Amino acid dipepetide frequency for Rhodococcus hoagii ATCC 33707

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.634AlaAla: 19.634 ± 0.158
0.945AlaCys: 0.945 ± 0.026
8.617AlaAsp: 8.617 ± 0.088
7.74AlaGlu: 7.74 ± 0.083
3.504AlaPhe: 3.504 ± 0.052
11.956AlaGly: 11.956 ± 0.1
2.55AlaHis: 2.55 ± 0.046
4.816AlaIle: 4.816 ± 0.07
2.749AlaLys: 2.749 ± 0.057
13.409AlaLeu: 13.409 ± 0.117
2.631AlaMet: 2.631 ± 0.045
2.308AlaAsn: 2.308 ± 0.045
6.529AlaPro: 6.529 ± 0.07
3.723AlaGln: 3.723 ± 0.047
9.053AlaArg: 9.053 ± 0.097
6.554AlaSer: 6.554 ± 0.072
7.295AlaThr: 7.295 ± 0.074
12.377AlaVal: 12.377 ± 0.104
1.568AlaTrp: 1.568 ± 0.03
2.267AlaTyr: 2.267 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
0.97CysAla: 0.97 ± 0.026
0.09CysCys: 0.09 ± 0.007
0.47CysAsp: 0.47 ± 0.017
0.413CysGlu: 0.413 ± 0.017
0.212CysPhe: 0.212 ± 0.012
0.898CysGly: 0.898 ± 0.028
0.18CysHis: 0.18 ± 0.011
0.268CysIle: 0.268 ± 0.013
0.126CysLys: 0.126 ± 0.01
0.593CysLeu: 0.593 ± 0.02
0.118CysMet: 0.118 ± 0.009
0.152CysAsn: 0.152 ± 0.011
0.452CysPro: 0.452 ± 0.021
0.158CysGln: 0.158 ± 0.009
0.575CysArg: 0.575 ± 0.019
0.481CysSer: 0.481 ± 0.018
0.508CysThr: 0.508 ± 0.019
0.633CysVal: 0.633 ± 0.019
0.109CysTrp: 0.109 ± 0.007
0.146CysTyr: 0.146 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
8.488AspAla: 8.488 ± 0.093
0.423AspCys: 0.423 ± 0.016
4.295AspAsp: 4.295 ± 0.063
4.103AspGlu: 4.103 ± 0.053
1.799AspPhe: 1.799 ± 0.033
6.505AspGly: 6.505 ± 0.073
1.366AspHis: 1.366 ± 0.03
2.383AspIle: 2.383 ± 0.041
1.163AspLys: 1.163 ± 0.032
6.596AspLeu: 6.596 ± 0.081
0.952AspMet: 0.952 ± 0.027
1.096AspAsn: 1.096 ± 0.029
4.625AspPro: 4.625 ± 0.06
1.5AspGln: 1.5 ± 0.028
5.244AspArg: 5.244 ± 0.074
2.902AspSer: 2.902 ± 0.042
3.344AspThr: 3.344 ± 0.049
5.981AspVal: 5.981 ± 0.078
0.915AspTrp: 0.915 ± 0.029
1.255AspTyr: 1.255 ± 0.027
0.0AspXaa: 0.0 ± 0.0
Glu
6.212GluAla: 6.212 ± 0.071
0.377GluCys: 0.377 ± 0.013
2.682GluAsp: 2.682 ± 0.041
2.759GluGlu: 2.759 ± 0.056
1.917GluPhe: 1.917 ± 0.033
3.722GluGly: 3.722 ± 0.055
1.582GluHis: 1.582 ± 0.033
2.802GluIle: 2.802 ± 0.05
1.432GluLys: 1.432 ± 0.033
6.505GluLeu: 6.505 ± 0.079
1.142GluMet: 1.142 ± 0.027
1.237GluAsn: 1.237 ± 0.032
3.002GluPro: 3.002 ± 0.047
2.208GluGln: 2.208 ± 0.037
4.97GluArg: 4.97 ± 0.065
3.176GluSer: 3.176 ± 0.044
2.937GluThr: 2.937 ± 0.042
4.524GluVal: 4.524 ± 0.068
0.842GluTrp: 0.842 ± 0.021
1.148GluTyr: 1.148 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
4.128PheAla: 4.128 ± 0.062
0.266PheCys: 0.266 ± 0.012
2.56PheAsp: 2.56 ± 0.045
1.68PheGlu: 1.68 ± 0.037
0.943PhePhe: 0.943 ± 0.028
3.54PheGly: 3.54 ± 0.05
0.628PheHis: 0.628 ± 0.019
0.766PheIle: 0.766 ± 0.022
0.473PheLys: 0.473 ± 0.02
2.531PheLeu: 2.531 ± 0.042
0.468PheMet: 0.468 ± 0.017
0.579PheAsn: 0.579 ± 0.018
1.45PhePro: 1.45 ± 0.03
0.655PheGln: 0.655 ± 0.021
1.737PheArg: 1.737 ± 0.04
1.549PheSer: 1.549 ± 0.03
2.058PheThr: 2.058 ± 0.042
2.963PheVal: 2.963 ± 0.046
0.397PheTrp: 0.397 ± 0.018
0.641PheTyr: 0.641 ± 0.019
0.0PheXaa: 0.0 ± 0.0
Gly
10.883GlyAla: 10.883 ± 0.098
0.777GlyCys: 0.777 ± 0.021
5.211GlyAsp: 5.211 ± 0.061
4.729GlyGlu: 4.729 ± 0.06
3.124GlyPhe: 3.124 ± 0.05
8.297GlyGly: 8.297 ± 0.092
1.986GlyHis: 1.986 ± 0.041
4.284GlyIle: 4.284 ± 0.054
2.303GlyLys: 2.303 ± 0.047
8.72GlyLeu: 8.72 ± 0.088
2.156GlyMet: 2.156 ± 0.042
1.963GlyAsn: 1.963 ± 0.042
4.589GlyPro: 4.589 ± 0.065
2.401GlyGln: 2.401 ± 0.041
6.962GlyArg: 6.962 ± 0.07
5.68GlySer: 5.68 ± 0.077
5.894GlyThr: 5.894 ± 0.073
8.047GlyVal: 8.047 ± 0.072
1.575GlyTrp: 1.575 ± 0.031
2.233GlyTyr: 2.233 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
2.327HisAla: 2.327 ± 0.043
0.201HisCys: 0.201 ± 0.011
1.369HisAsp: 1.369 ± 0.03
1.094HisGlu: 1.094 ± 0.026
0.629HisPhe: 0.629 ± 0.02
2.073HisGly: 2.073 ± 0.038
0.654HisHis: 0.654 ± 0.022
0.668HisIle: 0.668 ± 0.021
0.303HisLys: 0.303 ± 0.014
2.116HisLeu: 2.116 ± 0.038
0.367HisMet: 0.367 ± 0.016
0.41HisAsn: 0.41 ± 0.017
1.59HisPro: 1.59 ± 0.032
0.516HisGln: 0.516 ± 0.02
1.815HisArg: 1.815 ± 0.03
1.096HisSer: 1.096 ± 0.027
1.132HisThr: 1.132 ± 0.027
1.786HisVal: 1.786 ± 0.034
0.351HisTrp: 0.351 ± 0.016
0.464HisTyr: 0.464 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
6.107IleAla: 6.107 ± 0.063
0.324IleCys: 0.324 ± 0.015
3.236IleAsp: 3.236 ± 0.052
2.593IleGlu: 2.593 ± 0.041
0.953IlePhe: 0.953 ± 0.026
4.423IleGly: 4.423 ± 0.069
0.693IleHis: 0.693 ± 0.022
1.058IleIle: 1.058 ± 0.03
0.738IleLys: 0.738 ± 0.024
3.218IleLeu: 3.218 ± 0.05
0.552IleMet: 0.552 ± 0.018
0.784IleAsn: 0.784 ± 0.026
2.211IlePro: 2.211 ± 0.037
0.783IleGln: 0.783 ± 0.022
2.613IleArg: 2.613 ± 0.041
2.116IleSer: 2.116 ± 0.039
2.477IleThr: 2.477 ± 0.043
3.978IleVal: 3.978 ± 0.055
0.381IleTrp: 0.381 ± 0.018
0.69IleTyr: 0.69 ± 0.023
0.0IleXaa: 0.0 ± 0.0
Lys
2.556LysAla: 2.556 ± 0.053
0.125LysCys: 0.125 ± 0.009
1.103LysAsp: 1.103 ± 0.03
0.927LysGlu: 0.927 ± 0.027
0.634LysPhe: 0.634 ± 0.019
1.548LysGly: 1.548 ± 0.037
0.432LysHis: 0.432 ± 0.019
1.006LysIle: 1.006 ± 0.029
0.682LysLys: 0.682 ± 0.026
1.977LysLeu: 1.977 ± 0.042
0.461LysMet: 0.461 ± 0.018
0.505LysAsn: 0.505 ± 0.019
1.19LysPro: 1.19 ± 0.033
0.677LysGln: 0.677 ± 0.022
1.397LysArg: 1.397 ± 0.035
1.17LysSer: 1.17 ± 0.03
1.212LysThr: 1.212 ± 0.033
1.888LysVal: 1.888 ± 0.034
0.308LysTrp: 0.308 ± 0.014
0.465LysTyr: 0.465 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
13.896LeuAla: 13.896 ± 0.101
0.748LeuCys: 0.748 ± 0.024
7.29LeuAsp: 7.29 ± 0.09
4.924LeuGlu: 4.924 ± 0.064
2.711LeuPhe: 2.711 ± 0.047
9.371LeuGly: 9.371 ± 0.105
2.02LeuHis: 2.02 ± 0.038
3.576LeuIle: 3.576 ± 0.045
1.467LeuLys: 1.467 ± 0.038
9.578LeuLeu: 9.578 ± 0.099
1.586LeuMet: 1.586 ± 0.034
1.671LeuAsn: 1.671 ± 0.032
5.849LeuPro: 5.849 ± 0.083
2.361LeuGln: 2.361 ± 0.038
7.504LeuArg: 7.504 ± 0.076
5.516LeuSer: 5.516 ± 0.07
6.376LeuThr: 6.376 ± 0.068
9.26LeuVal: 9.26 ± 0.086
1.18LeuTrp: 1.18 ± 0.03
1.58LeuTyr: 1.58 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
2.227MetAla: 2.227 ± 0.038
0.181MetCys: 0.181 ± 0.009
0.909MetAsp: 0.909 ± 0.025
0.717MetGlu: 0.717 ± 0.021
0.64MetPhe: 0.64 ± 0.019
1.455MetGly: 1.455 ± 0.034
0.392MetHis: 0.392 ± 0.015
0.946MetIle: 0.946 ± 0.025
0.417MetLys: 0.417 ± 0.019
1.993MetLeu: 1.993 ± 0.036
0.397MetMet: 0.397 ± 0.018
0.478MetAsn: 0.478 ± 0.019
1.191MetPro: 1.191 ± 0.027
0.574MetGln: 0.574 ± 0.018
1.495MetArg: 1.495 ± 0.031
1.531MetSer: 1.531 ± 0.031
1.77MetThr: 1.77 ± 0.032
1.568MetVal: 1.568 ± 0.03
0.273MetTrp: 0.273 ± 0.013
0.364MetTyr: 0.364 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
2.43AsnAla: 2.43 ± 0.039
0.178AsnCys: 0.178 ± 0.011
1.004AsnAsp: 1.004 ± 0.024
1.001AsnGlu: 1.001 ± 0.025
0.597AsnPhe: 0.597 ± 0.021
1.917AsnGly: 1.917 ± 0.039
0.394AsnHis: 0.394 ± 0.015
0.805AsnIle: 0.805 ± 0.022
0.444AsnLys: 0.444 ± 0.018
1.974AsnLeu: 1.974 ± 0.034
0.402AsnMet: 0.402 ± 0.016
0.465AsnAsn: 0.465 ± 0.019
1.614AsnPro: 1.614 ± 0.035
0.52AsnGln: 0.52 ± 0.02
1.308AsnArg: 1.308 ± 0.033
1.077AsnSer: 1.077 ± 0.03
1.175AsnThr: 1.175 ± 0.035
1.664AsnVal: 1.664 ± 0.035
0.36AsnTrp: 0.36 ± 0.016
0.488AsnTyr: 0.488 ± 0.017
0.0AsnXaa: 0.0 ± 0.0
Pro
7.236ProAla: 7.236 ± 0.085
0.273ProCys: 0.273 ± 0.014
4.602ProAsp: 4.602 ± 0.055
3.934ProGlu: 3.934 ± 0.064
1.623ProPhe: 1.623 ± 0.033
5.592ProGly: 5.592 ± 0.064
1.177ProHis: 1.177 ± 0.029
2.126ProIle: 2.126 ± 0.036
1.137ProLys: 1.137 ± 0.027
4.853ProLeu: 4.853 ± 0.067
1.094ProMet: 1.094 ± 0.029
1.111ProAsn: 1.111 ± 0.03
2.748ProPro: 2.748 ± 0.056
1.57ProGln: 1.57 ± 0.036
3.603ProArg: 3.603 ± 0.052
3.224ProSer: 3.224 ± 0.044
3.579ProThr: 3.579 ± 0.051
5.304ProVal: 5.304 ± 0.071
0.806ProTrp: 0.806 ± 0.023
1.056ProTyr: 1.056 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
3.243GlnAla: 3.243 ± 0.054
0.187GlnCys: 0.187 ± 0.011
1.237GlnAsp: 1.237 ± 0.025
1.115GlnGlu: 1.115 ± 0.027
0.935GlnPhe: 0.935 ± 0.025
1.896GlnGly: 1.896 ± 0.035
0.566GlnHis: 0.566 ± 0.02
1.352GlnIle: 1.352 ± 0.032
0.592GlnLys: 0.592 ± 0.023
3.089GlnLeu: 3.089 ± 0.046
0.619GlnMet: 0.619 ± 0.019
0.549GlnAsn: 0.549 ± 0.019
1.464GlnPro: 1.464 ± 0.035
1.144GlnGln: 1.144 ± 0.033
2.26GlnArg: 2.26 ± 0.043
1.438GlnSer: 1.438 ± 0.032
1.358GlnThr: 1.358 ± 0.029
2.537GlnVal: 2.537 ± 0.039
0.519GlnTrp: 0.519 ± 0.019
0.573GlnTyr: 0.573 ± 0.019
0.0GlnXaa: 0.0 ± 0.0
Arg
8.548ArgAla: 8.548 ± 0.067
0.56ArgCys: 0.56 ± 0.018
4.333ArgAsp: 4.333 ± 0.054
4.363ArgGlu: 4.363 ± 0.053
2.436ArgPhe: 2.436 ± 0.041
5.586ArgGly: 5.586 ± 0.069
1.644ArgHis: 1.644 ± 0.034
3.78ArgIle: 3.78 ± 0.047
1.639ArgLys: 1.639 ± 0.037
7.201ArgLeu: 7.201 ± 0.082
1.894ArgMet: 1.894 ± 0.034
1.593ArgAsn: 1.593 ± 0.03
4.042ArgPro: 4.042 ± 0.062
1.942ArgGln: 1.942 ± 0.037
6.794ArgArg: 6.794 ± 0.095
4.319ArgSer: 4.319 ± 0.056
4.848ArgThr: 4.848 ± 0.06
5.897ArgVal: 5.897 ± 0.065
1.254ArgTrp: 1.254 ± 0.03
1.725ArgTyr: 1.725 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
7.167SerAla: 7.167 ± 0.062
0.387SerCys: 0.387 ± 0.018
3.442SerAsp: 3.442 ± 0.052
2.799SerGlu: 2.799 ± 0.046
1.691SerPhe: 1.691 ± 0.032
6.092SerGly: 6.092 ± 0.067
0.953SerHis: 0.953 ± 0.024
2.267SerIle: 2.267 ± 0.04
1.146SerLys: 1.146 ± 0.028
5.021SerLeu: 5.021 ± 0.06
1.368SerMet: 1.368 ± 0.027
1.159SerAsn: 1.159 ± 0.026
3.04SerPro: 3.04 ± 0.048
1.273SerGln: 1.273 ± 0.03
3.818SerArg: 3.818 ± 0.052
3.128SerSer: 3.128 ± 0.05
3.661SerThr: 3.661 ± 0.055
4.891SerVal: 4.891 ± 0.061
0.885SerTrp: 0.885 ± 0.021
1.134SerTyr: 1.134 ± 0.027
0.0SerXaa: 0.0 ± 0.0
Thr
8.165ThrAla: 8.165 ± 0.091
0.442ThrCys: 0.442 ± 0.018
3.924ThrAsp: 3.924 ± 0.056
3.415ThrGlu: 3.415 ± 0.048
1.847ThrPhe: 1.847 ± 0.04
6.226ThrGly: 6.226 ± 0.071
1.144ThrHis: 1.144 ± 0.029
2.357ThrIle: 2.357 ± 0.037
1.159ThrLys: 1.159 ± 0.024
5.805ThrLeu: 5.805 ± 0.066
1.108ThrMet: 1.108 ± 0.027
1.121ThrAsn: 1.121 ± 0.034
3.871ThrPro: 3.871 ± 0.049
1.336ThrGln: 1.336 ± 0.03
3.848ThrArg: 3.848 ± 0.047
3.462ThrSer: 3.462 ± 0.053
4.168ThrThr: 4.168 ± 0.073
6.533ThrVal: 6.533 ± 0.084
0.831ThrTrp: 0.831 ± 0.026
1.259ThrTyr: 1.259 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
12.145ValAla: 12.145 ± 0.121
0.74ValCys: 0.74 ± 0.021
6.543ValAsp: 6.543 ± 0.079
5.17ValGlu: 5.17 ± 0.053
2.622ValPhe: 2.622 ± 0.046
7.761ValGly: 7.761 ± 0.071
1.884ValHis: 1.884 ± 0.036
3.39ValIle: 3.39 ± 0.045
1.617ValLys: 1.617 ± 0.039
9.554ValLeu: 9.554 ± 0.077
1.576ValMet: 1.576 ± 0.029
1.832ValAsn: 1.832 ± 0.036
5.325ValPro: 5.325 ± 0.06
2.235ValGln: 2.235 ± 0.04
6.531ValArg: 6.531 ± 0.066
4.878ValSer: 4.878 ± 0.061
6.091ValThr: 6.091 ± 0.075
9.553ValVal: 9.553 ± 0.081
1.154ValTrp: 1.154 ± 0.027
1.545ValTyr: 1.545 ± 0.028
0.0ValXaa: 0.0 ± 0.0
Trp
1.561TrpAla: 1.561 ± 0.032
0.147TrpCys: 0.147 ± 0.01
0.795TrpAsp: 0.795 ± 0.021
0.651TrpGlu: 0.651 ± 0.019
0.531TrpPhe: 0.531 ± 0.018
1.016TrpGly: 1.016 ± 0.028
0.322TrpHis: 0.322 ± 0.016
0.678TrpIle: 0.678 ± 0.021
0.334TrpLys: 0.334 ± 0.017
1.565TrpLeu: 1.565 ± 0.035
0.343TrpMet: 0.343 ± 0.013
0.403TrpAsn: 0.403 ± 0.016
0.712TrpPro: 0.712 ± 0.022
0.542TrpGln: 0.542 ± 0.018
1.132TrpArg: 1.132 ± 0.031
0.929TrpSer: 0.929 ± 0.021
0.978TrpThr: 0.978 ± 0.029
1.113TrpVal: 1.113 ± 0.029
0.332TrpTrp: 0.332 ± 0.017
0.286TrpTyr: 0.286 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.304TyrAla: 2.304 ± 0.039
0.178TyrCys: 0.178 ± 0.011
1.31TyrAsp: 1.31 ± 0.031
1.052TyrGlu: 1.052 ± 0.029
0.663TyrPhe: 0.663 ± 0.023
1.941TyrGly: 1.941 ± 0.037
0.395TyrHis: 0.395 ± 0.015
0.6TyrIle: 0.6 ± 0.02
0.342TyrLys: 0.342 ± 0.015
2.169TyrLeu: 2.169 ± 0.038
0.286TyrMet: 0.286 ± 0.013
0.402TyrAsn: 0.402 ± 0.016
1.154TyrPro: 1.154 ± 0.028
0.553TyrGln: 0.553 ± 0.019
1.739TyrArg: 1.739 ± 0.03
1.096TyrSer: 1.096 ± 0.028
1.159TyrThr: 1.159 ± 0.026
1.648TyrVal: 1.648 ± 0.036
0.331TyrTrp: 0.331 ± 0.013
0.434TyrTyr: 0.434 ± 0.017
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5029 proteins (1603601 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski