Amino acid dipepetide frequency for Paracoccus yeei

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.438AlaAla: 19.438 ± 0.198	1.155AlaCys: 1.155 ± 0.032	7.217AlaAsp: 7.217 ± 0.085	9.053AlaGlu: 9.053 ± 0.103	4.111AlaPhe: 4.111 ± 0.059	12.093AlaGly: 12.093 ± 0.115	2.384AlaHis: 2.384 ± 0.038	6.114AlaIle: 6.114 ± 0.071	2.962AlaLys: 2.962 ± 0.056	15.666AlaLeu: 15.666 ± 0.139	4.02AlaMet: 4.02 ± 0.058	2.423AlaAsn: 2.423 ± 0.046	6.816AlaPro: 6.816 ± 0.088	4.99AlaGln: 4.99 ± 0.07	11.39AlaArg: 11.39 ± 0.121	5.557AlaSer: 5.557 ± 0.066	6.046AlaThr: 6.046 ± 0.065	9.05AlaVal: 9.05 ± 0.1	1.696AlaTrp: 1.696 ± 0.035	2.338AlaTyr: 2.338 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.068CysAla: 1.068 ± 0.027	0.124CysCys: 0.124 ± 0.009	0.567CysAsp: 0.567 ± 0.021	0.374CysGlu: 0.374 ± 0.019	0.314CysPhe: 0.314 ± 0.015	0.951CysGly: 0.951 ± 0.024	0.278CysHis: 0.278 ± 0.014	0.386CysIle: 0.386 ± 0.019	0.179CysLys: 0.179 ± 0.013	0.806CysLeu: 0.806 ± 0.021	0.176CysMet: 0.176 ± 0.013	0.185CysAsn: 0.185 ± 0.012	0.526CysPro: 0.526 ± 0.024	0.263CysGln: 0.263 ± 0.014	0.622CysArg: 0.622 ± 0.023	0.444CysSer: 0.444 ± 0.02	0.394CysThr: 0.394 ± 0.017	0.571CysVal: 0.571 ± 0.02	0.132CysTrp: 0.132 ± 0.009	0.202CysTyr: 0.202 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.423AspAla: 7.423 ± 0.078	0.53AspCys: 0.53 ± 0.02	3.177AspAsp: 3.177 ± 0.066	3.353AspGlu: 3.353 ± 0.053	2.259AspPhe: 2.259 ± 0.047	5.307AspGly: 5.307 ± 0.063	1.507AspHis: 1.507 ± 0.038	2.672AspIle: 2.672 ± 0.043	1.389AspLys: 1.389 ± 0.036	6.941AspLeu: 6.941 ± 0.091	1.441AspMet: 1.441 ± 0.031	1.057AspAsn: 1.057 ± 0.026	4.172AspPro: 4.172 ± 0.049	1.97AspGln: 1.97 ± 0.041	5.245AspArg: 5.245 ± 0.067	2.173AspSer: 2.173 ± 0.049	2.475AspThr: 2.475 ± 0.047	3.484AspVal: 3.484 ± 0.044	1.261AspTrp: 1.261 ± 0.036	1.51AspTyr: 1.51 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	7.989GluAla: 7.989 ± 0.102	0.335GluCys: 0.335 ± 0.015	2.936GluAsp: 2.936 ± 0.045	2.7GluGlu: 2.7 ± 0.051	1.595GluPhe: 1.595 ± 0.035	4.607GluGly: 4.607 ± 0.065	1.039GluHis: 1.039 ± 0.03	3.224GluIle: 3.224 ± 0.057	1.734GluLys: 1.734 ± 0.043	4.968GluLeu: 4.968 ± 0.068	1.542GluMet: 1.542 ± 0.036	1.441GluAsn: 1.441 ± 0.032	2.806GluPro: 2.806 ± 0.047	1.773GluGln: 1.773 ± 0.038	4.512GluArg: 4.512 ± 0.069	2.169GluSer: 2.169 ± 0.04	3.255GluThr: 3.255 ± 0.052	3.833GluVal: 3.833 ± 0.053	0.769GluTrp: 0.769 ± 0.026	0.969GluTyr: 0.969 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.359PheAla: 4.359 ± 0.061	0.376PheCys: 0.376 ± 0.016	2.537PheAsp: 2.537 ± 0.05	1.696PheGlu: 1.696 ± 0.042	1.228PhePhe: 1.228 ± 0.036	3.437PheGly: 3.437 ± 0.057	0.76PheHis: 0.76 ± 0.024	1.424PheIle: 1.424 ± 0.03	0.695PheLys: 0.695 ± 0.021	3.389PheLeu: 3.389 ± 0.062	0.769PheMet: 0.769 ± 0.025	0.827PheAsn: 0.827 ± 0.023	1.547PhePro: 1.547 ± 0.032	1.031PheGln: 1.031 ± 0.026	2.368PheArg: 2.368 ± 0.047	1.973PheSer: 1.973 ± 0.043	1.753PheThr: 1.753 ± 0.033	2.448PheVal: 2.448 ± 0.049	0.562PheTrp: 0.562 ± 0.019	0.817PheTyr: 0.817 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	10.761GlyAla: 10.761 ± 0.104	0.842GlyCys: 0.842 ± 0.024	4.665GlyAsp: 4.665 ± 0.059	4.28GlyGlu: 4.28 ± 0.052	3.652GlyPhe: 3.652 ± 0.052	7.641GlyGly: 7.641 ± 0.098	2.093GlyHis: 2.093 ± 0.042	4.644GlyIle: 4.644 ± 0.055	2.843GlyLys: 2.843 ± 0.053	9.844GlyLeu: 9.844 ± 0.102	2.668GlyMet: 2.668 ± 0.048	2.068GlyAsn: 2.068 ± 0.062	4.236GlyPro: 4.236 ± 0.066	3.425GlyGln: 3.425 ± 0.054	7.146GlyArg: 7.146 ± 0.076	4.269GlySer: 4.269 ± 0.058	4.606GlyThr: 4.606 ± 0.066	6.214GlyVal: 6.214 ± 0.089	1.691GlyTrp: 1.691 ± 0.038	2.171GlyTyr: 2.171 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.503HisAla: 2.503 ± 0.042	0.223HisCys: 0.223 ± 0.013	1.446HisAsp: 1.446 ± 0.037	1.056HisGlu: 1.056 ± 0.028	0.788HisPhe: 0.788 ± 0.028	2.099HisGly: 2.099 ± 0.044	0.587HisHis: 0.587 ± 0.023	0.852HisIle: 0.852 ± 0.023	0.399HisLys: 0.399 ± 0.018	2.312HisLeu: 2.312 ± 0.043	0.496HisMet: 0.496 ± 0.017	0.403HisAsn: 0.403 ± 0.017	1.589HisPro: 1.589 ± 0.039	0.57HisGln: 0.57 ± 0.023	1.647HisArg: 1.647 ± 0.04	0.896HisSer: 0.896 ± 0.026	0.68HisThr: 0.68 ± 0.026	1.584HisVal: 1.584 ± 0.036	0.357HisTrp: 0.357 ± 0.016	0.513HisTyr: 0.513 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.26IleAla: 7.26 ± 0.075	0.536IleCys: 0.536 ± 0.02	3.255IleAsp: 3.255 ± 0.052	3.178IleGlu: 3.178 ± 0.051	1.575IlePhe: 1.575 ± 0.04	4.733IleGly: 4.733 ± 0.062	0.962IleHis: 0.962 ± 0.025	1.883IleIle: 1.883 ± 0.042	1.094IleLys: 1.094 ± 0.031	4.744IleLeu: 4.744 ± 0.066	0.981IleMet: 0.981 ± 0.028	1.09IleAsn: 1.09 ± 0.027	2.373IlePro: 2.373 ± 0.037	1.203IleGln: 1.203 ± 0.03	3.729IleArg: 3.729 ± 0.053	2.516IleSer: 2.516 ± 0.04	2.458IleThr: 2.458 ± 0.042	3.583IleVal: 3.583 ± 0.056	0.645IleTrp: 0.645 ± 0.025	0.954IleTyr: 0.954 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.49LysAla: 3.49 ± 0.065	0.127LysCys: 0.127 ± 0.011	1.375LysAsp: 1.375 ± 0.034	1.083LysGlu: 1.083 ± 0.029	0.68LysPhe: 0.68 ± 0.026	2.362LysGly: 2.362 ± 0.05	0.471LysHis: 0.471 ± 0.018	1.293LysIle: 1.293 ± 0.034	0.826LysLys: 0.826 ± 0.029	2.428LysLeu: 2.428 ± 0.05	0.601LysMet: 0.601 ± 0.022	0.62LysAsn: 0.62 ± 0.023	1.621LysPro: 1.621 ± 0.035	0.771LysGln: 0.771 ± 0.026	1.827LysArg: 1.827 ± 0.043	1.392LysSer: 1.392 ± 0.033	1.494LysThr: 1.494 ± 0.036	1.903LysVal: 1.903 ± 0.046	0.328LysTrp: 0.328 ± 0.017	0.511LysTyr: 0.511 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	15.66LeuAla: 15.66 ± 0.151	0.993LeuCys: 0.993 ± 0.025	6.469LeuAsp: 6.469 ± 0.071	4.836LeuGlu: 4.836 ± 0.074	3.298LeuPhe: 3.298 ± 0.059	9.162LeuGly: 9.162 ± 0.089	2.023LeuHis: 2.023 ± 0.044	5.045LeuIle: 5.045 ± 0.062	2.654LeuLys: 2.654 ± 0.049	9.223LeuLeu: 9.223 ± 0.11	2.661LeuMet: 2.661 ± 0.046	2.371LeuAsn: 2.371 ± 0.046	6.32LeuPro: 6.32 ± 0.073	2.617LeuGln: 2.617 ± 0.045	8.291LeuArg: 8.291 ± 0.085	6.295LeuSer: 6.295 ± 0.088	5.915LeuThr: 5.915 ± 0.078	7.477LeuVal: 7.477 ± 0.082	1.421LeuTrp: 1.421 ± 0.033	1.935LeuTyr: 1.935 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.75MetAla: 3.75 ± 0.063	0.162MetCys: 0.162 ± 0.01	1.346MetAsp: 1.346 ± 0.032	1.11MetGlu: 1.11 ± 0.029	0.685MetPhe: 0.685 ± 0.025	2.158MetGly: 2.158 ± 0.044	0.436MetHis: 0.436 ± 0.016	1.446MetIle: 1.446 ± 0.037	0.881MetLys: 0.881 ± 0.026	2.634MetLeu: 2.634 ± 0.055	0.685MetMet: 0.685 ± 0.024	0.8MetAsn: 0.8 ± 0.024	1.587MetPro: 1.587 ± 0.035	0.985MetGln: 0.985 ± 0.031	2.058MetArg: 2.058 ± 0.041	1.391MetSer: 1.391 ± 0.035	1.967MetThr: 1.967 ± 0.034	1.813MetVal: 1.813 ± 0.033	0.216MetTrp: 0.216 ± 0.012	0.265MetTyr: 0.265 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.893AsnAla: 2.893 ± 0.047	0.227AsnCys: 0.227 ± 0.015	1.351AsnAsp: 1.351 ± 0.046	0.96AsnGlu: 0.96 ± 0.026	0.779AsnPhe: 0.779 ± 0.025	2.002AsnGly: 2.002 ± 0.036	0.468AsnHis: 0.468 ± 0.017	1.14AsnIle: 1.14 ± 0.031	0.505AsnLys: 0.505 ± 0.021	2.369AsnLeu: 2.369 ± 0.043	0.559AsnMet: 0.559 ± 0.019	0.517AsnAsn: 0.517 ± 0.02	1.781AsnPro: 1.781 ± 0.041	0.669AsnGln: 0.669 ± 0.024	1.759AsnArg: 1.759 ± 0.04	0.963AsnSer: 0.963 ± 0.027	1.031AsnThr: 1.031 ± 0.033	1.518AsnVal: 1.518 ± 0.035	0.4AsnTrp: 0.4 ± 0.019	0.491AsnTyr: 0.491 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	7.871ProAla: 7.871 ± 0.101	0.399ProCys: 0.399 ± 0.016	4.26ProAsp: 4.26 ± 0.055	4.354ProGlu: 4.354 ± 0.06	1.864ProPhe: 1.864 ± 0.041	5.648ProGly: 5.648 ± 0.066	1.112ProHis: 1.112 ± 0.033	2.128ProIle: 2.128 ± 0.035	1.257ProLys: 1.257 ± 0.032	5.007ProLeu: 5.007 ± 0.071	1.41ProMet: 1.41 ± 0.032	1.173ProAsn: 1.173 ± 0.028	2.929ProPro: 2.929 ± 0.055	2.064ProGln: 2.064 ± 0.045	3.709ProArg: 3.709 ± 0.059	2.427ProSer: 2.427 ± 0.049	2.337ProThr: 2.337 ± 0.044	4.655ProVal: 4.655 ± 0.062	0.811ProTrp: 0.811 ± 0.027	1.038ProTyr: 1.038 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	4.803GlnAla: 4.803 ± 0.065	0.199GlnCys: 0.199 ± 0.013	1.927GlnAsp: 1.927 ± 0.04	1.364GlnGlu: 1.364 ± 0.034	0.983GlnPhe: 0.983 ± 0.026	3.329GlnGly: 3.329 ± 0.056	0.61GlnHis: 0.61 ± 0.022	2.01GlnIle: 2.01 ± 0.042	0.93GlnLys: 0.93 ± 0.029	2.752GlnLeu: 2.752 ± 0.053	1.028GlnMet: 1.028 ± 0.028	0.875GlnAsn: 0.875 ± 0.029	1.996GlnPro: 1.996 ± 0.038	1.102GlnGln: 1.102 ± 0.038	2.451GlnArg: 2.451 ± 0.042	1.607GlnSer: 1.607 ± 0.042	1.67GlnThr: 1.67 ± 0.038	2.537GlnVal: 2.537 ± 0.044	0.369GlnTrp: 0.369 ± 0.015	0.511GlnTyr: 0.511 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	10.004ArgAla: 10.004 ± 0.106	0.519ArgCys: 0.519 ± 0.024	5.162ArgAsp: 5.162 ± 0.063	4.008ArgGlu: 4.008 ± 0.06	2.812ArgPhe: 2.812 ± 0.045	5.603ArgGly: 5.603 ± 0.068	1.988ArgHis: 1.988 ± 0.044	4.503ArgIle: 4.503 ± 0.06	2.125ArgLys: 2.125 ± 0.047	9.112ArgLeu: 9.112 ± 0.089	2.216ArgMet: 2.216 ± 0.047	1.746ArgAsn: 1.746 ± 0.035	4.359ArgPro: 4.359 ± 0.068	2.996ArgGln: 2.996 ± 0.049	6.688ArgArg: 6.688 ± 0.092	3.381ArgSer: 3.381 ± 0.056	3.164ArgThr: 3.164 ± 0.049	5.15ArgVal: 5.15 ± 0.065	1.146ArgTrp: 1.146 ± 0.029	1.609ArgTyr: 1.609 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	5.754SerAla: 5.754 ± 0.074	0.432SerCys: 0.432 ± 0.02	2.922SerAsp: 2.922 ± 0.052	2.276SerGlu: 2.276 ± 0.04	1.933SerPhe: 1.933 ± 0.042	5.127SerGly: 5.127 ± 0.065	1.051SerHis: 1.051 ± 0.028	2.171SerIle: 2.171 ± 0.043	1.068SerLys: 1.068 ± 0.029	4.818SerLeu: 4.818 ± 0.055	1.226SerMet: 1.226 ± 0.033	1.005SerAsn: 1.005 ± 0.03	2.635SerPro: 2.635 ± 0.045	1.562SerGln: 1.562 ± 0.034	3.533SerArg: 3.533 ± 0.052	2.123SerSer: 2.123 ± 0.044	2.265SerThr: 2.265 ± 0.042	3.507SerVal: 3.507 ± 0.047	0.719SerTrp: 0.719 ± 0.024	1.098SerTyr: 1.098 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	6.099ThrAla: 6.099 ± 0.075	0.455ThrCys: 0.455 ± 0.02	2.783ThrAsp: 2.783 ± 0.041	2.67ThrGlu: 2.67 ± 0.048	1.618ThrPhe: 1.618 ± 0.035	5.184ThrGly: 5.184 ± 0.067	1.034ThrHis: 1.034 ± 0.03	2.452ThrIle: 2.452 ± 0.047	1.017ThrLys: 1.017 ± 0.03	5.648ThrLeu: 5.648 ± 0.07	1.141ThrMet: 1.141 ± 0.031	1.06ThrAsn: 1.06 ± 0.031	3.423ThrPro: 3.423 ± 0.053	1.446ThrGln: 1.446 ± 0.039	3.678ThrArg: 3.678 ± 0.057	2.195ThrSer: 2.195 ± 0.039	2.488ThrThr: 2.488 ± 0.049	3.997ThrVal: 3.997 ± 0.056	0.676ThrTrp: 0.676 ± 0.022	1.068ThrTyr: 1.068 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	9.526ValAla: 9.526 ± 0.108	0.578ValCys: 0.578 ± 0.024	3.724ValAsp: 3.724 ± 0.054	4.235ValGlu: 4.235 ± 0.058	2.534ValPhe: 2.534 ± 0.047	5.175ValGly: 5.175 ± 0.069	1.332ValHis: 1.332 ± 0.035	3.913ValIle: 3.913 ± 0.064	1.765ValLys: 1.765 ± 0.042	7.845ValLeu: 7.845 ± 0.089	1.969ValMet: 1.969 ± 0.038	1.784ValAsn: 1.784 ± 0.039	3.903ValPro: 3.903 ± 0.052	2.214ValGln: 2.214 ± 0.036	4.663ValArg: 4.663 ± 0.07	3.682ValSer: 3.682 ± 0.053	4.417ValThr: 4.417 ± 0.059	5.542ValVal: 5.542 ± 0.083	1.043ValTrp: 1.043 ± 0.032	1.32ValTyr: 1.32 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.475TrpAla: 1.475 ± 0.034	0.142TrpCys: 0.142 ± 0.011	0.78TrpAsp: 0.78 ± 0.025	0.559TrpGlu: 0.559 ± 0.021	0.573TrpPhe: 0.573 ± 0.021	1.101TrpGly: 1.101 ± 0.032	0.382TrpHis: 0.382 ± 0.017	0.723TrpIle: 0.723 ± 0.025	0.419TrpLys: 0.419 ± 0.02	1.978TrpLeu: 1.978 ± 0.044	0.382TrpMet: 0.382 ± 0.018	0.434TrpAsn: 0.434 ± 0.017	0.788TrpPro: 0.788 ± 0.025	0.731TrpGln: 0.731 ± 0.026	1.354TrpArg: 1.354 ± 0.036	0.816TrpSer: 0.816 ± 0.025	0.807TrpThr: 0.807 ± 0.025	0.867TrpVal: 0.867 ± 0.032	0.261TrpTrp: 0.261 ± 0.015	0.256TrpTyr: 0.256 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.395TyrAla: 2.395 ± 0.049	0.209TyrCys: 0.209 ± 0.012	1.45TyrAsp: 1.45 ± 0.031	1.051TyrGlu: 1.051 ± 0.034	0.715TyrPhe: 0.715 ± 0.028	2.041TyrGly: 2.041 ± 0.044	0.482TyrHis: 0.482 ± 0.02	0.727TyrIle: 0.727 ± 0.024	0.461TyrLys: 0.461 ± 0.02	2.182TyrLeu: 2.182 ± 0.041	0.401TyrMet: 0.401 ± 0.018	0.502TyrAsn: 0.502 ± 0.019	1.044TyrPro: 1.044 ± 0.029	0.673TyrGln: 0.673 ± 0.025	1.622TyrArg: 1.622 ± 0.038	0.956TyrSer: 0.956 ± 0.026	0.909TyrThr: 0.909 ± 0.026	1.431TyrVal: 1.431 ± 0.029	0.322TyrTrp: 0.322 ± 0.017	0.524TyrTyr: 0.524 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4275 proteins (1349426 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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