Amino acid dipepetide frequency for Alistipes timonensis JC136

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.242AlaAla: 11.242 ± 0.152
1.231AlaCys: 1.231 ± 0.035
5.85AlaAsp: 5.85 ± 0.081
6.74AlaGlu: 6.74 ± 0.104
3.472AlaPhe: 3.472 ± 0.066
7.874AlaGly: 7.874 ± 0.103
1.334AlaHis: 1.334 ± 0.037
4.029AlaIle: 4.029 ± 0.07
3.655AlaLys: 3.655 ± 0.069
8.339AlaLeu: 8.339 ± 0.104
2.127AlaMet: 2.127 ± 0.047
2.999AlaAsn: 2.999 ± 0.059
3.517AlaPro: 3.517 ± 0.071
2.925AlaGln: 2.925 ± 0.057
5.254AlaArg: 5.254 ± 0.079
5.184AlaSer: 5.184 ± 0.095
4.442AlaThr: 4.442 ± 0.067
7.378AlaVal: 7.378 ± 0.091
1.245AlaTrp: 1.245 ± 0.037
3.243AlaTyr: 3.243 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
1.04CysAla: 1.04 ± 0.035
0.248CysCys: 0.248 ± 0.017
0.79CysAsp: 0.79 ± 0.029
0.695CysGlu: 0.695 ± 0.025
0.506CysPhe: 0.506 ± 0.022
1.191CysGly: 1.191 ± 0.037
0.233CysHis: 0.233 ± 0.015
0.663CysIle: 0.663 ± 0.027
0.453CysLys: 0.453 ± 0.018
0.969CysLeu: 0.969 ± 0.034
0.255CysMet: 0.255 ± 0.015
0.465CysAsn: 0.465 ± 0.02
0.581CysPro: 0.581 ± 0.024
0.227CysGln: 0.227 ± 0.015
0.947CysArg: 0.947 ± 0.034
0.778CysSer: 0.778 ± 0.035
0.723CysThr: 0.723 ± 0.029
0.782CysVal: 0.782 ± 0.027
0.165CysTrp: 0.165 ± 0.012
0.511CysTyr: 0.511 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
5.415AspAla: 5.415 ± 0.065
0.65AspCys: 0.65 ± 0.023
3.27AspAsp: 3.27 ± 0.056
3.7AspGlu: 3.7 ± 0.052
2.893AspPhe: 2.893 ± 0.057
5.239AspGly: 5.239 ± 0.091
0.891AspHis: 0.891 ± 0.033
3.548AspIle: 3.548 ± 0.058
2.954AspLys: 2.954 ± 0.058
4.666AspLeu: 4.666 ± 0.062
1.43AspMet: 1.43 ± 0.037
2.46AspAsn: 2.46 ± 0.058
2.889AspPro: 2.889 ± 0.067
1.179AspGln: 1.179 ± 0.033
3.793AspArg: 3.793 ± 0.071
2.901AspSer: 2.901 ± 0.049
2.821AspThr: 2.821 ± 0.056
3.665AspVal: 3.665 ± 0.06
0.958AspTrp: 0.958 ± 0.035
2.822AspTyr: 2.822 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
5.9GluAla: 5.9 ± 0.094
0.666GluCys: 0.666 ± 0.023
2.663GluAsp: 2.663 ± 0.057
4.107GluGlu: 4.107 ± 0.067
2.492GluPhe: 2.492 ± 0.055
4.677GluGly: 4.677 ± 0.071
1.174GluHis: 1.174 ± 0.032
4.001GluIle: 4.001 ± 0.074
3.768GluLys: 3.768 ± 0.065
5.793GluLeu: 5.793 ± 0.076
1.891GluMet: 1.891 ± 0.041
2.907GluAsn: 2.907 ± 0.051
2.298GluPro: 2.298 ± 0.05
2.34GluGln: 2.34 ± 0.052
4.294GluArg: 4.294 ± 0.088
2.95GluSer: 2.95 ± 0.046
3.275GluThr: 3.275 ± 0.059
4.444GluVal: 4.444 ± 0.075
0.902GluTrp: 0.902 ± 0.032
2.547GluTyr: 2.547 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
3.811PheAla: 3.811 ± 0.063
0.519PheCys: 0.519 ± 0.023
3.046PheAsp: 3.046 ± 0.056
2.505PheGlu: 2.505 ± 0.049
1.866PhePhe: 1.866 ± 0.057
3.532PheGly: 3.532 ± 0.054
0.713PheHis: 0.713 ± 0.023
2.196PheIle: 2.196 ± 0.049
1.56PheLys: 1.56 ± 0.038
3.313PheLeu: 3.313 ± 0.062
1.024PheMet: 1.024 ± 0.034
1.839PheAsn: 1.839 ± 0.041
1.708PhePro: 1.708 ± 0.041
0.934PheGln: 0.934 ± 0.027
2.925PheArg: 2.925 ± 0.056
3.077PheSer: 3.077 ± 0.066
2.853PheThr: 2.853 ± 0.048
2.836PheVal: 2.836 ± 0.051
0.582PheTrp: 0.582 ± 0.023
1.804PheTyr: 1.804 ± 0.038
0.0PheXaa: 0.0 ± 0.0
Gly
6.248GlyAla: 6.248 ± 0.088
1.163GlyCys: 1.163 ± 0.037
4.462GlyAsp: 4.462 ± 0.061
4.971GlyGlu: 4.971 ± 0.066
3.465GlyPhe: 3.465 ± 0.059
6.116GlyGly: 6.116 ± 0.095
1.346GlyHis: 1.346 ± 0.04
4.99GlyIle: 4.99 ± 0.076
4.014GlyLys: 4.014 ± 0.071
6.21GlyLeu: 6.21 ± 0.094
2.103GlyMet: 2.103 ± 0.046
3.202GlyAsn: 3.202 ± 0.06
1.821GlyPro: 1.821 ± 0.045
2.157GlyGln: 2.157 ± 0.044
4.98GlyArg: 4.98 ± 0.079
4.83GlySer: 4.83 ± 0.078
4.794GlyThr: 4.794 ± 0.068
5.891GlyVal: 5.891 ± 0.075
1.298GlyTrp: 1.298 ± 0.037
3.686GlyTyr: 3.686 ± 0.066
0.0GlyXaa: 0.0 ± 0.0
His
1.309HisAla: 1.309 ± 0.04
0.251HisCys: 0.251 ± 0.016
1.027HisAsp: 1.027 ± 0.032
0.912HisGlu: 0.912 ± 0.031
0.86HisPhe: 0.86 ± 0.03
1.3HisGly: 1.3 ± 0.039
0.365HisHis: 0.365 ± 0.021
1.192HisIle: 1.192 ± 0.032
0.776HisLys: 0.776 ± 0.029
1.505HisLeu: 1.505 ± 0.038
0.351HisMet: 0.351 ± 0.018
0.774HisAsn: 0.774 ± 0.03
1.022HisPro: 1.022 ± 0.03
0.367HisGln: 0.367 ± 0.016
1.088HisArg: 1.088 ± 0.037
0.893HisSer: 0.893 ± 0.032
1.104HisThr: 1.104 ± 0.031
0.992HisVal: 0.992 ± 0.034
0.236HisTrp: 0.236 ± 0.015
0.792HisTyr: 0.792 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
5.477IleAla: 5.477 ± 0.069
0.707IleCys: 0.707 ± 0.024
3.873IleAsp: 3.873 ± 0.065
3.679IleGlu: 3.679 ± 0.072
2.191IlePhe: 2.191 ± 0.047
4.358IleGly: 4.358 ± 0.082
0.909IleHis: 0.909 ± 0.034
2.689IleIle: 2.689 ± 0.065
2.141IleLys: 2.141 ± 0.05
4.7IleLeu: 4.7 ± 0.084
1.01IleMet: 1.01 ± 0.035
2.125IleAsn: 2.125 ± 0.049
2.769IlePro: 2.769 ± 0.052
1.296IleGln: 1.296 ± 0.037
3.965IleArg: 3.965 ± 0.067
3.483IleSer: 3.483 ± 0.06
3.357IleThr: 3.357 ± 0.066
4.19IleVal: 4.19 ± 0.069
0.611IleTrp: 0.611 ± 0.025
2.183IleTyr: 2.183 ± 0.048
0.0IleXaa: 0.0 ± 0.0
Lys
4.083LysAla: 4.083 ± 0.08
0.414LysCys: 0.414 ± 0.021
2.416LysAsp: 2.416 ± 0.053
3.087LysGlu: 3.087 ± 0.064
1.765LysPhe: 1.765 ± 0.041
3.518LysGly: 3.518 ± 0.059
0.832LysHis: 0.832 ± 0.03
3.009LysIle: 3.009 ± 0.056
2.7LysLys: 2.7 ± 0.06
4.014LysLeu: 4.014 ± 0.073
1.548LysMet: 1.548 ± 0.039
2.197LysAsn: 2.197 ± 0.052
2.03LysPro: 2.03 ± 0.044
1.566LysGln: 1.566 ± 0.038
2.703LysArg: 2.703 ± 0.055
2.565LysSer: 2.565 ± 0.057
2.741LysThr: 2.741 ± 0.066
3.284LysVal: 3.284 ± 0.059
0.663LysTrp: 0.663 ± 0.026
2.164LysTyr: 2.164 ± 0.05
0.0LysXaa: 0.0 ± 0.0
Leu
8.204LeuAla: 8.204 ± 0.106
1.35LeuCys: 1.35 ± 0.036
4.967LeuAsp: 4.967 ± 0.068
4.85LeuGlu: 4.85 ± 0.067
4.055LeuPhe: 4.055 ± 0.072
6.262LeuGly: 6.262 ± 0.08
1.576LeuHis: 1.576 ± 0.039
4.341LeuIle: 4.341 ± 0.08
4.464LeuLys: 4.464 ± 0.075
8.728LeuLeu: 8.728 ± 0.137
2.157LeuMet: 2.157 ± 0.053
3.484LeuAsn: 3.484 ± 0.06
4.246LeuPro: 4.246 ± 0.063
2.595LeuGln: 2.595 ± 0.054
6.091LeuArg: 6.091 ± 0.082
5.945LeuSer: 5.945 ± 0.083
5.645LeuThr: 5.645 ± 0.073
5.344LeuVal: 5.344 ± 0.087
1.182LeuTrp: 1.182 ± 0.034
3.353LeuTyr: 3.353 ± 0.056
0.0LeuXaa: 0.0 ± 0.0
Met
2.239MetAla: 2.239 ± 0.053
0.252MetCys: 0.252 ± 0.016
1.183MetAsp: 1.183 ± 0.033
1.398MetGlu: 1.398 ± 0.041
0.832MetPhe: 0.832 ± 0.027
1.641MetGly: 1.641 ± 0.044
0.447MetHis: 0.447 ± 0.019
1.287MetIle: 1.287 ± 0.037
1.962MetLys: 1.962 ± 0.041
2.468MetLeu: 2.468 ± 0.051
0.656MetMet: 0.656 ± 0.024
1.256MetAsn: 1.256 ± 0.033
1.267MetPro: 1.267 ± 0.038
0.937MetGln: 0.937 ± 0.028
1.586MetArg: 1.586 ± 0.041
1.475MetSer: 1.475 ± 0.034
1.561MetThr: 1.561 ± 0.041
1.472MetVal: 1.472 ± 0.039
0.325MetTrp: 0.325 ± 0.017
0.774MetTyr: 0.774 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.417AsnAla: 3.417 ± 0.064
0.487AsnCys: 0.487 ± 0.023
2.291AsnAsp: 2.291 ± 0.05
2.096AsnGlu: 2.096 ± 0.048
1.734AsnPhe: 1.734 ± 0.04
3.392AsnGly: 3.392 ± 0.064
0.712AsnHis: 0.712 ± 0.025
2.651AsnIle: 2.651 ± 0.062
1.794AsnLys: 1.794 ± 0.048
3.661AsnLeu: 3.661 ± 0.061
1.007AsnMet: 1.007 ± 0.032
1.895AsnAsn: 1.895 ± 0.053
2.403AsnPro: 2.403 ± 0.047
1.017AsnGln: 1.017 ± 0.03
2.589AsnArg: 2.589 ± 0.054
2.286AsnSer: 2.286 ± 0.05
2.318AsnThr: 2.318 ± 0.052
2.721AsnVal: 2.721 ± 0.052
0.56AsnTrp: 0.56 ± 0.028
2.024AsnTyr: 2.024 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
4.691ProAla: 4.691 ± 0.065
0.401ProCys: 0.401 ± 0.02
3.048ProAsp: 3.048 ± 0.058
3.887ProGlu: 3.887 ± 0.07
1.728ProPhe: 1.728 ± 0.043
3.301ProGly: 3.301 ± 0.058
0.737ProHis: 0.737 ± 0.029
1.839ProIle: 1.839 ± 0.043
1.684ProLys: 1.684 ± 0.044
3.597ProLeu: 3.597 ± 0.061
1.006ProMet: 1.006 ± 0.029
1.405ProAsn: 1.405 ± 0.035
0.993ProPro: 0.993 ± 0.034
1.387ProGln: 1.387 ± 0.033
2.168ProArg: 2.168 ± 0.044
2.43ProSer: 2.43 ± 0.05
2.026ProThr: 2.026 ± 0.043
3.621ProVal: 3.621 ± 0.062
0.535ProTrp: 0.535 ± 0.023
1.75ProTyr: 1.75 ± 0.039
0.0ProXaa: 0.0 ± 0.0
Gln
2.488GlnAla: 2.488 ± 0.051
0.224GlnCys: 0.224 ± 0.016
1.218GlnAsp: 1.218 ± 0.031
1.664GlnGlu: 1.664 ± 0.041
1.125GlnPhe: 1.125 ± 0.033
2.016GlnGly: 2.016 ± 0.042
0.551GlnHis: 0.551 ± 0.02
1.917GlnIle: 1.917 ± 0.047
1.489GlnLys: 1.489 ± 0.042
2.742GlnLeu: 2.742 ± 0.049
0.85GlnMet: 0.85 ± 0.028
1.396GlnAsn: 1.396 ± 0.043
1.262GlnPro: 1.262 ± 0.034
1.278GlnGln: 1.278 ± 0.043
1.863GlnArg: 1.863 ± 0.042
1.678GlnSer: 1.678 ± 0.043
1.861GlnThr: 1.861 ± 0.042
1.839GlnVal: 1.839 ± 0.054
0.435GlnTrp: 0.435 ± 0.018
1.236GlnTyr: 1.236 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
4.697ArgAla: 4.697 ± 0.084
0.716ArgCys: 0.716 ± 0.028
3.235ArgAsp: 3.235 ± 0.062
4.319ArgGlu: 4.319 ± 0.08
3.032ArgPhe: 3.032 ± 0.06
3.802ArgGly: 3.802 ± 0.056
1.247ArgHis: 1.247 ± 0.04
4.453ArgIle: 4.453 ± 0.07
3.016ArgLys: 3.016 ± 0.059
5.967ArgLeu: 5.967 ± 0.09
1.925ArgMet: 1.925 ± 0.043
2.798ArgAsn: 2.798 ± 0.057
2.432ArgPro: 2.432 ± 0.057
2.1ArgGln: 2.1 ± 0.049
4.661ArgArg: 4.661 ± 0.093
3.336ArgSer: 3.336 ± 0.052
3.803ArgThr: 3.803 ± 0.065
3.848ArgVal: 3.848 ± 0.071
1.015ArgTrp: 1.015 ± 0.033
2.911ArgTyr: 2.911 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
5.123SerAla: 5.123 ± 0.077
0.723SerCys: 0.723 ± 0.028
3.476SerAsp: 3.476 ± 0.056
3.358SerGlu: 3.358 ± 0.053
2.634SerPhe: 2.634 ± 0.06
5.186SerGly: 5.186 ± 0.085
1.012SerHis: 1.012 ± 0.033
3.088SerIle: 3.088 ± 0.059
2.556SerLys: 2.556 ± 0.054
5.479SerLeu: 5.479 ± 0.08
1.377SerMet: 1.377 ± 0.034
2.176SerAsn: 2.176 ± 0.052
2.481SerPro: 2.481 ± 0.042
1.709SerGln: 1.709 ± 0.049
3.238SerArg: 3.238 ± 0.058
3.477SerSer: 3.477 ± 0.072
3.096SerThr: 3.096 ± 0.058
4.748SerVal: 4.748 ± 0.076
0.831SerTrp: 0.831 ± 0.03
2.747SerTyr: 2.747 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
5.682ThrAla: 5.682 ± 0.086
0.528ThrCys: 0.528 ± 0.024
3.627ThrAsp: 3.627 ± 0.06
3.277ThrGlu: 3.277 ± 0.06
2.63ThrPhe: 2.63 ± 0.055
4.902ThrGly: 4.902 ± 0.081
0.945ThrHis: 0.945 ± 0.03
3.166ThrIle: 3.166 ± 0.059
2.233ThrLys: 2.233 ± 0.049
5.853ThrLeu: 5.853 ± 0.075
1.202ThrMet: 1.202 ± 0.033
1.882ThrAsn: 1.882 ± 0.045
3.3ThrPro: 3.3 ± 0.062
1.618ThrGln: 1.618 ± 0.037
2.892ThrArg: 2.892 ± 0.06
3.16ThrSer: 3.16 ± 0.062
3.463ThrThr: 3.463 ± 0.076
4.965ThrVal: 4.965 ± 0.077
0.747ThrTrp: 0.747 ± 0.032
2.222ThrTyr: 2.222 ± 0.057
0.0ThrXaa: 0.0 ± 0.0
Val
6.353ValAla: 6.353 ± 0.081
0.998ValCys: 0.998 ± 0.033
4.029ValAsp: 4.029 ± 0.061
4.62ValGlu: 4.62 ± 0.07
2.854ValPhe: 2.854 ± 0.057
5.007ValGly: 5.007 ± 0.08
1.094ValHis: 1.094 ± 0.031
3.774ValIle: 3.774 ± 0.066
3.458ValLys: 3.458 ± 0.074
5.951ValLeu: 5.951 ± 0.089
1.739ValMet: 1.739 ± 0.043
2.937ValAsn: 2.937 ± 0.052
2.98ValPro: 2.98 ± 0.051
1.89ValGln: 1.89 ± 0.042
4.664ValArg: 4.664 ± 0.071
4.707ValSer: 4.707 ± 0.078
4.729ValThr: 4.729 ± 0.084
5.708ValVal: 5.708 ± 0.081
1.023ValTrp: 1.023 ± 0.034
2.727ValTyr: 2.727 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
0.984TrpAla: 0.984 ± 0.032
0.208TrpCys: 0.208 ± 0.015
0.747TrpAsp: 0.747 ± 0.033
0.808TrpGlu: 0.808 ± 0.026
0.651TrpPhe: 0.651 ± 0.025
1.119TrpGly: 1.119 ± 0.036
0.295TrpHis: 0.295 ± 0.017
0.777TrpIle: 0.777 ± 0.031
0.688TrpLys: 0.688 ± 0.025
1.322TrpLeu: 1.322 ± 0.035
0.417TrpMet: 0.417 ± 0.023
0.764TrpAsn: 0.764 ± 0.029
0.346TrpPro: 0.346 ± 0.017
0.564TrpGln: 0.564 ± 0.023
0.895TrpArg: 0.895 ± 0.034
0.904TrpSer: 0.904 ± 0.033
0.944TrpThr: 0.944 ± 0.035
0.834TrpVal: 0.834 ± 0.035
0.288TrpTrp: 0.288 ± 0.016
0.59TrpTyr: 0.59 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.676TyrAla: 3.676 ± 0.059
0.489TyrCys: 0.489 ± 0.021
2.928TyrAsp: 2.928 ± 0.061
2.416TyrGlu: 2.416 ± 0.049
1.86TyrPhe: 1.86 ± 0.045
3.317TyrGly: 3.317 ± 0.056
0.701TyrHis: 0.701 ± 0.026
2.1TyrIle: 2.1 ± 0.043
1.933TyrLys: 1.933 ± 0.044
3.563TyrLeu: 3.563 ± 0.053
0.943TyrMet: 0.943 ± 0.03
2.093TyrAsn: 2.093 ± 0.055
1.89TyrPro: 1.89 ± 0.046
1.046TyrGln: 1.046 ± 0.032
2.717TyrArg: 2.717 ± 0.046
2.455TyrSer: 2.455 ± 0.051
2.737TyrThr: 2.737 ± 0.062
2.678TyrVal: 2.678 ± 0.049
0.544TyrTrp: 0.544 ± 0.025
2.076TyrTyr: 2.076 ± 0.057
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2701 proteins (1072632 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski