Amino acid dipepetide frequency for Acidipila dinghuensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.569AlaAla: 14.569 ± 0.175
1.023AlaCys: 1.023 ± 0.029
5.272AlaAsp: 5.272 ± 0.065
6.709AlaGlu: 6.709 ± 0.088
3.872AlaPhe: 3.872 ± 0.054
9.282AlaGly: 9.282 ± 0.1
2.462AlaHis: 2.462 ± 0.045
5.518AlaIle: 5.518 ± 0.07
3.911AlaLys: 3.911 ± 0.064
11.455AlaLeu: 11.455 ± 0.105
2.758AlaMet: 2.758 ± 0.05
3.175AlaAsn: 3.175 ± 0.053
5.362AlaPro: 5.362 ± 0.072
4.777AlaGln: 4.777 ± 0.067
6.308AlaArg: 6.308 ± 0.086
7.025AlaSer: 7.025 ± 0.084
6.105AlaThr: 6.105 ± 0.07
8.009AlaVal: 8.009 ± 0.086
1.633AlaTrp: 1.633 ± 0.031
2.787AlaTyr: 2.787 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
0.898CysAla: 0.898 ± 0.028
0.139CysCys: 0.139 ± 0.011
0.412CysAsp: 0.412 ± 0.016
0.376CysGlu: 0.376 ± 0.017
0.36CysPhe: 0.36 ± 0.015
0.874CysGly: 0.874 ± 0.027
0.2CysHis: 0.2 ± 0.012
0.368CysIle: 0.368 ± 0.018
0.181CysLys: 0.181 ± 0.013
0.78CysLeu: 0.78 ± 0.024
0.191CysMet: 0.191 ± 0.012
0.24CysAsn: 0.24 ± 0.012
0.431CysPro: 0.431 ± 0.019
0.214CysGln: 0.214 ± 0.013
0.485CysArg: 0.485 ± 0.02
0.552CysSer: 0.552 ± 0.021
0.48CysThr: 0.48 ± 0.023
0.564CysVal: 0.564 ± 0.023
0.116CysTrp: 0.116 ± 0.009
0.25CysTyr: 0.25 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
5.934AspAla: 5.934 ± 0.076
0.384AspCys: 0.384 ± 0.016
2.477AspAsp: 2.477 ± 0.048
2.975AspGlu: 2.975 ± 0.05
2.163AspPhe: 2.163 ± 0.044
4.521AspGly: 4.521 ± 0.066
1.284AspHis: 1.284 ± 0.032
2.344AspIle: 2.344 ± 0.042
1.596AspLys: 1.596 ± 0.03
5.033AspLeu: 5.033 ± 0.065
0.922AspMet: 0.922 ± 0.024
1.392AspAsn: 1.392 ± 0.035
3.266AspPro: 3.266 ± 0.047
1.779AspGln: 1.779 ± 0.038
3.171AspArg: 3.171 ± 0.049
2.799AspSer: 2.799 ± 0.043
2.745AspThr: 2.745 ± 0.044
3.534AspVal: 3.534 ± 0.051
0.904AspTrp: 0.904 ± 0.026
1.758AspTyr: 1.758 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
6.417GluAla: 6.417 ± 0.093
0.346GluCys: 0.346 ± 0.017
2.722GluAsp: 2.722 ± 0.052
3.533GluGlu: 3.533 ± 0.073
1.902GluPhe: 1.902 ± 0.036
3.72GluGly: 3.72 ± 0.052
1.491GluHis: 1.491 ± 0.031
3.243GluIle: 3.243 ± 0.056
2.553GluLys: 2.553 ± 0.048
5.62GluLeu: 5.62 ± 0.074
1.493GluMet: 1.493 ± 0.033
1.85GluAsn: 1.85 ± 0.035
2.558GluPro: 2.558 ± 0.042
2.74GluGln: 2.74 ± 0.049
4.052GluArg: 4.052 ± 0.074
3.17GluSer: 3.17 ± 0.048
3.304GluThr: 3.304 ± 0.048
3.708GluVal: 3.708 ± 0.053
0.727GluTrp: 0.727 ± 0.022
1.458GluTyr: 1.458 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
4.352PheAla: 4.352 ± 0.064
0.374PheCys: 0.374 ± 0.015
2.395PheAsp: 2.395 ± 0.044
2.052PheGlu: 2.052 ± 0.038
1.704PhePhe: 1.704 ± 0.038
3.54PheGly: 3.54 ± 0.064
1.1PheHis: 1.1 ± 0.027
1.358PheIle: 1.358 ± 0.031
0.89PheLys: 0.89 ± 0.025
3.789PheLeu: 3.789 ± 0.06
0.671PheMet: 0.671 ± 0.02
1.306PheAsn: 1.306 ± 0.04
1.883PhePro: 1.883 ± 0.035
1.245PheGln: 1.245 ± 0.032
2.325PheArg: 2.325 ± 0.045
2.788PheSer: 2.788 ± 0.051
2.484PheThr: 2.484 ± 0.043
2.51PheVal: 2.51 ± 0.039
0.563PheTrp: 0.563 ± 0.024
1.214PheTyr: 1.214 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
7.752GlyAla: 7.752 ± 0.08
0.74GlyCys: 0.74 ± 0.029
3.904GlyAsp: 3.904 ± 0.059
4.216GlyGlu: 4.216 ± 0.06
3.47GlyPhe: 3.47 ± 0.057
6.49GlyGly: 6.49 ± 0.109
1.998GlyHis: 1.998 ± 0.04
4.498GlyIle: 4.498 ± 0.055
3.285GlyLys: 3.285 ± 0.051
7.59GlyLeu: 7.59 ± 0.075
2.028GlyMet: 2.028 ± 0.038
2.755GlyAsn: 2.755 ± 0.064
3.055GlyPro: 3.055 ± 0.053
3.034GlyGln: 3.034 ± 0.049
4.809GlyArg: 4.809 ± 0.067
5.469GlySer: 5.469 ± 0.075
5.2GlyThr: 5.2 ± 0.098
5.846GlyVal: 5.846 ± 0.063
1.414GlyTrp: 1.414 ± 0.034
2.754GlyTyr: 2.754 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
2.702HisAla: 2.702 ± 0.053
0.232HisCys: 0.232 ± 0.013
1.289HisAsp: 1.289 ± 0.029
1.238HisGlu: 1.238 ± 0.03
1.109HisPhe: 1.109 ± 0.026
2.212HisGly: 2.212 ± 0.039
0.718HisHis: 0.718 ± 0.023
1.137HisIle: 1.137 ± 0.027
0.563HisLys: 0.563 ± 0.02
2.47HisLeu: 2.47 ± 0.041
0.477HisMet: 0.477 ± 0.018
0.661HisAsn: 0.661 ± 0.021
1.649HisPro: 1.649 ± 0.04
0.753HisGln: 0.753 ± 0.025
1.481HisArg: 1.481 ± 0.034
1.331HisSer: 1.331 ± 0.03
1.358HisThr: 1.358 ± 0.03
1.623HisVal: 1.623 ± 0.037
0.457HisTrp: 0.457 ± 0.02
0.758HisTyr: 0.758 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
6.141IleAla: 6.141 ± 0.072
0.401IleCys: 0.401 ± 0.015
3.06IleAsp: 3.06 ± 0.048
3.178IleGlu: 3.178 ± 0.052
1.833IlePhe: 1.833 ± 0.036
4.203IleGly: 4.203 ± 0.062
1.202IleHis: 1.202 ± 0.028
1.607IleIle: 1.607 ± 0.039
1.227IleLys: 1.227 ± 0.031
4.615IleLeu: 4.615 ± 0.066
0.637IleMet: 0.637 ± 0.021
1.447IleAsn: 1.447 ± 0.038
2.852IlePro: 2.852 ± 0.042
1.641IleGln: 1.641 ± 0.036
3.1IleArg: 3.1 ± 0.047
3.111IleSer: 3.111 ± 0.056
3.016IleThr: 3.016 ± 0.048
3.557IleVal: 3.557 ± 0.06
0.535IleTrp: 0.535 ± 0.02
1.364IleTyr: 1.364 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
3.603LysAla: 3.603 ± 0.056
0.152LysCys: 0.152 ± 0.011
1.852LysAsp: 1.852 ± 0.04
1.825LysGlu: 1.825 ± 0.041
1.054LysPhe: 1.054 ± 0.032
2.24LysGly: 2.24 ± 0.039
0.767LysHis: 0.767 ± 0.02
1.722LysIle: 1.722 ± 0.036
1.575LysLys: 1.575 ± 0.044
3.476LysLeu: 3.476 ± 0.06
0.832LysMet: 0.832 ± 0.024
1.145LysAsn: 1.145 ± 0.032
2.149LysPro: 2.149 ± 0.042
1.462LysGln: 1.462 ± 0.032
2.001LysArg: 2.001 ± 0.044
1.916LysSer: 1.916 ± 0.04
2.182LysThr: 2.182 ± 0.042
2.284LysVal: 2.284 ± 0.049
0.4LysTrp: 0.4 ± 0.015
0.97LysTyr: 0.97 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
11.882LeuAla: 11.882 ± 0.13
0.945LeuCys: 0.945 ± 0.025
5.238LeuAsp: 5.238 ± 0.066
5.842LeuGlu: 5.842 ± 0.083
3.718LeuPhe: 3.718 ± 0.055
7.586LeuGly: 7.586 ± 0.084
2.553LeuHis: 2.553 ± 0.046
4.441LeuIle: 4.441 ± 0.07
3.484LeuLys: 3.484 ± 0.057
10.782LeuLeu: 10.782 ± 0.144
1.988LeuMet: 1.988 ± 0.043
3.165LeuAsn: 3.165 ± 0.052
5.793LeuPro: 5.793 ± 0.071
3.386LeuGln: 3.386 ± 0.045
7.136LeuArg: 7.136 ± 0.084
6.515LeuSer: 6.515 ± 0.072
6.082LeuThr: 6.082 ± 0.064
6.448LeuVal: 6.448 ± 0.08
1.317LeuTrp: 1.317 ± 0.032
2.634LeuTyr: 2.634 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
2.544MetAla: 2.544 ± 0.05
0.129MetCys: 0.129 ± 0.009
0.973MetAsp: 0.973 ± 0.029
1.09MetGlu: 1.09 ± 0.029
0.613MetPhe: 0.613 ± 0.021
1.522MetGly: 1.522 ± 0.03
0.552MetHis: 0.552 ± 0.02
1.028MetIle: 1.028 ± 0.028
0.937MetLys: 0.937 ± 0.022
2.324MetLeu: 2.324 ± 0.044
0.547MetMet: 0.547 ± 0.023
0.735MetAsn: 0.735 ± 0.024
1.42MetPro: 1.42 ± 0.032
1.025MetGln: 1.025 ± 0.027
1.625MetArg: 1.625 ± 0.037
1.4MetSer: 1.4 ± 0.03
1.426MetThr: 1.426 ± 0.032
1.375MetVal: 1.375 ± 0.03
0.218MetTrp: 0.218 ± 0.012
0.423MetTyr: 0.423 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.324AsnAla: 3.324 ± 0.056
0.248AsnCys: 0.248 ± 0.014
1.637AsnAsp: 1.637 ± 0.036
1.54AsnGlu: 1.54 ± 0.033
1.437AsnPhe: 1.437 ± 0.038
3.007AsnGly: 3.007 ± 0.062
0.736AsnHis: 0.736 ± 0.024
1.59AsnIle: 1.59 ± 0.037
0.796AsnLys: 0.796 ± 0.027
3.227AsnLeu: 3.227 ± 0.052
0.573AsnMet: 0.573 ± 0.018
1.153AsnAsn: 1.153 ± 0.044
2.276AsnPro: 2.276 ± 0.047
1.279AsnGln: 1.279 ± 0.036
1.81AsnArg: 1.81 ± 0.032
1.945AsnSer: 1.945 ± 0.049
1.963AsnThr: 1.963 ± 0.046
2.127AsnVal: 2.127 ± 0.047
0.55AsnTrp: 0.55 ± 0.02
1.254AsnTyr: 1.254 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
6.518ProAla: 6.518 ± 0.079
0.353ProCys: 0.353 ± 0.015
3.099ProAsp: 3.099 ± 0.058
3.831ProGlu: 3.831 ± 0.058
1.993ProPhe: 1.993 ± 0.037
4.688ProGly: 4.688 ± 0.067
1.275ProHis: 1.275 ± 0.028
2.301ProIle: 2.301 ± 0.044
1.68ProLys: 1.68 ± 0.037
4.846ProLeu: 4.846 ± 0.055
1.129ProMet: 1.129 ± 0.028
1.743ProAsn: 1.743 ± 0.042
2.461ProPro: 2.461 ± 0.052
2.245ProGln: 2.245 ± 0.042
2.674ProArg: 2.674 ± 0.049
3.361ProSer: 3.361 ± 0.054
2.735ProThr: 2.735 ± 0.048
4.174ProVal: 4.174 ± 0.059
0.775ProTrp: 0.775 ± 0.023
1.563ProTyr: 1.563 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
4.271GlnAla: 4.271 ± 0.059
0.201GlnCys: 0.201 ± 0.012
1.766GlnAsp: 1.766 ± 0.039
1.902GlnGlu: 1.902 ± 0.04
1.354GlnPhe: 1.354 ± 0.031
2.643GlnGly: 2.643 ± 0.039
0.97GlnHis: 0.97 ± 0.024
2.078GlnIle: 2.078 ± 0.039
1.507GlnLys: 1.507 ± 0.032
3.752GlnLeu: 3.752 ± 0.053
1.007GlnMet: 1.007 ± 0.031
1.372GlnAsn: 1.372 ± 0.037
2.283GlnPro: 2.283 ± 0.039
2.236GlnGln: 2.236 ± 0.063
2.546GlnArg: 2.546 ± 0.046
2.38GlnSer: 2.38 ± 0.041
2.314GlnThr: 2.314 ± 0.045
2.655GlnVal: 2.655 ± 0.04
0.582GlnTrp: 0.582 ± 0.022
1.162GlnTyr: 1.162 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
6.066ArgAla: 6.066 ± 0.079
0.457ArgCys: 0.457 ± 0.017
2.957ArgAsp: 2.957 ± 0.05
4.142ArgGlu: 4.142 ± 0.07
2.595ArgPhe: 2.595 ± 0.041
4.032ArgGly: 4.032 ± 0.054
1.459ArgHis: 1.459 ± 0.03
3.72ArgIle: 3.72 ± 0.058
2.228ArgLys: 2.228 ± 0.045
6.347ArgLeu: 6.347 ± 0.075
1.798ArgMet: 1.798 ± 0.039
2.14ArgAsn: 2.14 ± 0.041
2.826ArgPro: 2.826 ± 0.055
2.419ArgGln: 2.419 ± 0.041
4.523ArgArg: 4.523 ± 0.067
3.767ArgSer: 3.767 ± 0.056
3.349ArgThr: 3.349 ± 0.05
4.259ArgVal: 4.259 ± 0.061
1.036ArgTrp: 1.036 ± 0.03
1.94ArgTyr: 1.94 ± 0.033
0.0ArgXaa: 0.0 ± 0.0
Ser
6.747SerAla: 6.747 ± 0.086
0.534SerCys: 0.534 ± 0.018
3.006SerAsp: 3.006 ± 0.052
3.065SerGlu: 3.065 ± 0.049
2.657SerPhe: 2.657 ± 0.046
6.17SerGly: 6.17 ± 0.092
1.38SerHis: 1.38 ± 0.031
3.247SerIle: 3.247 ± 0.047
1.763SerLys: 1.763 ± 0.035
6.536SerLeu: 6.536 ± 0.073
1.366SerMet: 1.366 ± 0.03
2.069SerAsn: 2.069 ± 0.056
3.417SerPro: 3.417 ± 0.055
2.192SerGln: 2.192 ± 0.04
3.519SerArg: 3.519 ± 0.048
4.87SerSer: 4.87 ± 0.104
4.047SerThr: 4.047 ± 0.086
4.286SerVal: 4.286 ± 0.059
0.94SerTrp: 0.94 ± 0.028
1.974SerTyr: 1.974 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
6.804ThrAla: 6.804 ± 0.08
0.463ThrCys: 0.463 ± 0.02
2.838ThrAsp: 2.838 ± 0.052
2.829ThrGlu: 2.829 ± 0.043
2.153ThrPhe: 2.153 ± 0.037
5.458ThrGly: 5.458 ± 0.083
1.352ThrHis: 1.352 ± 0.032
3.03ThrIle: 3.03 ± 0.054
1.588ThrLys: 1.588 ± 0.037
6.431ThrLeu: 6.431 ± 0.074
1.14ThrMet: 1.14 ± 0.03
1.946ThrAsn: 1.946 ± 0.048
3.86ThrPro: 3.86 ± 0.057
2.152ThrGln: 2.152 ± 0.044
3.049ThrArg: 3.049 ± 0.046
3.838ThrSer: 3.838 ± 0.084
3.657ThrThr: 3.657 ± 0.077
4.75ThrVal: 4.75 ± 0.081
0.847ThrTrp: 0.847 ± 0.027
1.702ThrTyr: 1.702 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
7.326ValAla: 7.326 ± 0.075
0.623ValCys: 0.623 ± 0.021
3.734ValAsp: 3.734 ± 0.052
4.03ValGlu: 4.03 ± 0.059
2.629ValPhe: 2.629 ± 0.045
4.542ValGly: 4.542 ± 0.067
1.635ValHis: 1.635 ± 0.033
3.579ValIle: 3.579 ± 0.056
2.323ValLys: 2.323 ± 0.045
7.444ValLeu: 7.444 ± 0.09
1.463ValMet: 1.463 ± 0.034
2.369ValAsn: 2.369 ± 0.044
3.753ValPro: 3.753 ± 0.047
2.455ValGln: 2.455 ± 0.04
4.408ValArg: 4.408 ± 0.064
4.666ValSer: 4.666 ± 0.065
4.678ValThr: 4.678 ± 0.067
5.157ValVal: 5.157 ± 0.067
0.892ValTrp: 0.892 ± 0.024
1.864ValTyr: 1.864 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.142TrpAla: 1.142 ± 0.026
0.129TrpCys: 0.129 ± 0.01
0.661TrpAsp: 0.661 ± 0.025
0.689TrpGlu: 0.689 ± 0.021
0.607TrpPhe: 0.607 ± 0.02
0.979TrpGly: 0.979 ± 0.027
0.397TrpHis: 0.397 ± 0.016
0.79TrpIle: 0.79 ± 0.024
0.689TrpLys: 0.689 ± 0.021
1.587TrpLeu: 1.587 ± 0.032
0.427TrpMet: 0.427 ± 0.016
0.712TrpAsn: 0.712 ± 0.025
0.645TrpPro: 0.645 ± 0.022
0.751TrpGln: 0.751 ± 0.023
0.977TrpArg: 0.977 ± 0.03
1.011TrpSer: 1.011 ± 0.033
0.912TrpThr: 0.912 ± 0.026
0.852TrpVal: 0.852 ± 0.025
0.259TrpTrp: 0.259 ± 0.015
0.411TrpTyr: 0.411 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.019TyrAla: 3.019 ± 0.051
0.24TyrCys: 0.24 ± 0.012
1.694TyrAsp: 1.694 ± 0.039
1.543TyrGlu: 1.543 ± 0.036
1.319TyrPhe: 1.319 ± 0.027
2.598TyrGly: 2.598 ± 0.049
0.687TyrHis: 0.687 ± 0.021
1.128TyrIle: 1.128 ± 0.028
0.832TyrLys: 0.832 ± 0.025
2.83TyrLeu: 2.83 ± 0.042
0.457TyrMet: 0.457 ± 0.017
1.096TyrAsn: 1.096 ± 0.03
1.507TyrPro: 1.507 ± 0.038
1.197TyrGln: 1.197 ± 0.034
2.058TyrArg: 2.058 ± 0.038
1.873TyrSer: 1.873 ± 0.049
1.85TyrThr: 1.85 ± 0.051
1.85TyrVal: 1.85 ± 0.034
0.463TyrTrp: 0.463 ± 0.019
0.979TyrTyr: 0.979 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3909 proteins (1493901 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski