Amino acid dipepetide frequency for Comamonas terrigena

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.04AlaAla: 19.04 ± 0.214
1.352AlaCys: 1.352 ± 0.037
6.402AlaAsp: 6.402 ± 0.081
6.187AlaGlu: 6.187 ± 0.08
3.82AlaPhe: 3.82 ± 0.057
10.626AlaGly: 10.626 ± 0.113
2.964AlaHis: 2.964 ± 0.054
4.94AlaIle: 4.94 ± 0.067
3.924AlaLys: 3.924 ± 0.083
15.598AlaLeu: 15.598 ± 0.142
3.69AlaMet: 3.69 ± 0.054
2.772AlaAsn: 2.772 ± 0.063
6.683AlaPro: 6.683 ± 0.126
7.72AlaGln: 7.72 ± 0.112
8.06AlaArg: 8.06 ± 0.101
6.833AlaSer: 6.833 ± 0.089
6.404AlaThr: 6.404 ± 0.093
9.645AlaVal: 9.645 ± 0.107
2.022AlaTrp: 2.022 ± 0.048
2.463AlaTyr: 2.463 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
1.229CysAla: 1.229 ± 0.034
0.128CysCys: 0.128 ± 0.01
0.449CysAsp: 0.449 ± 0.017
0.462CysGlu: 0.462 ± 0.017
0.302CysPhe: 0.302 ± 0.015
0.942CysGly: 0.942 ± 0.031
0.267CysHis: 0.267 ± 0.017
0.417CysIle: 0.417 ± 0.016
0.237CysLys: 0.237 ± 0.012
0.884CysLeu: 0.884 ± 0.026
0.262CysMet: 0.262 ± 0.012
0.229CysAsn: 0.229 ± 0.012
0.471CysPro: 0.471 ± 0.024
0.333CysGln: 0.333 ± 0.017
0.495CysArg: 0.495 ± 0.02
0.527CysSer: 0.527 ± 0.022
0.553CysThr: 0.553 ± 0.02
0.702CysVal: 0.702 ± 0.026
0.138CysTrp: 0.138 ± 0.012
0.197CysTyr: 0.197 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
6.991AspAla: 6.991 ± 0.089
0.473AspCys: 0.473 ± 0.019
2.264AspAsp: 2.264 ± 0.052
2.463AspGlu: 2.463 ± 0.05
1.965AspPhe: 1.965 ± 0.04
4.359AspGly: 4.359 ± 0.075
1.095AspHis: 1.095 ± 0.034
2.299AspIle: 2.299 ± 0.043
1.765AspLys: 1.765 ± 0.042
5.082AspLeu: 5.082 ± 0.068
1.341AspMet: 1.341 ± 0.034
1.218AspAsn: 1.218 ± 0.039
2.467AspPro: 2.467 ± 0.05
1.825AspGln: 1.825 ± 0.039
2.835AspArg: 2.835 ± 0.049
2.472AspSer: 2.472 ± 0.053
2.644AspThr: 2.644 ± 0.055
3.852AspVal: 3.852 ± 0.056
0.965AspTrp: 0.965 ± 0.028
1.376AspTyr: 1.376 ± 0.032
0.0AspXaa: 0.0 ± 0.0
Glu
6.432GluAla: 6.432 ± 0.125
0.342GluCys: 0.342 ± 0.016
2.135GluAsp: 2.135 ± 0.048
2.41GluGlu: 2.41 ± 0.056
1.553GluPhe: 1.553 ± 0.035
3.687GluGly: 3.687 ± 0.05
1.262GluHis: 1.262 ± 0.032
2.283GluIle: 2.283 ± 0.048
1.77GluLys: 1.77 ± 0.05
5.455GluLeu: 5.455 ± 0.075
1.217GluMet: 1.217 ± 0.034
1.166GluAsn: 1.166 ± 0.031
2.075GluPro: 2.075 ± 0.043
2.881GluGln: 2.881 ± 0.053
4.009GluArg: 4.009 ± 0.069
2.26GluSer: 2.26 ± 0.046
2.188GluThr: 2.188 ± 0.042
4.005GluVal: 4.005 ± 0.066
0.677GluTrp: 0.677 ± 0.025
0.922GluTyr: 0.922 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
4.05PheAla: 4.05 ± 0.06
0.371PheCys: 0.371 ± 0.017
2.088PheAsp: 2.088 ± 0.041
1.626PheGlu: 1.626 ± 0.036
1.277PhePhe: 1.277 ± 0.037
3.023PheGly: 3.023 ± 0.055
0.736PheHis: 0.736 ± 0.023
1.403PheIle: 1.403 ± 0.038
1.105PheLys: 1.105 ± 0.03
2.769PheLeu: 2.769 ± 0.054
0.812PheMet: 0.812 ± 0.026
1.038PheAsn: 1.038 ± 0.027
1.406PhePro: 1.406 ± 0.036
1.199PheGln: 1.199 ± 0.03
1.582PheArg: 1.582 ± 0.036
2.015PheSer: 2.015 ± 0.039
1.914PheThr: 1.914 ± 0.042
2.565PheVal: 2.565 ± 0.045
0.538PheTrp: 0.538 ± 0.019
0.819PheTyr: 0.819 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
9.199GlyAla: 9.199 ± 0.115
0.92GlyCys: 0.92 ± 0.028
3.788GlyAsp: 3.788 ± 0.067
3.946GlyGlu: 3.946 ± 0.06
2.996GlyPhe: 2.996 ± 0.051
6.959GlyGly: 6.959 ± 0.109
1.967GlyHis: 1.967 ± 0.04
3.743GlyIle: 3.743 ± 0.06
3.471GlyLys: 3.471 ± 0.068
9.006GlyLeu: 9.006 ± 0.096
2.681GlyMet: 2.681 ± 0.047
2.362GlyAsn: 2.362 ± 0.075
2.856GlyPro: 2.856 ± 0.049
4.185GlyGln: 4.185 ± 0.059
4.748GlyArg: 4.748 ± 0.069
4.92GlySer: 4.92 ± 0.125
4.722GlyThr: 4.722 ± 0.122
6.599GlyVal: 6.599 ± 0.078
1.616GlyTrp: 1.616 ± 0.043
2.246GlyTyr: 2.246 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
3.159HisAla: 3.159 ± 0.059
0.313HisCys: 0.313 ± 0.017
1.202HisAsp: 1.202 ± 0.034
0.989HisGlu: 0.989 ± 0.028
0.887HisPhe: 0.887 ± 0.024
2.195HisGly: 2.195 ± 0.044
0.683HisHis: 0.683 ± 0.026
1.074HisIle: 1.074 ± 0.032
0.556HisLys: 0.556 ± 0.025
2.308HisLeu: 2.308 ± 0.041
0.587HisMet: 0.587 ± 0.021
0.578HisAsn: 0.578 ± 0.022
1.543HisPro: 1.543 ± 0.033
1.01HisGln: 1.01 ± 0.031
1.424HisArg: 1.424 ± 0.031
1.306HisSer: 1.306 ± 0.031
1.325HisThr: 1.325 ± 0.034
1.599HisVal: 1.599 ± 0.035
0.54HisTrp: 0.54 ± 0.02
0.646HisTyr: 0.646 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
5.809IleAla: 5.809 ± 0.081
0.358IleCys: 0.358 ± 0.015
2.571IleAsp: 2.571 ± 0.045
2.381IleGlu: 2.381 ± 0.057
1.227IlePhe: 1.227 ± 0.035
3.739IleGly: 3.739 ± 0.065
0.891IleHis: 0.891 ± 0.027
1.489IleIle: 1.489 ± 0.04
1.417IleLys: 1.417 ± 0.036
3.204IleLeu: 3.204 ± 0.057
0.739IleMet: 0.739 ± 0.03
1.358IleAsn: 1.358 ± 0.033
2.078IlePro: 2.078 ± 0.046
1.493IleGln: 1.493 ± 0.039
2.298IleArg: 2.298 ± 0.051
2.371IleSer: 2.371 ± 0.049
2.616IleThr: 2.616 ± 0.069
3.072IleVal: 3.072 ± 0.052
0.474IleTrp: 0.474 ± 0.021
0.921IleTyr: 0.921 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
4.161LysAla: 4.161 ± 0.079
0.15LysCys: 0.15 ± 0.011
1.739LysAsp: 1.739 ± 0.047
1.682LysGlu: 1.682 ± 0.047
0.848LysPhe: 0.848 ± 0.031
2.449LysGly: 2.449 ± 0.047
0.622LysHis: 0.622 ± 0.024
1.373LysIle: 1.373 ± 0.04
1.436LysLys: 1.436 ± 0.049
3.436LysLeu: 3.436 ± 0.06
0.776LysMet: 0.776 ± 0.035
0.937LysAsn: 0.937 ± 0.032
1.936LysPro: 1.936 ± 0.047
1.316LysGln: 1.316 ± 0.038
1.835LysArg: 1.835 ± 0.044
1.689LysSer: 1.689 ± 0.04
1.839LysThr: 1.839 ± 0.047
2.517LysVal: 2.517 ± 0.061
0.349LysTrp: 0.349 ± 0.015
0.644LysTyr: 0.644 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
14.636LeuAla: 14.636 ± 0.134
1.154LeuCys: 1.154 ± 0.036
5.478LeuAsp: 5.478 ± 0.066
5.292LeuGlu: 5.292 ± 0.074
3.144LeuPhe: 3.144 ± 0.06
9.151LeuGly: 9.151 ± 0.122
2.775LeuHis: 2.775 ± 0.049
3.84LeuIle: 3.84 ± 0.069
3.177LeuLys: 3.177 ± 0.067
12.133LeuLeu: 12.133 ± 0.147
2.493LeuMet: 2.493 ± 0.042
2.842LeuAsn: 2.842 ± 0.073
6.486LeuPro: 6.486 ± 0.08
6.307LeuGln: 6.307 ± 0.084
7.428LeuArg: 7.428 ± 0.094
6.341LeuSer: 6.341 ± 0.088
5.517LeuThr: 5.517 ± 0.107
8.054LeuVal: 8.054 ± 0.093
1.604LeuTrp: 1.604 ± 0.048
2.059LeuTyr: 2.059 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
3.498MetAla: 3.498 ± 0.052
0.169MetCys: 0.169 ± 0.013
1.29MetAsp: 1.29 ± 0.034
1.228MetGlu: 1.228 ± 0.028
0.691MetPhe: 0.691 ± 0.026
2.13MetGly: 2.13 ± 0.045
0.652MetHis: 0.652 ± 0.027
0.772MetIle: 0.772 ± 0.03
0.855MetLys: 0.855 ± 0.028
2.838MetLeu: 2.838 ± 0.051
0.518MetMet: 0.518 ± 0.024
0.757MetAsn: 0.757 ± 0.02
1.591MetPro: 1.591 ± 0.035
1.435MetGln: 1.435 ± 0.036
1.605MetArg: 1.605 ± 0.042
1.485MetSer: 1.485 ± 0.038
1.451MetThr: 1.451 ± 0.041
1.99MetVal: 1.99 ± 0.042
0.251MetTrp: 0.251 ± 0.013
0.389MetTyr: 0.389 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
3.463AsnAla: 3.463 ± 0.07
0.216AsnCys: 0.216 ± 0.013
1.29AsnAsp: 1.29 ± 0.032
1.082AsnGlu: 1.082 ± 0.033
0.929AsnPhe: 0.929 ± 0.036
2.221AsnGly: 2.221 ± 0.075
0.514AsnHis: 0.514 ± 0.018
1.147AsnIle: 1.147 ± 0.034
0.818AsnLys: 0.818 ± 0.029
2.653AsnLeu: 2.653 ± 0.062
0.606AsnMet: 0.606 ± 0.026
0.761AsnAsn: 0.761 ± 0.036
1.802AsnPro: 1.802 ± 0.039
1.049AsnGln: 1.049 ± 0.033
1.526AsnArg: 1.526 ± 0.036
1.267AsnSer: 1.267 ± 0.057
1.508AsnThr: 1.508 ± 0.041
1.916AsnVal: 1.916 ± 0.046
0.41AsnTrp: 0.41 ± 0.018
0.681AsnTyr: 0.681 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
7.464ProAla: 7.464 ± 0.107
0.364ProCys: 0.364 ± 0.021
2.902ProAsp: 2.902 ± 0.044
3.102ProGlu: 3.102 ± 0.052
1.598ProPhe: 1.598 ± 0.039
4.404ProGly: 4.404 ± 0.065
1.256ProHis: 1.256 ± 0.032
1.734ProIle: 1.734 ± 0.042
1.413ProLys: 1.413 ± 0.037
5.625ProLeu: 5.625 ± 0.083
1.331ProMet: 1.331 ± 0.034
1.137ProAsn: 1.137 ± 0.033
2.592ProPro: 2.592 ± 0.069
2.818ProGln: 2.818 ± 0.055
2.717ProArg: 2.717 ± 0.051
2.846ProSer: 2.846 ± 0.057
2.602ProThr: 2.602 ± 0.101
4.381ProVal: 4.381 ± 0.072
0.839ProTrp: 0.839 ± 0.026
1.139ProTyr: 1.139 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
7.403GlnAla: 7.403 ± 0.093
0.349GlnCys: 0.349 ± 0.02
2.12GlnAsp: 2.12 ± 0.042
2.142GlnGlu: 2.142 ± 0.042
1.391GlnPhe: 1.391 ± 0.031
4.047GlnGly: 4.047 ± 0.067
1.37GlnHis: 1.37 ± 0.035
1.977GlnIle: 1.977 ± 0.042
1.286GlnLys: 1.286 ± 0.038
5.895GlnLeu: 5.895 ± 0.076
1.192GlnMet: 1.192 ± 0.026
1.043GlnAsn: 1.043 ± 0.028
2.906GlnPro: 2.906 ± 0.059
3.174GlnGln: 3.174 ± 0.078
3.999GlnArg: 3.999 ± 0.073
2.422GlnSer: 2.422 ± 0.048
2.363GlnThr: 2.363 ± 0.048
3.802GlnVal: 3.802 ± 0.062
0.96GlnTrp: 0.96 ± 0.03
0.863GlnTyr: 0.863 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
6.879ArgAla: 6.879 ± 0.087
0.599ArgCys: 0.599 ± 0.021
3.064ArgAsp: 3.064 ± 0.053
3.236ArgGlu: 3.236 ± 0.065
2.358ArgPhe: 2.358 ± 0.043
3.902ArgGly: 3.902 ± 0.065
1.82ArgHis: 1.82 ± 0.04
3.049ArgIle: 3.049 ± 0.046
2.0ArgLys: 2.0 ± 0.047
7.111ArgLeu: 7.111 ± 0.089
1.997ArgMet: 1.997 ± 0.04
1.802ArgAsn: 1.802 ± 0.039
2.855ArgPro: 2.855 ± 0.048
3.243ArgGln: 3.243 ± 0.063
4.229ArgArg: 4.229 ± 0.069
3.661ArgSer: 3.661 ± 0.058
3.275ArgThr: 3.275 ± 0.061
4.472ArgVal: 4.472 ± 0.07
1.29ArgTrp: 1.29 ± 0.035
1.611ArgTyr: 1.611 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
6.842SerAla: 6.842 ± 0.094
0.395SerCys: 0.395 ± 0.019
2.573SerAsp: 2.573 ± 0.053
2.326SerGlu: 2.326 ± 0.043
1.938SerPhe: 1.938 ± 0.037
5.255SerGly: 5.255 ± 0.128
1.252SerHis: 1.252 ± 0.035
2.361SerIle: 2.361 ± 0.054
1.653SerLys: 1.653 ± 0.043
5.81SerLeu: 5.81 ± 0.07
1.459SerMet: 1.459 ± 0.036
1.551SerAsn: 1.551 ± 0.043
2.87SerPro: 2.87 ± 0.046
2.258SerGln: 2.258 ± 0.035
3.153SerArg: 3.153 ± 0.055
3.341SerSer: 3.341 ± 0.076
3.282SerThr: 3.282 ± 0.079
4.086SerVal: 4.086 ± 0.061
0.882SerTrp: 0.882 ± 0.025
1.345SerTyr: 1.345 ± 0.035
0.0SerXaa: 0.0 ± 0.0
Thr
6.915ThrAla: 6.915 ± 0.09
0.382ThrCys: 0.382 ± 0.017
2.484ThrAsp: 2.484 ± 0.052
2.47ThrGlu: 2.47 ± 0.092
1.559ThrPhe: 1.559 ± 0.035
4.882ThrGly: 4.882 ± 0.091
1.183ThrHis: 1.183 ± 0.031
2.062ThrIle: 2.062 ± 0.044
1.31ThrLys: 1.31 ± 0.04
6.509ThrLeu: 6.509 ± 0.135
1.121ThrMet: 1.121 ± 0.032
1.232ThrAsn: 1.232 ± 0.042
3.733ThrPro: 3.733 ± 0.058
2.351ThrGln: 2.351 ± 0.044
2.956ThrArg: 2.956 ± 0.053
2.8ThrSer: 2.8 ± 0.075
3.129ThrThr: 3.129 ± 0.08
4.542ThrVal: 4.542 ± 0.082
0.682ThrTrp: 0.682 ± 0.023
1.104ThrTyr: 1.104 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
9.708ValAla: 9.708 ± 0.108
0.735ValCys: 0.735 ± 0.021
4.031ValAsp: 4.031 ± 0.048
3.998ValGlu: 3.998 ± 0.064
2.481ValPhe: 2.481 ± 0.05
5.755ValGly: 5.755 ± 0.082
1.766ValHis: 1.766 ± 0.037
3.134ValIle: 3.134 ± 0.059
2.319ValLys: 2.319 ± 0.055
8.953ValLeu: 8.953 ± 0.098
1.847ValMet: 1.847 ± 0.042
2.085ValAsn: 2.085 ± 0.058
4.025ValPro: 4.025 ± 0.056
4.096ValGln: 4.096 ± 0.067
4.898ValArg: 4.898 ± 0.076
4.001ValSer: 4.001 ± 0.064
4.016ValThr: 4.016 ± 0.079
6.588ValVal: 6.588 ± 0.079
1.088ValTrp: 1.088 ± 0.032
1.528ValTyr: 1.528 ± 0.03
0.0ValXaa: 0.0 ± 0.0
Trp
1.612TrpAla: 1.612 ± 0.044
0.2TrpCys: 0.2 ± 0.014
0.663TrpAsp: 0.663 ± 0.021
0.645TrpGlu: 0.645 ± 0.023
0.553TrpPhe: 0.553 ± 0.019
1.212TrpGly: 1.212 ± 0.036
0.396TrpHis: 0.396 ± 0.017
0.641TrpIle: 0.641 ± 0.026
0.529TrpLys: 0.529 ± 0.022
2.328TrpLeu: 2.328 ± 0.048
0.478TrpMet: 0.478 ± 0.019
0.443TrpAsn: 0.443 ± 0.019
0.761TrpPro: 0.761 ± 0.029
1.001TrpGln: 1.001 ± 0.034
1.133TrpArg: 1.133 ± 0.035
0.916TrpSer: 0.916 ± 0.029
0.777TrpThr: 0.777 ± 0.026
1.115TrpVal: 1.115 ± 0.032
0.362TrpTrp: 0.362 ± 0.019
0.281TrpTyr: 0.281 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.655TyrAla: 2.655 ± 0.043
0.255TyrCys: 0.255 ± 0.016
1.221TyrAsp: 1.221 ± 0.031
1.062TyrGlu: 1.062 ± 0.027
0.816TyrPhe: 0.816 ± 0.028
1.99TyrGly: 1.99 ± 0.043
0.451TyrHis: 0.451 ± 0.019
0.767TyrIle: 0.767 ± 0.025
0.693TyrLys: 0.693 ± 0.023
2.315TyrLeu: 2.315 ± 0.045
0.446TyrMet: 0.446 ± 0.019
0.546TyrAsn: 0.546 ± 0.025
1.131TyrPro: 1.131 ± 0.033
1.013TyrGln: 1.013 ± 0.029
1.522TyrArg: 1.522 ± 0.039
1.164TyrSer: 1.164 ± 0.032
1.28TyrThr: 1.28 ± 0.034
1.55TyrVal: 1.55 ± 0.041
0.36TyrTrp: 0.36 ± 0.016
0.568TyrTyr: 0.568 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4009 proteins (1308246 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski