Amino acid dipepetide frequency for Mycobacterium phage Maroc7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.479AlaAla: 13.479 ± 1.424
0.842AlaCys: 0.842 ± 0.214
6.439AlaAsp: 6.439 ± 0.613
7.041AlaGlu: 7.041 ± 0.741
3.069AlaPhe: 3.069 ± 0.527
7.883AlaGly: 7.883 ± 0.808
1.444AlaHis: 1.444 ± 0.328
4.393AlaIle: 4.393 ± 0.631
3.911AlaLys: 3.911 ± 0.452
8.846AlaLeu: 8.846 ± 0.907
2.588AlaMet: 2.588 ± 0.426
2.588AlaAsn: 2.588 ± 0.387
4.634AlaPro: 4.634 ± 0.547
3.249AlaGln: 3.249 ± 0.427
5.897AlaArg: 5.897 ± 0.556
5.295AlaSer: 5.295 ± 0.627
6.018AlaThr: 6.018 ± 0.717
8.545AlaVal: 8.545 ± 0.848
1.865AlaTrp: 1.865 ± 0.322
2.588AlaTyr: 2.588 ± 0.382
0.0AlaXaa: 0.0 ± 0.0
Cys
0.722CysAla: 0.722 ± 0.239
0.06CysCys: 0.06 ± 0.058
0.602CysAsp: 0.602 ± 0.2
0.782CysGlu: 0.782 ± 0.199
0.181CysPhe: 0.181 ± 0.101
0.722CysGly: 0.722 ± 0.248
0.12CysHis: 0.12 ± 0.09
0.421CysIle: 0.421 ± 0.167
0.241CysLys: 0.241 ± 0.139
0.361CysLeu: 0.361 ± 0.159
0.181CysMet: 0.181 ± 0.107
0.241CysAsn: 0.241 ± 0.127
0.421CysPro: 0.421 ± 0.206
0.181CysGln: 0.181 ± 0.122
0.421CysArg: 0.421 ± 0.163
0.241CysSer: 0.241 ± 0.11
0.421CysThr: 0.421 ± 0.154
0.481CysVal: 0.481 ± 0.154
0.181CysTrp: 0.181 ± 0.102
0.12CysTyr: 0.12 ± 0.086
0.0CysXaa: 0.0 ± 0.0
Asp
6.078AspAla: 6.078 ± 0.608
0.602AspCys: 0.602 ± 0.141
4.513AspAsp: 4.513 ± 0.447
3.972AspGlu: 3.972 ± 0.56
2.166AspPhe: 2.166 ± 0.378
6.258AspGly: 6.258 ± 0.574
1.324AspHis: 1.324 ± 0.294
2.768AspIle: 2.768 ± 0.466
2.347AspLys: 2.347 ± 0.401
6.8AspLeu: 6.8 ± 0.71
1.083AspMet: 1.083 ± 0.192
1.805AspAsn: 1.805 ± 0.3
4.995AspPro: 4.995 ± 0.661
1.745AspGln: 1.745 ± 0.383
3.671AspArg: 3.671 ± 0.424
3.249AspSer: 3.249 ± 0.451
3.972AspThr: 3.972 ± 0.394
4.874AspVal: 4.874 ± 0.544
1.926AspTrp: 1.926 ± 0.346
2.106AspTyr: 2.106 ± 0.367
0.0AspXaa: 0.0 ± 0.0
Glu
6.198GluAla: 6.198 ± 0.698
0.301GluCys: 0.301 ± 0.16
4.513GluAsp: 4.513 ± 0.578
5.175GluGlu: 5.175 ± 0.6
2.106GluPhe: 2.106 ± 0.415
3.851GluGly: 3.851 ± 0.407
1.444GluHis: 1.444 ± 0.336
3.31GluIle: 3.31 ± 0.479
3.009GluLys: 3.009 ± 0.52
7.341GluLeu: 7.341 ± 0.644
1.745GluMet: 1.745 ± 0.359
1.685GluAsn: 1.685 ± 0.331
2.407GluPro: 2.407 ± 0.375
2.407GluGln: 2.407 ± 0.384
3.611GluArg: 3.611 ± 0.591
3.31GluSer: 3.31 ± 0.479
4.032GluThr: 4.032 ± 0.555
5.957GluVal: 5.957 ± 0.623
1.805GluTrp: 1.805 ± 0.386
2.588GluTyr: 2.588 ± 0.46
0.0GluXaa: 0.0 ± 0.0
Phe
2.287PheAla: 2.287 ± 0.317
0.361PheCys: 0.361 ± 0.191
2.828PheAsp: 2.828 ± 0.389
1.986PheGlu: 1.986 ± 0.322
0.421PhePhe: 0.421 ± 0.14
3.671PheGly: 3.671 ± 0.513
0.662PheHis: 0.662 ± 0.246
1.143PheIle: 1.143 ± 0.262
1.324PheLys: 1.324 ± 0.308
2.527PheLeu: 2.527 ± 0.439
0.542PheMet: 0.542 ± 0.191
1.023PheAsn: 1.023 ± 0.208
1.444PhePro: 1.444 ± 0.268
0.842PheGln: 0.842 ± 0.256
1.865PheArg: 1.865 ± 0.283
1.865PheSer: 1.865 ± 0.437
1.865PheThr: 1.865 ± 0.343
2.287PheVal: 2.287 ± 0.462
0.542PheTrp: 0.542 ± 0.166
1.023PheTyr: 1.023 ± 0.237
0.0PheXaa: 0.0 ± 0.0
Gly
7.161GlyAla: 7.161 ± 0.952
0.842GlyCys: 0.842 ± 0.21
6.559GlyAsp: 6.559 ± 0.604
4.393GlyGlu: 4.393 ± 0.455
2.588GlyPhe: 2.588 ± 0.416
9.748GlyGly: 9.748 ± 2.08
1.865GlyHis: 1.865 ± 0.367
4.212GlyIle: 4.212 ± 0.694
3.611GlyLys: 3.611 ± 0.504
7.883GlyLeu: 7.883 ± 0.842
1.625GlyMet: 1.625 ± 0.31
3.43GlyAsn: 3.43 ± 0.526
4.152GlyPro: 4.152 ± 0.487
2.227GlyGln: 2.227 ± 0.361
4.814GlyArg: 4.814 ± 0.568
5.777GlySer: 5.777 ± 0.75
5.235GlyThr: 5.235 ± 0.676
5.175GlyVal: 5.175 ± 0.536
2.467GlyTrp: 2.467 ± 0.388
2.828GlyTyr: 2.828 ± 0.431
0.0GlyXaa: 0.0 ± 0.0
His
1.625HisAla: 1.625 ± 0.334
0.241HisCys: 0.241 ± 0.148
1.083HisAsp: 1.083 ± 0.241
1.444HisGlu: 1.444 ± 0.297
0.602HisPhe: 0.602 ± 0.196
1.745HisGly: 1.745 ± 0.41
0.542HisHis: 0.542 ± 0.197
0.963HisIle: 0.963 ± 0.197
1.143HisLys: 1.143 ± 0.308
1.384HisLeu: 1.384 ± 0.352
0.06HisMet: 0.06 ± 0.065
0.301HisAsn: 0.301 ± 0.14
1.324HisPro: 1.324 ± 0.254
1.023HisGln: 1.023 ± 0.257
1.685HisArg: 1.685 ± 0.334
0.662HisSer: 0.662 ± 0.204
1.083HisThr: 1.083 ± 0.292
1.565HisVal: 1.565 ± 0.298
0.602HisTrp: 0.602 ± 0.188
0.842HisTyr: 0.842 ± 0.25
0.0HisXaa: 0.0 ± 0.0
Ile
6.559IleAla: 6.559 ± 0.769
0.301IleCys: 0.301 ± 0.135
2.828IleAsp: 2.828 ± 0.337
3.791IleGlu: 3.791 ± 0.448
0.842IlePhe: 0.842 ± 0.225
3.911IleGly: 3.911 ± 0.484
0.842IleHis: 0.842 ± 0.204
1.504IleIle: 1.504 ± 0.318
1.685IleLys: 1.685 ± 0.287
3.671IleLeu: 3.671 ± 0.493
0.782IleMet: 0.782 ± 0.174
2.407IleAsn: 2.407 ± 0.332
3.249IlePro: 3.249 ± 0.471
1.504IleGln: 1.504 ± 0.371
3.49IleArg: 3.49 ± 0.385
3.069IleSer: 3.069 ± 0.432
3.189IleThr: 3.189 ± 0.432
2.708IleVal: 2.708 ± 0.559
0.782IleTrp: 0.782 ± 0.195
1.745IleTyr: 1.745 ± 0.317
0.0IleXaa: 0.0 ± 0.0
Lys
3.851LysAla: 3.851 ± 0.524
0.241LysCys: 0.241 ± 0.122
2.347LysAsp: 2.347 ± 0.444
2.347LysGlu: 2.347 ± 0.373
1.625LysPhe: 1.625 ± 0.309
2.768LysGly: 2.768 ± 0.411
1.324LysHis: 1.324 ± 0.289
2.527LysIle: 2.527 ± 0.449
2.227LysLys: 2.227 ± 0.493
3.55LysLeu: 3.55 ± 0.481
1.023LysMet: 1.023 ± 0.238
1.685LysAsn: 1.685 ± 0.293
2.347LysPro: 2.347 ± 0.394
1.444LysGln: 1.444 ± 0.292
3.069LysArg: 3.069 ± 0.544
2.467LysSer: 2.467 ± 0.39
2.347LysThr: 2.347 ± 0.397
3.069LysVal: 3.069 ± 0.436
0.842LysTrp: 0.842 ± 0.195
1.204LysTyr: 1.204 ± 0.305
0.0LysXaa: 0.0 ± 0.0
Leu
9.207LeuAla: 9.207 ± 0.785
0.301LeuCys: 0.301 ± 0.146
6.138LeuAsp: 6.138 ± 0.563
5.777LeuGlu: 5.777 ± 0.611
1.926LeuPhe: 1.926 ± 0.334
7.341LeuGly: 7.341 ± 0.796
1.565LeuHis: 1.565 ± 0.327
5.055LeuIle: 5.055 ± 0.549
3.972LeuLys: 3.972 ± 0.509
5.416LeuLeu: 5.416 ± 0.578
1.805LeuMet: 1.805 ± 0.315
2.708LeuAsn: 2.708 ± 0.374
5.115LeuPro: 5.115 ± 0.537
2.407LeuGln: 2.407 ± 0.361
6.439LeuArg: 6.439 ± 0.563
5.416LeuSer: 5.416 ± 0.609
6.138LeuThr: 6.138 ± 0.567
4.995LeuVal: 4.995 ± 0.688
0.963LeuTrp: 0.963 ± 0.279
2.106LeuTyr: 2.106 ± 0.417
0.0LeuXaa: 0.0 ± 0.0
Met
2.467MetAla: 2.467 ± 0.28
0.0MetCys: 0.0 ± 0.0
1.324MetAsp: 1.324 ± 0.261
1.384MetGlu: 1.384 ± 0.32
0.602MetPhe: 0.602 ± 0.17
1.324MetGly: 1.324 ± 0.299
0.301MetHis: 0.301 ± 0.149
0.842MetIle: 0.842 ± 0.231
1.384MetLys: 1.384 ± 0.248
1.264MetLeu: 1.264 ± 0.295
0.241MetMet: 0.241 ± 0.15
0.782MetAsn: 0.782 ± 0.178
0.963MetPro: 0.963 ± 0.252
0.542MetGln: 0.542 ± 0.168
1.204MetArg: 1.204 ± 0.296
2.046MetSer: 2.046 ± 0.397
2.227MetThr: 2.227 ± 0.266
1.023MetVal: 1.023 ± 0.302
0.301MetTrp: 0.301 ± 0.128
0.361MetTyr: 0.361 ± 0.139
0.0MetXaa: 0.0 ± 0.0
Asn
3.069AsnAla: 3.069 ± 0.496
0.12AsnCys: 0.12 ± 0.075
2.166AsnAsp: 2.166 ± 0.474
1.805AsnGlu: 1.805 ± 0.318
0.842AsnPhe: 0.842 ± 0.243
3.671AsnGly: 3.671 ± 0.55
0.903AsnHis: 0.903 ± 0.241
1.504AsnIle: 1.504 ± 0.322
0.662AsnLys: 0.662 ± 0.17
2.347AsnLeu: 2.347 ± 0.312
0.542AsnMet: 0.542 ± 0.19
0.782AsnAsn: 0.782 ± 0.213
2.648AsnPro: 2.648 ± 0.438
1.083AsnGln: 1.083 ± 0.219
1.745AsnArg: 1.745 ± 0.342
1.865AsnSer: 1.865 ± 0.476
1.745AsnThr: 1.745 ± 0.318
2.347AsnVal: 2.347 ± 0.397
0.782AsnTrp: 0.782 ± 0.192
1.264AsnTyr: 1.264 ± 0.323
0.0AsnXaa: 0.0 ± 0.0
Pro
5.235ProAla: 5.235 ± 0.488
0.542ProCys: 0.542 ± 0.216
4.032ProAsp: 4.032 ± 0.469
4.272ProGlu: 4.272 ± 0.523
2.106ProPhe: 2.106 ± 0.386
4.754ProGly: 4.754 ± 0.592
0.782ProHis: 0.782 ± 0.216
2.347ProIle: 2.347 ± 0.398
2.046ProLys: 2.046 ± 0.281
4.212ProLeu: 4.212 ± 0.578
0.903ProMet: 0.903 ± 0.282
1.745ProAsn: 1.745 ± 0.338
2.828ProPro: 2.828 ± 0.482
1.625ProGln: 1.625 ± 0.355
3.249ProArg: 3.249 ± 0.516
3.671ProSer: 3.671 ± 0.53
3.851ProThr: 3.851 ± 0.529
3.55ProVal: 3.55 ± 0.432
0.782ProTrp: 0.782 ± 0.297
1.685ProTyr: 1.685 ± 0.371
0.0ProXaa: 0.0 ± 0.0
Gln
3.31GlnAla: 3.31 ± 0.516
0.06GlnCys: 0.06 ± 0.065
1.264GlnAsp: 1.264 ± 0.29
1.504GlnGlu: 1.504 ± 0.28
1.083GlnPhe: 1.083 ± 0.216
2.648GlnGly: 2.648 ± 0.353
0.481GlnHis: 0.481 ± 0.146
2.828GlnIle: 2.828 ± 0.57
1.204GlnLys: 1.204 ± 0.257
3.43GlnLeu: 3.43 ± 0.456
0.903GlnMet: 0.903 ± 0.222
0.542GlnAsn: 0.542 ± 0.141
2.166GlnPro: 2.166 ± 0.413
1.865GlnGln: 1.865 ± 0.397
1.805GlnArg: 1.805 ± 0.394
1.745GlnSer: 1.745 ± 0.264
1.565GlnThr: 1.565 ± 0.308
2.648GlnVal: 2.648 ± 0.341
0.662GlnTrp: 0.662 ± 0.159
0.722GlnTyr: 0.722 ± 0.185
0.0GlnXaa: 0.0 ± 0.0
Arg
5.657ArgAla: 5.657 ± 0.643
0.782ArgCys: 0.782 ± 0.265
3.249ArgAsp: 3.249 ± 0.383
4.874ArgGlu: 4.874 ± 0.635
2.166ArgPhe: 2.166 ± 0.412
5.115ArgGly: 5.115 ± 0.609
1.324ArgHis: 1.324 ± 0.276
3.129ArgIle: 3.129 ± 0.481
3.43ArgLys: 3.43 ± 0.514
5.957ArgLeu: 5.957 ± 0.844
1.926ArgMet: 1.926 ± 0.338
2.227ArgAsn: 2.227 ± 0.424
2.227ArgPro: 2.227 ± 0.344
1.986ArgGln: 1.986 ± 0.318
4.995ArgArg: 4.995 ± 0.646
3.851ArgSer: 3.851 ± 0.507
2.888ArgThr: 2.888 ± 0.449
5.055ArgVal: 5.055 ± 0.587
1.324ArgTrp: 1.324 ± 0.281
1.805ArgTyr: 1.805 ± 0.321
0.0ArgXaa: 0.0 ± 0.0
Ser
6.198SerAla: 6.198 ± 0.696
0.421SerCys: 0.421 ± 0.167
3.49SerAsp: 3.49 ± 0.354
4.092SerGlu: 4.092 ± 0.564
1.625SerPhe: 1.625 ± 0.356
5.957SerGly: 5.957 ± 0.711
1.324SerHis: 1.324 ± 0.306
2.768SerIle: 2.768 ± 0.426
2.708SerLys: 2.708 ± 0.456
4.934SerLeu: 4.934 ± 0.619
1.625SerMet: 1.625 ± 0.353
2.106SerAsn: 2.106 ± 0.35
3.009SerPro: 3.009 ± 0.43
1.926SerGln: 1.926 ± 0.324
3.189SerArg: 3.189 ± 0.405
3.069SerSer: 3.069 ± 0.5
3.009SerThr: 3.009 ± 0.442
3.791SerVal: 3.791 ± 0.478
1.384SerTrp: 1.384 ± 0.314
1.565SerTyr: 1.565 ± 0.342
0.0SerXaa: 0.0 ± 0.0
Thr
6.379ThrAla: 6.379 ± 0.722
0.301ThrCys: 0.301 ± 0.142
4.212ThrAsp: 4.212 ± 0.66
4.212ThrGlu: 4.212 ± 0.556
2.527ThrPhe: 2.527 ± 0.395
6.559ThrGly: 6.559 ± 0.667
1.083ThrHis: 1.083 ± 0.329
2.648ThrIle: 2.648 ± 0.462
2.347ThrLys: 2.347 ± 0.327
5.657ThrLeu: 5.657 ± 0.656
0.903ThrMet: 0.903 ± 0.173
1.745ThrAsn: 1.745 ± 0.344
3.972ThrPro: 3.972 ± 0.497
1.805ThrGln: 1.805 ± 0.351
3.31ThrArg: 3.31 ± 0.609
3.189ThrSer: 3.189 ± 0.483
3.731ThrThr: 3.731 ± 0.561
5.536ThrVal: 5.536 ± 0.592
0.842ThrTrp: 0.842 ± 0.22
1.805ThrTyr: 1.805 ± 0.346
0.0ThrXaa: 0.0 ± 0.0
Val
7.101ValAla: 7.101 ± 0.654
0.301ValCys: 0.301 ± 0.134
5.717ValAsp: 5.717 ± 0.598
4.694ValGlu: 4.694 ± 0.578
2.287ValPhe: 2.287 ± 0.394
4.453ValGly: 4.453 ± 0.609
1.504ValHis: 1.504 ± 0.224
4.152ValIle: 4.152 ± 0.568
3.129ValLys: 3.129 ± 0.426
4.874ValLeu: 4.874 ± 0.603
1.204ValMet: 1.204 ± 0.31
2.106ValAsn: 2.106 ± 0.333
4.272ValPro: 4.272 ± 0.484
2.227ValGln: 2.227 ± 0.341
5.657ValArg: 5.657 ± 0.745
4.754ValSer: 4.754 ± 0.433
5.416ValThr: 5.416 ± 0.563
4.573ValVal: 4.573 ± 0.671
1.143ValTrp: 1.143 ± 0.264
2.407ValTyr: 2.407 ± 0.392
0.0ValXaa: 0.0 ± 0.0
Trp
1.504TrpAla: 1.504 ± 0.327
0.181TrpCys: 0.181 ± 0.107
1.444TrpAsp: 1.444 ± 0.287
1.083TrpGlu: 1.083 ± 0.218
0.903TrpPhe: 0.903 ± 0.241
1.565TrpGly: 1.565 ± 0.277
0.361TrpHis: 0.361 ± 0.156
0.842TrpIle: 0.842 ± 0.218
0.361TrpLys: 0.361 ± 0.187
1.865TrpLeu: 1.865 ± 0.274
0.361TrpMet: 0.361 ± 0.164
0.662TrpAsn: 0.662 ± 0.206
0.842TrpPro: 0.842 ± 0.279
1.204TrpGln: 1.204 ± 0.249
1.264TrpArg: 1.264 ± 0.317
1.023TrpSer: 1.023 ± 0.242
1.745TrpThr: 1.745 ± 0.357
2.046TrpVal: 2.046 ± 0.282
0.662TrpTrp: 0.662 ± 0.243
0.421TrpTyr: 0.421 ± 0.146
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.527TyrAla: 2.527 ± 0.363
0.301TyrCys: 0.301 ± 0.149
1.504TyrAsp: 1.504 ± 0.329
2.166TyrGlu: 2.166 ± 0.324
0.842TyrPhe: 0.842 ± 0.232
2.648TyrGly: 2.648 ± 0.436
0.722TyrHis: 0.722 ± 0.18
1.504TyrIle: 1.504 ± 0.3
1.565TyrLys: 1.565 ± 0.339
2.467TyrLeu: 2.467 ± 0.354
0.481TyrMet: 0.481 ± 0.136
1.324TyrAsn: 1.324 ± 0.32
1.204TyrPro: 1.204 ± 0.28
1.143TyrGln: 1.143 ± 0.303
2.588TyrArg: 2.588 ± 0.43
1.625TyrSer: 1.625 ± 0.278
2.287TyrThr: 2.287 ± 0.396
1.805TyrVal: 1.805 ± 0.312
0.481TyrTrp: 0.481 ± 0.172
0.722TyrTyr: 0.722 ± 0.233
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 92 proteins (16619 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski