Amino acid dipepetide frequency for Rhodococcus sp. C9-5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.562AlaAla: 20.562 ± 0.177	0.922AlaCys: 0.922 ± 0.026	8.418AlaAsp: 8.418 ± 0.099	7.886AlaGlu: 7.886 ± 0.083	3.45AlaPhe: 3.45 ± 0.054	12.498AlaGly: 12.498 ± 0.103	2.528AlaHis: 2.528 ± 0.045	4.786AlaIle: 4.786 ± 0.07	3.014AlaLys: 3.014 ± 0.066	13.9AlaLeu: 13.9 ± 0.12	2.713AlaMet: 2.713 ± 0.044	2.54AlaAsn: 2.54 ± 0.048	6.698AlaPro: 6.698 ± 0.089	3.951AlaGln: 3.951 ± 0.057	8.815AlaArg: 8.815 ± 0.09	6.309AlaSer: 6.309 ± 0.067	7.729AlaThr: 7.729 ± 0.08	12.588AlaVal: 12.588 ± 0.127	1.595AlaTrp: 1.595 ± 0.039	2.257AlaTyr: 2.257 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.014CysAla: 1.014 ± 0.031	0.087CysCys: 0.087 ± 0.008	0.414CysAsp: 0.414 ± 0.019	0.372CysGlu: 0.372 ± 0.018	0.213CysPhe: 0.213 ± 0.015	0.846CysGly: 0.846 ± 0.03	0.169CysHis: 0.169 ± 0.009	0.251CysIle: 0.251 ± 0.013	0.122CysLys: 0.122 ± 0.009	0.594CysLeu: 0.594 ± 0.02	0.124CysMet: 0.124 ± 0.009	0.129CysAsn: 0.129 ± 0.01	0.444CysPro: 0.444 ± 0.02	0.159CysGln: 0.159 ± 0.011	0.481CysArg: 0.481 ± 0.021	0.48CysSer: 0.48 ± 0.018	0.481CysThr: 0.481 ± 0.02	0.621CysVal: 0.621 ± 0.022	0.115CysTrp: 0.115 ± 0.009	0.145CysTyr: 0.145 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.985AspAla: 7.985 ± 0.082	0.434AspCys: 0.434 ± 0.021	3.547AspAsp: 3.547 ± 0.058	3.964AspGlu: 3.964 ± 0.058	1.673AspPhe: 1.673 ± 0.04	6.167AspGly: 6.167 ± 0.07	1.357AspHis: 1.357 ± 0.032	2.148AspIle: 2.148 ± 0.042	1.26AspLys: 1.26 ± 0.032	6.676AspLeu: 6.676 ± 0.094	0.911AspMet: 0.911 ± 0.025	1.133AspAsn: 1.133 ± 0.028	4.505AspPro: 4.505 ± 0.059	1.701AspGln: 1.701 ± 0.036	4.958AspArg: 4.958 ± 0.068	2.937AspSer: 2.937 ± 0.043	3.203AspThr: 3.203 ± 0.049	5.084AspVal: 5.084 ± 0.073	0.983AspTrp: 0.983 ± 0.028	1.308AspTyr: 1.308 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	6.167GluAla: 6.167 ± 0.079	0.341GluCys: 0.341 ± 0.016	2.489GluAsp: 2.489 ± 0.045	2.54GluGlu: 2.54 ± 0.053	1.905GluPhe: 1.905 ± 0.038	3.539GluGly: 3.539 ± 0.053	1.529GluHis: 1.529 ± 0.032	2.565GluIle: 2.565 ± 0.048	1.297GluLys: 1.297 ± 0.039	6.604GluLeu: 6.604 ± 0.09	1.052GluMet: 1.052 ± 0.03	1.147GluAsn: 1.147 ± 0.032	2.893GluPro: 2.893 ± 0.053	2.261GluGln: 2.261 ± 0.044	4.74GluArg: 4.74 ± 0.066	3.148GluSer: 3.148 ± 0.055	2.664GluThr: 2.664 ± 0.039	4.879GluVal: 4.879 ± 0.066	0.709GluTrp: 0.709 ± 0.023	1.116GluTyr: 1.116 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.072PheAla: 4.072 ± 0.06	0.236PheCys: 0.236 ± 0.013	2.426PheAsp: 2.426 ± 0.06	1.691PheGlu: 1.691 ± 0.045	0.896PhePhe: 0.896 ± 0.028	3.49PheGly: 3.49 ± 0.062	0.594PheHis: 0.594 ± 0.023	0.773PheIle: 0.773 ± 0.023	0.49PheLys: 0.49 ± 0.022	2.564PheLeu: 2.564 ± 0.047	0.445PheMet: 0.445 ± 0.021	0.627PheAsn: 0.627 ± 0.023	1.326PhePro: 1.326 ± 0.034	0.675PheGln: 0.675 ± 0.024	1.619PheArg: 1.619 ± 0.033	1.579PheSer: 1.579 ± 0.035	2.064PheThr: 2.064 ± 0.037	2.795PheVal: 2.795 ± 0.049	0.431PheTrp: 0.431 ± 0.019	0.624PheTyr: 0.624 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	11.121GlyAla: 11.121 ± 0.117	0.799GlyCys: 0.799 ± 0.029	5.139GlyAsp: 5.139 ± 0.066	4.771GlyGlu: 4.771 ± 0.07	3.119GlyPhe: 3.119 ± 0.052	8.333GlyGly: 8.333 ± 0.121	1.987GlyHis: 1.987 ± 0.041	4.099GlyIle: 4.099 ± 0.063	2.451GlyLys: 2.451 ± 0.051	9.071GlyLeu: 9.071 ± 0.106	2.174GlyMet: 2.174 ± 0.044	1.925GlyAsn: 1.925 ± 0.04	4.588GlyPro: 4.588 ± 0.058	2.721GlyGln: 2.721 ± 0.048	6.731GlyArg: 6.731 ± 0.072	5.818GlySer: 5.818 ± 0.084	5.89GlyThr: 5.89 ± 0.072	8.087GlyVal: 8.087 ± 0.085	1.664GlyTrp: 1.664 ± 0.039	2.258GlyTyr: 2.258 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.321HisAla: 2.321 ± 0.039	0.201HisCys: 0.201 ± 0.013	1.261HisAsp: 1.261 ± 0.028	1.05HisGlu: 1.05 ± 0.027	0.605HisPhe: 0.605 ± 0.02	2.109HisGly: 2.109 ± 0.036	0.615HisHis: 0.615 ± 0.023	0.659HisIle: 0.659 ± 0.022	0.343HisLys: 0.343 ± 0.015	2.084HisLeu: 2.084 ± 0.038	0.354HisMet: 0.354 ± 0.014	0.392HisAsn: 0.392 ± 0.016	1.531HisPro: 1.531 ± 0.034	0.594HisGln: 0.594 ± 0.022	1.736HisArg: 1.736 ± 0.039	1.094HisSer: 1.094 ± 0.026	1.15HisThr: 1.15 ± 0.029	1.639HisVal: 1.639 ± 0.032	0.326HisTrp: 0.326 ± 0.016	0.459HisTyr: 0.459 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	5.975IleAla: 5.975 ± 0.08	0.322IleCys: 0.322 ± 0.014	2.952IleAsp: 2.952 ± 0.05	2.433IleGlu: 2.433 ± 0.05	0.921IlePhe: 0.921 ± 0.031	4.498IleGly: 4.498 ± 0.067	0.609IleHis: 0.609 ± 0.022	1.088IleIle: 1.088 ± 0.034	0.748IleLys: 0.748 ± 0.028	3.007IleLeu: 3.007 ± 0.049	0.545IleMet: 0.545 ± 0.02	0.829IleAsn: 0.829 ± 0.028	2.249IlePro: 2.249 ± 0.038	0.757IleGln: 0.757 ± 0.025	2.48IleArg: 2.48 ± 0.044	2.03IleSer: 2.03 ± 0.036	2.507IleThr: 2.507 ± 0.049	3.716IleVal: 3.716 ± 0.056	0.396IleTrp: 0.396 ± 0.017	0.689IleTyr: 0.689 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	2.683LysAla: 2.683 ± 0.069	0.106LysCys: 0.106 ± 0.009	1.152LysAsp: 1.152 ± 0.033	0.945LysGlu: 0.945 ± 0.031	0.64LysPhe: 0.64 ± 0.02	1.577LysGly: 1.577 ± 0.042	0.445LysHis: 0.445 ± 0.02	1.05LysIle: 1.05 ± 0.027	0.701LysLys: 0.701 ± 0.032	2.077LysLeu: 2.077 ± 0.038	0.491LysMet: 0.491 ± 0.019	0.533LysAsn: 0.533 ± 0.023	1.259LysPro: 1.259 ± 0.03	0.689LysGln: 0.689 ± 0.024	1.371LysArg: 1.371 ± 0.038	1.266LysSer: 1.266 ± 0.031	1.328LysThr: 1.328 ± 0.034	1.99LysVal: 1.99 ± 0.045	0.29LysTrp: 0.29 ± 0.015	0.492LysTyr: 0.492 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	14.656LeuAla: 14.656 ± 0.122	0.739LeuCys: 0.739 ± 0.025	7.16LeuAsp: 7.16 ± 0.099	4.776LeuGlu: 4.776 ± 0.067	2.698LeuPhe: 2.698 ± 0.05	9.803LeuGly: 9.803 ± 0.12	1.975LeuHis: 1.975 ± 0.038	3.752LeuIle: 3.752 ± 0.057	1.57LeuLys: 1.57 ± 0.045	9.884LeuLeu: 9.884 ± 0.118	1.608LeuMet: 1.608 ± 0.035	1.777LeuAsn: 1.777 ± 0.031	5.832LeuPro: 5.832 ± 0.082	2.273LeuGln: 2.273 ± 0.041	7.612LeuArg: 7.612 ± 0.082	5.598LeuSer: 5.598 ± 0.071	6.767LeuThr: 6.767 ± 0.073	9.366LeuVal: 9.366 ± 0.105	1.165LeuTrp: 1.165 ± 0.029	1.607LeuTyr: 1.607 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	2.333MetAla: 2.333 ± 0.044	0.163MetCys: 0.163 ± 0.011	0.889MetAsp: 0.889 ± 0.027	0.617MetGlu: 0.617 ± 0.023	0.63MetPhe: 0.63 ± 0.021	1.38MetGly: 1.38 ± 0.034	0.406MetHis: 0.406 ± 0.017	0.833MetIle: 0.833 ± 0.026	0.431MetLys: 0.431 ± 0.019	2.016MetLeu: 2.016 ± 0.044	0.352MetMet: 0.352 ± 0.017	0.502MetAsn: 0.502 ± 0.019	1.164MetPro: 1.164 ± 0.031	0.5MetGln: 0.5 ± 0.022	1.483MetArg: 1.483 ± 0.034	1.57MetSer: 1.57 ± 0.034	1.722MetThr: 1.722 ± 0.036	1.644MetVal: 1.644 ± 0.04	0.255MetTrp: 0.255 ± 0.017	0.357MetTyr: 0.357 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.458AsnAla: 2.458 ± 0.045	0.176AsnCys: 0.176 ± 0.011	0.985AsnAsp: 0.985 ± 0.027	0.947AsnGlu: 0.947 ± 0.026	0.618AsnPhe: 0.618 ± 0.021	1.982AsnGly: 1.982 ± 0.045	0.41AsnHis: 0.41 ± 0.015	0.821AsnIle: 0.821 ± 0.023	0.475AsnLys: 0.475 ± 0.019	2.087AsnLeu: 2.087 ± 0.046	0.383AsnMet: 0.383 ± 0.016	0.502AsnAsn: 0.502 ± 0.023	1.705AsnPro: 1.705 ± 0.033	0.613AsnGln: 0.613 ± 0.025	1.366AsnArg: 1.366 ± 0.031	1.226AsnSer: 1.226 ± 0.03	1.27AsnThr: 1.27 ± 0.027	1.653AsnVal: 1.653 ± 0.04	0.352AsnTrp: 0.352 ± 0.017	0.486AsnTyr: 0.486 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	7.722ProAla: 7.722 ± 0.092	0.269ProCys: 0.269 ± 0.014	4.365ProAsp: 4.365 ± 0.06	3.717ProGlu: 3.717 ± 0.058	1.536ProPhe: 1.536 ± 0.035	5.672ProGly: 5.672 ± 0.074	1.107ProHis: 1.107 ± 0.026	2.013ProIle: 2.013 ± 0.036	1.224ProLys: 1.224 ± 0.034	4.86ProLeu: 4.86 ± 0.068	1.103ProMet: 1.103 ± 0.034	1.239ProAsn: 1.239 ± 0.034	2.868ProPro: 2.868 ± 0.068	1.565ProGln: 1.565 ± 0.036	3.365ProArg: 3.365 ± 0.053	3.105ProSer: 3.105 ± 0.044	3.816ProThr: 3.816 ± 0.066	5.325ProVal: 5.325 ± 0.078	0.729ProTrp: 0.729 ± 0.023	1.071ProTyr: 1.071 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.455GlnAla: 3.455 ± 0.054	0.191GlnCys: 0.191 ± 0.012	1.229GlnAsp: 1.229 ± 0.03	1.069GlnGlu: 1.069 ± 0.029	0.929GlnPhe: 0.929 ± 0.028	1.887GlnGly: 1.887 ± 0.033	0.583GlnHis: 0.583 ± 0.019	1.359GlnIle: 1.359 ± 0.033	0.604GlnLys: 0.604 ± 0.02	3.286GlnLeu: 3.286 ± 0.057	0.596GlnMet: 0.596 ± 0.022	0.541GlnAsn: 0.541 ± 0.02	1.548GlnPro: 1.548 ± 0.034	1.168GlnGln: 1.168 ± 0.031	2.375GlnArg: 2.375 ± 0.042	1.571GlnSer: 1.571 ± 0.033	1.44GlnThr: 1.44 ± 0.035	2.779GlnVal: 2.779 ± 0.062	0.566GlnTrp: 0.566 ± 0.024	0.625GlnTyr: 0.625 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.582ArgAla: 8.582 ± 0.092	0.494ArgCys: 0.494 ± 0.018	4.171ArgAsp: 4.171 ± 0.057	4.165ArgGlu: 4.165 ± 0.046	2.315ArgPhe: 2.315 ± 0.036	5.602ArgGly: 5.602 ± 0.07	1.505ArgHis: 1.505 ± 0.034	3.37ArgIle: 3.37 ± 0.047	1.552ArgLys: 1.552 ± 0.041	7.229ArgLeu: 7.229 ± 0.089	1.738ArgMet: 1.738 ± 0.036	1.459ArgAsn: 1.459 ± 0.035	3.988ArgPro: 3.988 ± 0.06	2.005ArgGln: 2.005 ± 0.042	6.338ArgArg: 6.338 ± 0.091	4.246ArgSer: 4.246 ± 0.058	4.644ArgThr: 4.644 ± 0.055	5.848ArgVal: 5.848 ± 0.067	1.253ArgTrp: 1.253 ± 0.029	1.708ArgTyr: 1.708 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	7.288SerAla: 7.288 ± 0.079	0.365SerCys: 0.365 ± 0.02	3.215SerAsp: 3.215 ± 0.049	2.681SerGlu: 2.681 ± 0.042	1.673SerPhe: 1.673 ± 0.041	6.186SerGly: 6.186 ± 0.073	0.958SerHis: 0.958 ± 0.026	2.19SerIle: 2.19 ± 0.044	1.187SerLys: 1.187 ± 0.028	5.067SerLeu: 5.067 ± 0.066	1.397SerMet: 1.397 ± 0.033	1.141SerAsn: 1.141 ± 0.032	3.031SerPro: 3.031 ± 0.049	1.409SerGln: 1.409 ± 0.035	3.679SerArg: 3.679 ± 0.049	3.219SerSer: 3.219 ± 0.055	3.76SerThr: 3.76 ± 0.056	4.977SerVal: 4.977 ± 0.063	0.926SerTrp: 0.926 ± 0.026	1.174SerTyr: 1.174 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	8.487ThrAla: 8.487 ± 0.096	0.41ThrCys: 0.41 ± 0.018	3.87ThrAsp: 3.87 ± 0.056	3.455ThrGlu: 3.455 ± 0.053	1.815ThrPhe: 1.815 ± 0.039	6.357ThrGly: 6.357 ± 0.074	1.153ThrHis: 1.153 ± 0.029	2.231ThrIle: 2.231 ± 0.042	1.269ThrLys: 1.269 ± 0.034	5.983ThrLeu: 5.983 ± 0.065	1.124ThrMet: 1.124 ± 0.032	1.252ThrAsn: 1.252 ± 0.035	3.958ThrPro: 3.958 ± 0.066	1.454ThrGln: 1.454 ± 0.035	3.759ThrArg: 3.759 ± 0.06	3.321ThrSer: 3.321 ± 0.05	4.2ThrThr: 4.2 ± 0.088	6.776ThrVal: 6.776 ± 0.077	0.792ThrTrp: 0.792 ± 0.024	1.24ThrTyr: 1.24 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	12.501ValAla: 12.501 ± 0.12	0.703ValCys: 0.703 ± 0.022	6.275ValAsp: 6.275 ± 0.08	4.869ValGlu: 4.869 ± 0.06	2.591ValPhe: 2.591 ± 0.046	7.864ValGly: 7.864 ± 0.085	1.891ValHis: 1.891 ± 0.039	3.535ValIle: 3.535 ± 0.056	1.675ValLys: 1.675 ± 0.033	9.7ValLeu: 9.7 ± 0.103	1.516ValMet: 1.516 ± 0.036	2.017ValAsn: 2.017 ± 0.044	5.172ValPro: 5.172 ± 0.074	2.131ValGln: 2.131 ± 0.041	6.411ValArg: 6.411 ± 0.067	4.883ValSer: 4.883 ± 0.052	6.136ValThr: 6.136 ± 0.079	9.309ValVal: 9.309 ± 0.113	1.075ValTrp: 1.075 ± 0.028	1.55ValTyr: 1.55 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.494TrpAla: 1.494 ± 0.036	0.141TrpCys: 0.141 ± 0.011	0.753TrpAsp: 0.753 ± 0.023	0.624TrpGlu: 0.624 ± 0.021	0.506TrpPhe: 0.506 ± 0.021	1.015TrpGly: 1.015 ± 0.027	0.32TrpHis: 0.32 ± 0.016	0.661TrpIle: 0.661 ± 0.024	0.316TrpLys: 0.316 ± 0.017	1.619TrpLeu: 1.619 ± 0.041	0.341TrpMet: 0.341 ± 0.018	0.387TrpAsn: 0.387 ± 0.019	0.734TrpPro: 0.734 ± 0.026	0.547TrpGln: 0.547 ± 0.018	1.126TrpArg: 1.126 ± 0.032	0.999TrpSer: 0.999 ± 0.028	0.957TrpThr: 0.957 ± 0.026	1.136TrpVal: 1.136 ± 0.029	0.33TrpTrp: 0.33 ± 0.019	0.317TrpTyr: 0.317 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.284TyrAla: 2.284 ± 0.044	0.164TyrCys: 0.164 ± 0.009	1.223TyrAsp: 1.223 ± 0.033	1.015TyrGlu: 1.015 ± 0.029	0.687TyrPhe: 0.687 ± 0.023	1.941TyrGly: 1.941 ± 0.041	0.382TyrHis: 0.382 ± 0.019	0.569TyrIle: 0.569 ± 0.021	0.353TyrLys: 0.353 ± 0.018	2.31TyrLeu: 2.31 ± 0.041	0.275TyrMet: 0.275 ± 0.019	0.443TyrAsn: 0.443 ± 0.019	1.176TyrPro: 1.176 ± 0.03	0.631TyrGln: 0.631 ± 0.022	1.767TyrArg: 1.767 ± 0.038	1.123TyrSer: 1.123 ± 0.026	1.178TyrThr: 1.178 ± 0.03	1.591TyrVal: 1.591 ± 0.042	0.369TyrTrp: 0.369 ± 0.018	0.427TyrTyr: 0.427 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4272 proteins (1430120 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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