Amino acid dipepetide frequency for Mycobacterium phage Cuke

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.954AlaAla: 5.954 ± 1.15
0.641AlaCys: 0.641 ± 0.203
5.45AlaAsp: 5.45 ± 0.414
5.038AlaGlu: 5.038 ± 0.476
2.565AlaPhe: 2.565 ± 0.306
4.992AlaGly: 4.992 ± 0.81
1.42AlaHis: 1.42 ± 0.253
5.404AlaIle: 5.404 ± 0.59
6.412AlaLys: 6.412 ± 0.61
7.374AlaLeu: 7.374 ± 0.819
2.977AlaMet: 2.977 ± 0.388
3.847AlaAsn: 3.847 ± 0.786
2.244AlaPro: 2.244 ± 0.388
3.527AlaGln: 3.527 ± 0.694
3.893AlaArg: 3.893 ± 0.499
4.717AlaSer: 4.717 ± 0.621
5.13AlaThr: 5.13 ± 0.535
4.855AlaVal: 4.855 ± 0.542
1.145AlaTrp: 1.145 ± 0.234
2.015AlaTyr: 2.015 ± 0.251
0.0AlaXaa: 0.0 ± 0.0
Cys
0.733CysAla: 0.733 ± 0.219
0.183CysCys: 0.183 ± 0.089
0.87CysAsp: 0.87 ± 0.246
0.962CysGlu: 0.962 ± 0.271
0.412CysPhe: 0.412 ± 0.144
0.962CysGly: 0.962 ± 0.291
0.183CysHis: 0.183 ± 0.096
0.366CysIle: 0.366 ± 0.137
1.145CysLys: 1.145 ± 0.278
0.55CysLeu: 0.55 ± 0.165
0.183CysMet: 0.183 ± 0.108
0.229CysAsn: 0.229 ± 0.098
0.779CysPro: 0.779 ± 0.213
0.458CysGln: 0.458 ± 0.152
0.733CysArg: 0.733 ± 0.192
0.824CysSer: 0.824 ± 0.207
0.366CysThr: 0.366 ± 0.127
0.275CysVal: 0.275 ± 0.122
0.137CysTrp: 0.137 ± 0.076
0.55CysTyr: 0.55 ± 0.159
0.0CysXaa: 0.0 ± 0.0
Asp
5.267AspAla: 5.267 ± 0.526
1.053AspCys: 1.053 ± 0.202
5.267AspAsp: 5.267 ± 0.74
5.496AspGlu: 5.496 ± 0.646
3.298AspPhe: 3.298 ± 0.436
4.809AspGly: 4.809 ± 0.514
1.328AspHis: 1.328 ± 0.333
3.023AspIle: 3.023 ± 0.36
2.794AspLys: 2.794 ± 0.365
5.13AspLeu: 5.13 ± 0.415
1.511AspMet: 1.511 ± 0.246
1.969AspAsn: 1.969 ± 0.256
4.03AspPro: 4.03 ± 0.371
2.427AspGln: 2.427 ± 0.401
3.16AspArg: 3.16 ± 0.512
4.672AspSer: 4.672 ± 0.484
3.023AspThr: 3.023 ± 0.353
4.122AspVal: 4.122 ± 0.511
1.328AspTrp: 1.328 ± 0.291
2.382AspTyr: 2.382 ± 0.327
0.0AspXaa: 0.0 ± 0.0
Glu
5.175GluAla: 5.175 ± 0.509
1.053GluCys: 1.053 ± 0.231
4.03GluAsp: 4.03 ± 0.421
3.389GluGlu: 3.389 ± 0.481
3.023GluPhe: 3.023 ± 0.281
3.985GluGly: 3.985 ± 0.449
1.42GluHis: 1.42 ± 0.346
4.58GluIle: 4.58 ± 0.602
3.298GluLys: 3.298 ± 0.429
6.046GluLeu: 6.046 ± 0.698
1.557GluMet: 1.557 ± 0.29
2.336GluAsn: 2.336 ± 0.349
2.565GluPro: 2.565 ± 0.358
2.107GluGln: 2.107 ± 0.293
4.534GluArg: 4.534 ± 0.555
5.359GluSer: 5.359 ± 0.506
3.939GluThr: 3.939 ± 0.417
3.939GluVal: 3.939 ± 0.365
0.824GluTrp: 0.824 ± 0.231
2.427GluTyr: 2.427 ± 0.386
0.0GluXaa: 0.0 ± 0.0
Phe
3.389PheAla: 3.389 ± 0.344
0.229PheCys: 0.229 ± 0.1
2.702PheAsp: 2.702 ± 0.268
2.702PheGlu: 2.702 ± 0.415
1.557PhePhe: 1.557 ± 0.266
4.534PheGly: 4.534 ± 0.447
0.733PheHis: 0.733 ± 0.193
1.557PheIle: 1.557 ± 0.271
2.153PheLys: 2.153 ± 0.316
2.427PheLeu: 2.427 ± 0.269
0.733PheMet: 0.733 ± 0.201
1.832PheAsn: 1.832 ± 0.236
1.328PhePro: 1.328 ± 0.22
1.42PheGln: 1.42 ± 0.219
1.786PheArg: 1.786 ± 0.293
2.748PheSer: 2.748 ± 0.379
2.748PheThr: 2.748 ± 0.296
2.656PheVal: 2.656 ± 0.328
0.779PheTrp: 0.779 ± 0.204
1.145PheTyr: 1.145 ± 0.269
0.0PheXaa: 0.0 ± 0.0
Gly
4.672GlyAla: 4.672 ± 0.718
0.641GlyCys: 0.641 ± 0.213
5.267GlyAsp: 5.267 ± 0.606
3.893GlyGlu: 3.893 ± 0.446
3.435GlyPhe: 3.435 ± 0.473
6.504GlyGly: 6.504 ± 0.829
1.74GlyHis: 1.74 ± 0.259
5.313GlyIle: 5.313 ± 0.808
4.992GlyLys: 4.992 ± 0.506
6.137GlyLeu: 6.137 ± 0.498
2.061GlyMet: 2.061 ± 0.29
4.351GlyAsn: 4.351 ± 0.52
2.84GlyPro: 2.84 ± 0.377
4.076GlyGln: 4.076 ± 0.47
4.534GlyArg: 4.534 ± 0.478
4.672GlySer: 4.672 ± 0.567
5.13GlyThr: 5.13 ± 0.644
4.992GlyVal: 4.992 ± 0.489
1.649GlyTrp: 1.649 ± 0.326
3.252GlyTyr: 3.252 ± 0.483
0.0GlyXaa: 0.0 ± 0.0
His
0.916HisAla: 0.916 ± 0.231
0.275HisCys: 0.275 ± 0.11
1.282HisAsp: 1.282 ± 0.23
1.466HisGlu: 1.466 ± 0.32
0.595HisPhe: 0.595 ± 0.15
1.649HisGly: 1.649 ± 0.276
0.366HisHis: 0.366 ± 0.137
1.191HisIle: 1.191 ± 0.212
0.962HisLys: 0.962 ± 0.222
1.557HisLeu: 1.557 ± 0.293
0.687HisMet: 0.687 ± 0.183
0.641HisAsn: 0.641 ± 0.153
1.374HisPro: 1.374 ± 0.282
0.824HisGln: 0.824 ± 0.219
1.008HisArg: 1.008 ± 0.248
1.924HisSer: 1.924 ± 0.319
0.87HisThr: 0.87 ± 0.205
1.237HisVal: 1.237 ± 0.292
0.55HisTrp: 0.55 ± 0.147
0.733HisTyr: 0.733 ± 0.212
0.0HisXaa: 0.0 ± 0.0
Ile
5.679IleAla: 5.679 ± 0.565
0.504IleCys: 0.504 ± 0.16
4.03IleAsp: 4.03 ± 0.457
4.351IleGlu: 4.351 ± 0.428
1.924IlePhe: 1.924 ± 0.301
4.076IleGly: 4.076 ± 0.443
1.374IleHis: 1.374 ± 0.286
2.611IleIle: 2.611 ± 0.474
2.198IleLys: 2.198 ± 0.285
4.214IleLeu: 4.214 ± 0.495
1.282IleMet: 1.282 ± 0.235
2.015IleAsn: 2.015 ± 0.353
3.16IlePro: 3.16 ± 0.363
2.198IleGln: 2.198 ± 0.339
3.481IleArg: 3.481 ± 0.406
3.069IleSer: 3.069 ± 0.434
2.931IleThr: 2.931 ± 0.301
3.481IleVal: 3.481 ± 0.396
0.962IleTrp: 0.962 ± 0.227
1.145IleTyr: 1.145 ± 0.194
0.0IleXaa: 0.0 ± 0.0
Lys
6.046LysAla: 6.046 ± 0.628
0.824LysCys: 0.824 ± 0.233
3.16LysAsp: 3.16 ± 0.406
3.893LysGlu: 3.893 ± 0.41
1.695LysPhe: 1.695 ± 0.266
4.259LysGly: 4.259 ± 0.393
0.962LysHis: 0.962 ± 0.22
3.114LysIle: 3.114 ± 0.371
3.985LysLys: 3.985 ± 0.495
4.855LysLeu: 4.855 ± 0.49
1.969LysMet: 1.969 ± 0.371
2.29LysAsn: 2.29 ± 0.306
3.435LysPro: 3.435 ± 0.453
2.702LysGln: 2.702 ± 0.506
4.214LysArg: 4.214 ± 0.503
3.114LysSer: 3.114 ± 0.435
3.435LysThr: 3.435 ± 0.422
3.527LysVal: 3.527 ± 0.379
1.145LysTrp: 1.145 ± 0.222
1.466LysTyr: 1.466 ± 0.211
0.0LysXaa: 0.0 ± 0.0
Leu
7.328LeuAla: 7.328 ± 0.519
0.733LeuCys: 0.733 ± 0.203
5.175LeuAsp: 5.175 ± 0.495
5.267LeuGlu: 5.267 ± 0.529
2.885LeuPhe: 2.885 ± 0.392
5.862LeuGly: 5.862 ± 0.669
1.511LeuHis: 1.511 ± 0.244
3.939LeuIle: 3.939 ± 0.336
4.763LeuLys: 4.763 ± 0.452
5.633LeuLeu: 5.633 ± 0.599
2.29LeuMet: 2.29 ± 0.382
4.03LeuAsn: 4.03 ± 0.411
4.488LeuPro: 4.488 ± 0.469
3.389LeuGln: 3.389 ± 0.319
4.076LeuArg: 4.076 ± 0.395
5.542LeuSer: 5.542 ± 0.45
4.122LeuThr: 4.122 ± 0.381
4.855LeuVal: 4.855 ± 0.509
0.962LeuTrp: 0.962 ± 0.217
1.328LeuTyr: 1.328 ± 0.261
0.0LeuXaa: 0.0 ± 0.0
Met
2.931MetAla: 2.931 ± 0.417
0.275MetCys: 0.275 ± 0.116
1.374MetAsp: 1.374 ± 0.278
0.87MetGlu: 0.87 ± 0.184
0.595MetPhe: 0.595 ± 0.145
2.015MetGly: 2.015 ± 0.293
0.504MetHis: 0.504 ± 0.14
1.466MetIle: 1.466 ± 0.345
1.878MetLys: 1.878 ± 0.314
1.557MetLeu: 1.557 ± 0.239
0.55MetMet: 0.55 ± 0.158
1.145MetAsn: 1.145 ± 0.243
1.786MetPro: 1.786 ± 0.299
1.328MetGln: 1.328 ± 0.259
1.466MetArg: 1.466 ± 0.3
2.519MetSer: 2.519 ± 0.368
2.015MetThr: 2.015 ± 0.278
1.695MetVal: 1.695 ± 0.281
0.092MetTrp: 0.092 ± 0.065
0.504MetTyr: 0.504 ± 0.177
0.0MetXaa: 0.0 ± 0.0
Asn
3.985AsnAla: 3.985 ± 0.431
0.275AsnCys: 0.275 ± 0.098
3.114AsnAsp: 3.114 ± 0.441
3.252AsnGlu: 3.252 ± 0.415
1.328AsnPhe: 1.328 ± 0.262
4.397AsnGly: 4.397 ± 0.438
1.282AsnHis: 1.282 ± 0.297
1.786AsnIle: 1.786 ± 0.246
2.015AsnLys: 2.015 ± 0.229
3.252AsnLeu: 3.252 ± 0.372
0.916AsnMet: 0.916 ± 0.218
1.649AsnAsn: 1.649 ± 0.381
3.252AsnPro: 3.252 ± 0.421
1.924AsnGln: 1.924 ± 0.312
2.565AsnArg: 2.565 ± 0.357
2.656AsnSer: 2.656 ± 0.318
1.924AsnThr: 1.924 ± 0.273
2.336AsnVal: 2.336 ± 0.31
1.237AsnTrp: 1.237 ± 0.268
1.466AsnTyr: 1.466 ± 0.203
0.0AsnXaa: 0.0 ± 0.0
Pro
2.611ProAla: 2.611 ± 0.291
0.55ProCys: 0.55 ± 0.155
2.656ProAsp: 2.656 ± 0.337
3.939ProGlu: 3.939 ± 0.544
2.153ProPhe: 2.153 ± 0.301
4.443ProGly: 4.443 ± 0.463
1.008ProHis: 1.008 ± 0.213
2.702ProIle: 2.702 ± 0.399
3.114ProLys: 3.114 ± 0.33
3.435ProLeu: 3.435 ± 0.345
1.557ProMet: 1.557 ± 0.304
2.244ProAsn: 2.244 ± 0.33
1.969ProPro: 1.969 ± 0.323
1.786ProGln: 1.786 ± 0.305
2.198ProArg: 2.198 ± 0.356
2.794ProSer: 2.794 ± 0.342
3.206ProThr: 3.206 ± 0.331
2.611ProVal: 2.611 ± 0.389
0.962ProTrp: 0.962 ± 0.238
1.695ProTyr: 1.695 ± 0.27
0.0ProXaa: 0.0 ± 0.0
Gln
3.618GlnAla: 3.618 ± 0.667
0.458GlnCys: 0.458 ± 0.165
1.695GlnAsp: 1.695 ± 0.317
2.153GlnGlu: 2.153 ± 0.252
1.786GlnPhe: 1.786 ± 0.299
4.397GlnGly: 4.397 ± 0.775
0.641GlnHis: 0.641 ± 0.192
2.198GlnIle: 2.198 ± 0.311
2.427GlnLys: 2.427 ± 0.415
3.298GlnLeu: 3.298 ± 0.374
1.466GlnMet: 1.466 ± 0.267
2.061GlnAsn: 2.061 ± 0.332
1.466GlnPro: 1.466 ± 0.302
1.786GlnGln: 1.786 ± 0.479
2.565GlnArg: 2.565 ± 0.349
2.336GlnSer: 2.336 ± 0.386
1.924GlnThr: 1.924 ± 0.347
2.84GlnVal: 2.84 ± 0.362
0.504GlnTrp: 0.504 ± 0.184
1.008GlnTyr: 1.008 ± 0.235
0.0GlnXaa: 0.0 ± 0.0
Arg
3.572ArgAla: 3.572 ± 0.441
1.099ArgCys: 1.099 ± 0.216
4.076ArgAsp: 4.076 ± 0.485
3.893ArgGlu: 3.893 ± 0.474
2.473ArgPhe: 2.473 ± 0.399
3.481ArgGly: 3.481 ± 0.348
1.237ArgHis: 1.237 ± 0.263
3.847ArgIle: 3.847 ± 0.482
3.939ArgLys: 3.939 ± 0.457
4.901ArgLeu: 4.901 ± 0.543
1.649ArgMet: 1.649 ± 0.323
2.931ArgAsn: 2.931 ± 0.449
2.198ArgPro: 2.198 ± 0.334
2.153ArgGln: 2.153 ± 0.314
2.519ArgArg: 2.519 ± 0.439
2.656ArgSer: 2.656 ± 0.4
2.29ArgThr: 2.29 ± 0.335
3.893ArgVal: 3.893 ± 0.421
0.824ArgTrp: 0.824 ± 0.21
1.557ArgTyr: 1.557 ± 0.338
0.0ArgXaa: 0.0 ± 0.0
Ser
5.496SerAla: 5.496 ± 0.742
0.504SerCys: 0.504 ± 0.145
4.534SerAsp: 4.534 ± 0.489
4.488SerGlu: 4.488 ± 0.453
2.427SerPhe: 2.427 ± 0.296
6.504SerGly: 6.504 ± 0.58
1.145SerHis: 1.145 ± 0.236
3.16SerIle: 3.16 ± 0.388
3.756SerLys: 3.756 ± 0.419
4.305SerLeu: 4.305 ± 0.448
1.603SerMet: 1.603 ± 0.311
3.527SerAsn: 3.527 ± 0.421
2.427SerPro: 2.427 ± 0.359
2.382SerGln: 2.382 ± 0.446
2.885SerArg: 2.885 ± 0.435
4.259SerSer: 4.259 ± 0.436
3.618SerThr: 3.618 ± 0.395
3.939SerVal: 3.939 ± 0.459
1.649SerTrp: 1.649 ± 0.248
2.198SerTyr: 2.198 ± 0.32
0.0SerXaa: 0.0 ± 0.0
Thr
4.076ThrAla: 4.076 ± 0.45
0.458ThrCys: 0.458 ± 0.167
3.389ThrAsp: 3.389 ± 0.429
3.023ThrGlu: 3.023 ± 0.344
2.931ThrPhe: 2.931 ± 0.312
4.717ThrGly: 4.717 ± 0.46
1.008ThrHis: 1.008 ± 0.201
2.931ThrIle: 2.931 ± 0.388
4.214ThrLys: 4.214 ± 0.394
4.717ThrLeu: 4.717 ± 0.487
1.053ThrMet: 1.053 ± 0.214
2.519ThrAsn: 2.519 ± 0.368
2.931ThrPro: 2.931 ± 0.36
1.878ThrGln: 1.878 ± 0.316
2.565ThrArg: 2.565 ± 0.384
3.389ThrSer: 3.389 ± 0.474
2.794ThrThr: 2.794 ± 0.465
3.847ThrVal: 3.847 ± 0.321
1.145ThrTrp: 1.145 ± 0.211
1.832ThrTyr: 1.832 ± 0.354
0.0ThrXaa: 0.0 ± 0.0
Val
5.084ValAla: 5.084 ± 0.587
0.641ValCys: 0.641 ± 0.199
4.58ValAsp: 4.58 ± 0.402
4.809ValGlu: 4.809 ± 0.485
2.427ValPhe: 2.427 ± 0.305
4.443ValGly: 4.443 ± 0.363
1.008ValHis: 1.008 ± 0.207
3.206ValIle: 3.206 ± 0.386
3.298ValLys: 3.298 ± 0.353
4.259ValLeu: 4.259 ± 0.379
1.466ValMet: 1.466 ± 0.264
2.565ValAsn: 2.565 ± 0.258
3.114ValPro: 3.114 ± 0.38
2.473ValGln: 2.473 ± 0.371
3.481ValArg: 3.481 ± 0.419
4.855ValSer: 4.855 ± 0.424
3.893ValThr: 3.893 ± 0.476
4.855ValVal: 4.855 ± 0.435
1.053ValTrp: 1.053 ± 0.232
1.74ValTyr: 1.74 ± 0.305
0.0ValXaa: 0.0 ± 0.0
Trp
1.099TrpAla: 1.099 ± 0.209
0.183TrpCys: 0.183 ± 0.097
1.191TrpAsp: 1.191 ± 0.25
1.191TrpGlu: 1.191 ± 0.238
0.55TrpPhe: 0.55 ± 0.157
1.008TrpGly: 1.008 ± 0.246
0.595TrpHis: 0.595 ± 0.172
1.008TrpIle: 1.008 ± 0.298
1.099TrpLys: 1.099 ± 0.252
1.603TrpLeu: 1.603 ± 0.275
0.275TrpMet: 0.275 ± 0.13
1.099TrpAsn: 1.099 ± 0.182
0.504TrpPro: 0.504 ± 0.168
0.916TrpGln: 0.916 ± 0.218
0.87TrpArg: 0.87 ± 0.182
1.466TrpSer: 1.466 ± 0.26
0.87TrpThr: 0.87 ± 0.211
1.328TrpVal: 1.328 ± 0.275
0.275TrpTrp: 0.275 ± 0.11
0.55TrpTyr: 0.55 ± 0.169
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.969TyrAla: 1.969 ± 0.342
0.321TyrCys: 0.321 ± 0.128
2.244TyrAsp: 2.244 ± 0.358
1.511TyrGlu: 1.511 ± 0.238
1.099TyrPhe: 1.099 ± 0.246
3.114TyrGly: 3.114 ± 0.408
0.641TyrHis: 0.641 ± 0.199
1.282TyrIle: 1.282 ± 0.316
1.695TyrLys: 1.695 ± 0.339
2.931TyrLeu: 2.931 ± 0.376
0.733TyrMet: 0.733 ± 0.192
1.328TyrAsn: 1.328 ± 0.224
1.74TyrPro: 1.74 ± 0.291
0.87TyrGln: 0.87 ± 0.193
2.656TyrArg: 2.656 ± 0.405
1.237TyrSer: 1.237 ± 0.241
1.191TyrThr: 1.191 ± 0.229
1.969TyrVal: 1.969 ± 0.246
0.458TyrTrp: 0.458 ± 0.128
0.687TyrTyr: 0.687 ± 0.161
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 127 proteins (21835 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski