Human papillomavirus 184

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Gammapapillomavirus; Gammapapillomavirus 25

Average proteome isoelectric point is 6.24

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 6 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|U6EMG5|U6EMG5_9PAPI Protein E6 OS=Human papillomavirus 184 OX=1472343 GN=E6 PE=3 SV=1
MM1 pKa = 7.3YY2 pKa = 10.34KK3 pKa = 9.86RR4 pKa = 11.84AKK6 pKa = 9.53RR7 pKa = 11.84KK8 pKa = 10.03KK9 pKa = 9.58RR10 pKa = 11.84DD11 pKa = 3.59SVDD14 pKa = 2.89NLYY17 pKa = 10.62RR18 pKa = 11.84KK19 pKa = 9.64CALGADD25 pKa = 4.31CPPDD29 pKa = 3.37VRR31 pKa = 11.84NKK33 pKa = 10.19VEE35 pKa = 4.02NTTLADD41 pKa = 3.06ILLQIFGSAVYY52 pKa = 10.24LGNLGIGTGKK62 pKa = 8.8GTGGTTGYY70 pKa = 10.82SSLAPSITRR79 pKa = 11.84PLPKK83 pKa = 8.64PTRR86 pKa = 11.84PTRR89 pKa = 11.84PFNIPLDD96 pKa = 4.51PIGGGFGSRR105 pKa = 11.84PIGQEE110 pKa = 3.76VPTDD114 pKa = 3.64IIDD117 pKa = 4.12PLSSSIVPLQEE128 pKa = 3.93EE129 pKa = 4.3VGEE132 pKa = 4.26TNIVITADD140 pKa = 3.49PGTSLGGGEE149 pKa = 4.6VVTSTTTVLNPAYY162 pKa = 9.37EE163 pKa = 4.4SEE165 pKa = 4.06GLPDD169 pKa = 3.37VFSRR173 pKa = 11.84GDD175 pKa = 3.28SSIAVLDD182 pKa = 4.48VIPSEE187 pKa = 4.33PPLKK191 pKa = 10.3KK192 pKa = 10.47VAIDD196 pKa = 4.08LPAPSDD202 pKa = 3.73VEE204 pKa = 4.54NVITTLTSVGSDD216 pKa = 2.88FNVYY220 pKa = 9.97VDD222 pKa = 3.88PLEE225 pKa = 4.46TGDD228 pKa = 5.15LIGLEE233 pKa = 4.43EE234 pKa = 5.48IEE236 pKa = 4.58LQPIPKK242 pKa = 10.03YY243 pKa = 9.29STFDD247 pKa = 3.18IEE249 pKa = 4.69EE250 pKa = 4.61PPSTSTPANTVQRR263 pKa = 11.84YY264 pKa = 8.45AGKK267 pKa = 10.43AKK269 pKa = 10.29SLYY272 pKa = 10.3SKK274 pKa = 10.28YY275 pKa = 10.13IKK277 pKa = 9.95QLQTRR282 pKa = 11.84NPDD285 pKa = 3.53FVRR288 pKa = 11.84QPSRR292 pKa = 11.84AVQFEE297 pKa = 4.23FEE299 pKa = 4.7NPAFDD304 pKa = 6.11DD305 pKa = 5.08DD306 pKa = 5.48ISLQFQQDD314 pKa = 3.61LDD316 pKa = 4.08EE317 pKa = 4.63VAAAPDD323 pKa = 3.48IDD325 pKa = 4.2FQDD328 pKa = 2.93VRR330 pKa = 11.84YY331 pKa = 10.04LGRR334 pKa = 11.84PQFLTTEE341 pKa = 4.17SGTVRR346 pKa = 11.84LSRR349 pKa = 11.84LGSKK353 pKa = 9.05ATVTTRR359 pKa = 11.84SGLTVGQKK367 pKa = 8.01VHH369 pKa = 6.95FYY371 pKa = 10.77YY372 pKa = 10.71DD373 pKa = 3.66FSTIYY378 pKa = 10.13PEE380 pKa = 4.68QSFEE384 pKa = 4.04LQPIGEE390 pKa = 4.16FSGLNTYY397 pKa = 9.41VNPLQEE403 pKa = 4.2STFFDD408 pKa = 3.6SSFAHH413 pKa = 6.66ADD415 pKa = 3.08VGEE418 pKa = 4.19IEE420 pKa = 4.4FPEE423 pKa = 4.43VDD425 pKa = 4.49LEE427 pKa = 5.4DD428 pKa = 4.1NMLEE432 pKa = 4.2NFDD435 pKa = 4.09NAHH438 pKa = 6.91LIITGITDD446 pKa = 3.18EE447 pKa = 4.49NEE449 pKa = 3.81QLFIPTLASNIPLKK463 pKa = 10.73PFIPYY468 pKa = 9.57IHH470 pKa = 7.0FGNSTDD476 pKa = 3.88RR477 pKa = 11.84PIVPDD482 pKa = 3.68DD483 pKa = 4.17TIISPTYY490 pKa = 9.55PYY492 pKa = 10.61TPLEE496 pKa = 4.11PANAIEE502 pKa = 4.2VYY504 pKa = 10.96YY505 pKa = 10.91DD506 pKa = 3.94FFLHH510 pKa = 7.13PALQKK515 pKa = 10.16RR516 pKa = 11.84KK517 pKa = 9.36RR518 pKa = 11.84RR519 pKa = 11.84RR520 pKa = 11.84LDD522 pKa = 3.06VFF524 pKa = 3.78

Molecular weight: 57.7 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|U6ELR9|U6ELR9_9PAPI Minor capsid protein L2 OS=Human papillomavirus 184 OX=1472343 GN=L2 PE=3 SV=1
MM1 pKa = 7.0NQADD5 pKa = 3.68LTARR9 pKa = 11.84FDD11 pKa = 3.89ALQDD15 pKa = 3.63TLMTLYY21 pKa = 10.16EE22 pKa = 4.33RR23 pKa = 11.84NATDD27 pKa = 3.18IDD29 pKa = 3.99SQILHH34 pKa = 6.73WEE36 pKa = 4.49TVRR39 pKa = 11.84KK40 pKa = 9.93QYY42 pKa = 9.59VTMYY46 pKa = 8.64YY47 pKa = 10.46ARR49 pKa = 11.84KK50 pKa = 9.03EE51 pKa = 4.47GYY53 pKa = 9.35RR54 pKa = 11.84SLGMQPLPALTVSEE68 pKa = 4.61YY69 pKa = 10.1KK70 pKa = 10.68AKK72 pKa = 10.46EE73 pKa = 4.13AIQMVILLRR82 pKa = 11.84SLRR85 pKa = 11.84QSQFSNEE92 pKa = 3.85LWTLTDD98 pKa = 3.58TSAEE102 pKa = 4.07LLHH105 pKa = 5.96TQPKK109 pKa = 10.13NCFKK113 pKa = 10.62KK114 pKa = 9.62HH115 pKa = 5.14GYY117 pKa = 6.11TVEE120 pKa = 4.13VYY122 pKa = 10.56FDD124 pKa = 3.94EE125 pKa = 5.18NPANVFPYY133 pKa = 9.96TNWDD137 pKa = 3.45SIYY140 pKa = 10.4YY141 pKa = 9.41QDD143 pKa = 5.58SHH145 pKa = 5.73EE146 pKa = 4.27QWHH149 pKa = 5.67KK150 pKa = 9.01TAGLVDD156 pKa = 3.78YY157 pKa = 10.94DD158 pKa = 3.56GMYY161 pKa = 10.43FQEE164 pKa = 4.52TNGDD168 pKa = 3.03RR169 pKa = 11.84TYY171 pKa = 11.18FQLFHH176 pKa = 7.28KK177 pKa = 10.64DD178 pKa = 2.85ALRR181 pKa = 11.84YY182 pKa = 9.84GSTGRR187 pKa = 11.84WSVHH191 pKa = 5.37YY192 pKa = 10.0KK193 pKa = 9.97NQTILPSASVSSSTRR208 pKa = 11.84QPVDD212 pKa = 3.45EE213 pKa = 4.59PAEE216 pKa = 4.26TTAYY220 pKa = 9.8PSTPPQIAAGGSQRR234 pKa = 11.84SQTEE238 pKa = 3.53EE239 pKa = 4.01RR240 pKa = 11.84GTVSSTQQTPPATISSVRR258 pKa = 11.84LRR260 pKa = 11.84RR261 pKa = 11.84RR262 pKa = 11.84RR263 pKa = 11.84GQGEE267 pKa = 3.79RR268 pKa = 11.84TTRR271 pKa = 11.84EE272 pKa = 3.72RR273 pKa = 11.84EE274 pKa = 4.12SPTKK278 pKa = 10.16RR279 pKa = 11.84RR280 pKa = 11.84RR281 pKa = 11.84TTEE284 pKa = 3.53TDD286 pKa = 3.01SARR289 pKa = 11.84LEE291 pKa = 4.33SVPAPEE297 pKa = 4.78AVGTRR302 pKa = 11.84HH303 pKa = 5.32RR304 pKa = 11.84TVPSTGLSRR313 pKa = 11.84LGRR316 pKa = 11.84LQEE319 pKa = 4.04EE320 pKa = 4.47ARR322 pKa = 11.84DD323 pKa = 3.79PPAILVTGPGNSLKK337 pKa = 10.28CWRR340 pKa = 11.84WRR342 pKa = 11.84LKK344 pKa = 10.64KK345 pKa = 10.56FSRR348 pKa = 11.84YY349 pKa = 6.52YY350 pKa = 11.26LRR352 pKa = 11.84MSTVWSWAGEE362 pKa = 4.25VCPKK366 pKa = 10.26ASKK369 pKa = 10.84NRR371 pKa = 11.84MLIAFRR377 pKa = 11.84DD378 pKa = 3.66NEE380 pKa = 4.01QRR382 pKa = 11.84SVFLKK387 pKa = 10.22LVSMPKK393 pKa = 8.51HH394 pKa = 4.54TTFGLAQLGILL405 pKa = 4.22

Molecular weight: 46.52 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

6

0

6

2293

97

603

382.2

43.32

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.582 ± 0.565

2.268 ± 0.809

6.28 ± 0.468

6.149 ± 0.439

4.797 ± 0.392

5.451 ± 0.83

1.57 ± 0.194

4.841 ± 0.624

5.539 ± 0.653

9.202 ± 0.517

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.875 ± 0.448

4.928 ± 0.673

5.931 ± 1.139

4.361 ± 0.326

5.408 ± 0.688

7.327 ± 0.836

6.847 ± 0.728

6.149 ± 0.336

1.221 ± 0.316

4.274 ± 0.5
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski