Amino acid dipepetide frequency for Oceanihabitans sediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.298AlaAla: 4.298 ± 0.085	0.608AlaCys: 0.608 ± 0.029	3.315AlaAsp: 3.315 ± 0.071	4.337AlaGlu: 4.337 ± 0.077	3.554AlaPhe: 3.554 ± 0.069	3.914AlaGly: 3.914 ± 0.088	1.089AlaHis: 1.089 ± 0.035	5.646AlaIle: 5.646 ± 0.092	5.095AlaLys: 5.095 ± 0.103	6.38AlaLeu: 6.38 ± 0.095	1.505AlaMet: 1.505 ± 0.046	3.582AlaAsn: 3.582 ± 0.076	1.811AlaPro: 1.811 ± 0.059	2.254AlaGln: 2.254 ± 0.051	1.871AlaArg: 1.871 ± 0.051	4.461AlaSer: 4.461 ± 0.084	3.82AlaThr: 3.82 ± 0.102	4.034AlaVal: 4.034 ± 0.072	0.563AlaTrp: 0.563 ± 0.025	2.57AlaTyr: 2.57 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	0.451CysAla: 0.451 ± 0.024	0.099CysCys: 0.099 ± 0.011	0.451CysAsp: 0.451 ± 0.029	0.488CysGlu: 0.488 ± 0.025	0.41CysPhe: 0.41 ± 0.022	0.64CysGly: 0.64 ± 0.032	0.158CysHis: 0.158 ± 0.014	0.626CysIle: 0.626 ± 0.025	0.512CysLys: 0.512 ± 0.027	0.59CysLeu: 0.59 ± 0.029	0.137CysMet: 0.137 ± 0.013	0.454CysAsn: 0.454 ± 0.029	0.363CysPro: 0.363 ± 0.027	0.168CysGln: 0.168 ± 0.013	0.193CysArg: 0.193 ± 0.015	0.531CysSer: 0.531 ± 0.03	0.456CysThr: 0.456 ± 0.037	0.489CysVal: 0.489 ± 0.026	0.078CysTrp: 0.078 ± 0.021	0.288CysTyr: 0.288 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.069AspAla: 4.069 ± 0.089	0.461AspCys: 0.461 ± 0.027	2.687AspAsp: 2.687 ± 0.069	3.696AspGlu: 3.696 ± 0.077	3.616AspPhe: 3.616 ± 0.071	3.33AspGly: 3.33 ± 0.09	0.831AspHis: 0.831 ± 0.03	4.605AspIle: 4.605 ± 0.075	4.313AspLys: 4.313 ± 0.079	5.295AspLeu: 5.295 ± 0.087	1.079AspMet: 1.079 ± 0.034	3.158AspAsn: 3.158 ± 0.081	1.547AspPro: 1.547 ± 0.05	1.308AspGln: 1.308 ± 0.042	1.767AspArg: 1.767 ± 0.047	3.128AspSer: 3.128 ± 0.068	2.951AspThr: 2.951 ± 0.068	3.712AspVal: 3.712 ± 0.065	0.662AspTrp: 0.662 ± 0.026	2.887AspTyr: 2.887 ± 0.057	0.0AspXaa: 0.0 ± 0.0
Glu	5.126GluAla: 5.126 ± 0.089	0.336GluCys: 0.336 ± 0.023	4.026GluAsp: 4.026 ± 0.083	5.625GluGlu: 5.625 ± 0.101	3.095GluPhe: 3.095 ± 0.068	3.691GluGly: 3.691 ± 0.064	1.169GluHis: 1.169 ± 0.04	5.656GluIle: 5.656 ± 0.108	6.101GluLys: 6.101 ± 0.103	6.377GluLeu: 6.377 ± 0.095	1.506GluMet: 1.506 ± 0.043	4.924GluAsn: 4.924 ± 0.093	1.54GluPro: 1.54 ± 0.046	2.317GluGln: 2.317 ± 0.058	2.492GluArg: 2.492 ± 0.066	3.424GluSer: 3.424 ± 0.067	4.107GluThr: 4.107 ± 0.072	4.746GluVal: 4.746 ± 0.077	0.56GluTrp: 0.56 ± 0.024	2.507GluTyr: 2.507 ± 0.064	0.0GluXaa: 0.0 ± 0.0
Phe	2.956PheAla: 2.956 ± 0.056	0.411PheCys: 0.411 ± 0.02	3.074PheAsp: 3.074 ± 0.07	3.467PheGlu: 3.467 ± 0.077	2.581PhePhe: 2.581 ± 0.073	3.585PheGly: 3.585 ± 0.081	0.929PheHis: 0.929 ± 0.033	4.063PheIle: 4.063 ± 0.089	3.97PheLys: 3.97 ± 0.076	4.56PheLeu: 4.56 ± 0.085	1.068PheMet: 1.068 ± 0.038	3.376PheAsn: 3.376 ± 0.08	1.737PhePro: 1.737 ± 0.046	1.674PheGln: 1.674 ± 0.046	1.536PheArg: 1.536 ± 0.039	4.006PheSer: 4.006 ± 0.076	3.181PheThr: 3.181 ± 0.064	3.068PheVal: 3.068 ± 0.066	0.517PheTrp: 0.517 ± 0.03	2.115PheTyr: 2.115 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	4.033GlyAla: 4.033 ± 0.087	0.54GlyCys: 0.54 ± 0.031	3.356GlyAsp: 3.356 ± 0.087	3.682GlyGlu: 3.682 ± 0.067	3.578GlyPhe: 3.578 ± 0.077	4.161GlyGly: 4.161 ± 0.094	1.079GlyHis: 1.079 ± 0.039	4.986GlyIle: 4.986 ± 0.086	4.741GlyLys: 4.741 ± 0.085	5.432GlyLeu: 5.432 ± 0.094	1.53GlyMet: 1.53 ± 0.044	3.498GlyAsn: 3.498 ± 0.08	1.249GlyPro: 1.249 ± 0.051	1.709GlyGln: 1.709 ± 0.051	1.924GlyArg: 1.924 ± 0.054	3.69GlySer: 3.69 ± 0.066	3.907GlyThr: 3.907 ± 0.128	4.366GlyVal: 4.366 ± 0.079	0.624GlyTrp: 0.624 ± 0.031	2.62GlyTyr: 2.62 ± 0.068	0.0GlyXaa: 0.0 ± 0.0
His	1.092HisAla: 1.092 ± 0.036	0.186HisCys: 0.186 ± 0.015	0.849HisAsp: 0.849 ± 0.028	1.045HisGlu: 1.045 ± 0.038	1.222HisPhe: 1.222 ± 0.038	1.023HisGly: 1.023 ± 0.04	0.495HisHis: 0.495 ± 0.023	1.584HisIle: 1.584 ± 0.049	1.33HisLys: 1.33 ± 0.042	1.835HisLeu: 1.835 ± 0.054	0.291HisMet: 0.291 ± 0.02	1.014HisAsn: 1.014 ± 0.037	0.833HisPro: 0.833 ± 0.033	0.671HisGln: 0.671 ± 0.032	0.615HisArg: 0.615 ± 0.023	1.057HisSer: 1.057 ± 0.036	1.032HisThr: 1.032 ± 0.035	0.978HisVal: 0.978 ± 0.035	0.208HisTrp: 0.208 ± 0.016	0.87HisTyr: 0.87 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	5.771IleAla: 5.771 ± 0.101	0.617IleCys: 0.617 ± 0.027	5.016IleAsp: 5.016 ± 0.082	5.745IleGlu: 5.745 ± 0.095	3.535IlePhe: 3.535 ± 0.07	4.993IleGly: 4.993 ± 0.103	1.454IleHis: 1.454 ± 0.043	6.406IleIle: 6.406 ± 0.102	6.21IleLys: 6.21 ± 0.09	7.219IleLeu: 7.219 ± 0.115	1.326IleMet: 1.326 ± 0.038	4.901IleAsn: 4.901 ± 0.082	3.2IlePro: 3.2 ± 0.053	2.716IleGln: 2.716 ± 0.056	2.458IleArg: 2.458 ± 0.057	5.762IleSer: 5.762 ± 0.1	4.881IleThr: 4.881 ± 0.085	4.782IleVal: 4.782 ± 0.077	0.641IleTrp: 0.641 ± 0.03	2.836IleTyr: 2.836 ± 0.063	0.0IleXaa: 0.0 ± 0.0
Lys	5.127LysAla: 5.127 ± 0.103	0.358LysCys: 0.358 ± 0.02	4.627LysAsp: 4.627 ± 0.08	6.899LysGlu: 6.899 ± 0.12	2.867LysPhe: 2.867 ± 0.059	4.414LysGly: 4.414 ± 0.079	1.755LysHis: 1.755 ± 0.044	6.059LysIle: 6.059 ± 0.102	7.13LysLys: 7.13 ± 0.12	7.035LysLeu: 7.035 ± 0.107	2.093LysMet: 2.093 ± 0.061	5.299LysAsn: 5.299 ± 0.093	2.556LysPro: 2.556 ± 0.057	3.177LysGln: 3.177 ± 0.07	3.129LysArg: 3.129 ± 0.069	4.496LysSer: 4.496 ± 0.09	5.016LysThr: 5.016 ± 0.078	4.904LysVal: 4.904 ± 0.078	0.779LysTrp: 0.779 ± 0.029	3.194LysTyr: 3.194 ± 0.07	0.0LysXaa: 0.0 ± 0.0
Leu	5.925LeuAla: 5.925 ± 0.099	0.676LeuCys: 0.676 ± 0.028	5.166LeuAsp: 5.166 ± 0.075	6.54LeuGlu: 6.54 ± 0.103	4.668LeuPhe: 4.668 ± 0.087	5.649LeuGly: 5.649 ± 0.106	1.679LeuHis: 1.679 ± 0.05	7.06LeuIle: 7.06 ± 0.113	8.116LeuLys: 8.116 ± 0.116	8.639LeuLeu: 8.639 ± 0.14	1.902LeuMet: 1.902 ± 0.047	5.693LeuAsn: 5.693 ± 0.088	3.408LeuPro: 3.408 ± 0.064	3.408LeuGln: 3.408 ± 0.061	3.11LeuArg: 3.11 ± 0.06	6.492LeuSer: 6.492 ± 0.101	4.951LeuThr: 4.951 ± 0.076	5.595LeuVal: 5.595 ± 0.086	0.719LeuTrp: 0.719 ± 0.029	3.217LeuTyr: 3.217 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	1.425MetAla: 1.425 ± 0.046	0.15MetCys: 0.15 ± 0.014	1.043MetAsp: 1.043 ± 0.039	1.291MetGlu: 1.291 ± 0.042	0.921MetPhe: 0.921 ± 0.035	1.148MetGly: 1.148 ± 0.039	0.464MetHis: 0.464 ± 0.025	1.496MetIle: 1.496 ± 0.047	2.096MetLys: 2.096 ± 0.047	1.989MetLeu: 1.989 ± 0.048	0.52MetMet: 0.52 ± 0.029	1.241MetAsn: 1.241 ± 0.039	0.798MetPro: 0.798 ± 0.03	0.978MetGln: 0.978 ± 0.033	0.795MetArg: 0.795 ± 0.031	1.356MetSer: 1.356 ± 0.042	1.069MetThr: 1.069 ± 0.036	1.31MetVal: 1.31 ± 0.039	0.132MetTrp: 0.132 ± 0.013	0.739MetTyr: 0.739 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.876AsnAla: 3.876 ± 0.08	0.546AsnCys: 0.546 ± 0.038	2.995AsnAsp: 2.995 ± 0.071	3.859AsnGlu: 3.859 ± 0.071	2.966AsnPhe: 2.966 ± 0.068	3.783AsnGly: 3.783 ± 0.107	1.141AsnHis: 1.141 ± 0.039	5.227AsnIle: 5.227 ± 0.096	5.052AsnLys: 5.052 ± 0.095	5.428AsnLeu: 5.428 ± 0.095	1.297AsnMet: 1.297 ± 0.04	4.288AsnAsn: 4.288 ± 0.097	2.774AsnPro: 2.774 ± 0.067	2.288AsnGln: 2.288 ± 0.061	2.105AsnArg: 2.105 ± 0.058	3.723AsnSer: 3.723 ± 0.071	3.945AsnThr: 3.945 ± 0.084	3.329AsnVal: 3.329 ± 0.073	0.72AsnTrp: 0.72 ± 0.029	3.076AsnTyr: 3.076 ± 0.072	0.0AsnXaa: 0.0 ± 0.0
Pro	1.857ProAla: 1.857 ± 0.064	0.229ProCys: 0.229 ± 0.019	1.731ProAsp: 1.731 ± 0.051	2.801ProGlu: 2.801 ± 0.054	1.863ProPhe: 1.863 ± 0.053	1.726ProGly: 1.726 ± 0.053	0.597ProHis: 0.597 ± 0.028	2.81ProIle: 2.81 ± 0.061	2.67ProLys: 2.67 ± 0.062	2.829ProLeu: 2.829 ± 0.059	0.685ProMet: 0.685 ± 0.03	2.278ProAsn: 2.278 ± 0.065	0.747ProPro: 0.747 ± 0.045	1.04ProGln: 1.04 ± 0.04	0.888ProArg: 0.888 ± 0.045	2.062ProSer: 2.062 ± 0.056	2.087ProThr: 2.087 ± 0.075	2.168ProVal: 2.168 ± 0.053	0.266ProTrp: 0.266 ± 0.02	1.303ProTyr: 1.303 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	2.153GlnAla: 2.153 ± 0.046	0.165GlnCys: 0.165 ± 0.015	1.837GlnAsp: 1.837 ± 0.043	2.608GlnGlu: 2.608 ± 0.064	1.652GlnPhe: 1.652 ± 0.046	1.871GlnGly: 1.871 ± 0.061	0.614GlnHis: 0.614 ± 0.023	2.612GlnIle: 2.612 ± 0.058	2.799GlnLys: 2.799 ± 0.072	3.356GlnLeu: 3.356 ± 0.072	0.74GlnMet: 0.74 ± 0.031	2.135GlnAsn: 2.135 ± 0.059	1.015GlnPro: 1.015 ± 0.035	1.403GlnGln: 1.403 ± 0.049	1.14GlnArg: 1.14 ± 0.041	1.814GlnSer: 1.814 ± 0.048	1.961GlnThr: 1.961 ± 0.047	2.203GlnVal: 2.203 ± 0.051	0.296GlnTrp: 0.296 ± 0.018	1.313GlnTyr: 1.313 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	2.016ArgAla: 2.016 ± 0.049	0.188ArgCys: 0.188 ± 0.015	1.765ArgAsp: 1.765 ± 0.054	2.228ArgGlu: 2.228 ± 0.055	1.773ArgPhe: 1.773 ± 0.05	1.88ArgGly: 1.88 ± 0.047	0.579ArgHis: 0.579 ± 0.029	2.728ArgIle: 2.728 ± 0.054	2.79ArgLys: 2.79 ± 0.066	3.157ArgLeu: 3.157 ± 0.061	0.83ArgMet: 0.83 ± 0.036	2.021ArgAsn: 2.021 ± 0.049	0.999ArgPro: 0.999 ± 0.045	1.042ArgGln: 1.042 ± 0.037	1.267ArgArg: 1.267 ± 0.044	1.773ArgSer: 1.773 ± 0.054	1.744ArgThr: 1.744 ± 0.045	2.202ArgVal: 2.202 ± 0.053	0.334ArgTrp: 0.334 ± 0.017	1.471ArgTyr: 1.471 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	3.698SerAla: 3.698 ± 0.065	0.64SerCys: 0.64 ± 0.035	3.368SerAsp: 3.368 ± 0.067	4.195SerGlu: 4.195 ± 0.08	3.856SerPhe: 3.856 ± 0.066	4.226SerGly: 4.226 ± 0.087	1.119SerHis: 1.119 ± 0.037	5.26SerIle: 5.26 ± 0.083	5.196SerLys: 5.196 ± 0.094	5.941SerLeu: 5.941 ± 0.092	1.19SerMet: 1.19 ± 0.043	3.952SerAsn: 3.952 ± 0.079	1.951SerPro: 1.951 ± 0.052	2.113SerGln: 2.113 ± 0.052	2.004SerArg: 2.004 ± 0.055	4.13SerSer: 4.13 ± 0.081	3.379SerThr: 3.379 ± 0.072	4.063SerVal: 4.063 ± 0.074	0.613SerTrp: 0.613 ± 0.028	2.786SerTyr: 2.786 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	3.68ThrAla: 3.68 ± 0.09	0.461ThrCys: 0.461 ± 0.031	3.182ThrAsp: 3.182 ± 0.074	3.854ThrGlu: 3.854 ± 0.076	3.098ThrPhe: 3.098 ± 0.066	3.851ThrGly: 3.851 ± 0.088	1.015ThrHis: 1.015 ± 0.038	5.092ThrIle: 5.092 ± 0.084	4.078ThrLys: 4.078 ± 0.072	5.451ThrLeu: 5.451 ± 0.081	0.978ThrMet: 0.978 ± 0.039	3.63ThrAsn: 3.63 ± 0.094	2.428ThrPro: 2.428 ± 0.066	1.822ThrGln: 1.822 ± 0.053	1.706ThrArg: 1.706 ± 0.043	3.981ThrSer: 3.981 ± 0.087	3.729ThrThr: 3.729 ± 0.115	3.903ThrVal: 3.903 ± 0.099	0.578ThrTrp: 0.578 ± 0.034	2.42ThrTyr: 2.42 ± 0.071	0.0ThrXaa: 0.0 ± 0.0
Val	4.175ValAla: 4.175 ± 0.077	0.513ValCys: 0.513 ± 0.025	3.683ValAsp: 3.683 ± 0.085	4.164ValGlu: 4.164 ± 0.076	3.631ValPhe: 3.631 ± 0.083	3.841ValGly: 3.841 ± 0.073	1.007ValHis: 1.007 ± 0.04	4.852ValIle: 4.852 ± 0.079	4.523ValLys: 4.523 ± 0.08	6.289ValLeu: 6.289 ± 0.095	1.262ValMet: 1.262 ± 0.037	3.592ValAsn: 3.592 ± 0.066	2.087ValPro: 2.087 ± 0.057	1.759ValGln: 1.759 ± 0.043	1.975ValArg: 1.975 ± 0.05	4.669ValSer: 4.669 ± 0.081	3.631ValThr: 3.631 ± 0.113	4.378ValVal: 4.378 ± 0.105	0.55ValTrp: 0.55 ± 0.023	2.439ValTyr: 2.439 ± 0.065	0.0ValXaa: 0.0 ± 0.0
Trp	0.5TrpAla: 0.5 ± 0.025	0.086TrpCys: 0.086 ± 0.009	0.576TrpAsp: 0.576 ± 0.03	0.566TrpGlu: 0.566 ± 0.031	0.577TrpPhe: 0.577 ± 0.03	0.499TrpGly: 0.499 ± 0.023	0.186TrpHis: 0.186 ± 0.016	0.696TrpIle: 0.696 ± 0.03	0.765TrpLys: 0.765 ± 0.032	0.972TrpLeu: 0.972 ± 0.037	0.283TrpMet: 0.283 ± 0.018	0.658TrpAsn: 0.658 ± 0.03	0.189TrpPro: 0.189 ± 0.015	0.359TrpGln: 0.359 ± 0.023	0.351TrpArg: 0.351 ± 0.022	0.577TrpSer: 0.577 ± 0.03	0.506TrpThr: 0.506 ± 0.026	0.539TrpVal: 0.539 ± 0.026	0.109TrpTrp: 0.109 ± 0.011	0.415TrpTyr: 0.415 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.484TyrAla: 2.484 ± 0.058	0.312TyrCys: 0.312 ± 0.022	2.356TyrAsp: 2.356 ± 0.054	2.234TyrGlu: 2.234 ± 0.052	2.413TyrPhe: 2.413 ± 0.056	2.48TyrGly: 2.48 ± 0.059	0.866TyrHis: 0.866 ± 0.03	3.006TyrIle: 3.006 ± 0.058	3.426TyrLys: 3.426 ± 0.073	3.84TyrLeu: 3.84 ± 0.074	0.737TyrMet: 0.737 ± 0.026	2.723TyrAsn: 2.723 ± 0.062	1.404TyrPro: 1.404 ± 0.038	1.481TyrGln: 1.481 ± 0.039	1.46TyrArg: 1.46 ± 0.044	2.548TyrSer: 2.548 ± 0.068	2.58TyrThr: 2.58 ± 0.076	2.253TyrVal: 2.253 ± 0.046	0.46TyrTrp: 0.46 ± 0.026	1.878TyrTyr: 1.878 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2601 proteins (861170 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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