Amino acid dipepetide frequency for Verruconis gallopava

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.176AlaAla: 9.176 ± 0.063	1.064AlaCys: 1.064 ± 0.016	4.275AlaAsp: 4.275 ± 0.031	5.45AlaGlu: 5.45 ± 0.041	3.15AlaPhe: 3.15 ± 0.027	5.633AlaGly: 5.633 ± 0.038	1.829AlaHis: 1.829 ± 0.02	4.35AlaIle: 4.35 ± 0.032	4.517AlaLys: 4.517 ± 0.035	7.737AlaLeu: 7.737 ± 0.051	2.032AlaMet: 2.032 ± 0.019	3.106AlaAsn: 3.106 ± 0.022	4.639AlaPro: 4.639 ± 0.036	3.601AlaGln: 3.601 ± 0.03	5.165AlaArg: 5.165 ± 0.036	7.618AlaSer: 7.618 ± 0.045	5.244AlaThr: 5.244 ± 0.034	5.39AlaVal: 5.39 ± 0.033	1.131AlaTrp: 1.131 ± 0.016	2.207AlaTyr: 2.207 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	0.966CysAla: 0.966 ± 0.013	0.253CysCys: 0.253 ± 0.007	0.651CysAsp: 0.651 ± 0.013	0.623CysGlu: 0.623 ± 0.011	0.54CysPhe: 0.54 ± 0.01	0.923CysGly: 0.923 ± 0.014	0.324CysHis: 0.324 ± 0.009	0.723CysIle: 0.723 ± 0.012	0.569CysLys: 0.569 ± 0.012	1.217CysLeu: 1.217 ± 0.016	0.283CysMet: 0.283 ± 0.007	0.432CysAsn: 0.432 ± 0.011	0.632CysPro: 0.632 ± 0.012	0.434CysGln: 0.434 ± 0.008	0.757CysArg: 0.757 ± 0.012	0.928CysSer: 0.928 ± 0.016	0.663CysThr: 0.663 ± 0.013	0.812CysVal: 0.812 ± 0.014	0.202CysTrp: 0.202 ± 0.006	0.371CysTyr: 0.371 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.891AspAla: 4.891 ± 0.031	0.605AspCys: 0.605 ± 0.011	4.238AspAsp: 4.238 ± 0.042	4.814AspGlu: 4.814 ± 0.038	2.22AspPhe: 2.22 ± 0.019	3.982AspGly: 3.982 ± 0.033	1.195AspHis: 1.195 ± 0.014	2.975AspIle: 2.975 ± 0.029	2.398AspLys: 2.398 ± 0.025	4.905AspLeu: 4.905 ± 0.029	1.278AspMet: 1.278 ± 0.018	1.744AspAsn: 1.744 ± 0.018	3.152AspPro: 3.152 ± 0.027	1.795AspGln: 1.795 ± 0.018	3.024AspArg: 3.024 ± 0.028	3.934AspSer: 3.934 ± 0.031	2.768AspThr: 2.768 ± 0.024	3.839AspVal: 3.839 ± 0.025	0.886AspTrp: 0.886 ± 0.012	1.559AspTyr: 1.559 ± 0.016	0.0AspXaa: 0.0 ± 0.0
Glu	5.49GluAla: 5.49 ± 0.038	0.628GluCys: 0.628 ± 0.01	4.298GluAsp: 4.298 ± 0.036	5.58GluGlu: 5.58 ± 0.06	1.955GluPhe: 1.955 ± 0.021	3.68GluGly: 3.68 ± 0.027	1.509GluHis: 1.509 ± 0.019	3.174GluIle: 3.174 ± 0.025	4.021GluLys: 4.021 ± 0.036	5.529GluLeu: 5.529 ± 0.041	1.523GluMet: 1.523 ± 0.018	2.429GluAsn: 2.429 ± 0.022	2.763GluPro: 2.763 ± 0.03	2.712GluGln: 2.712 ± 0.025	4.406GluArg: 4.406 ± 0.036	4.264GluSer: 4.264 ± 0.032	3.346GluThr: 3.346 ± 0.025	3.483GluVal: 3.483 ± 0.025	0.863GluTrp: 0.863 ± 0.013	1.713GluTyr: 1.713 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.155PheAla: 3.155 ± 0.024	0.576PheCys: 0.576 ± 0.011	2.303PheAsp: 2.303 ± 0.022	2.274PheGlu: 2.274 ± 0.023	1.604PhePhe: 1.604 ± 0.021	2.903PheGly: 2.903 ± 0.027	0.876PheHis: 0.876 ± 0.013	1.766PheIle: 1.766 ± 0.021	1.653PheLys: 1.653 ± 0.017	3.33PheLeu: 3.33 ± 0.028	0.801PheMet: 0.801 ± 0.014	1.417PheAsn: 1.417 ± 0.016	1.866PhePro: 1.866 ± 0.022	1.322PheGln: 1.322 ± 0.017	1.941PheArg: 1.941 ± 0.021	2.978PheSer: 2.978 ± 0.028	2.082PheThr: 2.082 ± 0.019	2.409PheVal: 2.409 ± 0.022	0.638PheTrp: 0.638 ± 0.013	1.089PheTyr: 1.089 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	5.18GlyAla: 5.18 ± 0.039	0.824GlyCys: 0.824 ± 0.013	3.416GlyAsp: 3.416 ± 0.027	3.609GlyGlu: 3.609 ± 0.03	2.759GlyPhe: 2.759 ± 0.026	5.376GlyGly: 5.376 ± 0.052	1.585GlyHis: 1.585 ± 0.018	3.459GlyIle: 3.459 ± 0.029	3.546GlyLys: 3.546 ± 0.029	5.79GlyLeu: 5.79 ± 0.042	1.625GlyMet: 1.625 ± 0.02	2.449GlyAsn: 2.449 ± 0.023	3.091GlyPro: 3.091 ± 0.031	2.514GlyGln: 2.514 ± 0.027	4.049GlyArg: 4.049 ± 0.032	5.645GlySer: 5.645 ± 0.043	3.844GlyThr: 3.844 ± 0.028	4.228GlyVal: 4.228 ± 0.033	1.135GlyTrp: 1.135 ± 0.017	2.093GlyTyr: 2.093 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.918HisAla: 1.918 ± 0.02	0.328HisCys: 0.328 ± 0.008	1.325HisAsp: 1.325 ± 0.014	1.436HisGlu: 1.436 ± 0.018	0.928HisPhe: 0.928 ± 0.014	1.683HisGly: 1.683 ± 0.018	0.797HisHis: 0.797 ± 0.016	1.223HisIle: 1.223 ± 0.016	0.981HisLys: 0.981 ± 0.015	2.146HisLeu: 2.146 ± 0.021	0.498HisMet: 0.498 ± 0.009	0.833HisAsn: 0.833 ± 0.014	1.551HisPro: 1.551 ± 0.018	0.915HisGln: 0.915 ± 0.015	1.5HisArg: 1.5 ± 0.018	1.845HisSer: 1.845 ± 0.022	1.191HisThr: 1.191 ± 0.015	1.545HisVal: 1.545 ± 0.016	0.342HisTrp: 0.342 ± 0.008	0.688HisTyr: 0.688 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.376IleAla: 4.376 ± 0.037	0.763IleCys: 0.763 ± 0.012	2.901IleAsp: 2.901 ± 0.025	3.072IleGlu: 3.072 ± 0.026	1.99IlePhe: 1.99 ± 0.025	3.182IleGly: 3.182 ± 0.031	1.126IleHis: 1.126 ± 0.014	2.498IleIle: 2.498 ± 0.026	2.398IleLys: 2.398 ± 0.026	4.466IleLeu: 4.466 ± 0.029	1.04IleMet: 1.04 ± 0.013	1.803IleAsn: 1.803 ± 0.021	2.891IlePro: 2.891 ± 0.025	1.883IleGln: 1.883 ± 0.017	2.865IleArg: 2.865 ± 0.025	3.889IleSer: 3.889 ± 0.03	2.788IleThr: 2.788 ± 0.026	3.207IleVal: 3.207 ± 0.029	0.73IleTrp: 0.73 ± 0.013	1.394IleTyr: 1.394 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.581LysAla: 4.581 ± 0.039	0.535LysCys: 0.535 ± 0.012	3.012LysAsp: 3.012 ± 0.03	3.735LysGlu: 3.735 ± 0.035	1.556LysPhe: 1.556 ± 0.018	3.017LysGly: 3.017 ± 0.025	1.271LysHis: 1.271 ± 0.016	2.506LysIle: 2.506 ± 0.023	3.67LysLys: 3.67 ± 0.052	4.373LysLeu: 4.373 ± 0.033	1.125LysMet: 1.125 ± 0.015	1.9LysAsn: 1.9 ± 0.02	2.789LysPro: 2.789 ± 0.027	2.06LysGln: 2.06 ± 0.022	3.822LysArg: 3.822 ± 0.033	3.759LysSer: 3.759 ± 0.027	2.903LysThr: 2.903 ± 0.025	2.922LysVal: 2.922 ± 0.024	0.715LysTrp: 0.715 ± 0.012	1.46LysTyr: 1.46 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	7.748LeuAla: 7.748 ± 0.047	1.23LeuCys: 1.23 ± 0.019	5.092LeuAsp: 5.092 ± 0.034	5.5LeuGlu: 5.5 ± 0.043	3.264LeuPhe: 3.264 ± 0.032	5.676LeuGly: 5.676 ± 0.039	2.207LeuHis: 2.207 ± 0.022	3.923LeuIle: 3.923 ± 0.031	4.549LeuLys: 4.549 ± 0.033	8.136LeuLeu: 8.136 ± 0.056	1.803LeuMet: 1.803 ± 0.018	3.236LeuAsn: 3.236 ± 0.026	5.4LeuPro: 5.4 ± 0.034	3.848LeuGln: 3.848 ± 0.033	5.927LeuArg: 5.927 ± 0.036	7.197LeuSer: 7.197 ± 0.043	4.615LeuThr: 4.615 ± 0.031	5.258LeuVal: 5.258 ± 0.033	1.187LeuTrp: 1.187 ± 0.015	2.322LeuTyr: 2.322 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.225MetAla: 2.225 ± 0.021	0.265MetCys: 0.265 ± 0.008	1.257MetAsp: 1.257 ± 0.015	1.257MetGlu: 1.257 ± 0.017	0.787MetPhe: 0.787 ± 0.012	1.395MetGly: 1.395 ± 0.019	0.527MetHis: 0.527 ± 0.011	1.024MetIle: 1.024 ± 0.013	1.095MetLys: 1.095 ± 0.015	1.959MetLeu: 1.959 ± 0.021	0.593MetMet: 0.593 ± 0.012	0.886MetAsn: 0.886 ± 0.015	1.338MetPro: 1.338 ± 0.016	0.926MetGln: 0.926 ± 0.015	1.357MetArg: 1.357 ± 0.016	1.969MetSer: 1.969 ± 0.02	1.329MetThr: 1.329 ± 0.016	1.239MetVal: 1.239 ± 0.015	0.269MetTrp: 0.269 ± 0.008	0.598MetTyr: 0.598 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.358AsnAla: 3.358 ± 0.026	0.465AsnCys: 0.465 ± 0.01	1.961AsnAsp: 1.961 ± 0.018	2.21AsnGlu: 2.21 ± 0.022	1.431AsnPhe: 1.431 ± 0.017	3.003AsnGly: 3.003 ± 0.028	0.85AsnHis: 0.85 ± 0.013	2.017AsnIle: 2.017 ± 0.021	1.676AsnLys: 1.676 ± 0.019	3.282AsnLeu: 3.282 ± 0.029	0.873AsnMet: 0.873 ± 0.012	1.449AsnAsn: 1.449 ± 0.018	2.302AsnPro: 2.302 ± 0.024	1.318AsnGln: 1.318 ± 0.017	1.919AsnArg: 1.919 ± 0.021	2.853AsnSer: 2.853 ± 0.027	2.145AsnThr: 2.145 ± 0.022	2.449AsnVal: 2.449 ± 0.022	0.55AsnTrp: 0.55 ± 0.011	1.052AsnTyr: 1.052 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	5.077ProAla: 5.077 ± 0.044	0.493ProCys: 0.493 ± 0.009	3.013ProAsp: 3.013 ± 0.027	3.645ProGlu: 3.645 ± 0.031	2.02ProPhe: 2.02 ± 0.021	3.614ProGly: 3.614 ± 0.031	1.312ProHis: 1.312 ± 0.017	2.51ProIle: 2.51 ± 0.026	2.814ProLys: 2.814 ± 0.025	4.624ProLeu: 4.624 ± 0.035	1.094ProMet: 1.094 ± 0.016	2.269ProAsn: 2.269 ± 0.021	5.085ProPro: 5.085 ± 0.061	2.431ProGln: 2.431 ± 0.028	3.382ProArg: 3.382 ± 0.03	5.851ProSer: 5.851 ± 0.049	3.769ProThr: 3.769 ± 0.03	3.425ProVal: 3.425 ± 0.026	0.702ProTrp: 0.702 ± 0.011	1.532ProTyr: 1.532 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.557GlnAla: 3.557 ± 0.03	0.456GlnCys: 0.456 ± 0.01	2.076GlnAsp: 2.076 ± 0.019	2.385GlnGlu: 2.385 ± 0.026	1.289GlnPhe: 1.289 ± 0.017	2.232GlnGly: 2.232 ± 0.022	1.126GlnHis: 1.126 ± 0.014	1.998GlnIle: 1.998 ± 0.022	2.109GlnLys: 2.109 ± 0.021	3.552GlnLeu: 3.552 ± 0.03	0.913GlnMet: 0.913 ± 0.014	1.633GlnAsn: 1.633 ± 0.022	2.423GlnPro: 2.423 ± 0.028	2.329GlnGln: 2.329 ± 0.035	2.844GlnArg: 2.844 ± 0.029	3.161GlnSer: 3.161 ± 0.03	2.306GlnThr: 2.306 ± 0.023	2.139GlnVal: 2.139 ± 0.022	0.565GlnTrp: 0.565 ± 0.011	1.163GlnTyr: 1.163 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.949ArgAla: 4.949 ± 0.03	0.73ArgCys: 0.73 ± 0.013	3.391ArgAsp: 3.391 ± 0.033	4.07ArgGlu: 4.07 ± 0.039	2.117ArgPhe: 2.117 ± 0.022	3.619ArgGly: 3.619 ± 0.032	1.549ArgHis: 1.549 ± 0.018	3.026ArgIle: 3.026 ± 0.022	3.884ArgLys: 3.884 ± 0.032	5.585ArgLeu: 5.585 ± 0.033	1.415ArgMet: 1.415 ± 0.019	2.408ArgAsn: 2.408 ± 0.024	3.577ArgPro: 3.577 ± 0.033	2.727ArgGln: 2.727 ± 0.026	5.487ArgArg: 5.487 ± 0.048	5.051ArgSer: 5.051 ± 0.041	3.444ArgThr: 3.444 ± 0.026	3.28ArgVal: 3.28 ± 0.028	0.935ArgTrp: 0.935 ± 0.014	1.696ArgTyr: 1.696 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	6.946SerAla: 6.946 ± 0.043	0.899SerCys: 0.899 ± 0.014	4.108SerAsp: 4.108 ± 0.029	4.322SerGlu: 4.322 ± 0.032	3.022SerPhe: 3.022 ± 0.027	5.564SerGly: 5.564 ± 0.036	1.909SerHis: 1.909 ± 0.021	3.99SerIle: 3.99 ± 0.028	4.077SerLys: 4.077 ± 0.034	6.997SerLeu: 6.997 ± 0.041	1.835SerMet: 1.835 ± 0.019	3.132SerAsn: 3.132 ± 0.029	5.454SerPro: 5.454 ± 0.057	3.254SerGln: 3.254 ± 0.03	5.241SerArg: 5.241 ± 0.041	9.217SerSer: 9.217 ± 0.075	5.607SerThr: 5.607 ± 0.041	4.609SerVal: 4.609 ± 0.031	1.127SerTrp: 1.127 ± 0.016	2.037SerTyr: 2.037 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.146ThrAla: 5.146 ± 0.033	0.751ThrCys: 0.751 ± 0.013	2.643ThrAsp: 2.643 ± 0.025	3.005ThrGlu: 3.005 ± 0.024	2.232ThrPhe: 2.232 ± 0.022	3.916ThrGly: 3.916 ± 0.033	1.184ThrHis: 1.184 ± 0.015	2.995ThrIle: 2.995 ± 0.024	2.734ThrLys: 2.734 ± 0.023	4.993ThrLeu: 4.993 ± 0.032	1.246ThrMet: 1.246 ± 0.017	2.09ThrAsn: 2.09 ± 0.018	4.125ThrPro: 4.125 ± 0.037	2.075ThrGln: 2.075 ± 0.02	3.135ThrArg: 3.135 ± 0.027	5.496ThrSer: 5.496 ± 0.04	3.976ThrThr: 3.976 ± 0.033	3.59ThrVal: 3.59 ± 0.028	0.829ThrTrp: 0.829 ± 0.012	1.579ThrTyr: 1.579 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	5.231ValAla: 5.231 ± 0.033	0.821ValCys: 0.821 ± 0.012	3.74ValAsp: 3.74 ± 0.027	3.92ValGlu: 3.92 ± 0.031	2.375ValPhe: 2.375 ± 0.021	3.88ValGly: 3.88 ± 0.035	1.444ValHis: 1.444 ± 0.017	2.928ValIle: 2.928 ± 0.025	3.013ValLys: 3.013 ± 0.024	5.536ValLeu: 5.536 ± 0.038	1.311ValMet: 1.311 ± 0.016	2.234ValAsn: 2.234 ± 0.024	3.531ValPro: 3.531 ± 0.027	2.453ValGln: 2.453 ± 0.026	3.537ValArg: 3.537 ± 0.026	4.526ValSer: 4.526 ± 0.028	3.298ValThr: 3.298 ± 0.027	4.169ValVal: 4.169 ± 0.031	0.846ValTrp: 0.846 ± 0.015	1.688ValTyr: 1.688 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.102TrpAla: 1.102 ± 0.014	0.197TrpCys: 0.197 ± 0.006	0.839TrpAsp: 0.839 ± 0.014	0.799TrpGlu: 0.799 ± 0.013	0.548TrpPhe: 0.548 ± 0.011	0.849TrpGly: 0.849 ± 0.014	0.355TrpHis: 0.355 ± 0.008	0.817TrpIle: 0.817 ± 0.015	0.828TrpLys: 0.828 ± 0.014	1.367TrpLeu: 1.367 ± 0.019	0.372TrpMet: 0.372 ± 0.009	0.609TrpAsn: 0.609 ± 0.011	0.623TrpPro: 0.623 ± 0.011	0.582TrpGln: 0.582 ± 0.01	0.981TrpArg: 0.981 ± 0.014	1.093TrpSer: 1.093 ± 0.016	0.902TrpThr: 0.902 ± 0.012	0.799TrpVal: 0.799 ± 0.013	0.289TrpTrp: 0.289 ± 0.008	0.428TrpTyr: 0.428 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.241TyrAla: 2.241 ± 0.023	0.421TyrCys: 0.421 ± 0.009	1.664TyrAsp: 1.664 ± 0.018	1.664TyrGlu: 1.664 ± 0.017	1.198TyrPhe: 1.198 ± 0.016	2.087TyrGly: 2.087 ± 0.023	0.697TyrHis: 0.697 ± 0.013	1.36TyrIle: 1.36 ± 0.017	1.182TyrLys: 1.182 ± 0.014	2.591TyrLeu: 2.591 ± 0.024	0.633TyrMet: 0.633 ± 0.012	1.103TyrAsn: 1.103 ± 0.017	1.432TyrPro: 1.432 ± 0.017	1.076TyrGln: 1.076 ± 0.015	1.601TyrArg: 1.601 ± 0.018	2.074TyrSer: 2.074 ± 0.023	1.521TyrThr: 1.521 ± 0.017	1.688TyrVal: 1.688 ± 0.021	0.438TyrTrp: 0.438 ± 0.01	0.932TyrTyr: 0.932 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10768 proteins (5262068 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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