Amino acid dipepetide frequency for Actinomyces sp. oral taxon 180 str. F0310

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.761AlaAla: 16.761 ± 0.257	1.32AlaCys: 1.32 ± 0.054	7.487AlaAsp: 7.487 ± 0.119	6.119AlaGlu: 6.119 ± 0.121	3.535AlaPhe: 3.535 ± 0.071	10.743AlaGly: 10.743 ± 0.136	2.666AlaHis: 2.666 ± 0.069	5.611AlaIle: 5.611 ± 0.102	2.816AlaLys: 2.816 ± 0.079	13.714AlaLeu: 13.714 ± 0.196	2.942AlaMet: 2.942 ± 0.064	2.62AlaAsn: 2.62 ± 0.059	6.866AlaPro: 6.866 ± 0.168	4.542AlaGln: 4.542 ± 0.084	10.01AlaArg: 10.01 ± 0.164	9.546AlaSer: 9.546 ± 0.155	7.471AlaThr: 7.471 ± 0.12	8.979AlaVal: 8.979 ± 0.131	2.146AlaTrp: 2.146 ± 0.066	2.513AlaTyr: 2.513 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	1.262CysAla: 1.262 ± 0.048	0.092CysCys: 0.092 ± 0.012	0.527CysAsp: 0.527 ± 0.03	0.501CysGlu: 0.501 ± 0.027	0.264CysPhe: 0.264 ± 0.021	0.906CysGly: 0.906 ± 0.04	0.199CysHis: 0.199 ± 0.016	0.261CysIle: 0.261 ± 0.021	0.121CysLys: 0.121 ± 0.012	0.698CysLeu: 0.698 ± 0.033	0.136CysMet: 0.136 ± 0.014	0.136CysAsn: 0.136 ± 0.016	0.49CysPro: 0.49 ± 0.03	0.175CysGln: 0.175 ± 0.015	0.513CysArg: 0.513 ± 0.034	0.531CysSer: 0.531 ± 0.029	0.427CysThr: 0.427 ± 0.026	0.713CysVal: 0.713 ± 0.031	0.087CysTrp: 0.087 ± 0.012	0.155CysTyr: 0.155 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.781AspAla: 7.781 ± 0.118	0.394AspCys: 0.394 ± 0.025	3.323AspAsp: 3.323 ± 0.086	4.263AspGlu: 4.263 ± 0.092	1.654AspPhe: 1.654 ± 0.048	5.634AspGly: 5.634 ± 0.115	1.228AspHis: 1.228 ± 0.043	2.643AspIle: 2.643 ± 0.065	1.369AspLys: 1.369 ± 0.04	5.725AspLeu: 5.725 ± 0.108	1.294AspMet: 1.294 ± 0.049	1.285AspAsn: 1.285 ± 0.044	3.973AspPro: 3.973 ± 0.09	1.804AspGln: 1.804 ± 0.053	3.678AspArg: 3.678 ± 0.083	3.319AspSer: 3.319 ± 0.076	3.085AspThr: 3.085 ± 0.081	4.967AspVal: 4.967 ± 0.091	0.822AspTrp: 0.822 ± 0.031	1.489AspTyr: 1.489 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	8.217GluAla: 8.217 ± 0.125	0.42GluCys: 0.42 ± 0.03	3.525GluAsp: 3.525 ± 0.073	4.256GluGlu: 4.256 ± 0.106	1.476GluPhe: 1.476 ± 0.052	4.896GluGly: 4.896 ± 0.069	1.298GluHis: 1.298 ± 0.045	2.636GluIle: 2.636 ± 0.072	1.604GluLys: 1.604 ± 0.059	5.069GluLeu: 5.069 ± 0.095	1.18GluMet: 1.18 ± 0.038	1.297GluAsn: 1.297 ± 0.044	2.565GluPro: 2.565 ± 0.115	1.95GluGln: 1.95 ± 0.05	4.847GluArg: 4.847 ± 0.113	2.971GluSer: 2.971 ± 0.068	2.688GluThr: 2.688 ± 0.072	4.465GluVal: 4.465 ± 0.078	0.765GluTrp: 0.765 ± 0.04	1.225GluTyr: 1.225 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.505PheAla: 3.505 ± 0.076	0.238PheCys: 0.238 ± 0.02	2.152PheAsp: 2.152 ± 0.057	1.658PheGlu: 1.658 ± 0.051	1.122PhePhe: 1.122 ± 0.048	2.669PheGly: 2.669 ± 0.07	0.595PheHis: 0.595 ± 0.031	1.281PheIle: 1.281 ± 0.048	0.602PheLys: 0.602 ± 0.033	2.604PheLeu: 2.604 ± 0.071	0.604PheMet: 0.604 ± 0.034	0.748PheAsn: 0.748 ± 0.033	1.36PhePro: 1.36 ± 0.037	0.741PheGln: 0.741 ± 0.036	1.483PheArg: 1.483 ± 0.046	1.997PheSer: 1.997 ± 0.061	1.921PheThr: 1.921 ± 0.057	2.509PheVal: 2.509 ± 0.062	0.351PheTrp: 0.351 ± 0.022	0.647PheTyr: 0.647 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	11.304GlyAla: 11.304 ± 0.159	0.68GlyCys: 0.68 ± 0.03	4.685GlyAsp: 4.685 ± 0.09	5.159GlyGlu: 5.159 ± 0.096	2.838GlyPhe: 2.838 ± 0.066	7.819GlyGly: 7.819 ± 0.15	1.831GlyHis: 1.831 ± 0.055	4.405GlyIle: 4.405 ± 0.089	2.563GlyLys: 2.563 ± 0.064	7.602GlyLeu: 7.602 ± 0.129	2.097GlyMet: 2.097 ± 0.057	1.935GlyAsn: 1.935 ± 0.065	3.592GlyPro: 3.592 ± 0.063	2.936GlyGln: 2.936 ± 0.092	6.184GlyArg: 6.184 ± 0.108	5.564GlySer: 5.564 ± 0.107	5.606GlyThr: 5.606 ± 0.105	7.849GlyVal: 7.849 ± 0.105	1.667GlyTrp: 1.667 ± 0.071	2.227GlyTyr: 2.227 ± 0.068	0.0GlyXaa: 0.0 ± 0.0
His	2.441HisAla: 2.441 ± 0.057	0.169HisCys: 0.169 ± 0.015	1.129HisAsp: 1.129 ± 0.047	1.138HisGlu: 1.138 ± 0.041	0.576HisPhe: 0.576 ± 0.033	1.73HisGly: 1.73 ± 0.05	0.5HisHis: 0.5 ± 0.028	0.829HisIle: 0.829 ± 0.037	0.367HisLys: 0.367 ± 0.024	1.953HisLeu: 1.953 ± 0.059	0.468HisMet: 0.468 ± 0.027	0.462HisAsn: 0.462 ± 0.027	1.524HisPro: 1.524 ± 0.045	0.55HisGln: 0.55 ± 0.027	1.399HisArg: 1.399 ± 0.05	1.134HisSer: 1.134 ± 0.049	1.124HisThr: 1.124 ± 0.042	1.805HisVal: 1.805 ± 0.052	0.287HisTrp: 0.287 ± 0.02	0.495HisTyr: 0.495 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.096IleAla: 6.096 ± 0.12	0.377IleCys: 0.377 ± 0.024	3.668IleAsp: 3.668 ± 0.071	2.937IleGlu: 2.937 ± 0.071	1.167IlePhe: 1.167 ± 0.046	4.398IleGly: 4.398 ± 0.087	0.88IleHis: 0.88 ± 0.037	2.27IleIle: 2.27 ± 0.077	1.074IleLys: 1.074 ± 0.046	3.934IleLeu: 3.934 ± 0.091	0.921IleMet: 0.921 ± 0.039	1.256IleAsn: 1.256 ± 0.048	2.649IlePro: 2.649 ± 0.063	1.098IleGln: 1.098 ± 0.041	2.711IleArg: 2.711 ± 0.065	2.569IleSer: 2.569 ± 0.067	2.78IleThr: 2.78 ± 0.072	4.481IleVal: 4.481 ± 0.099	0.41IleTrp: 0.41 ± 0.023	0.852IleTyr: 0.852 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	2.995LysAla: 2.995 ± 0.083	0.123LysCys: 0.123 ± 0.013	1.501LysAsp: 1.501 ± 0.055	1.525LysGlu: 1.525 ± 0.055	0.503LysPhe: 0.503 ± 0.029	1.886LysGly: 1.886 ± 0.056	0.469LysHis: 0.469 ± 0.024	1.131LysIle: 1.131 ± 0.045	1.16LysLys: 1.16 ± 0.053	1.912LysLeu: 1.912 ± 0.062	0.524LysMet: 0.524 ± 0.028	0.75LysAsn: 0.75 ± 0.035	1.242LysPro: 1.242 ± 0.041	0.771LysGln: 0.771 ± 0.032	1.869LysArg: 1.869 ± 0.057	1.389LysSer: 1.389 ± 0.046	1.449LysThr: 1.449 ± 0.052	1.838LysVal: 1.838 ± 0.063	0.342LysTrp: 0.342 ± 0.025	0.55LysTyr: 0.55 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	13.45LeuAla: 13.45 ± 0.181	0.754LeuCys: 0.754 ± 0.036	5.718LeuAsp: 5.718 ± 0.11	4.887LeuGlu: 4.887 ± 0.095	2.386LeuPhe: 2.386 ± 0.055	8.29LeuGly: 8.29 ± 0.127	1.667LeuHis: 1.667 ± 0.053	4.359LeuIle: 4.359 ± 0.087	2.003LeuLys: 2.003 ± 0.061	8.313LeuLeu: 8.313 ± 0.15	1.889LeuMet: 1.889 ± 0.056	1.831LeuAsn: 1.831 ± 0.056	4.982LeuPro: 4.982 ± 0.104	1.974LeuGln: 1.974 ± 0.056	6.591LeuArg: 6.591 ± 0.118	6.453LeuSer: 6.453 ± 0.121	6.281LeuThr: 6.281 ± 0.104	8.19LeuVal: 8.19 ± 0.143	1.089LeuTrp: 1.089 ± 0.046	1.672LeuTyr: 1.672 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.527MetAla: 2.527 ± 0.068	0.157MetCys: 0.157 ± 0.015	1.096MetAsp: 1.096 ± 0.041	1.044MetGlu: 1.044 ± 0.035	0.565MetPhe: 0.565 ± 0.032	1.821MetGly: 1.821 ± 0.054	0.445MetHis: 0.445 ± 0.027	1.072MetIle: 1.072 ± 0.043	0.617MetLys: 0.617 ± 0.027	1.843MetLeu: 1.843 ± 0.05	0.514MetMet: 0.514 ± 0.029	0.738MetAsn: 0.738 ± 0.034	1.243MetPro: 1.243 ± 0.044	0.474MetGln: 0.474 ± 0.027	1.786MetArg: 1.786 ± 0.052	1.996MetSer: 1.996 ± 0.06	1.71MetThr: 1.71 ± 0.044	1.72MetVal: 1.72 ± 0.05	0.261MetTrp: 0.261 ± 0.018	0.377MetTyr: 0.377 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.805AsnAla: 2.805 ± 0.072	0.163AsnCys: 0.163 ± 0.016	1.277AsnAsp: 1.277 ± 0.049	1.324AsnGlu: 1.324 ± 0.042	0.618AsnPhe: 0.618 ± 0.035	2.122AsnGly: 2.122 ± 0.084	0.491AsnHis: 0.491 ± 0.029	1.05AsnIle: 1.05 ± 0.036	0.546AsnLys: 0.546 ± 0.028	2.025AsnLeu: 2.025 ± 0.067	0.466AsnMet: 0.466 ± 0.028	0.607AsnAsn: 0.607 ± 0.039	1.773AsnPro: 1.773 ± 0.059	0.751AsnGln: 0.751 ± 0.036	1.313AsnArg: 1.313 ± 0.048	1.17AsnSer: 1.17 ± 0.044	1.246AsnThr: 1.246 ± 0.051	1.812AsnVal: 1.812 ± 0.06	0.341AsnTrp: 0.341 ± 0.022	0.583AsnTyr: 0.583 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	6.802ProAla: 6.802 ± 0.156	0.309ProCys: 0.309 ± 0.024	3.527ProAsp: 3.527 ± 0.089	3.564ProGlu: 3.564 ± 0.099	1.525ProPhe: 1.525 ± 0.045	4.92ProGly: 4.92 ± 0.102	1.089ProHis: 1.089 ± 0.038	2.227ProIle: 2.227 ± 0.06	1.093ProLys: 1.093 ± 0.037	4.493ProLeu: 4.493 ± 0.087	1.021ProMet: 1.021 ± 0.046	1.135ProAsn: 1.135 ± 0.041	2.158ProPro: 2.158 ± 0.094	1.672ProGln: 1.672 ± 0.065	3.489ProArg: 3.489 ± 0.079	4.048ProSer: 4.048 ± 0.094	3.895ProThr: 3.895 ± 0.118	4.321ProVal: 4.321 ± 0.1	0.854ProTrp: 0.854 ± 0.041	1.154ProTyr: 1.154 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	4.024GlnAla: 4.024 ± 0.095	0.214GlnCys: 0.214 ± 0.017	1.434GlnAsp: 1.434 ± 0.051	1.502GlnGlu: 1.502 ± 0.052	0.778GlnPhe: 0.778 ± 0.035	2.438GlnGly: 2.438 ± 0.068	0.543GlnHis: 0.543 ± 0.026	1.597GlnIle: 1.597 ± 0.045	0.68GlnLys: 0.68 ± 0.034	2.757GlnLeu: 2.757 ± 0.063	0.911GlnMet: 0.911 ± 0.042	0.598GlnAsn: 0.598 ± 0.03	1.363GlnPro: 1.363 ± 0.058	0.97GlnGln: 0.97 ± 0.041	2.293GlnArg: 2.293 ± 0.059	1.609GlnSer: 1.609 ± 0.053	1.456GlnThr: 1.456 ± 0.051	2.712GlnVal: 2.712 ± 0.059	0.592GlnTrp: 0.592 ± 0.032	0.648GlnTyr: 0.648 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	9.347ArgAla: 9.347 ± 0.174	0.569ArgCys: 0.569 ± 0.034	4.019ArgAsp: 4.019 ± 0.086	4.619ArgGlu: 4.619 ± 0.089	2.153ArgPhe: 2.153 ± 0.059	5.645ArgGly: 5.645 ± 0.107	1.401ArgHis: 1.401 ± 0.045	3.668ArgIle: 3.668 ± 0.072	1.641ArgLys: 1.641 ± 0.052	6.406ArgLeu: 6.406 ± 0.116	1.719ArgMet: 1.719 ± 0.05	1.327ArgAsn: 1.327 ± 0.045	3.377ArgPro: 3.377 ± 0.08	1.994ArgGln: 1.994 ± 0.057	6.162ArgArg: 6.162 ± 0.152	4.721ArgSer: 4.721 ± 0.085	3.917ArgThr: 3.917 ± 0.098	5.975ArgVal: 5.975 ± 0.104	1.193ArgTrp: 1.193 ± 0.045	1.619ArgTyr: 1.619 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	8.124SerAla: 8.124 ± 0.139	0.559SerCys: 0.559 ± 0.029	3.677SerAsp: 3.677 ± 0.084	3.151SerGlu: 3.151 ± 0.074	2.238SerPhe: 2.238 ± 0.056	6.77SerGly: 6.77 ± 0.115	1.271SerHis: 1.271 ± 0.042	2.857SerIle: 2.857 ± 0.077	1.464SerLys: 1.464 ± 0.058	6.259SerLeu: 6.259 ± 0.103	1.555SerMet: 1.555 ± 0.047	1.42SerAsn: 1.42 ± 0.053	3.527SerPro: 3.527 ± 0.085	2.02SerGln: 2.02 ± 0.06	4.4SerArg: 4.4 ± 0.097	5.131SerSer: 5.131 ± 0.111	3.908SerThr: 3.908 ± 0.073	5.268SerVal: 5.268 ± 0.11	1.115SerTrp: 1.115 ± 0.045	1.573SerTyr: 1.573 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	6.042ThrAla: 6.042 ± 0.116	0.51ThrCys: 0.51 ± 0.028	3.439ThrAsp: 3.439 ± 0.075	2.67ThrGlu: 2.67 ± 0.064	1.69ThrPhe: 1.69 ± 0.047	5.333ThrGly: 5.333 ± 0.097	1.397ThrHis: 1.397 ± 0.046	3.08ThrIle: 3.08 ± 0.064	1.475ThrLys: 1.475 ± 0.056	6.148ThrLeu: 6.148 ± 0.11	1.261ThrMet: 1.261 ± 0.041	1.476ThrAsn: 1.476 ± 0.05	4.309ThrPro: 4.309 ± 0.095	1.847ThrGln: 1.847 ± 0.047	4.117ThrArg: 4.117 ± 0.089	3.875ThrSer: 3.875 ± 0.085	3.759ThrThr: 3.759 ± 0.083	5.164ThrVal: 5.164 ± 0.115	1.098ThrTrp: 1.098 ± 0.049	1.538ThrTyr: 1.538 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	10.73ValAla: 10.73 ± 0.148	0.809ValCys: 0.809 ± 0.041	5.313ValAsp: 5.313 ± 0.087	4.799ValGlu: 4.799 ± 0.1	2.425ValPhe: 2.425 ± 0.07	7.303ValGly: 7.303 ± 0.109	1.44ValHis: 1.44 ± 0.042	4.063ValIle: 4.063 ± 0.088	1.798ValLys: 1.798 ± 0.055	7.679ValLeu: 7.679 ± 0.141	1.617ValMet: 1.617 ± 0.057	1.849ValAsn: 1.849 ± 0.057	4.533ValPro: 4.533 ± 0.093	1.73ValGln: 1.73 ± 0.051	5.959ValArg: 5.959 ± 0.108	5.944ValSer: 5.944 ± 0.115	5.387ValThr: 5.387 ± 0.117	7.611ValVal: 7.611 ± 0.134	1.021ValTrp: 1.021 ± 0.036	1.586ValTyr: 1.586 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	1.668TrpAla: 1.668 ± 0.055	0.15TrpCys: 0.15 ± 0.015	0.891TrpAsp: 0.891 ± 0.041	0.888TrpGlu: 0.888 ± 0.036	0.481TrpPhe: 0.481 ± 0.03	1.18TrpGly: 1.18 ± 0.047	0.248TrpHis: 0.248 ± 0.017	0.747TrpIle: 0.747 ± 0.032	0.474TrpLys: 0.474 ± 0.025	1.47TrpLeu: 1.47 ± 0.052	0.419TrpMet: 0.419 ± 0.024	0.49TrpAsn: 0.49 ± 0.032	0.544TrpPro: 0.544 ± 0.029	0.452TrpGln: 0.452 ± 0.027	1.077TrpArg: 1.077 ± 0.039	0.976TrpSer: 0.976 ± 0.039	0.861TrpThr: 0.861 ± 0.034	1.295TrpVal: 1.295 ± 0.053	0.4TrpTrp: 0.4 ± 0.027	0.455TrpTyr: 0.455 ± 0.046	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.526TyrAla: 2.526 ± 0.069	0.186TyrCys: 0.186 ± 0.017	1.342TyrAsp: 1.342 ± 0.044	1.345TyrGlu: 1.345 ± 0.042	0.793TyrPhe: 0.793 ± 0.039	2.041TyrGly: 2.041 ± 0.062	0.423TyrHis: 0.423 ± 0.028	0.744TyrIle: 0.744 ± 0.033	0.461TyrLys: 0.461 ± 0.028	2.175TyrLeu: 2.175 ± 0.065	0.466TyrMet: 0.466 ± 0.027	0.524TyrAsn: 0.524 ± 0.032	1.226TyrPro: 1.226 ± 0.043	0.669TyrGln: 0.669 ± 0.031	1.589TyrArg: 1.589 ± 0.046	1.345TyrSer: 1.345 ± 0.046	1.259TyrThr: 1.259 ± 0.047	1.919TyrVal: 1.919 ± 0.046	0.326TyrTrp: 0.326 ± 0.023	0.66TyrTyr: 0.66 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2070 proteins (692431 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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