Amino acid dipepetide frequency for Listeria fleischmannii subsp. fleischmannii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.719AlaAla: 5.719 ± 0.123
0.619AlaCys: 0.619 ± 0.033
3.889AlaAsp: 3.889 ± 0.068
5.166AlaGlu: 5.166 ± 0.098
3.693AlaPhe: 3.693 ± 0.072
5.216AlaGly: 5.216 ± 0.088
1.342AlaHis: 1.342 ± 0.042
6.209AlaIle: 6.209 ± 0.1
5.524AlaLys: 5.524 ± 0.095
7.666AlaLeu: 7.666 ± 0.104
2.005AlaMet: 2.005 ± 0.054
3.074AlaAsn: 3.074 ± 0.068
2.128AlaPro: 2.128 ± 0.057
2.177AlaGln: 2.177 ± 0.054
2.967AlaArg: 2.967 ± 0.073
4.53AlaSer: 4.53 ± 0.092
4.261AlaThr: 4.261 ± 0.094
5.136AlaVal: 5.136 ± 0.093
0.533AlaTrp: 0.533 ± 0.027
2.579AlaTyr: 2.579 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
0.395CysAla: 0.395 ± 0.022
0.067CysCys: 0.067 ± 0.009
0.346CysAsp: 0.346 ± 0.022
0.372CysGlu: 0.372 ± 0.022
0.354CysPhe: 0.354 ± 0.021
0.586CysGly: 0.586 ± 0.033
0.16CysHis: 0.16 ± 0.015
0.44CysIle: 0.44 ± 0.026
0.235CysLys: 0.235 ± 0.018
0.664CysLeu: 0.664 ± 0.03
0.166CysMet: 0.166 ± 0.013
0.203CysAsn: 0.203 ± 0.018
0.251CysPro: 0.251 ± 0.019
0.223CysGln: 0.223 ± 0.018
0.233CysArg: 0.233 ± 0.015
0.384CysSer: 0.384 ± 0.024
0.348CysThr: 0.348 ± 0.02
0.41CysVal: 0.41 ± 0.024
0.047CysTrp: 0.047 ± 0.008
0.267CysTyr: 0.267 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
4.147AspAla: 4.147 ± 0.076
0.304AspCys: 0.304 ± 0.02
2.479AspAsp: 2.479 ± 0.056
4.319AspGlu: 4.319 ± 0.087
3.023AspPhe: 3.023 ± 0.062
3.633AspGly: 3.633 ± 0.081
0.835AspHis: 0.835 ± 0.03
3.965AspIle: 3.965 ± 0.066
3.611AspLys: 3.611 ± 0.075
4.98AspLeu: 4.98 ± 0.084
1.431AspMet: 1.431 ± 0.038
1.848AspAsn: 1.848 ± 0.053
1.702AspPro: 1.702 ± 0.061
1.389AspGln: 1.389 ± 0.044
1.793AspArg: 1.793 ± 0.054
2.791AspSer: 2.791 ± 0.064
2.938AspThr: 2.938 ± 0.064
4.041AspVal: 4.041 ± 0.067
0.492AspTrp: 0.492 ± 0.027
2.316AspTyr: 2.316 ± 0.055
0.0AspXaa: 0.0 ± 0.0
Glu
5.723GluAla: 5.723 ± 0.098
0.278GluCys: 0.278 ± 0.019
3.292GluAsp: 3.292 ± 0.065
6.148GluGlu: 6.148 ± 0.102
2.699GluPhe: 2.699 ± 0.06
3.77GluGly: 3.77 ± 0.071
1.235GluHis: 1.235 ± 0.035
5.612GluIle: 5.612 ± 0.08
7.146GluLys: 7.146 ± 0.087
6.962GluLeu: 6.962 ± 0.109
2.327GluMet: 2.327 ± 0.056
4.209GluAsn: 4.209 ± 0.075
1.788GluPro: 1.788 ± 0.048
2.822GluGln: 2.822 ± 0.059
3.41GluArg: 3.41 ± 0.071
3.393GluSer: 3.393 ± 0.066
4.284GluThr: 4.284 ± 0.063
4.826GluVal: 4.826 ± 0.084
0.674GluTrp: 0.674 ± 0.03
1.947GluTyr: 1.947 ± 0.054
0.0GluXaa: 0.0 ± 0.0
Phe
3.286PheAla: 3.286 ± 0.069
0.346PheCys: 0.346 ± 0.02
2.661PheAsp: 2.661 ± 0.052
3.005PheGlu: 3.005 ± 0.072
2.684PhePhe: 2.684 ± 0.069
3.367PheGly: 3.367 ± 0.07
0.958PheHis: 0.958 ± 0.038
4.312PheIle: 4.312 ± 0.094
2.721PheLys: 2.721 ± 0.06
5.091PheLeu: 5.091 ± 0.097
1.354PheMet: 1.354 ± 0.04
1.929PheAsn: 1.929 ± 0.049
1.592PhePro: 1.592 ± 0.043
1.715PheGln: 1.715 ± 0.049
1.612PheArg: 1.612 ± 0.047
3.486PheSer: 3.486 ± 0.077
2.671PheThr: 2.671 ± 0.058
3.405PheVal: 3.405 ± 0.063
0.508PheTrp: 0.508 ± 0.027
2.056PheTyr: 2.056 ± 0.052
0.0PheXaa: 0.0 ± 0.0
Gly
5.003GlyAla: 5.003 ± 0.098
0.46GlyCys: 0.46 ± 0.029
3.41GlyAsp: 3.41 ± 0.069
4.524GlyGlu: 4.524 ± 0.082
3.356GlyPhe: 3.356 ± 0.071
4.518GlyGly: 4.518 ± 0.107
1.265GlyHis: 1.265 ± 0.039
5.776GlyIle: 5.776 ± 0.088
4.908GlyLys: 4.908 ± 0.087
6.26GlyLeu: 6.26 ± 0.109
1.899GlyMet: 1.899 ± 0.053
2.682GlyAsn: 2.682 ± 0.067
1.508GlyPro: 1.508 ± 0.048
2.13GlyGln: 2.13 ± 0.057
2.569GlyArg: 2.569 ± 0.068
3.672GlySer: 3.672 ± 0.072
4.213GlyThr: 4.213 ± 0.111
5.051GlyVal: 5.051 ± 0.078
0.608GlyTrp: 0.608 ± 0.031
2.654GlyTyr: 2.654 ± 0.064
0.0GlyXaa: 0.0 ± 0.0
His
1.344HisAla: 1.344 ± 0.047
0.156HisCys: 0.156 ± 0.016
1.087HisAsp: 1.087 ± 0.039
1.243HisGlu: 1.243 ± 0.039
1.214HisPhe: 1.214 ± 0.041
1.191HisGly: 1.191 ± 0.044
0.535HisHis: 0.535 ± 0.029
1.395HisIle: 1.395 ± 0.05
0.933HisLys: 0.933 ± 0.037
2.066HisLeu: 2.066 ± 0.052
0.49HisMet: 0.49 ± 0.027
0.649HisAsn: 0.649 ± 0.028
0.901HisPro: 0.901 ± 0.039
0.672HisGln: 0.672 ± 0.028
0.75HisArg: 0.75 ± 0.031
1.012HisSer: 1.012 ± 0.037
0.988HisThr: 0.988 ± 0.037
1.315HisVal: 1.315 ± 0.039
0.148HisTrp: 0.148 ± 0.013
0.856HisTyr: 0.856 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
6.194IleAla: 6.194 ± 0.095
0.669IleCys: 0.669 ± 0.027
3.914IleAsp: 3.914 ± 0.079
4.932IleGlu: 4.932 ± 0.084
3.71IlePhe: 3.71 ± 0.083
5.714IleGly: 5.714 ± 0.092
1.599IleHis: 1.599 ± 0.042
5.965IleIle: 5.965 ± 0.106
4.258IleLys: 4.258 ± 0.072
8.214IleLeu: 8.214 ± 0.116
1.803IleMet: 1.803 ± 0.047
2.959IleAsn: 2.959 ± 0.067
3.336IlePro: 3.336 ± 0.066
2.936IleGln: 2.936 ± 0.059
3.312IleArg: 3.312 ± 0.069
5.32IleSer: 5.32 ± 0.073
4.514IleThr: 4.514 ± 0.09
5.313IleVal: 5.313 ± 0.084
0.689IleTrp: 0.689 ± 0.028
2.526IleTyr: 2.526 ± 0.056
0.0IleXaa: 0.0 ± 0.0
Lys
5.074LysAla: 5.074 ± 0.079
0.291LysCys: 0.291 ± 0.018
3.526LysAsp: 3.526 ± 0.08
6.702LysGlu: 6.702 ± 0.1
2.086LysPhe: 2.086 ± 0.058
4.169LysGly: 4.169 ± 0.073
1.215LysHis: 1.215 ± 0.036
5.219LysIle: 5.219 ± 0.104
6.673LysLys: 6.673 ± 0.11
5.995LysLeu: 5.995 ± 0.085
2.748LysMet: 2.748 ± 0.065
3.915LysAsn: 3.915 ± 0.072
2.201LysPro: 2.201 ± 0.048
3.128LysGln: 3.128 ± 0.062
3.511LysArg: 3.511 ± 0.067
3.668LysSer: 3.668 ± 0.075
4.352LysThr: 4.352 ± 0.09
4.629LysVal: 4.629 ± 0.094
0.817LysTrp: 0.817 ± 0.03
2.261LysTyr: 2.261 ± 0.071
0.0LysXaa: 0.0 ± 0.0
Leu
7.726LeuAla: 7.726 ± 0.111
0.628LeuCys: 0.628 ± 0.028
5.239LeuAsp: 5.239 ± 0.089
6.782LeuGlu: 6.782 ± 0.111
5.176LeuPhe: 5.176 ± 0.117
6.218LeuGly: 6.218 ± 0.109
1.853LeuHis: 1.853 ± 0.05
7.3LeuIle: 7.3 ± 0.111
6.803LeuLys: 6.803 ± 0.106
10.059LeuLeu: 10.059 ± 0.147
2.555LeuMet: 2.555 ± 0.055
4.444LeuAsn: 4.444 ± 0.081
3.885LeuPro: 3.885 ± 0.068
3.271LeuGln: 3.271 ± 0.069
3.709LeuArg: 3.709 ± 0.083
6.461LeuSer: 6.461 ± 0.092
5.961LeuThr: 5.961 ± 0.093
6.497LeuVal: 6.497 ± 0.102
0.701LeuTrp: 0.701 ± 0.028
3.077LeuTyr: 3.077 ± 0.063
0.0LeuXaa: 0.0 ± 0.0
Met
2.196MetAla: 2.196 ± 0.059
0.146MetCys: 0.146 ± 0.011
1.502MetAsp: 1.502 ± 0.043
1.961MetGlu: 1.961 ± 0.054
1.027MetPhe: 1.027 ± 0.04
1.677MetGly: 1.677 ± 0.045
0.453MetHis: 0.453 ± 0.025
2.067MetIle: 2.067 ± 0.051
2.551MetLys: 2.551 ± 0.052
2.57MetLeu: 2.57 ± 0.055
0.84MetMet: 0.84 ± 0.034
1.443MetAsn: 1.443 ± 0.044
1.089MetPro: 1.089 ± 0.036
0.941MetGln: 0.941 ± 0.034
1.224MetArg: 1.224 ± 0.041
1.641MetSer: 1.641 ± 0.049
1.779MetThr: 1.779 ± 0.044
1.684MetVal: 1.684 ± 0.053
0.186MetTrp: 0.186 ± 0.016
0.747MetTyr: 0.747 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
3.075AsnAla: 3.075 ± 0.062
0.246AsnCys: 0.246 ± 0.018
2.273AsnAsp: 2.273 ± 0.058
3.476AsnGlu: 3.476 ± 0.064
1.909AsnPhe: 1.909 ± 0.053
3.503AsnGly: 3.503 ± 0.079
1.014AsnHis: 1.014 ± 0.039
3.23AsnIle: 3.23 ± 0.067
2.967AsnLys: 2.967 ± 0.056
4.077AsnLeu: 4.077 ± 0.089
1.284AsnMet: 1.284 ± 0.039
1.879AsnAsn: 1.879 ± 0.058
2.187AsnPro: 2.187 ± 0.056
2.204AsnGln: 2.204 ± 0.061
2.001AsnArg: 2.001 ± 0.053
2.236AsnSer: 2.236 ± 0.056
2.241AsnThr: 2.241 ± 0.062
3.037AsnVal: 3.037 ± 0.06
0.499AsnTrp: 0.499 ± 0.021
1.733AsnTyr: 1.733 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
2.272ProAla: 2.272 ± 0.068
0.177ProCys: 0.177 ± 0.016
1.957ProAsp: 1.957 ± 0.051
2.881ProGlu: 2.881 ± 0.059
2.105ProPhe: 2.105 ± 0.053
1.985ProGly: 1.985 ± 0.053
0.719ProHis: 0.719 ± 0.039
2.626ProIle: 2.626 ± 0.056
2.242ProLys: 2.242 ± 0.043
3.282ProLeu: 3.282 ± 0.072
0.669ProMet: 0.669 ± 0.032
1.797ProAsn: 1.797 ± 0.051
0.736ProPro: 0.736 ± 0.032
0.961ProGln: 0.961 ± 0.041
0.962ProArg: 0.962 ± 0.035
2.08ProSer: 2.08 ± 0.06
1.884ProThr: 1.884 ± 0.053
2.746ProVal: 2.746 ± 0.067
0.258ProTrp: 0.258 ± 0.018
1.351ProTyr: 1.351 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
2.776GlnAla: 2.776 ± 0.062
0.104GlnCys: 0.104 ± 0.012
1.742GlnAsp: 1.742 ± 0.044
2.42GlnGlu: 2.42 ± 0.056
1.705GlnPhe: 1.705 ± 0.047
1.75GlnGly: 1.75 ± 0.05
0.531GlnHis: 0.531 ± 0.024
3.109GlnIle: 3.109 ± 0.049
3.237GlnLys: 3.237 ± 0.07
3.356GlnLeu: 3.356 ± 0.07
1.127GlnMet: 1.127 ± 0.038
2.234GlnAsn: 2.234 ± 0.061
0.913GlnPro: 0.913 ± 0.033
1.138GlnGln: 1.138 ± 0.046
0.951GlnArg: 0.951 ± 0.039
1.698GlnSer: 1.698 ± 0.044
2.253GlnThr: 2.253 ± 0.06
2.569GlnVal: 2.569 ± 0.061
0.2GlnTrp: 0.2 ± 0.017
1.075GlnTyr: 1.075 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
2.748ArgAla: 2.748 ± 0.062
0.175ArgCys: 0.175 ± 0.014
2.203ArgAsp: 2.203 ± 0.059
3.241ArgGlu: 3.241 ± 0.067
2.085ArgPhe: 2.085 ± 0.053
2.298ArgGly: 2.298 ± 0.059
0.788ArgHis: 0.788 ± 0.03
2.998ArgIle: 2.998 ± 0.064
3.088ArgLys: 3.088 ± 0.065
3.965ArgLeu: 3.965 ± 0.078
1.179ArgMet: 1.179 ± 0.045
1.748ArgAsn: 1.748 ± 0.048
1.198ArgPro: 1.198 ± 0.044
1.401ArgGln: 1.401 ± 0.043
1.73ArgArg: 1.73 ± 0.047
2.072ArgSer: 2.072 ± 0.054
2.071ArgThr: 2.071 ± 0.05
2.746ArgVal: 2.746 ± 0.058
0.271ArgTrp: 0.271 ± 0.019
1.542ArgTyr: 1.542 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
4.213SerAla: 4.213 ± 0.079
0.349SerCys: 0.349 ± 0.022
3.282SerAsp: 3.282 ± 0.07
4.216SerGlu: 4.216 ± 0.079
3.274SerPhe: 3.274 ± 0.059
4.836SerGly: 4.836 ± 0.097
1.11SerHis: 1.11 ± 0.041
4.393SerIle: 4.393 ± 0.075
4.05SerLys: 4.05 ± 0.078
5.822SerLeu: 5.822 ± 0.09
1.49SerMet: 1.49 ± 0.043
2.528SerAsn: 2.528 ± 0.065
1.84SerPro: 1.84 ± 0.048
1.846SerGln: 1.846 ± 0.051
2.257SerArg: 2.257 ± 0.057
3.756SerSer: 3.756 ± 0.081
2.993SerThr: 2.993 ± 0.067
4.166SerVal: 4.166 ± 0.069
0.544SerTrp: 0.544 ± 0.03
2.268SerTyr: 2.268 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
4.191ThrAla: 4.191 ± 0.088
0.311ThrCys: 0.311 ± 0.019
3.085ThrAsp: 3.085 ± 0.067
3.879ThrGlu: 3.879 ± 0.083
2.97ThrPhe: 2.97 ± 0.063
4.554ThrGly: 4.554 ± 0.094
1.107ThrHis: 1.107 ± 0.039
4.807ThrIle: 4.807 ± 0.092
4.022ThrLys: 4.022 ± 0.077
5.698ThrLeu: 5.698 ± 0.091
1.295ThrMet: 1.295 ± 0.04
2.752ThrAsn: 2.752 ± 0.068
2.303ThrPro: 2.303 ± 0.054
1.599ThrGln: 1.599 ± 0.053
1.911ThrArg: 1.911 ± 0.042
3.548ThrSer: 3.548 ± 0.074
3.357ThrThr: 3.357 ± 0.083
4.196ThrVal: 4.196 ± 0.095
0.533ThrTrp: 0.533 ± 0.025
2.196ThrTyr: 2.196 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
5.427ValAla: 5.427 ± 0.095
0.564ValCys: 0.564 ± 0.029
3.588ValAsp: 3.588 ± 0.088
4.434ValGlu: 4.434 ± 0.074
3.139ValPhe: 3.139 ± 0.068
4.521ValGly: 4.521 ± 0.081
1.209ValHis: 1.209 ± 0.038
5.401ValIle: 5.401 ± 0.092
4.549ValLys: 4.549 ± 0.079
7.013ValLeu: 7.013 ± 0.099
1.848ValMet: 1.848 ± 0.048
2.82ValAsn: 2.82 ± 0.065
2.617ValPro: 2.617 ± 0.059
2.372ValGln: 2.372 ± 0.058
2.692ValArg: 2.692 ± 0.065
4.928ValSer: 4.928 ± 0.085
4.66ValThr: 4.66 ± 0.096
5.094ValVal: 5.094 ± 0.093
0.571ValTrp: 0.571 ± 0.028
2.247ValTyr: 2.247 ± 0.06
0.0ValXaa: 0.0 ± 0.0
Trp
0.503TrpAla: 0.503 ± 0.025
0.044TrpCys: 0.044 ± 0.008
0.482TrpAsp: 0.482 ± 0.024
0.507TrpGlu: 0.507 ± 0.029
0.474TrpPhe: 0.474 ± 0.021
0.554TrpGly: 0.554 ± 0.027
0.192TrpHis: 0.192 ± 0.016
0.682TrpIle: 0.682 ± 0.03
0.569TrpLys: 0.569 ± 0.024
1.012TrpLeu: 1.012 ± 0.042
0.296TrpMet: 0.296 ± 0.017
0.47TrpAsn: 0.47 ± 0.027
0.22TrpPro: 0.22 ± 0.019
0.417TrpGln: 0.417 ± 0.023
0.381TrpArg: 0.381 ± 0.023
0.47TrpSer: 0.47 ± 0.026
0.442TrpThr: 0.442 ± 0.024
0.541TrpVal: 0.541 ± 0.026
0.114TrpTrp: 0.114 ± 0.013
0.331TrpTyr: 0.331 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.422TyrAla: 2.422 ± 0.056
0.221TyrCys: 0.221 ± 0.017
2.078TyrAsp: 2.078 ± 0.063
2.338TyrGlu: 2.338 ± 0.058
2.076TyrPhe: 2.076 ± 0.049
2.404TyrGly: 2.404 ± 0.055
0.823TyrHis: 0.823 ± 0.033
2.372TyrIle: 2.372 ± 0.048
2.091TyrLys: 2.091 ± 0.056
3.592TyrLeu: 3.592 ± 0.073
0.919TyrMet: 0.919 ± 0.035
1.487TyrAsn: 1.487 ± 0.046
1.294TyrPro: 1.294 ± 0.043
1.548TyrGln: 1.548 ± 0.047
1.573TyrArg: 1.573 ± 0.042
2.087TyrSer: 2.087 ± 0.063
2.105TyrThr: 2.105 ± 0.054
2.291TyrVal: 2.291 ± 0.053
0.307TyrTrp: 0.307 ± 0.02
1.385TyrTyr: 1.385 ± 0.04
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2943 proteins (801550 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski