Amino acid dipepetide frequency for Enterococcus rivorum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.685AlaAla: 4.685 ± 0.096	0.546AlaCys: 0.546 ± 0.025	3.186AlaAsp: 3.186 ± 0.066	4.632AlaGlu: 4.632 ± 0.085	2.977AlaPhe: 2.977 ± 0.057	4.727AlaGly: 4.727 ± 0.081	1.016AlaHis: 1.016 ± 0.031	5.651AlaIle: 5.651 ± 0.09	4.916AlaLys: 4.916 ± 0.078	6.31AlaLeu: 6.31 ± 0.088	1.815AlaMet: 1.815 ± 0.041	2.949AlaAsn: 2.949 ± 0.061	1.889AlaPro: 1.889 ± 0.054	2.248AlaGln: 2.248 ± 0.051	2.074AlaArg: 2.074 ± 0.05	4.009AlaSer: 4.009 ± 0.071	4.05AlaThr: 4.05 ± 0.067	4.715AlaVal: 4.715 ± 0.079	0.495AlaTrp: 0.495 ± 0.023	2.358AlaTyr: 2.358 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.354CysAla: 0.354 ± 0.021	0.092CysCys: 0.092 ± 0.009	0.356CysAsp: 0.356 ± 0.02	0.439CysGlu: 0.439 ± 0.023	0.379CysPhe: 0.379 ± 0.02	0.63CysGly: 0.63 ± 0.029	0.182CysHis: 0.182 ± 0.015	0.535CysIle: 0.535 ± 0.024	0.337CysLys: 0.337 ± 0.018	0.753CysLeu: 0.753 ± 0.03	0.173CysMet: 0.173 ± 0.013	0.285CysAsn: 0.285 ± 0.018	0.254CysPro: 0.254 ± 0.016	0.272CysGln: 0.272 ± 0.017	0.234CysArg: 0.234 ± 0.015	0.53CysSer: 0.53 ± 0.027	0.337CysThr: 0.337 ± 0.017	0.404CysVal: 0.404 ± 0.019	0.068CysTrp: 0.068 ± 0.007	0.314CysTyr: 0.314 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.094AspAla: 3.094 ± 0.058	0.408AspCys: 0.408 ± 0.02	2.334AspAsp: 2.334 ± 0.059	4.07AspGlu: 4.07 ± 0.072	2.867AspPhe: 2.867 ± 0.059	3.228AspGly: 3.228 ± 0.059	0.838AspHis: 0.838 ± 0.03	4.011AspIle: 4.011 ± 0.071	3.477AspLys: 3.477 ± 0.066	4.878AspLeu: 4.878 ± 0.07	1.236AspMet: 1.236 ± 0.033	2.081AspAsn: 2.081 ± 0.044	1.645AspPro: 1.645 ± 0.039	1.829AspGln: 1.829 ± 0.046	1.752AspArg: 1.752 ± 0.043	3.261AspSer: 3.261 ± 0.064	2.666AspThr: 2.666 ± 0.05	3.346AspVal: 3.346 ± 0.069	0.544AspTrp: 0.544 ± 0.023	2.571AspTyr: 2.571 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	5.238GluAla: 5.238 ± 0.08	0.378GluCys: 0.378 ± 0.021	3.408GluAsp: 3.408 ± 0.066	6.92GluGlu: 6.92 ± 0.108	2.682GluPhe: 2.682 ± 0.052	3.987GluGly: 3.987 ± 0.074	1.128GluHis: 1.128 ± 0.036	6.024GluIle: 6.024 ± 0.085	7.946GluLys: 7.946 ± 0.089	7.599GluLeu: 7.599 ± 0.102	2.307GluMet: 2.307 ± 0.049	4.587GluAsn: 4.587 ± 0.063	1.855GluPro: 1.855 ± 0.047	3.39GluGln: 3.39 ± 0.063	2.889GluArg: 2.889 ± 0.067	3.791GluSer: 3.791 ± 0.058	4.44GluThr: 4.44 ± 0.076	4.989GluVal: 4.989 ± 0.072	0.658GluTrp: 0.658 ± 0.025	2.407GluTyr: 2.407 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	2.651PheAla: 2.651 ± 0.055	0.356PheCys: 0.356 ± 0.018	2.671PheAsp: 2.671 ± 0.046	3.088PheGlu: 3.088 ± 0.052	2.66PhePhe: 2.66 ± 0.071	3.107PheGly: 3.107 ± 0.061	0.814PheHis: 0.814 ± 0.028	3.763PheIle: 3.763 ± 0.09	2.661PheLys: 2.661 ± 0.052	4.832PheLeu: 4.832 ± 0.103	1.155PheMet: 1.155 ± 0.034	2.246PheAsn: 2.246 ± 0.05	1.667PhePro: 1.667 ± 0.038	1.647PheGln: 1.647 ± 0.04	1.4PheArg: 1.4 ± 0.037	3.966PheSer: 3.966 ± 0.075	2.589PheThr: 2.589 ± 0.053	3.142PheVal: 3.142 ± 0.06	0.458PheTrp: 0.458 ± 0.025	1.946PheTyr: 1.946 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	4.336GlyAla: 4.336 ± 0.084	0.51GlyCys: 0.51 ± 0.024	2.875GlyAsp: 2.875 ± 0.062	4.299GlyGlu: 4.299 ± 0.062	3.105GlyPhe: 3.105 ± 0.062	4.439GlyGly: 4.439 ± 0.092	1.117GlyHis: 1.117 ± 0.035	5.838GlyIle: 5.838 ± 0.09	5.124GlyLys: 5.124 ± 0.075	6.167GlyLeu: 6.167 ± 0.081	1.975GlyMet: 1.975 ± 0.041	3.135GlyAsn: 3.135 ± 0.069	1.32GlyPro: 1.32 ± 0.04	2.27GlyGln: 2.27 ± 0.052	2.107GlyArg: 2.107 ± 0.052	3.819GlySer: 3.819 ± 0.07	4.22GlyThr: 4.22 ± 0.086	4.676GlyVal: 4.676 ± 0.078	0.599GlyTrp: 0.599 ± 0.023	2.663GlyTyr: 2.663 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	0.933HisAla: 0.933 ± 0.034	0.177HisCys: 0.177 ± 0.013	0.744HisAsp: 0.744 ± 0.027	1.115HisGlu: 1.115 ± 0.032	1.023HisPhe: 1.023 ± 0.034	1.12HisGly: 1.12 ± 0.036	0.398HisHis: 0.398 ± 0.021	1.107HisIle: 1.107 ± 0.03	0.913HisLys: 0.913 ± 0.031	1.879HisLeu: 1.879 ± 0.041	0.384HisMet: 0.384 ± 0.019	0.617HisAsn: 0.617 ± 0.022	0.809HisPro: 0.809 ± 0.028	0.782HisGln: 0.782 ± 0.027	0.663HisArg: 0.663 ± 0.028	1.123HisSer: 1.123 ± 0.035	0.83HisThr: 0.83 ± 0.027	0.987HisVal: 0.987 ± 0.036	0.189HisTrp: 0.189 ± 0.013	0.763HisTyr: 0.763 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.773IleAla: 5.773 ± 0.077	0.701IleCys: 0.701 ± 0.027	4.586IleAsp: 4.586 ± 0.077	5.932IleGlu: 5.932 ± 0.084	3.652IlePhe: 3.652 ± 0.077	5.495IleGly: 5.495 ± 0.084	1.497IleHis: 1.497 ± 0.041	5.889IleIle: 5.889 ± 0.09	4.974IleLys: 4.974 ± 0.073	7.524IleLeu: 7.524 ± 0.112	1.657IleMet: 1.657 ± 0.042	3.802IleAsn: 3.802 ± 0.07	3.257IlePro: 3.257 ± 0.053	3.33IleGln: 3.33 ± 0.054	2.848IleArg: 2.848 ± 0.057	5.387IleSer: 5.387 ± 0.08	4.469IleThr: 4.469 ± 0.07	5.525IleVal: 5.525 ± 0.081	0.559IleTrp: 0.559 ± 0.025	2.772IleTyr: 2.772 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	4.632LysAla: 4.632 ± 0.068	0.289LysCys: 0.289 ± 0.017	3.971LysAsp: 3.971 ± 0.069	8.025LysGlu: 8.025 ± 0.099	2.175LysPhe: 2.175 ± 0.039	4.09LysGly: 4.09 ± 0.053	1.041LysHis: 1.041 ± 0.031	6.219LysIle: 6.219 ± 0.08	7.882LysLys: 7.882 ± 0.124	6.192LysLeu: 6.192 ± 0.087	2.559LysMet: 2.559 ± 0.049	4.783LysAsn: 4.783 ± 0.07	1.97LysPro: 1.97 ± 0.048	3.4LysGln: 3.4 ± 0.059	3.064LysArg: 3.064 ± 0.056	3.747LysSer: 3.747 ± 0.062	4.059LysThr: 4.059 ± 0.065	5.059LysVal: 5.059 ± 0.079	0.621LysTrp: 0.621 ± 0.024	2.726LysTyr: 2.726 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	7.151LeuAla: 7.151 ± 0.089	0.671LeuCys: 0.671 ± 0.027	4.976LeuAsp: 4.976 ± 0.082	6.952LeuGlu: 6.952 ± 0.098	5.092LeuPhe: 5.092 ± 0.091	6.282LeuGly: 6.282 ± 0.098	1.403LeuHis: 1.403 ± 0.038	7.203LeuIle: 7.203 ± 0.088	7.078LeuLys: 7.078 ± 0.088	10.166LeuLeu: 10.166 ± 0.149	2.512LeuMet: 2.512 ± 0.053	4.939LeuAsn: 4.939 ± 0.069	3.781LeuPro: 3.781 ± 0.06	3.093LeuGln: 3.093 ± 0.055	3.138LeuArg: 3.138 ± 0.056	7.091LeuSer: 7.091 ± 0.099	6.098LeuThr: 6.098 ± 0.083	6.456LeuVal: 6.456 ± 0.072	0.671LeuTrp: 0.671 ± 0.025	3.076LeuTyr: 3.076 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	1.818MetAla: 1.818 ± 0.041	0.145MetCys: 0.145 ± 0.011	1.447MetAsp: 1.447 ± 0.038	1.827MetGlu: 1.827 ± 0.044	0.952MetPhe: 0.952 ± 0.03	1.673MetGly: 1.673 ± 0.04	0.369MetHis: 0.369 ± 0.021	2.223MetIle: 2.223 ± 0.046	2.465MetLys: 2.465 ± 0.042	2.318MetLeu: 2.318 ± 0.048	0.816MetMet: 0.816 ± 0.03	1.722MetAsn: 1.722 ± 0.038	0.907MetPro: 0.907 ± 0.029	0.849MetGln: 0.849 ± 0.028	0.959MetArg: 0.959 ± 0.032	1.675MetSer: 1.675 ± 0.036	1.696MetThr: 1.696 ± 0.037	1.623MetVal: 1.623 ± 0.042	0.148MetTrp: 0.148 ± 0.012	0.726MetTyr: 0.726 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.873AsnAla: 2.873 ± 0.05	0.323AsnCys: 0.323 ± 0.017	2.462AsnAsp: 2.462 ± 0.047	3.775AsnGlu: 3.775 ± 0.067	2.25AsnPhe: 2.25 ± 0.045	3.495AsnGly: 3.495 ± 0.062	1.035AsnHis: 1.035 ± 0.031	3.752AsnIle: 3.752 ± 0.063	3.619AsnLys: 3.619 ± 0.074	4.44AsnLeu: 4.44 ± 0.08	1.231AsnMet: 1.231 ± 0.032	2.628AsnAsn: 2.628 ± 0.068	2.114AsnPro: 2.114 ± 0.042	2.902AsnGln: 2.902 ± 0.059	1.958AsnArg: 1.958 ± 0.052	2.922AsnSer: 2.922 ± 0.062	2.57AsnThr: 2.57 ± 0.052	3.15AsnVal: 3.15 ± 0.07	0.533AsnTrp: 0.533 ± 0.024	2.212AsnTyr: 2.212 ± 0.052	0.0AsnXaa: 0.0 ± 0.0
Pro	1.942ProAla: 1.942 ± 0.048	0.194ProCys: 0.194 ± 0.015	1.761ProAsp: 1.761 ± 0.044	3.029ProGlu: 3.029 ± 0.06	1.665ProPhe: 1.665 ± 0.048	1.691ProGly: 1.691 ± 0.048	0.522ProHis: 0.522 ± 0.024	2.823ProIle: 2.823 ± 0.061	2.496ProLys: 2.496 ± 0.047	3.05ProLeu: 3.05 ± 0.054	0.803ProMet: 0.803 ± 0.025	1.653ProAsn: 1.653 ± 0.043	0.65ProPro: 0.65 ± 0.026	1.096ProGln: 1.096 ± 0.032	0.888ProArg: 0.888 ± 0.031	1.965ProSer: 1.965 ± 0.051	2.205ProThr: 2.205 ± 0.05	2.562ProVal: 2.562 ± 0.057	0.254ProTrp: 0.254 ± 0.015	1.323ProTyr: 1.323 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.896GlnAla: 2.896 ± 0.055	0.203GlnCys: 0.203 ± 0.015	1.499GlnAsp: 1.499 ± 0.038	3.404GlnGlu: 3.404 ± 0.061	1.627GlnPhe: 1.627 ± 0.042	2.225GlnGly: 2.225 ± 0.051	0.612GlnHis: 0.612 ± 0.025	2.774GlnIle: 2.774 ± 0.054	3.39GlnLys: 3.39 ± 0.056	4.565GlnLeu: 4.565 ± 0.079	1.081GlnMet: 1.081 ± 0.03	1.88GlnAsn: 1.88 ± 0.049	1.276GlnPro: 1.276 ± 0.033	2.144GlnGln: 2.144 ± 0.067	1.441GlnArg: 1.441 ± 0.043	2.098GlnSer: 2.098 ± 0.048	2.286GlnThr: 2.286 ± 0.047	2.638GlnVal: 2.638 ± 0.056	0.388GlnTrp: 0.388 ± 0.02	1.273GlnTyr: 1.273 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	1.872ArgAla: 1.872 ± 0.048	0.249ArgCys: 0.249 ± 0.016	1.522ArgAsp: 1.522 ± 0.043	2.758ArgGlu: 2.758 ± 0.053	1.698ArgPhe: 1.698 ± 0.044	1.981ArgGly: 1.981 ± 0.045	0.607ArgHis: 0.607 ± 0.021	2.803ArgIle: 2.803 ± 0.058	3.147ArgLys: 3.147 ± 0.063	3.5ArgLeu: 3.5 ± 0.054	1.071ArgMet: 1.071 ± 0.035	1.787ArgAsn: 1.787 ± 0.042	1.043ArgPro: 1.043 ± 0.039	1.466ArgGln: 1.466 ± 0.042	1.56ArgArg: 1.56 ± 0.051	1.902ArgSer: 1.902 ± 0.044	1.751ArgThr: 1.751 ± 0.041	2.329ArgVal: 2.329 ± 0.05	0.331ArgTrp: 0.331 ± 0.019	1.477ArgTyr: 1.477 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	3.602SerAla: 3.602 ± 0.062	0.396SerCys: 0.396 ± 0.019	3.155SerAsp: 3.155 ± 0.064	4.516SerGlu: 4.516 ± 0.064	3.497SerPhe: 3.497 ± 0.067	4.603SerGly: 4.603 ± 0.081	0.989SerHis: 0.989 ± 0.031	5.228SerIle: 5.228 ± 0.079	4.579SerLys: 4.579 ± 0.067	6.386SerLeu: 6.386 ± 0.079	1.516SerMet: 1.516 ± 0.037	3.022SerAsn: 3.022 ± 0.064	1.792SerPro: 1.792 ± 0.041	2.385SerGln: 2.385 ± 0.049	2.034SerArg: 2.034 ± 0.049	4.307SerSer: 4.307 ± 0.098	3.524SerThr: 3.524 ± 0.052	4.264SerVal: 4.264 ± 0.057	0.609SerTrp: 0.609 ± 0.027	2.594SerTyr: 2.594 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	3.81ThrAla: 3.81 ± 0.066	0.352ThrCys: 0.352 ± 0.019	3.051ThrAsp: 3.051 ± 0.069	3.975ThrGlu: 3.975 ± 0.071	2.828ThrPhe: 2.828 ± 0.051	4.163ThrGly: 4.163 ± 0.09	0.985ThrHis: 0.985 ± 0.032	5.426ThrIle: 5.426 ± 0.074	4.043ThrLys: 4.043 ± 0.068	5.664ThrLeu: 5.664 ± 0.077	1.352ThrMet: 1.352 ± 0.037	2.836ThrAsn: 2.836 ± 0.065	2.251ThrPro: 2.251 ± 0.049	1.831ThrGln: 1.831 ± 0.039	1.684ThrArg: 1.684 ± 0.041	3.534ThrSer: 3.534 ± 0.057	3.588ThrThr: 3.588 ± 0.08	4.269ThrVal: 4.269 ± 0.074	0.492ThrTrp: 0.492 ± 0.022	2.139ThrTyr: 2.139 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	5.011ValAla: 5.011 ± 0.081	0.559ValCys: 0.559 ± 0.025	3.657ValAsp: 3.657 ± 0.062	4.741ValGlu: 4.741 ± 0.075	3.035ValPhe: 3.035 ± 0.065	4.596ValGly: 4.596 ± 0.068	1.058ValHis: 1.058 ± 0.032	5.411ValIle: 5.411 ± 0.073	4.674ValLys: 4.674 ± 0.078	6.436ValLeu: 6.436 ± 0.082	1.675ValMet: 1.675 ± 0.043	3.168ValAsn: 3.168 ± 0.065	2.525ValPro: 2.525 ± 0.052	2.21ValGln: 2.21 ± 0.053	2.201ValArg: 2.201 ± 0.051	4.767ValSer: 4.767 ± 0.074	4.363ValThr: 4.363 ± 0.082	4.925ValVal: 4.925 ± 0.091	0.518ValTrp: 0.518 ± 0.022	2.266ValTyr: 2.266 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.454TrpAla: 0.454 ± 0.021	0.07TrpCys: 0.07 ± 0.008	0.429TrpAsp: 0.429 ± 0.02	0.588TrpGlu: 0.588 ± 0.026	0.454TrpPhe: 0.454 ± 0.022	0.597TrpGly: 0.597 ± 0.025	0.173TrpHis: 0.173 ± 0.011	0.624TrpIle: 0.624 ± 0.022	0.576TrpLys: 0.576 ± 0.025	1.016TrpLeu: 1.016 ± 0.035	0.249TrpMet: 0.249 ± 0.015	0.481TrpAsn: 0.481 ± 0.022	0.181TrpPro: 0.181 ± 0.015	0.485TrpGln: 0.485 ± 0.022	0.341TrpArg: 0.341 ± 0.018	0.542TrpSer: 0.542 ± 0.024	0.488TrpThr: 0.488 ± 0.024	0.478TrpVal: 0.478 ± 0.02	0.106TrpTrp: 0.106 ± 0.009	0.312TrpTyr: 0.312 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.125TyrAla: 2.125 ± 0.049	0.307TyrCys: 0.307 ± 0.019	2.044TyrAsp: 2.044 ± 0.052	2.539TyrGlu: 2.539 ± 0.049	2.201TyrPhe: 2.201 ± 0.055	2.468TyrGly: 2.468 ± 0.056	0.771TyrHis: 0.771 ± 0.025	2.327TyrIle: 2.327 ± 0.052	2.206TyrLys: 2.206 ± 0.046	4.154TyrLeu: 4.154 ± 0.076	0.787TyrMet: 0.787 ± 0.027	1.643TyrAsn: 1.643 ± 0.04	1.388TyrPro: 1.388 ± 0.035	2.072TyrGln: 2.072 ± 0.046	1.621TyrArg: 1.621 ± 0.041	2.562TyrSer: 2.562 ± 0.052	2.043TyrThr: 2.043 ± 0.045	2.256TyrVal: 2.256 ± 0.045	0.403TyrTrp: 0.403 ± 0.021	1.778TyrTyr: 1.778 ± 0.054	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3427 proteins (1049214 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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