0.192TrpCys: 0.192 ± 0.011	0.832TrpAsp: 0.832 ± 0.022	0.921TrpGlu: 0.921 ± 0.022	0.59TrpPhe: 0.59 ± 0.02	0.995TrpGly: 0.995 ± 0.024	0.393TrpHis: 0.393 ± 0.014	0.98TrpIle: 0.98 ± 0.021	0.845TrpLys: 0.845 ± 0.02	1.487TrpLeu: 1.487 ± 0.027	0.436TrpMet: 0.436 ± 0.016	0.711TrpAsn: 0.711 ± 0.02	0.661TrpPro: 0.661 ± 0.021	0.595TrpGln: 0.595 ± 0.016	0.902TrpArg: 0.902 ± 0.021	1.07TrpSer: 1.07 ± 0.028	0.919TrpThr: 0.919 ± 0.022	0.939TrpVal: 0.939 ± 0.021	0.261TrpTrp: 0.261 ± 0.014	0.377TrpTyr: 0.377 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.784TyrAla: 1.784 ± 0.03	0.362TyrCys: 0.362 ± 0.014	1.564TyrAsp: 1.564 ± 0.037	1.596TyrGlu: 1.596 ± 0.029	1.123TyrPhe: 1.123 ± 0.027	1.982TyrGly: 1.982 ± 0.035	0.594TyrHis: 0.594 ± 0.02	0.888TyrIle: 0.888 ± 0.022	0.657TyrLys: 0.657 ± 0.02	2.452TyrLeu: 2.452 ± 0.037	0.356TyrMet: 0.356 ± 0.014	0.738TyrAsn: 0.738 ± 0.022	1.204TyrPro: 1.204 ± 0.026	1.138TyrGln: 1.138 ± 0.026	1.902TyrArg: 1.902 ± 0.031	1.683TyrSer: 1.683 ± 0.032	1.06TyrThr: 1.06 ± 0.029	1.534TyrVal: 1.534 ± 0.033	0.434TyrTrp: 0.434 ± 0.014	0.719TyrTyr: 0.719 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.001XaaSer: 0.001 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5460 proteins (1904778 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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