Amino acid dipepetide frequency for Streptococcus phage P0095

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.243AlaAla: 5.243 ± 2.651
0.271AlaCys: 0.271 ± 0.143
3.706AlaAsp: 3.706 ± 0.572
4.43AlaGlu: 4.43 ± 0.486
2.802AlaPhe: 2.802 ± 0.738
4.791AlaGly: 4.791 ± 1.275
0.814AlaHis: 0.814 ± 0.266
6.147AlaIle: 6.147 ± 1.62
5.424AlaLys: 5.424 ± 0.732
6.238AlaLeu: 6.238 ± 0.946
3.074AlaMet: 3.074 ± 0.908
4.249AlaAsn: 4.249 ± 0.876
2.441AlaPro: 2.441 ± 0.441
3.616AlaGln: 3.616 ± 0.761
3.254AlaArg: 3.254 ± 0.522
4.43AlaSer: 4.43 ± 0.794
4.791AlaThr: 4.791 ± 1.439
4.882AlaVal: 4.882 ± 1.303
0.723AlaTrp: 0.723 ± 0.297
2.531AlaTyr: 2.531 ± 0.446
0.0AlaXaa: 0.0 ± 0.0
Cys
0.362CysAla: 0.362 ± 0.167
0.181CysCys: 0.181 ± 0.194
0.633CysAsp: 0.633 ± 0.257
0.723CysGlu: 0.723 ± 0.319
0.09CysPhe: 0.09 ± 0.104
0.542CysGly: 0.542 ± 0.192
0.271CysHis: 0.271 ± 0.147
0.181CysIle: 0.181 ± 0.117
0.633CysLys: 0.633 ± 0.304
0.723CysLeu: 0.723 ± 0.289
0.0CysMet: 0.0 ± 0.0
0.181CysAsn: 0.181 ± 0.137
0.181CysPro: 0.181 ± 0.127
0.181CysGln: 0.181 ± 0.135
0.271CysArg: 0.271 ± 0.163
0.814CysSer: 0.814 ± 0.308
0.09CysThr: 0.09 ± 0.084
0.362CysVal: 0.362 ± 0.176
0.181CysTrp: 0.181 ± 0.115
0.362CysTyr: 0.362 ± 0.201
0.0CysXaa: 0.0 ± 0.0
Asp
3.164AspAla: 3.164 ± 0.556
0.452AspCys: 0.452 ± 0.229
5.424AspAsp: 5.424 ± 1.141
3.526AspGlu: 3.526 ± 0.536
4.791AspPhe: 4.791 ± 0.893
4.339AspGly: 4.339 ± 0.568
0.542AspHis: 0.542 ± 0.21
3.616AspIle: 3.616 ± 0.654
5.062AspLys: 5.062 ± 0.852
4.068AspLeu: 4.068 ± 0.902
2.35AspMet: 2.35 ± 0.383
3.616AspAsn: 3.616 ± 0.684
1.085AspPro: 1.085 ± 0.299
1.718AspGln: 1.718 ± 0.284
2.441AspArg: 2.441 ± 0.655
3.164AspSer: 3.164 ± 0.853
3.526AspThr: 3.526 ± 0.45
3.164AspVal: 3.164 ± 0.605
0.452AspTrp: 0.452 ± 0.205
2.531AspTyr: 2.531 ± 0.641
0.0AspXaa: 0.0 ± 0.0
Glu
4.339GluAla: 4.339 ± 0.624
0.452GluCys: 0.452 ± 0.284
3.616GluAsp: 3.616 ± 0.678
6.147GluGlu: 6.147 ± 1.299
2.26GluPhe: 2.26 ± 0.559
2.983GluGly: 2.983 ± 0.404
0.994GluHis: 0.994 ± 0.309
4.158GluIle: 4.158 ± 0.85
5.334GluLys: 5.334 ± 1.026
6.418GluLeu: 6.418 ± 0.986
1.898GluMet: 1.898 ± 0.453
4.52GluAsn: 4.52 ± 0.859
1.808GluPro: 1.808 ± 0.375
2.983GluGln: 2.983 ± 0.679
3.074GluArg: 3.074 ± 0.542
3.526GluSer: 3.526 ± 0.501
3.978GluThr: 3.978 ± 0.687
6.147GluVal: 6.147 ± 0.976
1.175GluTrp: 1.175 ± 0.385
2.622GluTyr: 2.622 ± 0.695
0.0GluXaa: 0.0 ± 0.0
Phe
2.983PheAla: 2.983 ± 0.559
0.362PheCys: 0.362 ± 0.171
3.526PheAsp: 3.526 ± 0.647
4.43PheGlu: 4.43 ± 0.735
1.627PhePhe: 1.627 ± 0.357
3.164PheGly: 3.164 ± 0.679
0.452PheHis: 0.452 ± 0.179
2.712PheIle: 2.712 ± 0.469
4.249PheLys: 4.249 ± 0.815
2.35PheLeu: 2.35 ± 0.624
1.085PheMet: 1.085 ± 0.286
3.797PheAsn: 3.797 ± 0.522
0.904PhePro: 0.904 ± 0.341
1.627PheGln: 1.627 ± 0.353
1.175PheArg: 1.175 ± 0.33
3.616PheSer: 3.616 ± 0.652
2.17PheThr: 2.17 ± 0.33
1.808PheVal: 1.808 ± 0.362
0.362PheTrp: 0.362 ± 0.174
1.989PheTyr: 1.989 ± 0.621
0.0PheXaa: 0.0 ± 0.0
Gly
3.978GlyAla: 3.978 ± 1.221
0.633GlyCys: 0.633 ± 0.288
3.254GlyAsp: 3.254 ± 0.591
3.074GlyGlu: 3.074 ± 0.583
3.797GlyPhe: 3.797 ± 0.622
3.435GlyGly: 3.435 ± 0.607
1.537GlyHis: 1.537 ± 0.425
6.69GlyIle: 6.69 ± 1.787
5.334GlyLys: 5.334 ± 0.788
5.876GlyLeu: 5.876 ± 1.019
2.17GlyMet: 2.17 ± 0.715
3.254GlyAsn: 3.254 ± 0.62
0.452GlyPro: 0.452 ± 0.191
2.531GlyGln: 2.531 ± 0.406
1.898GlyArg: 1.898 ± 0.453
3.887GlySer: 3.887 ± 1.107
5.153GlyThr: 5.153 ± 1.256
1.989GlyVal: 1.989 ± 0.447
0.271GlyTrp: 0.271 ± 0.124
2.622GlyTyr: 2.622 ± 0.514
0.0GlyXaa: 0.0 ± 0.0
His
0.452HisAla: 0.452 ± 0.199
0.181HisCys: 0.181 ± 0.135
0.814HisAsp: 0.814 ± 0.328
0.994HisGlu: 0.994 ± 0.328
0.362HisPhe: 0.362 ± 0.189
0.723HisGly: 0.723 ± 0.267
0.181HisHis: 0.181 ± 0.12
0.633HisIle: 0.633 ± 0.25
1.266HisLys: 1.266 ± 0.377
1.446HisLeu: 1.446 ± 0.39
0.181HisMet: 0.181 ± 0.109
0.452HisAsn: 0.452 ± 0.217
0.542HisPro: 0.542 ± 0.214
0.362HisGln: 0.362 ± 0.183
0.452HisArg: 0.452 ± 0.159
0.633HisSer: 0.633 ± 0.207
0.633HisThr: 0.633 ± 0.218
0.633HisVal: 0.633 ± 0.237
0.362HisTrp: 0.362 ± 0.171
0.181HisTyr: 0.181 ± 0.146
0.0HisXaa: 0.0 ± 0.0
Ile
6.78IleAla: 6.78 ± 1.208
0.271IleCys: 0.271 ± 0.141
5.334IleAsp: 5.334 ± 0.647
4.339IleGlu: 4.339 ± 0.715
1.446IlePhe: 1.446 ± 0.37
5.514IleGly: 5.514 ± 1.45
0.814IleHis: 0.814 ± 0.332
3.526IleIle: 3.526 ± 0.802
7.684IleLys: 7.684 ± 0.744
4.972IleLeu: 4.972 ± 0.857
1.989IleMet: 1.989 ± 0.455
4.339IleAsn: 4.339 ± 0.627
1.989IlePro: 1.989 ± 0.317
2.441IleGln: 2.441 ± 0.41
3.345IleArg: 3.345 ± 0.632
5.605IleSer: 5.605 ± 1.282
4.972IleThr: 4.972 ± 0.802
3.616IleVal: 3.616 ± 0.491
0.723IleTrp: 0.723 ± 0.304
2.17IleTyr: 2.17 ± 0.521
0.0IleXaa: 0.0 ± 0.0
Lys
6.87LysAla: 6.87 ± 0.803
0.904LysCys: 0.904 ± 0.344
3.616LysAsp: 3.616 ± 0.597
6.057LysGlu: 6.057 ± 1.15
3.435LysPhe: 3.435 ± 0.616
4.61LysGly: 4.61 ± 0.456
1.085LysHis: 1.085 ± 0.397
5.514LysIle: 5.514 ± 0.727
6.599LysLys: 6.599 ± 1.102
6.69LysLeu: 6.69 ± 0.919
2.531LysMet: 2.531 ± 0.509
3.526LysAsn: 3.526 ± 0.55
2.893LysPro: 2.893 ± 0.492
3.887LysGln: 3.887 ± 0.602
4.068LysArg: 4.068 ± 0.804
7.142LysSer: 7.142 ± 0.783
6.147LysThr: 6.147 ± 0.797
4.701LysVal: 4.701 ± 0.667
0.814LysTrp: 0.814 ± 0.281
4.52LysTyr: 4.52 ± 0.957
0.0LysXaa: 0.0 ± 0.0
Leu
6.238LeuAla: 6.238 ± 0.979
0.452LeuCys: 0.452 ± 0.207
5.243LeuAsp: 5.243 ± 0.77
6.509LeuGlu: 6.509 ± 1.104
3.616LeuPhe: 3.616 ± 0.614
5.605LeuGly: 5.605 ± 0.806
0.904LeuHis: 0.904 ± 0.341
4.249LeuIle: 4.249 ± 0.757
7.865LeuLys: 7.865 ± 1.054
4.791LeuLeu: 4.791 ± 0.915
1.808LeuMet: 1.808 ± 0.418
4.701LeuAsn: 4.701 ± 0.589
2.531LeuPro: 2.531 ± 0.541
2.893LeuGln: 2.893 ± 0.614
3.435LeuArg: 3.435 ± 0.643
6.057LeuSer: 6.057 ± 1.026
5.424LeuThr: 5.424 ± 0.674
4.158LeuVal: 4.158 ± 0.56
0.542LeuTrp: 0.542 ± 0.194
3.254LeuTyr: 3.254 ± 0.674
0.0LeuXaa: 0.0 ± 0.0
Met
2.35MetAla: 2.35 ± 0.847
0.09MetCys: 0.09 ± 0.083
1.266MetAsp: 1.266 ± 0.519
1.175MetGlu: 1.175 ± 0.305
1.266MetPhe: 1.266 ± 0.279
1.537MetGly: 1.537 ± 0.372
0.362MetHis: 0.362 ± 0.173
2.802MetIle: 2.802 ± 0.469
2.983MetLys: 2.983 ± 0.405
2.441MetLeu: 2.441 ± 0.558
1.446MetMet: 1.446 ± 0.415
0.994MetAsn: 0.994 ± 0.265
0.542MetPro: 0.542 ± 0.174
1.718MetGln: 1.718 ± 0.622
1.356MetArg: 1.356 ± 0.371
2.441MetSer: 2.441 ± 0.45
2.26MetThr: 2.26 ± 0.497
1.718MetVal: 1.718 ± 0.684
0.271MetTrp: 0.271 ± 0.156
0.904MetTyr: 0.904 ± 0.403
0.0MetXaa: 0.0 ± 0.0
Asn
3.797AsnAla: 3.797 ± 0.498
0.362AsnCys: 0.362 ± 0.18
3.797AsnAsp: 3.797 ± 0.672
3.074AsnGlu: 3.074 ± 0.562
2.531AsnPhe: 2.531 ± 0.504
3.706AsnGly: 3.706 ± 0.577
0.542AsnHis: 0.542 ± 0.196
3.797AsnIle: 3.797 ± 0.7
4.701AsnLys: 4.701 ± 0.924
3.797AsnLeu: 3.797 ± 0.526
1.175AsnMet: 1.175 ± 0.361
2.712AsnAsn: 2.712 ± 0.467
2.26AsnPro: 2.26 ± 0.45
2.802AsnGln: 2.802 ± 0.471
1.356AsnArg: 1.356 ± 0.392
4.52AsnSer: 4.52 ± 0.764
2.712AsnThr: 2.712 ± 0.522
2.983AsnVal: 2.983 ± 0.665
0.994AsnTrp: 0.994 ± 0.308
2.441AsnTyr: 2.441 ± 0.537
0.0AsnXaa: 0.0 ± 0.0
Pro
1.175ProAla: 1.175 ± 0.369
0.271ProCys: 0.271 ± 0.23
1.266ProAsp: 1.266 ± 0.28
1.808ProGlu: 1.808 ± 0.412
1.718ProPhe: 1.718 ± 0.379
1.085ProGly: 1.085 ± 0.293
0.181ProHis: 0.181 ± 0.137
2.079ProIle: 2.079 ± 0.471
3.164ProLys: 3.164 ± 0.563
1.898ProLeu: 1.898 ± 0.456
0.271ProMet: 0.271 ± 0.146
1.537ProAsn: 1.537 ± 0.473
0.542ProPro: 0.542 ± 0.155
1.627ProGln: 1.627 ± 0.366
1.175ProArg: 1.175 ± 0.394
2.079ProSer: 2.079 ± 0.537
1.718ProThr: 1.718 ± 0.34
1.537ProVal: 1.537 ± 0.364
0.181ProTrp: 0.181 ± 0.113
1.989ProTyr: 1.989 ± 0.458
0.0ProXaa: 0.0 ± 0.0
Gln
4.249GlnAla: 4.249 ± 1.17
0.181GlnCys: 0.181 ± 0.132
2.17GlnAsp: 2.17 ± 0.468
3.074GlnGlu: 3.074 ± 0.733
1.989GlnPhe: 1.989 ± 0.475
2.35GlnGly: 2.35 ± 0.646
0.09GlnHis: 0.09 ± 0.083
3.435GlnIle: 3.435 ± 0.77
3.526GlnLys: 3.526 ± 0.52
4.61GlnLeu: 4.61 ± 0.756
2.079GlnMet: 2.079 ± 0.411
1.718GlnAsn: 1.718 ± 0.396
0.452GlnPro: 0.452 ± 0.228
2.441GlnGln: 2.441 ± 0.522
1.356GlnArg: 1.356 ± 0.347
2.893GlnSer: 2.893 ± 0.717
2.531GlnThr: 2.531 ± 0.351
2.622GlnVal: 2.622 ± 0.351
0.723GlnTrp: 0.723 ± 0.247
0.994GlnTyr: 0.994 ± 0.416
0.0GlnXaa: 0.0 ± 0.0
Arg
2.35ArgAla: 2.35 ± 0.297
0.181ArgCys: 0.181 ± 0.117
2.893ArgAsp: 2.893 ± 0.622
3.164ArgGlu: 3.164 ± 0.668
1.446ArgPhe: 1.446 ± 0.484
1.989ArgGly: 1.989 ± 0.464
0.633ArgHis: 0.633 ± 0.199
2.26ArgIle: 2.26 ± 0.535
3.706ArgLys: 3.706 ± 0.93
3.435ArgLeu: 3.435 ± 0.572
1.266ArgMet: 1.266 ± 0.442
1.989ArgAsn: 1.989 ± 0.435
0.904ArgPro: 0.904 ± 0.345
1.989ArgGln: 1.989 ± 0.418
1.266ArgArg: 1.266 ± 0.427
1.808ArgSer: 1.808 ± 0.338
1.718ArgThr: 1.718 ± 0.386
2.26ArgVal: 2.26 ± 0.589
0.452ArgTrp: 0.452 ± 0.182
1.808ArgTyr: 1.808 ± 0.41
0.0ArgXaa: 0.0 ± 0.0
Ser
6.69SerAla: 6.69 ± 2.633
0.452SerCys: 0.452 ± 0.171
3.435SerAsp: 3.435 ± 0.611
3.797SerGlu: 3.797 ± 0.687
3.164SerPhe: 3.164 ± 0.515
5.062SerGly: 5.062 ± 1.068
0.814SerHis: 0.814 ± 0.251
6.328SerIle: 6.328 ± 0.753
5.695SerLys: 5.695 ± 0.764
7.142SerLeu: 7.142 ± 0.855
2.079SerMet: 2.079 ± 0.518
3.254SerAsn: 3.254 ± 0.626
1.989SerPro: 1.989 ± 0.384
3.526SerGln: 3.526 ± 0.93
2.17SerArg: 2.17 ± 0.567
5.966SerSer: 5.966 ± 1.23
3.435SerThr: 3.435 ± 0.699
5.153SerVal: 5.153 ± 0.756
0.542SerTrp: 0.542 ± 0.191
1.718SerTyr: 1.718 ± 0.438
0.0SerXaa: 0.0 ± 0.0
Thr
5.243ThrAla: 5.243 ± 1.339
0.271ThrCys: 0.271 ± 0.154
3.706ThrAsp: 3.706 ± 0.641
4.52ThrGlu: 4.52 ± 0.665
2.893ThrPhe: 2.893 ± 0.449
3.254ThrGly: 3.254 ± 0.707
0.271ThrHis: 0.271 ± 0.157
4.972ThrIle: 4.972 ± 0.647
5.514ThrLys: 5.514 ± 0.861
4.339ThrLeu: 4.339 ± 0.561
1.627ThrMet: 1.627 ± 0.578
2.983ThrAsn: 2.983 ± 0.604
2.17ThrPro: 2.17 ± 0.391
2.802ThrGln: 2.802 ± 0.729
1.537ThrArg: 1.537 ± 0.518
4.61ThrSer: 4.61 ± 1.221
3.616ThrThr: 3.616 ± 0.627
4.61ThrVal: 4.61 ± 0.614
0.271ThrTrp: 0.271 ± 0.138
2.622ThrTyr: 2.622 ± 0.545
0.0ThrXaa: 0.0 ± 0.0
Val
4.61ValAla: 4.61 ± 0.888
0.362ValCys: 0.362 ± 0.174
2.079ValAsp: 2.079 ± 0.491
4.61ValGlu: 4.61 ± 0.868
2.441ValPhe: 2.441 ± 0.544
3.616ValGly: 3.616 ± 0.772
0.362ValHis: 0.362 ± 0.203
4.791ValIle: 4.791 ± 0.477
3.887ValLys: 3.887 ± 0.598
3.616ValLeu: 3.616 ± 0.499
1.175ValMet: 1.175 ± 0.315
3.706ValAsn: 3.706 ± 0.524
2.17ValPro: 2.17 ± 0.344
1.898ValGln: 1.898 ± 0.54
1.446ValArg: 1.446 ± 0.321
4.882ValSer: 4.882 ± 0.694
4.158ValThr: 4.158 ± 0.523
3.526ValVal: 3.526 ± 0.538
1.175ValTrp: 1.175 ± 0.413
2.983ValTyr: 2.983 ± 0.587
0.0ValXaa: 0.0 ± 0.0
Trp
0.723TrpAla: 0.723 ± 0.251
0.0TrpCys: 0.0 ± 0.0
0.542TrpAsp: 0.542 ± 0.186
0.633TrpGlu: 0.633 ± 0.234
0.362TrpPhe: 0.362 ± 0.184
0.362TrpGly: 0.362 ± 0.169
0.09TrpHis: 0.09 ± 0.097
0.904TrpIle: 0.904 ± 0.291
0.542TrpLys: 0.542 ± 0.199
0.994TrpLeu: 0.994 ± 0.28
0.362TrpMet: 0.362 ± 0.173
0.814TrpAsn: 0.814 ± 0.248
0.181TrpPro: 0.181 ± 0.125
0.723TrpGln: 0.723 ± 0.234
0.814TrpArg: 0.814 ± 0.275
0.904TrpSer: 0.904 ± 0.326
1.085TrpThr: 1.085 ± 0.354
0.271TrpVal: 0.271 ± 0.159
0.181TrpTrp: 0.181 ± 0.115
0.362TrpTyr: 0.362 ± 0.172
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.26TyrAla: 2.26 ± 0.441
0.633TyrCys: 0.633 ± 0.304
2.712TyrAsp: 2.712 ± 0.625
2.35TyrGlu: 2.35 ± 0.535
2.35TyrPhe: 2.35 ± 0.572
3.164TyrGly: 3.164 ± 0.532
0.542TyrHis: 0.542 ± 0.265
3.074TyrIle: 3.074 ± 0.461
2.441TyrLys: 2.441 ± 0.497
4.43TyrLeu: 4.43 ± 0.843
1.266TyrMet: 1.266 ± 0.345
1.718TyrAsn: 1.718 ± 0.464
1.266TyrPro: 1.266 ± 0.457
1.718TyrGln: 1.718 ± 0.467
1.718TyrArg: 1.718 ± 0.515
3.435TyrSer: 3.435 ± 0.516
1.718TyrThr: 1.718 ± 0.463
1.356TyrVal: 1.356 ± 0.363
0.452TyrTrp: 0.452 ± 0.193
2.802TyrTyr: 2.802 ± 0.701
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 54 proteins (11063 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski