Amino acid dipepetide frequency for RML-105355 virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.4AlaAla: 4.4 ± 2.558
1.925AlaCys: 1.925 ± 1.308
1.925AlaAsp: 1.925 ± 0.967
2.75AlaGlu: 2.75 ± 0.935
1.925AlaPhe: 1.925 ± 1.314
2.475AlaGly: 2.475 ± 1.8
0.825AlaHis: 0.825 ± 0.424
5.226AlaIle: 5.226 ± 0.764
2.475AlaLys: 2.475 ± 0.791
5.501AlaLeu: 5.501 ± 0.916
0.55AlaMet: 0.55 ± 0.728
2.475AlaAsn: 2.475 ± 1.455
1.925AlaPro: 1.925 ± 0.492
1.1AlaGln: 1.1 ± 0.525
3.025AlaArg: 3.025 ± 1.778
4.675AlaSer: 4.675 ± 1.107
1.925AlaThr: 1.925 ± 0.733
3.575AlaVal: 3.575 ± 0.233
0.825AlaTrp: 0.825 ± 0.185
1.925AlaTyr: 1.925 ± 0.927
0.0AlaXaa: 0.0 ± 0.0
Cys
1.1CysAla: 1.1 ± 0.888
0.275CysCys: 0.275 ± 0.28
0.825CysAsp: 0.825 ± 0.47
1.1CysGlu: 1.1 ± 0.355
1.925CysPhe: 1.925 ± 1.16
1.375CysGly: 1.375 ± 0.326
1.375CysHis: 1.375 ± 0.326
2.75CysIle: 2.75 ± 0.925
2.475CysLys: 2.475 ± 0.962
2.2CysLeu: 2.2 ± 0.792
1.1CysMet: 1.1 ± 0.533
1.1CysAsn: 1.1 ± 1.121
1.1CysPro: 1.1 ± 0.719
1.375CysGln: 1.375 ± 0.821
1.1CysArg: 1.1 ± 0.572
3.3CysSer: 3.3 ± 1.869
1.1CysThr: 1.1 ± 1.121
0.825CysVal: 0.825 ± 0.841
0.275CysTrp: 0.275 ± 0.28
0.55CysTyr: 0.55 ± 0.571
0.0CysXaa: 0.0 ± 0.0
Asp
3.85AspAla: 3.85 ± 1.102
1.65AspCys: 1.65 ± 1.045
4.4AspAsp: 4.4 ± 0.676
3.025AspGlu: 3.025 ± 0.881
2.75AspPhe: 2.75 ± 0.887
3.3AspGly: 3.3 ± 1.51
1.65AspHis: 1.65 ± 0.943
3.575AspIle: 3.575 ± 1.445
2.2AspLys: 2.2 ± 0.81
6.326AspLeu: 6.326 ± 1.209
1.375AspMet: 1.375 ± 0.433
2.2AspAsn: 2.2 ± 0.44
3.3AspPro: 3.3 ± 0.803
1.65AspGln: 1.65 ± 0.478
1.65AspArg: 1.65 ± 0.369
3.575AspSer: 3.575 ± 2.044
3.575AspThr: 3.575 ± 1.009
4.4AspVal: 4.4 ± 1.384
0.825AspTrp: 0.825 ± 0.47
1.925AspTyr: 1.925 ± 0.552
0.0AspXaa: 0.0 ± 0.0
Glu
2.75GluAla: 2.75 ± 0.528
2.475GluCys: 2.475 ± 1.456
4.95GluAsp: 4.95 ± 2.099
5.226GluGlu: 5.226 ± 1.748
4.125GluPhe: 4.125 ± 0.873
1.925GluGly: 1.925 ± 0.336
1.1GluHis: 1.1 ± 0.954
3.575GluIle: 3.575 ± 0.662
2.75GluLys: 2.75 ± 1.312
2.475GluLeu: 2.475 ± 0.364
2.475GluMet: 2.475 ± 1.414
1.65GluAsn: 1.65 ± 0.425
1.65GluPro: 1.65 ± 0.425
3.3GluGln: 3.3 ± 0.816
4.675GluArg: 4.675 ± 1.883
3.575GluSer: 3.575 ± 0.95
3.85GluThr: 3.85 ± 0.373
3.85GluVal: 3.85 ± 1.478
1.375GluTrp: 1.375 ± 0.326
2.75GluTyr: 2.75 ± 0.935
0.0GluXaa: 0.0 ± 0.0
Phe
1.925PheAla: 1.925 ± 0.78
1.1PheCys: 1.1 ± 0.355
1.925PheAsp: 1.925 ± 0.544
1.65PheGlu: 1.65 ± 0.581
2.75PhePhe: 2.75 ± 1.572
3.025PheGly: 3.025 ± 0.479
1.65PheHis: 1.65 ± 0.581
2.75PheIle: 2.75 ± 0.528
4.4PheLys: 4.4 ± 1.445
5.501PheLeu: 5.501 ± 1.97
1.1PheMet: 1.1 ± 0.355
3.3PheAsn: 3.3 ± 0.879
2.475PhePro: 2.475 ± 1.137
3.85PheGln: 3.85 ± 1.209
2.2PheArg: 2.2 ± 0.375
4.4PheSer: 4.4 ± 0.822
3.025PheThr: 3.025 ± 0.398
1.375PheVal: 1.375 ± 1.041
1.65PheTrp: 1.65 ± 0.369
1.375PheTyr: 1.375 ± 0.433
0.0PheXaa: 0.0 ± 0.0
Gly
1.925GlyAla: 1.925 ± 0.464
0.825GlyCys: 0.825 ± 0.185
2.475GlyAsp: 2.475 ± 0.412
2.75GlyGlu: 2.75 ± 0.925
3.025GlyPhe: 3.025 ± 0.793
2.75GlyGly: 2.75 ± 0.865
0.55GlyHis: 0.55 ± 0.56
3.3GlyIle: 3.3 ± 0.651
3.025GlyLys: 3.025 ± 0.516
6.051GlyLeu: 6.051 ± 1.39
1.375GlyMet: 1.375 ± 0.545
1.925GlyAsn: 1.925 ± 0.529
1.1GlyPro: 1.1 ± 0.293
1.65GlyGln: 1.65 ± 0.478
2.2GlyArg: 2.2 ± 0.612
5.226GlySer: 5.226 ± 1.158
1.925GlyThr: 1.925 ± 0.927
4.125GlyVal: 4.125 ± 1.045
1.65GlyTrp: 1.65 ± 1.162
1.925GlyTyr: 1.925 ± 0.733
0.0GlyXaa: 0.0 ± 0.0
His
1.1HisAla: 1.1 ± 0.293
0.55HisCys: 0.55 ± 0.178
0.275HisAsp: 0.275 ± 0.157
0.825HisGlu: 0.825 ± 0.471
2.2HisPhe: 2.2 ± 0.44
2.2HisGly: 2.2 ± 0.586
1.375HisHis: 1.375 ± 0.786
1.65HisIle: 1.65 ± 0.369
1.1HisLys: 1.1 ± 0.355
2.75HisLeu: 2.75 ± 0.746
0.55HisMet: 0.55 ± 0.314
1.1HisAsn: 1.1 ± 0.362
1.375HisPro: 1.375 ± 0.786
0.275HisGln: 0.275 ± 0.509
2.2HisArg: 2.2 ± 0.45
2.475HisSer: 2.475 ± 1.044
1.1HisThr: 1.1 ± 0.355
1.925HisVal: 1.925 ± 0.492
0.55HisTrp: 0.55 ± 0.314
0.825HisTyr: 0.825 ± 0.185
0.0HisXaa: 0.0 ± 0.0
Ile
3.3IleAla: 3.3 ± 0.735
2.2IleCys: 2.2 ± 0.44
4.125IleAsp: 4.125 ± 1.036
3.025IleGlu: 3.025 ± 0.774
1.925IlePhe: 1.925 ± 0.464
3.3IleGly: 3.3 ± 0.442
2.2IleHis: 2.2 ± 0.711
7.426IleIle: 7.426 ± 1.336
4.675IleLys: 4.675 ± 0.711
6.601IleLeu: 6.601 ± 0.728
1.1IleMet: 1.1 ± 0.629
2.2IleAsn: 2.2 ± 0.655
3.025IlePro: 3.025 ± 0.679
1.925IleGln: 1.925 ± 0.919
3.85IleArg: 3.85 ± 0.791
9.351IleSer: 9.351 ± 4.32
4.675IleThr: 4.675 ± 1.306
2.75IleVal: 2.75 ± 0.81
1.375IleTrp: 1.375 ± 1.295
1.925IleTyr: 1.925 ± 0.809
0.0IleXaa: 0.0 ± 0.0
Lys
3.3LysAla: 3.3 ± 1.319
1.65LysCys: 1.65 ± 1.681
3.3LysAsp: 3.3 ± 1.15
3.3LysGlu: 3.3 ± 0.735
3.025LysPhe: 3.025 ± 1.012
2.2LysGly: 2.2 ± 0.45
1.65LysHis: 1.65 ± 0.759
4.675LysIle: 4.675 ± 0.76
7.976LysLys: 7.976 ± 2.669
6.326LysLeu: 6.326 ± 0.372
2.475LysMet: 2.475 ± 1.908
1.65LysAsn: 1.65 ± 0.533
2.475LysPro: 2.475 ± 0.722
1.375LysGln: 1.375 ± 0.362
3.85LysArg: 3.85 ± 1.084
6.326LysSer: 6.326 ± 1.498
3.575LysThr: 3.575 ± 0.618
4.125LysVal: 4.125 ± 0.64
1.1LysTrp: 1.1 ± 0.525
0.825LysTyr: 0.825 ± 0.471
0.0LysXaa: 0.0 ± 0.0
Leu
3.025LeuAla: 3.025 ± 0.467
1.925LeuCys: 1.925 ± 0.809
6.326LeuAsp: 6.326 ± 0.697
9.076LeuGlu: 9.076 ± 2.273
5.226LeuPhe: 5.226 ± 0.939
5.776LeuGly: 5.776 ± 1.026
2.2LeuHis: 2.2 ± 0.655
6.051LeuIle: 6.051 ± 1.96
6.876LeuLys: 6.876 ± 0.674
7.701LeuLeu: 7.701 ± 0.746
3.3LeuMet: 3.3 ± 0.651
2.475LeuAsn: 2.475 ± 0.412
3.3LeuPro: 3.3 ± 0.955
2.75LeuGln: 2.75 ± 0.67
6.601LeuArg: 6.601 ± 0.845
10.451LeuSer: 10.451 ± 2.022
4.95LeuThr: 4.95 ± 1.902
4.4LeuVal: 4.4 ± 0.609
1.65LeuTrp: 1.65 ± 0.581
1.1LeuTyr: 1.1 ± 0.643
0.0LeuXaa: 0.0 ± 0.0
Met
1.925MetAla: 1.925 ± 0.859
0.275MetCys: 0.275 ± 0.157
0.55MetAsp: 0.55 ± 0.314
1.1MetGlu: 1.1 ± 0.533
3.025MetPhe: 3.025 ± 0.661
1.65MetGly: 1.65 ± 0.919
1.1MetHis: 1.1 ± 0.624
2.2MetIle: 2.2 ± 1.066
0.825MetLys: 0.825 ± 0.461
2.75MetLeu: 2.75 ± 0.528
2.475MetMet: 2.475 ± 0.707
1.1MetAsn: 1.1 ± 0.572
1.1MetPro: 1.1 ± 0.381
0.275MetGln: 0.275 ± 0.157
1.1MetArg: 1.1 ± 0.525
1.925MetSer: 1.925 ± 0.829
1.925MetThr: 1.925 ± 0.544
1.375MetVal: 1.375 ± 0.454
0.0MetTrp: 0.0 ± 0.0
0.55MetTyr: 0.55 ± 0.314
0.0MetXaa: 0.0 ± 0.0
Asn
2.475AsnAla: 2.475 ± 0.772
1.65AsnCys: 1.65 ± 0.533
1.925AsnAsp: 1.925 ± 0.336
1.925AsnGlu: 1.925 ± 0.787
1.65AsnPhe: 1.65 ± 0.369
1.65AsnGly: 1.65 ± 0.533
1.1AsnHis: 1.1 ± 0.293
2.475AsnIle: 2.475 ± 0.723
1.925AsnLys: 1.925 ± 0.773
3.3AsnLeu: 3.3 ± 1.103
0.55AsnMet: 0.55 ± 0.56
1.925AsnAsn: 1.925 ± 0.91
2.475AsnPro: 2.475 ± 0.664
3.85AsnGln: 3.85 ± 0.552
1.65AsnArg: 1.65 ± 0.402
3.85AsnSer: 3.85 ± 0.984
2.475AsnThr: 2.475 ± 0.867
1.65AsnVal: 1.65 ± 0.425
1.1AsnTrp: 1.1 ± 0.362
0.275AsnTyr: 0.275 ± 0.28
0.0AsnXaa: 0.0 ± 0.0
Pro
3.575ProAla: 3.575 ± 0.233
0.55ProCys: 0.55 ± 0.178
3.025ProAsp: 3.025 ± 0.398
4.125ProGlu: 4.125 ± 0.792
3.025ProPhe: 3.025 ± 0.661
1.925ProGly: 1.925 ± 0.927
0.55ProHis: 0.55 ± 0.178
3.3ProIle: 3.3 ± 0.804
2.475ProLys: 2.475 ± 0.466
3.025ProLeu: 3.025 ± 1.284
0.825ProMet: 0.825 ± 0.424
1.65ProAsn: 1.65 ± 0.533
1.65ProPro: 1.65 ± 0.371
1.375ProGln: 1.375 ± 0.433
1.925ProArg: 1.925 ± 0.493
2.75ProSer: 2.75 ± 0.923
2.475ProThr: 2.475 ± 0.67
0.825ProVal: 0.825 ± 0.459
0.825ProTrp: 0.825 ± 0.461
0.55ProTyr: 0.55 ± 0.178
0.0ProXaa: 0.0 ± 0.0
Gln
1.65GlnAla: 1.65 ± 1.319
1.65GlnCys: 1.65 ± 1.277
1.65GlnAsp: 1.65 ± 0.402
3.575GlnGlu: 3.575 ± 0.233
0.275GlnPhe: 0.275 ± 0.157
2.2GlnGly: 2.2 ± 1.032
1.375GlnHis: 1.375 ± 0.433
0.825GlnIle: 0.825 ± 0.459
3.85GlnLys: 3.85 ± 1.535
3.3GlnLeu: 3.3 ± 0.697
1.1GlnMet: 1.1 ± 0.532
1.65GlnAsn: 1.65 ± 0.94
1.925GlnPro: 1.925 ± 0.544
0.825GlnGln: 0.825 ± 0.185
1.375GlnArg: 1.375 ± 0.433
2.75GlnSer: 2.75 ± 0.528
2.2GlnThr: 2.2 ± 0.762
1.925GlnVal: 1.925 ± 0.464
0.0GlnTrp: 0.0 ± 0.0
0.55GlnTyr: 0.55 ± 0.436
0.0GlnXaa: 0.0 ± 0.0
Arg
4.4ArgAla: 4.4 ± 1.051
1.925ArgCys: 1.925 ± 0.552
3.575ArgAsp: 3.575 ± 0.46
2.2ArgGlu: 2.2 ± 1.051
2.75ArgPhe: 2.75 ± 0.887
2.75ArgGly: 2.75 ± 1.324
0.825ArgHis: 0.825 ± 0.841
4.4ArgIle: 4.4 ± 0.98
2.2ArgLys: 2.2 ± 1.29
5.776ArgLeu: 5.776 ± 0.795
1.925ArgMet: 1.925 ± 0.336
2.75ArgAsn: 2.75 ± 0.731
2.2ArgPro: 2.2 ± 1.051
1.375ArgGln: 1.375 ± 0.786
3.3ArgArg: 3.3 ± 0.839
3.025ArgSer: 3.025 ± 0.678
3.3ArgThr: 3.3 ± 0.137
3.575ArgVal: 3.575 ± 1.029
0.825ArgTrp: 0.825 ± 0.471
2.2ArgTyr: 2.2 ± 0.836
0.0ArgXaa: 0.0 ± 0.0
Ser
3.025SerAla: 3.025 ± 0.705
2.475SerCys: 2.475 ± 2.174
6.051SerAsp: 6.051 ± 0.461
5.501SerGlu: 5.501 ± 0.791
4.125SerPhe: 4.125 ± 1.688
4.125SerGly: 4.125 ± 0.625
2.475SerHis: 2.475 ± 0.664
6.326SerIle: 6.326 ± 2.165
6.326SerLys: 6.326 ± 1.676
9.076SerLeu: 9.076 ± 0.822
1.65SerMet: 1.65 ± 0.667
2.75SerAsn: 2.75 ± 0.404
4.95SerPro: 4.95 ± 1.17
2.2SerGln: 2.2 ± 0.711
6.601SerArg: 6.601 ± 1.363
7.976SerSer: 7.976 ± 1.274
5.501SerThr: 5.501 ± 1.73
3.85SerVal: 3.85 ± 1.574
1.65SerTrp: 1.65 ± 0.681
2.475SerTyr: 2.475 ± 0.457
0.0SerXaa: 0.0 ± 0.0
Thr
3.575ThrAla: 3.575 ± 1.205
1.925ThrCys: 1.925 ± 0.91
3.575ThrAsp: 3.575 ± 1.528
4.4ThrGlu: 4.4 ± 0.676
3.3ThrPhe: 3.3 ± 0.496
3.025ThrGly: 3.025 ± 1.012
1.375ThrHis: 1.375 ± 0.476
5.776ThrIle: 5.776 ± 1.231
2.75ThrLys: 2.75 ± 0.56
5.776ThrLeu: 5.776 ± 0.884
1.1ThrMet: 1.1 ± 0.293
3.85ThrAsn: 3.85 ± 0.928
1.375ThrPro: 1.375 ± 0.433
1.375ThrGln: 1.375 ± 0.617
2.475ThrArg: 2.475 ± 0.791
4.4ThrSer: 4.4 ± 0.999
3.025ThrThr: 3.025 ± 0.679
3.025ThrVal: 3.025 ± 1.138
0.55ThrTrp: 0.55 ± 0.178
1.65ThrTyr: 1.65 ± 0.371
0.0ThrXaa: 0.0 ± 0.0
Val
3.025ValAla: 3.025 ± 0.774
1.375ValCys: 1.375 ± 0.613
4.4ValAsp: 4.4 ± 0.433
3.575ValGlu: 3.575 ± 0.647
1.375ValPhe: 1.375 ± 0.617
1.375ValGly: 1.375 ± 0.476
1.65ValHis: 1.65 ± 0.533
2.2ValIle: 2.2 ± 0.45
4.125ValLys: 4.125 ± 0.986
4.675ValLeu: 4.675 ± 0.774
0.55ValMet: 0.55 ± 0.436
1.925ValAsn: 1.925 ± 0.47
1.65ValPro: 1.65 ± 0.681
2.475ValGln: 2.475 ± 0.466
2.75ValArg: 2.75 ± 1.728
6.051ValSer: 6.051 ± 0.526
3.575ValThr: 3.575 ± 1.029
6.326ValVal: 6.326 ± 1.375
1.375ValTrp: 1.375 ± 0.326
1.65ValTyr: 1.65 ± 0.533
0.0ValXaa: 0.0 ± 0.0
Trp
1.1TrpAla: 1.1 ± 1.121
0.55TrpCys: 0.55 ± 0.314
1.375TrpAsp: 1.375 ± 0.613
0.55TrpGlu: 0.55 ± 1.018
2.475TrpPhe: 2.475 ± 0.364
1.375TrpGly: 1.375 ± 0.326
0.0TrpHis: 0.0 ± 0.0
1.1TrpIle: 1.1 ± 0.629
0.55TrpLys: 0.55 ± 0.56
2.75TrpLeu: 2.75 ± 0.528
0.55TrpMet: 0.55 ± 0.178
0.275TrpAsn: 0.275 ± 0.157
0.825TrpPro: 0.825 ± 1.045
0.825TrpGln: 0.825 ± 0.185
0.825TrpArg: 0.825 ± 0.471
0.55TrpSer: 0.55 ± 0.571
1.65TrpThr: 1.65 ± 0.478
0.55TrpVal: 0.55 ± 0.436
0.0TrpTrp: 0.0 ± 0.0
0.275TrpTyr: 0.275 ± 0.157
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
0.275TyrCys: 0.275 ± 0.28
0.55TyrAsp: 0.55 ± 0.178
0.825TyrGlu: 0.825 ± 0.471
0.55TyrPhe: 0.55 ± 0.56
1.65TyrGly: 1.65 ± 0.83
1.375TyrHis: 1.375 ± 0.433
1.375TyrIle: 1.375 ± 0.617
2.2TyrLys: 2.2 ± 0.375
3.3TyrLeu: 3.3 ± 0.851
0.825TyrMet: 0.825 ± 0.459
1.925TyrAsn: 1.925 ± 0.492
0.55TyrPro: 0.55 ± 0.436
0.825TyrGln: 0.825 ± 0.66
1.925TyrArg: 1.925 ± 0.315
2.475TyrSer: 2.475 ± 0.664
2.475TyrThr: 2.475 ± 0.722
1.65TyrVal: 1.65 ± 0.83
0.55TyrTrp: 0.55 ± 0.571
0.275TyrTyr: 0.275 ± 0.157
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (3637 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski