Amino acid dipepetide frequency for Lactobacillus helveticus CIRM-BIA 951

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.705AlaAla: 5.705 ± 0.126
0.541AlaCys: 0.541 ± 0.032
4.376AlaAsp: 4.376 ± 0.088
4.142AlaGlu: 4.142 ± 0.101
3.163AlaPhe: 3.163 ± 0.087
5.044AlaGly: 5.044 ± 0.12
1.446AlaHis: 1.446 ± 0.051
5.915AlaIle: 5.915 ± 0.116
6.222AlaLys: 6.222 ± 0.116
6.716AlaLeu: 6.716 ± 0.118
2.018AlaMet: 2.018 ± 0.057
3.464AlaAsn: 3.464 ± 0.092
1.994AlaPro: 1.994 ± 0.066
2.904AlaGln: 2.904 ± 0.09
2.812AlaArg: 2.812 ± 0.08
4.022AlaSer: 4.022 ± 0.089
4.099AlaThr: 4.099 ± 0.092
4.996AlaVal: 4.996 ± 0.112
0.661AlaTrp: 0.661 ± 0.041
2.563AlaTyr: 2.563 ± 0.071
0.0AlaXaa: 0.0 ± 0.0
Cys
0.38CysAla: 0.38 ± 0.025
0.081CysCys: 0.081 ± 0.013
0.386CysAsp: 0.386 ± 0.029
0.301CysGlu: 0.301 ± 0.027
0.348CysPhe: 0.348 ± 0.025
0.597CysGly: 0.597 ± 0.039
0.17CysHis: 0.17 ± 0.02
0.41CysIle: 0.41 ± 0.029
0.243CysLys: 0.243 ± 0.023
0.603CysLeu: 0.603 ± 0.033
0.185CysMet: 0.185 ± 0.018
0.253CysAsn: 0.253 ± 0.022
0.275CysPro: 0.275 ± 0.025
0.228CysGln: 0.228 ± 0.021
0.223CysArg: 0.223 ± 0.021
0.455CysSer: 0.455 ± 0.029
0.277CysThr: 0.277 ± 0.024
0.345CysVal: 0.345 ± 0.025
0.062CysTrp: 0.062 ± 0.011
0.236CysTyr: 0.236 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
3.898AspAla: 3.898 ± 0.09
0.339AspCys: 0.339 ± 0.025
3.625AspAsp: 3.625 ± 0.106
4.249AspGlu: 4.249 ± 0.095
2.94AspPhe: 2.94 ± 0.069
3.668AspGly: 3.668 ± 0.093
1.427AspHis: 1.427 ± 0.052
4.033AspIle: 4.033 ± 0.083
4.713AspLys: 4.713 ± 0.119
5.883AspLeu: 5.883 ± 0.108
1.592AspMet: 1.592 ± 0.066
3.043AspAsn: 3.043 ± 0.09
2.464AspPro: 2.464 ± 0.071
3.018AspGln: 3.018 ± 0.086
2.232AspArg: 2.232 ± 0.06
3.161AspSer: 3.161 ± 0.081
2.818AspThr: 2.818 ± 0.076
3.867AspVal: 3.867 ± 0.092
0.704AspTrp: 0.704 ± 0.035
2.73AspTyr: 2.73 ± 0.078
0.0AspXaa: 0.0 ± 0.0
Glu
4.116GluAla: 4.116 ± 0.096
0.272GluCys: 0.272 ± 0.023
3.53GluAsp: 3.53 ± 0.091
3.794GluGlu: 3.794 ± 0.087
2.234GluPhe: 2.234 ± 0.066
2.872GluGly: 2.872 ± 0.083
1.152GluHis: 1.152 ± 0.045
4.522GluIle: 4.522 ± 0.103
5.497GluLys: 5.497 ± 0.117
5.732GluLeu: 5.732 ± 0.123
1.766GluMet: 1.766 ± 0.056
3.53GluAsn: 3.53 ± 0.092
1.603GluPro: 1.603 ± 0.056
2.361GluGln: 2.361 ± 0.076
2.335GluArg: 2.335 ± 0.07
2.627GluSer: 2.627 ± 0.076
2.786GluThr: 2.786 ± 0.075
3.831GluVal: 3.831 ± 0.092
0.532GluTrp: 0.532 ± 0.031
1.968GluTyr: 1.968 ± 0.066
0.0GluXaa: 0.0 ± 0.0
Phe
3.256PheAla: 3.256 ± 0.081
0.335PheCys: 0.335 ± 0.027
2.973PheAsp: 2.973 ± 0.075
2.223PheGlu: 2.223 ± 0.07
2.123PhePhe: 2.123 ± 0.07
3.037PheGly: 3.037 ± 0.078
0.903PheHis: 0.903 ± 0.046
3.258PheIle: 3.258 ± 0.093
3.262PheLys: 3.262 ± 0.077
4.101PheLeu: 4.101 ± 0.114
1.185PheMet: 1.185 ± 0.051
2.535PheAsn: 2.535 ± 0.075
1.38PhePro: 1.38 ± 0.043
1.095PheGln: 1.095 ± 0.052
1.331PheArg: 1.331 ± 0.051
2.973PheSer: 2.973 ± 0.077
2.49PheThr: 2.49 ± 0.077
2.983PheVal: 2.983 ± 0.086
0.594PheTrp: 0.594 ± 0.032
1.751PheTyr: 1.751 ± 0.058
0.0PheXaa: 0.0 ± 0.0
Gly
4.342GlyAla: 4.342 ± 0.093
0.403GlyCys: 0.403 ± 0.028
3.436GlyAsp: 3.436 ± 0.093
3.406GlyGlu: 3.406 ± 0.084
2.951GlyPhe: 2.951 ± 0.073
3.953GlyGly: 3.953 ± 0.111
1.543GlyHis: 1.543 ± 0.054
5.413GlyIle: 5.413 ± 0.118
5.468GlyLys: 5.468 ± 0.113
6.029GlyLeu: 6.029 ± 0.12
2.054GlyMet: 2.054 ± 0.07
2.988GlyAsn: 2.988 ± 0.071
1.47GlyPro: 1.47 ± 0.067
2.56GlyGln: 2.56 ± 0.079
2.548GlyArg: 2.548 ± 0.078
3.779GlySer: 3.779 ± 0.079
3.687GlyThr: 3.687 ± 0.091
4.563GlyVal: 4.563 ± 0.113
0.753GlyTrp: 0.753 ± 0.044
2.724GlyTyr: 2.724 ± 0.072
0.0GlyXaa: 0.0 ± 0.0
His
1.384HisAla: 1.384 ± 0.051
0.137HisCys: 0.137 ± 0.014
1.431HisAsp: 1.431 ± 0.05
1.262HisGlu: 1.262 ± 0.047
1.097HisPhe: 1.097 ± 0.048
1.593HisGly: 1.593 ± 0.056
0.719HisHis: 0.719 ± 0.035
1.382HisIle: 1.382 ± 0.046
1.311HisLys: 1.311 ± 0.048
1.93HisLeu: 1.93 ± 0.055
0.573HisMet: 0.573 ± 0.034
1.107HisAsn: 1.107 ± 0.045
0.966HisPro: 0.966 ± 0.047
0.873HisGln: 0.873 ± 0.041
0.899HisArg: 0.899 ± 0.041
1.118HisSer: 1.118 ± 0.046
1.009HisThr: 1.009 ± 0.044
1.468HisVal: 1.468 ± 0.05
0.279HisTrp: 0.279 ± 0.026
1.02HisTyr: 1.02 ± 0.044
0.0HisXaa: 0.0 ± 0.0
Ile
6.128IleAla: 6.128 ± 0.112
0.624IleCys: 0.624 ± 0.033
4.76IleAsp: 4.76 ± 0.099
3.928IleGlu: 3.928 ± 0.077
3.412IlePhe: 3.412 ± 0.1
5.306IleGly: 5.306 ± 0.102
1.337IleHis: 1.337 ± 0.056
5.838IleIle: 5.838 ± 0.13
5.973IleLys: 5.973 ± 0.113
6.767IleLeu: 6.767 ± 0.156
1.964IleMet: 1.964 ± 0.062
4.264IleAsn: 4.264 ± 0.096
2.958IlePro: 2.958 ± 0.074
2.354IleGln: 2.354 ± 0.066
2.657IleArg: 2.657 ± 0.075
4.943IleSer: 4.943 ± 0.109
4.277IleThr: 4.277 ± 0.098
5.282IleVal: 5.282 ± 0.106
0.71IleTrp: 0.71 ± 0.04
2.642IleTyr: 2.642 ± 0.089
0.0IleXaa: 0.0 ± 0.0
Lys
5.316LysAla: 5.316 ± 0.128
0.311LysCys: 0.311 ± 0.03
5.114LysAsp: 5.114 ± 0.106
5.241LysGlu: 5.241 ± 0.132
2.779LysPhe: 2.779 ± 0.079
3.992LysGly: 3.992 ± 0.094
1.732LysHis: 1.732 ± 0.055
6.115LysIle: 6.115 ± 0.117
8.383LysLys: 8.383 ± 0.143
7.149LysLeu: 7.149 ± 0.134
2.82LysMet: 2.82 ± 0.068
5.101LysAsn: 5.101 ± 0.116
2.636LysPro: 2.636 ± 0.076
3.642LysGln: 3.642 ± 0.097
3.614LysArg: 3.614 ± 0.093
4.073LysSer: 4.073 ± 0.108
4.367LysThr: 4.367 ± 0.097
4.996LysVal: 4.996 ± 0.107
0.687LysTrp: 0.687 ± 0.041
3.346LysTyr: 3.346 ± 0.076
0.0LysXaa: 0.0 ± 0.0
Leu
7.686LeuAla: 7.686 ± 0.134
0.543LeuCys: 0.543 ± 0.03
5.514LeuAsp: 5.514 ± 0.109
4.578LeuGlu: 4.578 ± 0.111
3.981LeuPhe: 3.981 ± 0.117
6.007LeuGly: 6.007 ± 0.116
1.908LeuHis: 1.908 ± 0.057
7.437LeuIle: 7.437 ± 0.151
7.151LeuLys: 7.151 ± 0.112
8.4LeuLeu: 8.4 ± 0.176
2.438LeuMet: 2.438 ± 0.068
5.14LeuAsn: 5.14 ± 0.107
3.623LeuPro: 3.623 ± 0.086
3.179LeuGln: 3.179 ± 0.094
3.625LeuArg: 3.625 ± 0.095
6.074LeuSer: 6.074 ± 0.099
5.84LeuThr: 5.84 ± 0.1
6.293LeuVal: 6.293 ± 0.131
0.775LeuTrp: 0.775 ± 0.039
2.784LeuTyr: 2.784 ± 0.069
0.0LeuXaa: 0.0 ± 0.0
Met
2.253MetAla: 2.253 ± 0.067
0.159MetCys: 0.159 ± 0.015
1.455MetAsp: 1.455 ± 0.053
1.219MetGlu: 1.219 ± 0.048
1.067MetPhe: 1.067 ± 0.046
1.702MetGly: 1.702 ± 0.058
0.595MetHis: 0.595 ± 0.032
2.183MetIle: 2.183 ± 0.076
2.363MetLys: 2.363 ± 0.064
2.475MetLeu: 2.475 ± 0.073
0.824MetMet: 0.824 ± 0.038
1.711MetAsn: 1.711 ± 0.06
1.251MetPro: 1.251 ± 0.049
1.217MetGln: 1.217 ± 0.047
1.122MetArg: 1.122 ± 0.042
1.638MetSer: 1.638 ± 0.062
1.805MetThr: 1.805 ± 0.056
1.777MetVal: 1.777 ± 0.061
0.21MetTrp: 0.21 ± 0.021
0.762MetTyr: 0.762 ± 0.041
0.0MetXaa: 0.0 ± 0.0
Asn
3.722AsnAla: 3.722 ± 0.089
0.345AsnCys: 0.345 ± 0.028
3.134AsnAsp: 3.134 ± 0.084
3.082AsnGlu: 3.082 ± 0.092
2.406AsnPhe: 2.406 ± 0.074
3.923AsnGly: 3.923 ± 0.093
1.219AsnHis: 1.219 ± 0.049
3.797AsnIle: 3.797 ± 0.09
4.365AsnLys: 4.365 ± 0.101
5.054AsnLeu: 5.054 ± 0.111
1.475AsnMet: 1.475 ± 0.056
3.103AsnAsn: 3.103 ± 0.09
2.337AsnPro: 2.337 ± 0.067
2.311AsnGln: 2.311 ± 0.082
2.02AsnArg: 2.02 ± 0.054
3.178AsnSer: 3.178 ± 0.096
2.61AsnThr: 2.61 ± 0.073
3.348AsnVal: 3.348 ± 0.078
0.689AsnTrp: 0.689 ± 0.034
2.329AsnTyr: 2.329 ± 0.069
0.0AsnXaa: 0.0 ± 0.0
Pro
2.475ProAla: 2.475 ± 0.068
0.144ProCys: 0.144 ± 0.016
2.498ProAsp: 2.498 ± 0.076
2.837ProGlu: 2.837 ± 0.077
1.642ProPhe: 1.642 ± 0.062
2.133ProGly: 2.133 ± 0.064
0.721ProHis: 0.721 ± 0.035
2.532ProIle: 2.532 ± 0.078
2.713ProLys: 2.713 ± 0.085
2.829ProLeu: 2.829 ± 0.074
0.753ProMet: 0.753 ± 0.041
1.94ProAsn: 1.94 ± 0.071
0.498ProPro: 0.498 ± 0.029
1.331ProGln: 1.331 ± 0.046
1.108ProArg: 1.108 ± 0.048
1.927ProSer: 1.927 ± 0.058
2.047ProThr: 2.047 ± 0.068
2.724ProVal: 2.724 ± 0.072
0.315ProTrp: 0.315 ± 0.024
1.318ProTyr: 1.318 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
2.938GlnAla: 2.938 ± 0.077
0.15GlnCys: 0.15 ± 0.017
2.123GlnAsp: 2.123 ± 0.067
2.299GlnGlu: 2.299 ± 0.074
1.496GlnPhe: 1.496 ± 0.05
2.161GlnGly: 2.161 ± 0.06
0.753GlnHis: 0.753 ± 0.04
3.348GlnIle: 3.348 ± 0.085
3.707GlnLys: 3.707 ± 0.092
3.775GlnLeu: 3.775 ± 0.11
1.21GlnMet: 1.21 ± 0.047
2.234GlnAsn: 2.234 ± 0.067
1.161GlnPro: 1.161 ± 0.045
1.49GlnGln: 1.49 ± 0.059
1.556GlnArg: 1.556 ± 0.055
1.914GlnSer: 1.914 ± 0.074
2.174GlnThr: 2.174 ± 0.074
2.769GlnVal: 2.769 ± 0.073
0.337GlnTrp: 0.337 ± 0.026
1.442GlnTyr: 1.442 ± 0.055
0.0GlnXaa: 0.0 ± 0.0
Arg
2.46ArgAla: 2.46 ± 0.072
0.219ArgCys: 0.219 ± 0.023
2.144ArgAsp: 2.144 ± 0.068
2.434ArgGlu: 2.434 ± 0.066
1.642ArgPhe: 1.642 ± 0.057
2.221ArgGly: 2.221 ± 0.076
0.97ArgHis: 0.97 ± 0.044
2.964ArgIle: 2.964 ± 0.071
3.247ArgLys: 3.247 ± 0.089
3.567ArgLeu: 3.567 ± 0.087
1.185ArgMet: 1.185 ± 0.053
2.101ArgAsn: 2.101 ± 0.068
1.365ArgPro: 1.365 ± 0.056
1.586ArgGln: 1.586 ± 0.057
2.142ArgArg: 2.142 ± 0.084
2.121ArgSer: 2.121 ± 0.068
1.871ArgThr: 1.871 ± 0.07
2.599ArgVal: 2.599 ± 0.078
0.303ArgTrp: 0.303 ± 0.023
1.762ArgTyr: 1.762 ± 0.064
0.0ArgXaa: 0.0 ± 0.0
Ser
3.968SerAla: 3.968 ± 0.096
0.356SerCys: 0.356 ± 0.025
3.571SerAsp: 3.571 ± 0.083
3.155SerGlu: 3.155 ± 0.07
2.812SerPhe: 2.812 ± 0.079
4.275SerGly: 4.275 ± 0.098
1.234SerHis: 1.234 ± 0.049
4.08SerIle: 4.08 ± 0.093
4.192SerLys: 4.192 ± 0.093
5.584SerLeu: 5.584 ± 0.113
1.586SerMet: 1.586 ± 0.054
3.048SerAsn: 3.048 ± 0.073
1.786SerPro: 1.786 ± 0.062
2.196SerGln: 2.196 ± 0.062
2.209SerArg: 2.209 ± 0.061
4.114SerSer: 4.114 ± 0.137
3.266SerThr: 3.266 ± 0.088
3.662SerVal: 3.662 ± 0.089
0.678SerTrp: 0.678 ± 0.032
2.384SerTyr: 2.384 ± 0.064
0.0SerXaa: 0.0 ± 0.0
Thr
4.288ThrAla: 4.288 ± 0.092
0.3ThrCys: 0.3 ± 0.024
3.2ThrAsp: 3.2 ± 0.08
2.87ThrGlu: 2.87 ± 0.066
2.299ThrPhe: 2.299 ± 0.07
3.992ThrGly: 3.992 ± 0.089
1.069ThrHis: 1.069 ± 0.043
4.546ThrIle: 4.546 ± 0.077
4.299ThrLys: 4.299 ± 0.102
4.895ThrLeu: 4.895 ± 0.105
1.294ThrMet: 1.294 ± 0.055
2.829ThrAsn: 2.829 ± 0.073
2.378ThrPro: 2.378 ± 0.068
1.887ThrGln: 1.887 ± 0.06
1.929ThrArg: 1.929 ± 0.05
3.228ThrSer: 3.228 ± 0.083
3.427ThrThr: 3.427 ± 0.082
3.936ThrVal: 3.936 ± 0.098
0.53ThrTrp: 0.53 ± 0.033
2.037ThrTyr: 2.037 ± 0.064
0.0ThrXaa: 0.0 ± 0.0
Val
5.398ValAla: 5.398 ± 0.109
0.436ValCys: 0.436 ± 0.03
4.147ValAsp: 4.147 ± 0.086
3.636ValGlu: 3.636 ± 0.093
2.829ValPhe: 2.829 ± 0.073
4.391ValGly: 4.391 ± 0.105
1.337ValHis: 1.337 ± 0.047
5.228ValIle: 5.228 ± 0.11
5.52ValLys: 5.52 ± 0.109
6.261ValLeu: 6.261 ± 0.134
1.719ValMet: 1.719 ± 0.058
3.604ValAsn: 3.604 ± 0.087
2.556ValPro: 2.556 ± 0.074
2.352ValGln: 2.352 ± 0.069
2.361ValArg: 2.361 ± 0.068
3.973ValSer: 3.973 ± 0.085
3.917ValThr: 3.917 ± 0.079
5.044ValVal: 5.044 ± 0.107
0.595ValTrp: 0.595 ± 0.032
2.258ValTyr: 2.258 ± 0.068
0.0ValXaa: 0.0 ± 0.0
Trp
0.622TrpAla: 0.622 ± 0.043
0.084TrpCys: 0.084 ± 0.012
0.547TrpAsp: 0.547 ± 0.037
0.356TrpGlu: 0.356 ± 0.028
0.5TrpPhe: 0.5 ± 0.038
0.682TrpGly: 0.682 ± 0.043
0.296TrpHis: 0.296 ± 0.025
0.805TrpIle: 0.805 ± 0.037
0.582TrpLys: 0.582 ± 0.035
1.18TrpLeu: 1.18 ± 0.056
0.288TrpMet: 0.288 ± 0.026
0.536TrpAsn: 0.536 ± 0.035
0.29TrpPro: 0.29 ± 0.023
0.592TrpGln: 0.592 ± 0.032
0.373TrpArg: 0.373 ± 0.029
0.592TrpSer: 0.592 ± 0.031
0.438TrpThr: 0.438 ± 0.028
0.622TrpVal: 0.622 ± 0.037
0.135TrpTrp: 0.135 ± 0.015
0.453TrpTyr: 0.453 ± 0.033
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.468TyrAla: 2.468 ± 0.059
0.283TyrCys: 0.283 ± 0.022
2.44TyrAsp: 2.44 ± 0.072
2.045TyrGlu: 2.045 ± 0.067
2.067TyrPhe: 2.067 ± 0.054
2.52TyrGly: 2.52 ± 0.071
1.028TyrHis: 1.028 ± 0.049
2.316TyrIle: 2.316 ± 0.073
2.2TyrLys: 2.2 ± 0.08
4.05TyrLeu: 4.05 ± 0.094
0.858TyrMet: 0.858 ± 0.039
1.917TyrAsn: 1.917 ± 0.056
1.492TyrPro: 1.492 ± 0.051
1.859TyrGln: 1.859 ± 0.061
1.807TyrArg: 1.807 ± 0.062
2.247TyrSer: 2.247 ± 0.068
2.03TyrThr: 2.03 ± 0.074
2.46TyrVal: 2.46 ± 0.062
0.423TyrTrp: 0.423 ± 0.029
1.651TyrTyr: 1.651 ± 0.059
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2181 proteins (534064 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski