Amino acid dipepetide frequency for Dyella thiooxydans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.529AlaAla: 17.529 ± 0.175	1.218AlaCys: 1.218 ± 0.039	7.176AlaAsp: 7.176 ± 0.085	6.661AlaGlu: 6.661 ± 0.097	4.049AlaPhe: 4.049 ± 0.059	11.345AlaGly: 11.345 ± 0.116	2.96AlaHis: 2.96 ± 0.054	5.475AlaIle: 5.475 ± 0.072	3.34AlaLys: 3.34 ± 0.074	15.53AlaLeu: 15.53 ± 0.135	3.745AlaMet: 3.745 ± 0.063	2.653AlaAsn: 2.653 ± 0.065	6.552AlaPro: 6.552 ± 0.106	4.887AlaGln: 4.887 ± 0.065	9.665AlaArg: 9.665 ± 0.109	7.009AlaSer: 7.009 ± 0.088	6.343AlaThr: 6.343 ± 0.078	9.076AlaVal: 9.076 ± 0.1	2.122AlaTrp: 2.122 ± 0.049	2.527AlaTyr: 2.527 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.973CysAla: 0.973 ± 0.033	0.094CysCys: 0.094 ± 0.009	0.479CysAsp: 0.479 ± 0.02	0.4CysGlu: 0.4 ± 0.017	0.286CysPhe: 0.286 ± 0.015	0.884CysGly: 0.884 ± 0.029	0.254CysHis: 0.254 ± 0.018	0.321CysIle: 0.321 ± 0.017	0.147CysLys: 0.147 ± 0.01	0.825CysLeu: 0.825 ± 0.027	0.175CysMet: 0.175 ± 0.014	0.203CysAsn: 0.203 ± 0.012	0.428CysPro: 0.428 ± 0.02	0.238CysGln: 0.238 ± 0.013	0.669CysArg: 0.669 ± 0.026	0.453CysSer: 0.453 ± 0.018	0.44CysThr: 0.44 ± 0.019	0.634CysVal: 0.634 ± 0.024	0.135CysTrp: 0.135 ± 0.011	0.222CysTyr: 0.222 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.225AspAla: 8.225 ± 0.096	0.448AspCys: 0.448 ± 0.019	3.472AspAsp: 3.472 ± 0.063	3.3AspGlu: 3.3 ± 0.052	2.09AspPhe: 2.09 ± 0.044	5.664AspGly: 5.664 ± 0.081	1.431AspHis: 1.431 ± 0.032	2.32AspIle: 2.32 ± 0.04	1.51AspLys: 1.51 ± 0.043	5.69AspLeu: 5.69 ± 0.076	1.127AspMet: 1.127 ± 0.026	1.27AspAsn: 1.27 ± 0.031	3.605AspPro: 3.605 ± 0.06	1.861AspGln: 1.861 ± 0.043	4.267AspArg: 4.267 ± 0.065	2.38AspSer: 2.38 ± 0.044	2.989AspThr: 2.989 ± 0.047	4.105AspVal: 4.105 ± 0.055	1.102AspTrp: 1.102 ± 0.028	1.688AspTyr: 1.688 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	6.768GluAla: 6.768 ± 0.084	0.336GluCys: 0.336 ± 0.017	2.258GluAsp: 2.258 ± 0.045	2.169GluGlu: 2.169 ± 0.054	1.485GluPhe: 1.485 ± 0.038	3.719GluGly: 3.719 ± 0.055	1.64GluHis: 1.64 ± 0.036	2.133GluIle: 2.133 ± 0.047	1.483GluLys: 1.483 ± 0.045	6.116GluLeu: 6.116 ± 0.089	0.995GluMet: 0.995 ± 0.03	1.033GluAsn: 1.033 ± 0.029	2.592GluPro: 2.592 ± 0.045	2.587GluGln: 2.587 ± 0.044	4.886GluArg: 4.886 ± 0.082	2.403GluSer: 2.403 ± 0.053	2.22GluThr: 2.22 ± 0.044	3.849GluVal: 3.849 ± 0.061	0.587GluTrp: 0.587 ± 0.026	0.952GluTyr: 0.952 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.354PheAla: 4.354 ± 0.068	0.323PheCys: 0.323 ± 0.016	2.552PheAsp: 2.552 ± 0.05	1.761PheGlu: 1.761 ± 0.038	1.195PhePhe: 1.195 ± 0.034	3.506PheGly: 3.506 ± 0.053	0.829PheHis: 0.829 ± 0.025	1.189PheIle: 1.189 ± 0.039	0.838PheLys: 0.838 ± 0.028	2.997PheLeu: 2.997 ± 0.047	0.667PheMet: 0.667 ± 0.023	1.003PheAsn: 1.003 ± 0.033	1.455PhePro: 1.455 ± 0.037	1.006PheGln: 1.006 ± 0.03	2.25PheArg: 2.25 ± 0.043	1.782PheSer: 1.782 ± 0.035	1.744PheThr: 1.744 ± 0.036	2.642PheVal: 2.642 ± 0.05	0.487PheTrp: 0.487 ± 0.023	0.891PheTyr: 0.891 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	9.152GlyAla: 9.152 ± 0.1	0.852GlyCys: 0.852 ± 0.03	4.909GlyAsp: 4.909 ± 0.069	4.721GlyGlu: 4.721 ± 0.073	3.302GlyPhe: 3.302 ± 0.054	7.248GlyGly: 7.248 ± 0.121	2.443GlyHis: 2.443 ± 0.046	3.823GlyIle: 3.823 ± 0.059	3.109GlyLys: 3.109 ± 0.056	8.814GlyLeu: 8.814 ± 0.09	2.475GlyMet: 2.475 ± 0.046	2.234GlyAsn: 2.234 ± 0.06	3.27GlyPro: 3.27 ± 0.049	3.29GlyGln: 3.29 ± 0.064	6.263GlyArg: 6.263 ± 0.083	4.946GlySer: 4.946 ± 0.096	4.595GlyThr: 4.595 ± 0.117	6.687GlyVal: 6.687 ± 0.081	1.688GlyTrp: 1.688 ± 0.041	2.555GlyTyr: 2.555 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	3.385HisAla: 3.385 ± 0.063	0.253HisCys: 0.253 ± 0.014	1.572HisAsp: 1.572 ± 0.035	1.271HisGlu: 1.271 ± 0.031	0.964HisPhe: 0.964 ± 0.026	2.642HisGly: 2.642 ± 0.052	0.725HisHis: 0.725 ± 0.027	0.801HisIle: 0.801 ± 0.026	0.488HisLys: 0.488 ± 0.021	2.563HisLeu: 2.563 ± 0.049	0.562HisMet: 0.562 ± 0.019	0.48HisAsn: 0.48 ± 0.021	1.763HisPro: 1.763 ± 0.041	0.763HisGln: 0.763 ± 0.026	1.986HisArg: 1.986 ± 0.048	1.061HisSer: 1.061 ± 0.028	1.112HisThr: 1.112 ± 0.029	1.877HisVal: 1.877 ± 0.04	0.537HisTrp: 0.537 ± 0.023	0.744HisTyr: 0.744 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.972IleAla: 5.972 ± 0.075	0.318IleCys: 0.318 ± 0.015	3.234IleAsp: 3.234 ± 0.053	2.716IleGlu: 2.716 ± 0.058	1.094IlePhe: 1.094 ± 0.031	4.245IleGly: 4.245 ± 0.063	0.901IleHis: 0.901 ± 0.027	1.19IleIle: 1.19 ± 0.038	1.074IleLys: 1.074 ± 0.032	2.92IleLeu: 2.92 ± 0.057	0.548IleMet: 0.548 ± 0.025	1.159IleAsn: 1.159 ± 0.041	1.946IlePro: 1.946 ± 0.047	1.094IleGln: 1.094 ± 0.031	2.741IleArg: 2.741 ± 0.043	2.033IleSer: 2.033 ± 0.042	2.218IleThr: 2.218 ± 0.054	3.073IleVal: 3.073 ± 0.055	0.436IleTrp: 0.436 ± 0.02	0.947IleTyr: 0.947 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.45LysAla: 3.45 ± 0.073	0.122LysCys: 0.122 ± 0.009	1.415LysAsp: 1.415 ± 0.043	1.118LysGlu: 1.118 ± 0.036	0.678LysPhe: 0.678 ± 0.029	2.073LysGly: 2.073 ± 0.043	0.699LysHis: 0.699 ± 0.021	1.037LysIle: 1.037 ± 0.032	0.957LysLys: 0.957 ± 0.047	3.088LysLeu: 3.088 ± 0.058	0.572LysMet: 0.572 ± 0.023	0.632LysAsn: 0.632 ± 0.025	1.856LysPro: 1.856 ± 0.042	1.152LysGln: 1.152 ± 0.036	2.012LysArg: 2.012 ± 0.045	1.339LysSer: 1.339 ± 0.039	1.42LysThr: 1.42 ± 0.034	2.112LysVal: 2.112 ± 0.046	0.268LysTrp: 0.268 ± 0.015	0.594LysTyr: 0.594 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	16.271LeuAla: 16.271 ± 0.167	0.96LeuCys: 0.96 ± 0.026	7.006LeuAsp: 7.006 ± 0.084	5.204LeuGlu: 5.204 ± 0.073	3.471LeuPhe: 3.471 ± 0.055	9.207LeuGly: 9.207 ± 0.094	2.68LeuHis: 2.68 ± 0.044	3.845LeuIle: 3.845 ± 0.059	3.107LeuLys: 3.107 ± 0.058	12.268LeuLeu: 12.268 ± 0.15	2.118LeuMet: 2.118 ± 0.043	2.24LeuAsn: 2.24 ± 0.046	6.752LeuPro: 6.752 ± 0.081	3.609LeuGln: 3.609 ± 0.06	8.625LeuArg: 8.625 ± 0.121	5.763LeuSer: 5.763 ± 0.083	5.148LeuThr: 5.148 ± 0.087	8.094LeuVal: 8.094 ± 0.09	1.419LeuTrp: 1.419 ± 0.032	2.222LeuTyr: 2.222 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.914MetAla: 2.914 ± 0.055	0.128MetCys: 0.128 ± 0.01	1.201MetAsp: 1.201 ± 0.029	0.953MetGlu: 0.953 ± 0.028	0.665MetPhe: 0.665 ± 0.026	1.558MetGly: 1.558 ± 0.04	0.616MetHis: 0.616 ± 0.022	0.913MetIle: 0.913 ± 0.03	0.816MetLys: 0.816 ± 0.032	2.586MetLeu: 2.586 ± 0.051	0.437MetMet: 0.437 ± 0.02	0.683MetAsn: 0.683 ± 0.026	1.443MetPro: 1.443 ± 0.035	0.963MetGln: 0.963 ± 0.029	1.872MetArg: 1.872 ± 0.041	1.508MetSer: 1.508 ± 0.034	1.411MetThr: 1.411 ± 0.036	1.588MetVal: 1.588 ± 0.041	0.215MetTrp: 0.215 ± 0.012	0.397MetTyr: 0.397 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.981AsnAla: 2.981 ± 0.05	0.178AsnCys: 0.178 ± 0.013	1.317AsnAsp: 1.317 ± 0.038	1.034AsnGlu: 1.034 ± 0.029	0.843AsnPhe: 0.843 ± 0.027	2.175AsnGly: 2.175 ± 0.061	0.576AsnHis: 0.576 ± 0.022	0.934AsnIle: 0.934 ± 0.032	0.549AsnLys: 0.549 ± 0.025	2.517AsnLeu: 2.517 ± 0.055	0.423AsnMet: 0.423 ± 0.019	0.654AsnAsn: 0.654 ± 0.026	1.636AsnPro: 1.636 ± 0.042	0.782AsnGln: 0.782 ± 0.033	1.68AsnArg: 1.68 ± 0.043	0.99AsnSer: 0.99 ± 0.032	1.218AsnThr: 1.218 ± 0.034	1.688AsnVal: 1.688 ± 0.044	0.367AsnTrp: 0.367 ± 0.019	0.714AsnTyr: 0.714 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	7.792ProAla: 7.792 ± 0.108	0.374ProCys: 0.374 ± 0.017	3.713ProAsp: 3.713 ± 0.06	3.048ProGlu: 3.048 ± 0.048	1.747ProPhe: 1.747 ± 0.029	5.189ProGly: 5.189 ± 0.066	1.245ProHis: 1.245 ± 0.032	1.816ProIle: 1.816 ± 0.04	1.38ProLys: 1.38 ± 0.042	5.702ProLeu: 5.702 ± 0.073	1.373ProMet: 1.373 ± 0.035	1.139ProAsn: 1.139 ± 0.033	3.262ProPro: 3.262 ± 0.078	1.969ProGln: 1.969 ± 0.046	3.463ProArg: 3.463 ± 0.051	2.901ProSer: 2.901 ± 0.056	2.534ProThr: 2.534 ± 0.053	4.414ProVal: 4.414 ± 0.058	0.892ProTrp: 0.892 ± 0.025	1.27ProTyr: 1.27 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	5.348GlnAla: 5.348 ± 0.079	0.246GlnCys: 0.246 ± 0.014	1.545GlnAsp: 1.545 ± 0.036	1.267GlnGlu: 1.267 ± 0.036	1.157GlnPhe: 1.157 ± 0.032	2.824GlnGly: 2.824 ± 0.05	0.941GlnHis: 0.941 ± 0.028	1.501GlnIle: 1.501 ± 0.033	0.889GlnLys: 0.889 ± 0.031	4.201GlnLeu: 4.201 ± 0.065	0.849GlnMet: 0.849 ± 0.027	0.734GlnAsn: 0.734 ± 0.029	2.312GlnPro: 2.312 ± 0.043	1.889GlnGln: 1.889 ± 0.049	3.499GlnArg: 3.499 ± 0.058	1.837GlnSer: 1.837 ± 0.039	1.61GlnThr: 1.61 ± 0.037	2.967GlnVal: 2.967 ± 0.049	0.593GlnTrp: 0.593 ± 0.024	0.786GlnTyr: 0.786 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	8.713ArgAla: 8.713 ± 0.102	0.601ArgCys: 0.601 ± 0.02	4.364ArgAsp: 4.364 ± 0.066	4.664ArgGlu: 4.664 ± 0.071	2.9ArgPhe: 2.9 ± 0.046	5.376ArgGly: 5.376 ± 0.082	2.319ArgHis: 2.319 ± 0.05	3.558ArgIle: 3.558 ± 0.056	1.897ArgLys: 1.897 ± 0.048	8.854ArgLeu: 8.854 ± 0.104	2.002ArgMet: 2.002 ± 0.043	1.728ArgAsn: 1.728 ± 0.041	3.796ArgPro: 3.796 ± 0.057	3.153ArgGln: 3.153 ± 0.052	6.533ArgArg: 6.533 ± 0.089	3.752ArgSer: 3.752 ± 0.056	3.345ArgThr: 3.345 ± 0.048	5.448ArgVal: 5.448 ± 0.077	1.47ArgTrp: 1.47 ± 0.037	2.188ArgTyr: 2.188 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	6.213SerAla: 6.213 ± 0.079	0.417SerCys: 0.417 ± 0.019	2.7SerAsp: 2.7 ± 0.048	2.288SerGlu: 2.288 ± 0.047	1.927SerPhe: 1.927 ± 0.048	5.135SerGly: 5.135 ± 0.106	1.277SerHis: 1.277 ± 0.036	2.198SerIle: 2.198 ± 0.045	1.186SerLys: 1.186 ± 0.036	5.619SerLeu: 5.619 ± 0.086	1.204SerMet: 1.204 ± 0.031	1.291SerAsn: 1.291 ± 0.038	2.931SerPro: 2.931 ± 0.047	1.801SerGln: 1.801 ± 0.041	3.798SerArg: 3.798 ± 0.061	3.07SerSer: 3.07 ± 0.059	2.786SerThr: 2.786 ± 0.053	3.771SerVal: 3.771 ± 0.057	0.796SerTrp: 0.796 ± 0.027	1.363SerTyr: 1.363 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	5.853ThrAla: 5.853 ± 0.063	0.38ThrCys: 0.38 ± 0.019	2.712ThrAsp: 2.712 ± 0.05	2.117ThrGlu: 2.117 ± 0.044	1.613ThrPhe: 1.613 ± 0.042	4.764ThrGly: 4.764 ± 0.094	1.216ThrHis: 1.216 ± 0.029	2.011ThrIle: 2.011 ± 0.043	0.978ThrLys: 0.978 ± 0.032	6.359ThrLeu: 6.359 ± 0.095	1.01ThrMet: 1.01 ± 0.032	1.033ThrAsn: 1.033 ± 0.038	3.445ThrPro: 3.445 ± 0.055	1.624ThrGln: 1.624 ± 0.038	3.621ThrArg: 3.621 ± 0.054	2.411ThrSer: 2.411 ± 0.055	2.667ThrThr: 2.667 ± 0.074	4.181ThrVal: 4.181 ± 0.068	0.717ThrTrp: 0.717 ± 0.026	1.176ThrTyr: 1.176 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	9.7ValAla: 9.7 ± 0.098	0.656ValCys: 0.656 ± 0.028	4.811ValAsp: 4.811 ± 0.065	3.924ValGlu: 3.924 ± 0.069	2.489ValPhe: 2.489 ± 0.047	5.702ValGly: 5.702 ± 0.066	1.781ValHis: 1.781 ± 0.04	3.378ValIle: 3.378 ± 0.057	1.853ValLys: 1.853 ± 0.046	8.389ValLeu: 8.389 ± 0.095	1.713ValMet: 1.713 ± 0.038	1.944ValAsn: 1.944 ± 0.041	4.168ValPro: 4.168 ± 0.063	2.596ValGln: 2.596 ± 0.05	5.26ValArg: 5.26 ± 0.066	4.01ValSer: 4.01 ± 0.065	4.033ValThr: 4.033 ± 0.066	6.192ValVal: 6.192 ± 0.077	0.951ValTrp: 0.951 ± 0.031	1.631ValTyr: 1.631 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.275TrpAla: 1.275 ± 0.033	0.15TrpCys: 0.15 ± 0.012	0.66TrpAsp: 0.66 ± 0.021	0.502TrpGlu: 0.502 ± 0.02	0.58TrpPhe: 0.58 ± 0.024	0.937TrpGly: 0.937 ± 0.036	0.466TrpHis: 0.466 ± 0.02	0.687TrpIle: 0.687 ± 0.026	0.453TrpLys: 0.453 ± 0.02	2.332TrpLeu: 2.332 ± 0.047	0.476TrpMet: 0.476 ± 0.021	0.5TrpAsn: 0.5 ± 0.019	0.789TrpPro: 0.789 ± 0.026	0.844TrpGln: 0.844 ± 0.028	1.407TrpArg: 1.407 ± 0.039	0.957TrpSer: 0.957 ± 0.027	0.788TrpThr: 0.788 ± 0.03	0.965TrpVal: 0.965 ± 0.026	0.313TrpTrp: 0.313 ± 0.02	0.39TrpTyr: 0.39 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.993TyrAla: 2.993 ± 0.047	0.206TyrCys: 0.206 ± 0.014	1.45TyrAsp: 1.45 ± 0.035	1.095TyrGlu: 1.095 ± 0.032	0.937TyrPhe: 0.937 ± 0.027	2.184TyrGly: 2.184 ± 0.039	0.548TyrHis: 0.548 ± 0.021	0.73TyrIle: 0.73 ± 0.024	0.542TyrLys: 0.542 ± 0.021	2.639TyrLeu: 2.639 ± 0.057	0.395TyrMet: 0.395 ± 0.019	0.643TyrAsn: 0.643 ± 0.029	1.222TyrPro: 1.222 ± 0.033	0.885TyrGln: 0.885 ± 0.029	2.166TyrArg: 2.166 ± 0.041	1.162TyrSer: 1.162 ± 0.033	1.267TyrThr: 1.267 ± 0.036	1.817TyrVal: 1.817 ± 0.04	0.375TyrTrp: 0.375 ± 0.018	0.695TyrTyr: 0.695 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3854 proteins (1249098 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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