Amino acid dipepetide frequency for Ruminococcus albus 8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.645AlaAla: 8.645 ± 0.137	1.193AlaCys: 1.193 ± 0.038	6.178AlaAsp: 6.178 ± 0.087	7.327AlaGlu: 7.327 ± 0.103	3.108AlaPhe: 3.108 ± 0.061	5.822AlaGly: 5.822 ± 0.091	1.238AlaHis: 1.238 ± 0.038	4.322AlaIle: 4.322 ± 0.062	4.981AlaLys: 4.981 ± 0.076	6.943AlaLeu: 6.943 ± 0.088	2.313AlaMet: 2.313 ± 0.05	2.714AlaAsn: 2.714 ± 0.054	2.231AlaPro: 2.231 ± 0.054	2.239AlaGln: 2.239 ± 0.046	2.883AlaArg: 2.883 ± 0.057	3.858AlaSer: 3.858 ± 0.073	2.857AlaThr: 2.857 ± 0.066	7.472AlaVal: 7.472 ± 0.109	0.552AlaTrp: 0.552 ± 0.024	2.712AlaTyr: 2.712 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.43CysAla: 1.43 ± 0.038	0.348CysCys: 0.348 ± 0.019	1.187CysAsp: 1.187 ± 0.034	1.191CysGlu: 1.191 ± 0.036	0.749CysPhe: 0.749 ± 0.029	1.845CysGly: 1.845 ± 0.043	0.302CysHis: 0.302 ± 0.014	1.174CysIle: 1.174 ± 0.034	0.927CysLys: 0.927 ± 0.032	1.224CysLeu: 1.224 ± 0.037	0.434CysMet: 0.434 ± 0.018	0.551CysAsn: 0.551 ± 0.023	0.618CysPro: 0.618 ± 0.025	0.312CysGln: 0.312 ± 0.016	0.86CysArg: 0.86 ± 0.029	1.083CysSer: 1.083 ± 0.036	1.016CysThr: 1.016 ± 0.035	1.141CysVal: 1.141 ± 0.034	0.144CysTrp: 0.144 ± 0.011	0.695CysTyr: 0.695 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	4.268AspAla: 4.268 ± 0.066	1.056AspCys: 1.056 ± 0.026	4.559AspAsp: 4.559 ± 0.084	5.376AspGlu: 5.376 ± 0.092	2.925AspPhe: 2.925 ± 0.047	5.452AspGly: 5.452 ± 0.089	1.013AspHis: 1.013 ± 0.031	5.367AspIle: 5.367 ± 0.076	4.924AspLys: 4.924 ± 0.062	4.453AspLeu: 4.453 ± 0.064	2.114AspMet: 2.114 ± 0.047	3.023AspAsn: 3.023 ± 0.057	2.173AspPro: 2.173 ± 0.05	0.97AspGln: 0.97 ± 0.031	2.834AspArg: 2.834 ± 0.05	3.815AspSer: 3.815 ± 0.066	3.659AspThr: 3.659 ± 0.072	3.892AspVal: 3.892 ± 0.064	0.634AspTrp: 0.634 ± 0.026	2.975AspTyr: 2.975 ± 0.057	0.0AspXaa: 0.0 ± 0.0
Glu	4.654GluAla: 4.654 ± 0.075	1.061GluCys: 1.061 ± 0.031	4.172GluAsp: 4.172 ± 0.066	5.887GluGlu: 5.887 ± 0.12	2.812GluPhe: 2.812 ± 0.053	4.129GluGly: 4.129 ± 0.073	1.343GluHis: 1.343 ± 0.042	5.221GluIle: 5.221 ± 0.064	6.309GluLys: 6.309 ± 0.093	6.972GluLeu: 6.972 ± 0.089	2.318GluMet: 2.318 ± 0.047	4.338GluAsn: 4.338 ± 0.074	1.961GluPro: 1.961 ± 0.049	2.528GluGln: 2.528 ± 0.054	3.342GluArg: 3.342 ± 0.052	3.49GluSer: 3.49 ± 0.064	3.325GluThr: 3.325 ± 0.063	4.362GluVal: 4.362 ± 0.07	0.688GluTrp: 0.688 ± 0.022	3.314GluTyr: 3.314 ± 0.059	0.0GluXaa: 0.0 ± 0.0
Phe	3.358PheAla: 3.358 ± 0.057	0.897PheCys: 0.897 ± 0.031	3.286PheAsp: 3.286 ± 0.061	3.042PheGlu: 3.042 ± 0.062	1.916PhePhe: 1.916 ± 0.048	3.323PheGly: 3.323 ± 0.054	0.636PheHis: 0.636 ± 0.026	2.897PheIle: 2.897 ± 0.055	2.359PheLys: 2.359 ± 0.046	3.181PheLeu: 3.181 ± 0.069	1.226PheMet: 1.226 ± 0.036	1.734PheAsn: 1.734 ± 0.035	1.29PhePro: 1.29 ± 0.029	0.77PheGln: 0.77 ± 0.027	1.884PheArg: 1.884 ± 0.041	3.124PheSer: 3.124 ± 0.06	2.793PheThr: 2.793 ± 0.054	2.777PheVal: 2.777 ± 0.06	0.389PheTrp: 0.389 ± 0.02	1.748PheTyr: 1.748 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	5.107GlyAla: 5.107 ± 0.094	1.436GlyCys: 1.436 ± 0.042	4.231GlyAsp: 4.231 ± 0.068	4.955GlyGlu: 4.955 ± 0.074	3.248GlyPhe: 3.248 ± 0.064	5.531GlyGly: 5.531 ± 0.096	1.176GlyHis: 1.176 ± 0.034	5.333GlyIle: 5.333 ± 0.089	5.349GlyLys: 5.349 ± 0.086	5.628GlyLeu: 5.628 ± 0.091	2.216GlyMet: 2.216 ± 0.051	2.911GlyAsn: 2.911 ± 0.06	0.818GlyPro: 0.818 ± 0.034	1.791GlyGln: 1.791 ± 0.048	3.477GlyArg: 3.477 ± 0.062	4.45GlySer: 4.45 ± 0.082	3.958GlyThr: 3.958 ± 0.073	4.968GlyVal: 4.968 ± 0.069	0.761GlyTrp: 0.761 ± 0.031	3.441GlyTyr: 3.441 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	1.018HisAla: 1.018 ± 0.032	0.314HisCys: 0.314 ± 0.016	1.083HisAsp: 1.083 ± 0.034	1.074HisGlu: 1.074 ± 0.034	0.808HisPhe: 0.808 ± 0.026	1.161HisGly: 1.161 ± 0.032	0.43HisHis: 0.43 ± 0.04	1.325HisIle: 1.325 ± 0.035	1.048HisLys: 1.048 ± 0.032	1.233HisLeu: 1.233 ± 0.034	0.414HisMet: 0.414 ± 0.016	0.725HisAsn: 0.725 ± 0.025	0.699HisPro: 0.699 ± 0.026	0.399HisGln: 0.399 ± 0.018	0.836HisArg: 0.836 ± 0.029	1.122HisSer: 1.122 ± 0.034	0.958HisThr: 0.958 ± 0.035	0.923HisVal: 0.923 ± 0.03	0.17HisTrp: 0.17 ± 0.012	0.748HisTyr: 0.748 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.503IleAla: 5.503 ± 0.077	1.412IleCys: 1.412 ± 0.037	4.695IleAsp: 4.695 ± 0.071	4.646IleGlu: 4.646 ± 0.064	3.009IlePhe: 3.009 ± 0.053	4.572IleGly: 4.572 ± 0.082	1.078IleHis: 1.078 ± 0.036	4.88IleIle: 4.88 ± 0.078	4.486IleLys: 4.486 ± 0.063	5.062IleLeu: 5.062 ± 0.083	1.943IleMet: 1.943 ± 0.051	3.222IleAsn: 3.222 ± 0.051	2.825IlePro: 2.825 ± 0.052	1.53IleGln: 1.53 ± 0.041	3.079IleArg: 3.079 ± 0.057	5.335IleSer: 5.335 ± 0.074	4.317IleThr: 4.317 ± 0.062	4.425IleVal: 4.425 ± 0.063	0.543IleTrp: 0.543 ± 0.024	2.732IleTyr: 2.732 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	5.657LysAla: 5.657 ± 0.075	0.908LysCys: 0.908 ± 0.031	3.885LysAsp: 3.885 ± 0.065	4.846LysGlu: 4.846 ± 0.079	2.353LysPhe: 2.353 ± 0.051	4.355LysGly: 4.355 ± 0.061	1.189LysHis: 1.189 ± 0.033	4.443LysIle: 4.443 ± 0.067	5.554LysLys: 5.554 ± 0.091	6.176LysLeu: 6.176 ± 0.073	2.089LysMet: 2.089 ± 0.047	3.792LysAsn: 3.792 ± 0.062	2.266LysPro: 2.266 ± 0.059	2.117LysGln: 2.117 ± 0.043	3.187LysArg: 3.187 ± 0.061	3.761LysSer: 3.761 ± 0.059	3.992LysThr: 3.992 ± 0.069	4.232LysVal: 4.232 ± 0.072	0.667LysTrp: 0.667 ± 0.027	3.012LysTyr: 3.012 ± 0.058	0.0LysXaa: 0.0 ± 0.0
Leu	6.501LeuAla: 6.501 ± 0.09	1.689LeuCys: 1.689 ± 0.04	5.21LeuAsp: 5.21 ± 0.067	5.133LeuGlu: 5.133 ± 0.084	3.579LeuPhe: 3.579 ± 0.068	5.377LeuGly: 5.377 ± 0.077	1.353LeuHis: 1.353 ± 0.034	5.419LeuIle: 5.419 ± 0.079	5.779LeuLys: 5.779 ± 0.069	6.944LeuLeu: 6.944 ± 0.105	2.511LeuMet: 2.511 ± 0.043	3.507LeuAsn: 3.507 ± 0.057	3.306LeuPro: 3.306 ± 0.06	1.831LeuGln: 1.831 ± 0.045	3.825LeuArg: 3.825 ± 0.058	6.037LeuSer: 6.037 ± 0.076	5.664LeuThr: 5.664 ± 0.076	4.911LeuVal: 4.911 ± 0.076	0.705LeuTrp: 0.705 ± 0.025	3.187LeuTyr: 3.187 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.354MetAla: 2.354 ± 0.048	0.44MetCys: 0.44 ± 0.022	1.467MetAsp: 1.467 ± 0.036	1.704MetGlu: 1.704 ± 0.048	1.2MetPhe: 1.2 ± 0.035	2.036MetGly: 2.036 ± 0.043	0.403MetHis: 0.403 ± 0.018	2.029MetIle: 2.029 ± 0.045	2.22MetLys: 2.22 ± 0.039	2.907MetLeu: 2.907 ± 0.062	0.915MetMet: 0.915 ± 0.029	1.516MetAsn: 1.516 ± 0.038	1.224MetPro: 1.224 ± 0.038	0.927MetGln: 0.927 ± 0.027	1.36MetArg: 1.36 ± 0.033	1.877MetSer: 1.877 ± 0.037	2.025MetThr: 2.025 ± 0.046	1.652MetVal: 1.652 ± 0.041	0.224MetTrp: 0.224 ± 0.013	0.957MetTyr: 0.957 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.647AsnAla: 3.647 ± 0.066	0.832AsnCys: 0.832 ± 0.028	3.003AsnAsp: 3.003 ± 0.058	3.047AsnGlu: 3.047 ± 0.061	1.789AsnPhe: 1.789 ± 0.044	4.202AsnGly: 4.202 ± 0.082	0.6AsnHis: 0.6 ± 0.025	3.641AsnIle: 3.641 ± 0.063	2.747AsnLys: 2.747 ± 0.052	2.746AsnLeu: 2.746 ± 0.055	1.266AsnMet: 1.266 ± 0.038	2.253AsnAsn: 2.253 ± 0.061	1.428AsnPro: 1.428 ± 0.034	0.879AsnGln: 0.879 ± 0.032	1.747AsnArg: 1.747 ± 0.043	3.109AsnSer: 3.109 ± 0.053	2.637AsnThr: 2.637 ± 0.051	3.091AsnVal: 3.091 ± 0.06	0.418AsnTrp: 0.418 ± 0.02	1.992AsnTyr: 1.992 ± 0.053	0.0AsnXaa: 0.0 ± 0.0
Pro	2.911ProAla: 2.911 ± 0.053	0.45ProCys: 0.45 ± 0.019	2.824ProAsp: 2.824 ± 0.054	3.137ProGlu: 3.137 ± 0.055	1.493ProPhe: 1.493 ± 0.038	1.212ProGly: 1.212 ± 0.035	0.572ProHis: 0.572 ± 0.023	1.94ProIle: 1.94 ± 0.039	2.043ProLys: 2.043 ± 0.043	2.547ProLeu: 2.547 ± 0.054	0.927ProMet: 0.927 ± 0.027	1.359ProAsn: 1.359 ± 0.032	0.902ProPro: 0.902 ± 0.038	1.085ProGln: 1.085 ± 0.042	1.053ProArg: 1.053 ± 0.033	1.765ProSer: 1.765 ± 0.04	1.749ProThr: 1.749 ± 0.039	2.722ProVal: 2.722 ± 0.047	0.219ProTrp: 0.219 ± 0.016	1.372ProTyr: 1.372 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.057GlnAla: 2.057 ± 0.041	0.322GlnCys: 0.322 ± 0.018	1.143GlnAsp: 1.143 ± 0.032	1.53GlnGlu: 1.53 ± 0.042	1.05GlnPhe: 1.05 ± 0.031	1.563GlnGly: 1.563 ± 0.043	0.443GlnHis: 0.443 ± 0.02	1.869GlnIle: 1.869 ± 0.046	1.921GlnLys: 1.921 ± 0.044	2.448GlnLeu: 2.448 ± 0.045	0.849GlnMet: 0.849 ± 0.028	1.352GlnAsn: 1.352 ± 0.042	0.977GlnPro: 0.977 ± 0.038	1.029GlnGln: 1.029 ± 0.039	1.335GlnArg: 1.335 ± 0.034	1.523GlnSer: 1.523 ± 0.037	1.502GlnThr: 1.502 ± 0.04	1.483GlnVal: 1.483 ± 0.037	0.271GlnTrp: 0.271 ± 0.017	1.139GlnTyr: 1.139 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	3.068ArgAla: 3.068 ± 0.057	0.733ArgCys: 0.733 ± 0.028	2.443ArgAsp: 2.443 ± 0.051	3.347ArgGlu: 3.347 ± 0.065	1.986ArgPhe: 1.986 ± 0.051	2.453ArgGly: 2.453 ± 0.053	0.797ArgHis: 0.797 ± 0.032	3.272ArgIle: 3.272 ± 0.061	3.193ArgLys: 3.193 ± 0.058	4.16ArgLeu: 4.16 ± 0.068	1.295ArgMet: 1.295 ± 0.035	1.979ArgAsn: 1.979 ± 0.042	1.352ArgPro: 1.352 ± 0.041	1.451ArgGln: 1.451 ± 0.036	2.513ArgArg: 2.513 ± 0.058	2.605ArgSer: 2.605 ± 0.052	2.365ArgThr: 2.365 ± 0.049	2.765ArgVal: 2.765 ± 0.052	0.417ArgTrp: 0.417 ± 0.019	2.04ArgTyr: 2.04 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	5.801SerAla: 5.801 ± 0.085	1.013SerCys: 1.013 ± 0.032	4.233SerAsp: 4.233 ± 0.075	4.526SerGlu: 4.526 ± 0.066	2.798SerPhe: 2.798 ± 0.056	5.54SerGly: 5.54 ± 0.088	1.006SerHis: 1.006 ± 0.032	3.781SerIle: 3.781 ± 0.066	3.839SerLys: 3.839 ± 0.067	4.987SerLeu: 4.987 ± 0.067	1.683SerMet: 1.683 ± 0.038	2.286SerAsn: 2.286 ± 0.053	1.973SerPro: 1.973 ± 0.044	1.634SerGln: 1.634 ± 0.037	2.648SerArg: 2.648 ± 0.051	4.186SerSer: 4.186 ± 0.093	3.062SerThr: 3.062 ± 0.053	4.527SerVal: 4.527 ± 0.072	0.583SerTrp: 0.583 ± 0.027	2.566SerTyr: 2.566 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	5.852ThrAla: 5.852 ± 0.083	0.69ThrCys: 0.69 ± 0.03	4.285ThrAsp: 4.285 ± 0.072	4.222ThrGlu: 4.222 ± 0.076	2.292ThrPhe: 2.292 ± 0.057	4.312ThrGly: 4.312 ± 0.07	0.87ThrHis: 0.87 ± 0.032	3.655ThrIle: 3.655 ± 0.072	3.059ThrLys: 3.059 ± 0.052	4.711ThrLeu: 4.711 ± 0.076	1.396ThrMet: 1.396 ± 0.036	2.115ThrAsn: 2.115 ± 0.06	2.237ThrPro: 2.237 ± 0.049	1.304ThrGln: 1.304 ± 0.036	1.843ThrArg: 1.843 ± 0.039	3.183ThrSer: 3.183 ± 0.073	3.094ThrThr: 3.094 ± 0.084	5.191ThrVal: 5.191 ± 0.072	0.458ThrTrp: 0.458 ± 0.026	2.112ThrTyr: 2.112 ± 0.059	0.0ThrXaa: 0.0 ± 0.0
Val	4.245ValAla: 4.245 ± 0.071	1.463ValCys: 1.463 ± 0.039	3.804ValAsp: 3.804 ± 0.065	3.968ValGlu: 3.968 ± 0.058	3.17ValPhe: 3.17 ± 0.062	4.196ValGly: 4.196 ± 0.071	1.076ValHis: 1.076 ± 0.034	5.332ValIle: 5.332 ± 0.077	4.625ValLys: 4.625 ± 0.067	5.925ValLeu: 5.925 ± 0.072	2.276ValMet: 2.276 ± 0.05	3.095ValAsn: 3.095 ± 0.057	2.46ValPro: 2.46 ± 0.048	1.634ValGln: 1.634 ± 0.042	3.183ValArg: 3.183 ± 0.062	4.875ValSer: 4.875 ± 0.071	4.915ValThr: 4.915 ± 0.089	4.276ValVal: 4.276 ± 0.086	0.614ValTrp: 0.614 ± 0.023	2.84ValTyr: 2.84 ± 0.057	0.0ValXaa: 0.0 ± 0.0
Trp	0.608TrpAla: 0.608 ± 0.026	0.209TrpCys: 0.209 ± 0.013	0.623TrpAsp: 0.623 ± 0.025	0.542TrpGlu: 0.542 ± 0.024	0.43TrpPhe: 0.43 ± 0.019	0.698TrpGly: 0.698 ± 0.027	0.211TrpHis: 0.211 ± 0.014	0.47TrpIle: 0.47 ± 0.023	0.542TrpLys: 0.542 ± 0.022	0.899TrpLeu: 0.899 ± 0.03	0.166TrpMet: 0.166 ± 0.011	0.539TrpAsn: 0.539 ± 0.026	0.102TrpPro: 0.102 ± 0.008	0.377TrpGln: 0.377 ± 0.019	0.41TrpArg: 0.41 ± 0.019	0.547TrpSer: 0.547 ± 0.023	0.448TrpThr: 0.448 ± 0.022	0.538TrpVal: 0.538 ± 0.021	0.103TrpTrp: 0.103 ± 0.01	0.472TrpTyr: 0.472 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.904TyrAla: 2.904 ± 0.051	0.765TyrCys: 0.765 ± 0.028	3.172TyrAsp: 3.172 ± 0.056	2.724TyrGlu: 2.724 ± 0.055	1.92TyrPhe: 1.92 ± 0.043	3.006TyrGly: 3.006 ± 0.058	0.752TyrHis: 0.752 ± 0.027	2.922TyrIle: 2.922 ± 0.055	2.58TyrLys: 2.58 ± 0.052	3.323TyrLeu: 3.323 ± 0.066	1.083TyrMet: 1.083 ± 0.031	2.062TyrAsn: 2.062 ± 0.046	1.441TyrPro: 1.441 ± 0.037	0.997TyrGln: 0.997 ± 0.033	1.934TyrArg: 1.934 ± 0.046	2.927TyrSer: 2.927 ± 0.065	2.544TyrThr: 2.544 ± 0.064	2.622TyrVal: 2.622 ± 0.048	0.375TyrTrp: 0.375 ± 0.017	1.979TyrTyr: 1.979 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3826 proteins (1141692 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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