human papillomavirus 118

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Betapapillomavirus; Betapapillomavirus 1

Average proteome isoelectric point is 5.89

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 6 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|D6MM12|D6MM12_9PAPI Replication protein E1 OS=human papillomavirus 118 OX=927771 GN=E1 PE=3 SV=1
MM1 pKa = 7.18VGNEE5 pKa = 3.81VTLQDD10 pKa = 3.38IVLEE14 pKa = 4.57LEE16 pKa = 4.11PQAIDD21 pKa = 3.44LFCYY25 pKa = 10.38EE26 pKa = 4.69EE27 pKa = 4.17EE28 pKa = 4.97LPTEE32 pKa = 4.14QDD34 pKa = 2.97TSSEE38 pKa = 4.19EE39 pKa = 3.82EE40 pKa = 4.01PDD42 pKa = 3.7PVKK45 pKa = 10.61IPYY48 pKa = 9.65KK49 pKa = 10.38VVAPCGCCGPRR60 pKa = 11.84LRR62 pKa = 11.84LCLLATTFGIRR73 pKa = 11.84TLEE76 pKa = 3.95SLLLDD81 pKa = 5.34EE82 pKa = 6.1INLLCPPCRR91 pKa = 11.84HH92 pKa = 6.15SLQHH96 pKa = 6.44GNQQ99 pKa = 3.17

Molecular weight: 11.05 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|D6MM14|D6MM14_9PAPI Minor capsid protein L2 OS=human papillomavirus 118 OX=927771 GN=L2 PE=3 SV=1
MM1 pKa = 7.41EE2 pKa = 5.52ALNEE6 pKa = 4.14RR7 pKa = 11.84FSALQDD13 pKa = 3.24QLMNIYY19 pKa = 9.44EE20 pKa = 4.32AAKK23 pKa = 9.2STLDD27 pKa = 3.33AQIDD31 pKa = 3.61HH32 pKa = 6.39WQHH35 pKa = 5.04LRR37 pKa = 11.84KK38 pKa = 9.43EE39 pKa = 4.16AVLLFVARR47 pKa = 11.84QKK49 pKa = 11.28GILRR53 pKa = 11.84LGYY56 pKa = 10.26QPVPPQAVSEE66 pKa = 4.52SKK68 pKa = 10.83AKK70 pKa = 9.84NAIMMVLQLEE80 pKa = 4.46SLKK83 pKa = 10.64KK84 pKa = 10.09SQFAEE89 pKa = 4.53EE90 pKa = 4.36PWTLVDD96 pKa = 4.68TSLEE100 pKa = 4.36TYY102 pKa = 10.62KK103 pKa = 10.73NAPEE107 pKa = 3.94NTFKK111 pKa = 10.92KK112 pKa = 10.62GPINVEE118 pKa = 3.55VMYY121 pKa = 11.01DD122 pKa = 3.61KK123 pKa = 11.49DD124 pKa = 3.73PDD126 pKa = 3.68NTNLYY131 pKa = 9.13TMWKK135 pKa = 8.59YY136 pKa = 10.71IYY138 pKa = 10.41YY139 pKa = 10.38LDD141 pKa = 5.73AEE143 pKa = 4.66EE144 pKa = 4.52EE145 pKa = 4.2WQKK148 pKa = 11.68AEE150 pKa = 4.29SGANHH155 pKa = 5.94TGIYY159 pKa = 9.4YY160 pKa = 7.56MHH162 pKa = 7.19GSFRR166 pKa = 11.84HH167 pKa = 5.42YY168 pKa = 10.68YY169 pKa = 10.53VLFADD174 pKa = 4.18DD175 pKa = 4.35APRR178 pKa = 11.84FSRR181 pKa = 11.84TGHH184 pKa = 5.74WEE186 pKa = 3.89VIINKK191 pKa = 8.54DD192 pKa = 3.45TVFAPVTSSTPPEE205 pKa = 4.24SPGQSQGRR213 pKa = 11.84QPPDD217 pKa = 2.99KK218 pKa = 10.12GTGITTTDD226 pKa = 3.08AATNRR231 pKa = 11.84SPRR234 pKa = 11.84ASPTTTAVTEE244 pKa = 4.29RR245 pKa = 11.84PQKK248 pKa = 10.17RR249 pKa = 11.84RR250 pKa = 11.84YY251 pKa = 8.45GRR253 pKa = 11.84KK254 pKa = 9.58DD255 pKa = 3.21SSPTATPKK263 pKa = 10.31KK264 pKa = 10.02RR265 pKa = 11.84STRR268 pKa = 11.84QTWQRR273 pKa = 11.84RR274 pKa = 11.84RR275 pKa = 11.84PRR277 pKa = 11.84SRR279 pKa = 11.84SLRR282 pKa = 11.84AEE284 pKa = 3.9KK285 pKa = 10.27RR286 pKa = 11.84RR287 pKa = 11.84QTRR290 pKa = 11.84SRR292 pKa = 11.84STSSKK297 pKa = 8.95ASKK300 pKa = 9.69NRR302 pKa = 11.84RR303 pKa = 11.84RR304 pKa = 11.84RR305 pKa = 11.84SSSSSSSSSCSRR317 pKa = 11.84GSSSRR322 pKa = 11.84RR323 pKa = 11.84RR324 pKa = 11.84RR325 pKa = 11.84RR326 pKa = 11.84TRR328 pKa = 11.84SRR330 pKa = 11.84SASRR334 pKa = 11.84TKK336 pKa = 10.78SPASRR341 pKa = 11.84TRR343 pKa = 11.84SRR345 pKa = 11.84TRR347 pKa = 11.84SPTSKK352 pKa = 10.03AQSPGRR358 pKa = 11.84RR359 pKa = 11.84AGGRR363 pKa = 11.84SSRR366 pKa = 11.84RR367 pKa = 11.84STSSSTSPSKK377 pKa = 9.88RR378 pKa = 11.84RR379 pKa = 11.84KK380 pKa = 8.37RR381 pKa = 11.84ARR383 pKa = 11.84DD384 pKa = 3.19RR385 pKa = 11.84GPSYY389 pKa = 11.29NRR391 pKa = 11.84GISPGDD397 pKa = 3.28VGKK400 pKa = 10.58SVQTVSGRR408 pKa = 11.84HH409 pKa = 5.26KK410 pKa = 10.87GRR412 pKa = 11.84LGRR415 pKa = 11.84LLAEE419 pKa = 4.16AHH421 pKa = 6.97DD422 pKa = 4.36PPVILVKK429 pKa = 10.75GDD431 pKa = 3.86PNTLKK436 pKa = 10.73CFRR439 pKa = 11.84NRR441 pKa = 11.84SKK443 pKa = 9.95TKK445 pKa = 10.16YY446 pKa = 9.29RR447 pKa = 11.84DD448 pKa = 3.39LIKK451 pKa = 10.6AVSTTWSWVSTDD463 pKa = 2.65GCDD466 pKa = 3.32RR467 pKa = 11.84IGRR470 pKa = 11.84ARR472 pKa = 11.84MLFSFASYY480 pKa = 8.17EE481 pKa = 4.02QRR483 pKa = 11.84NTFDD487 pKa = 3.96NKK489 pKa = 8.19VTYY492 pKa = 9.03PKK494 pKa = 10.54NVEE497 pKa = 3.88RR498 pKa = 11.84TFGNFDD504 pKa = 3.51SLL506 pKa = 4.21

Molecular weight: 57.49 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

6

0

6

2375

99

606

395.8

44.79

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.937 ± 0.555

2.105 ± 0.875

5.768 ± 0.49

6.274 ± 0.643

4.295 ± 0.561

5.768 ± 0.733

2.189 ± 0.236

5.011 ± 0.6

4.884 ± 0.975

7.916 ± 0.891

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.432 ± 0.303

4.421 ± 0.672

5.979 ± 0.873

4.968 ± 0.382

7.284 ± 1.292

8.295 ± 1.319

6.863 ± 1.147

5.895 ± 0.853

1.263 ± 0.382

3.453 ± 0.315
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski