Amino acid dipepetide frequency for Brucella phage Wb

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.442AlaAla: 9.442 ± 1.075
0.745AlaCys: 0.745 ± 0.259
5.88AlaAsp: 5.88 ± 0.68
5.383AlaGlu: 5.383 ± 0.918
3.23AlaPhe: 3.23 ± 0.528
6.791AlaGly: 6.791 ± 1.042
1.491AlaHis: 1.491 ± 0.288
5.301AlaIle: 5.301 ± 0.763
5.052AlaLys: 5.052 ± 0.712
9.359AlaLeu: 9.359 ± 0.922
2.153AlaMet: 2.153 ± 0.333
3.975AlaAsn: 3.975 ± 0.555
3.561AlaPro: 3.561 ± 0.765
5.715AlaGln: 5.715 ± 0.984
5.301AlaArg: 5.301 ± 0.66
7.123AlaSer: 7.123 ± 0.819
4.804AlaThr: 4.804 ± 0.742
5.549AlaVal: 5.549 ± 0.708
1.739AlaTrp: 1.739 ± 0.334
1.988AlaTyr: 1.988 ± 0.378
0.0AlaXaa: 0.0 ± 0.0
Cys
0.58CysAla: 0.58 ± 0.236
0.083CysCys: 0.083 ± 0.076
0.663CysAsp: 0.663 ± 0.245
1.077CysGlu: 1.077 ± 0.271
0.331CysPhe: 0.331 ± 0.147
1.16CysGly: 1.16 ± 0.354
0.083CysHis: 0.083 ± 0.076
0.828CysIle: 0.828 ± 0.229
0.331CysLys: 0.331 ± 0.188
0.745CysLeu: 0.745 ± 0.271
0.497CysMet: 0.497 ± 0.189
0.331CysAsn: 0.331 ± 0.142
1.077CysPro: 1.077 ± 0.315
0.414CysGln: 0.414 ± 0.218
1.077CysArg: 1.077 ± 0.242
0.58CysSer: 0.58 ± 0.266
0.331CysThr: 0.331 ± 0.162
0.911CysVal: 0.911 ± 0.23
0.0CysTrp: 0.0 ± 0.0
0.331CysTyr: 0.331 ± 0.143
0.0CysXaa: 0.0 ± 0.0
Asp
5.135AspAla: 5.135 ± 0.604
0.828AspCys: 0.828 ± 0.242
3.81AspAsp: 3.81 ± 0.507
4.224AspGlu: 4.224 ± 0.736
2.485AspPhe: 2.485 ± 0.36
4.804AspGly: 4.804 ± 0.582
1.739AspHis: 1.739 ± 0.415
4.887AspIle: 4.887 ± 0.589
2.568AspLys: 2.568 ± 0.487
4.39AspLeu: 4.39 ± 0.558
1.822AspMet: 1.822 ± 0.313
2.319AspAsn: 2.319 ± 0.385
2.816AspPro: 2.816 ± 0.434
2.319AspGln: 2.319 ± 0.421
3.396AspArg: 3.396 ± 0.559
2.65AspSer: 2.65 ± 0.534
2.402AspThr: 2.402 ± 0.486
2.982AspVal: 2.982 ± 0.55
0.745AspTrp: 0.745 ± 0.283
2.899AspTyr: 2.899 ± 0.464
0.0AspXaa: 0.0 ± 0.0
Glu
6.957GluAla: 6.957 ± 0.891
0.497GluCys: 0.497 ± 0.183
3.644GluAsp: 3.644 ± 0.615
3.644GluGlu: 3.644 ± 0.677
1.988GluPhe: 1.988 ± 0.431
4.058GluGly: 4.058 ± 0.736
1.656GluHis: 1.656 ± 0.33
3.893GluIle: 3.893 ± 0.698
3.81GluLys: 3.81 ± 0.65
6.709GluLeu: 6.709 ± 1.027
2.236GluMet: 2.236 ± 0.343
2.733GluAsn: 2.733 ± 0.441
2.153GluPro: 2.153 ± 0.507
3.313GluGln: 3.313 ± 0.663
4.638GluArg: 4.638 ± 0.452
3.23GluSer: 3.23 ± 0.496
2.899GluThr: 2.899 ± 0.504
5.549GluVal: 5.549 ± 0.885
1.242GluTrp: 1.242 ± 0.383
2.153GluTyr: 2.153 ± 0.397
0.0GluXaa: 0.0 ± 0.0
Phe
3.479PheAla: 3.479 ± 0.496
1.16PheCys: 1.16 ± 0.296
1.905PheAsp: 1.905 ± 0.366
1.574PheGlu: 1.574 ± 0.284
1.077PhePhe: 1.077 ± 0.265
2.899PheGly: 2.899 ± 0.475
0.745PheHis: 0.745 ± 0.234
1.242PheIle: 1.242 ± 0.306
1.574PheLys: 1.574 ± 0.343
1.739PheLeu: 1.739 ± 0.329
1.242PheMet: 1.242 ± 0.291
1.822PheAsn: 1.822 ± 0.366
1.408PhePro: 1.408 ± 0.234
1.408PheGln: 1.408 ± 0.366
1.325PheArg: 1.325 ± 0.355
2.733PheSer: 2.733 ± 0.412
2.319PheThr: 2.319 ± 0.41
1.574PheVal: 1.574 ± 0.364
0.331PheTrp: 0.331 ± 0.153
0.745PheTyr: 0.745 ± 0.239
0.0PheXaa: 0.0 ± 0.0
Gly
6.543GlyAla: 6.543 ± 1.118
0.497GlyCys: 0.497 ± 0.201
4.472GlyAsp: 4.472 ± 0.754
3.975GlyGlu: 3.975 ± 0.553
3.396GlyPhe: 3.396 ± 0.492
7.868GlyGly: 7.868 ± 1.552
0.663GlyHis: 0.663 ± 0.247
3.644GlyIle: 3.644 ± 0.536
5.632GlyLys: 5.632 ± 0.639
6.709GlyLeu: 6.709 ± 0.724
2.071GlyMet: 2.071 ± 0.404
4.472GlyAsn: 4.472 ± 0.684
2.402GlyPro: 2.402 ± 0.362
2.733GlyGln: 2.733 ± 0.59
4.224GlyArg: 4.224 ± 0.712
5.715GlySer: 5.715 ± 0.874
4.307GlyThr: 4.307 ± 0.714
5.301GlyVal: 5.301 ± 0.646
1.408GlyTrp: 1.408 ± 0.387
2.816GlyTyr: 2.816 ± 0.598
0.0GlyXaa: 0.0 ± 0.0
His
1.242HisAla: 1.242 ± 0.38
0.166HisCys: 0.166 ± 0.108
0.828HisAsp: 0.828 ± 0.224
0.828HisGlu: 0.828 ± 0.208
0.745HisPhe: 0.745 ± 0.281
1.077HisGly: 1.077 ± 0.305
0.58HisHis: 0.58 ± 0.182
1.408HisIle: 1.408 ± 0.329
1.077HisLys: 1.077 ± 0.279
1.574HisLeu: 1.574 ± 0.347
0.166HisMet: 0.166 ± 0.102
0.828HisAsn: 0.828 ± 0.326
1.077HisPro: 1.077 ± 0.247
0.663HisGln: 0.663 ± 0.217
1.325HisArg: 1.325 ± 0.412
0.663HisSer: 0.663 ± 0.227
0.497HisThr: 0.497 ± 0.205
1.242HisVal: 1.242 ± 0.251
0.248HisTrp: 0.248 ± 0.139
0.58HisTyr: 0.58 ± 0.25
0.0HisXaa: 0.0 ± 0.0
Ile
5.135IleAla: 5.135 ± 0.594
0.828IleCys: 0.828 ± 0.223
4.472IleAsp: 4.472 ± 0.783
4.887IleGlu: 4.887 ± 0.752
1.491IlePhe: 1.491 ± 0.314
4.472IleGly: 4.472 ± 0.579
0.497IleHis: 0.497 ± 0.198
3.727IleIle: 3.727 ± 0.511
3.23IleLys: 3.23 ± 0.5
4.721IleLeu: 4.721 ± 0.479
1.242IleMet: 1.242 ± 0.351
2.485IleAsn: 2.485 ± 0.438
2.816IlePro: 2.816 ± 0.566
2.236IleGln: 2.236 ± 0.352
2.071IleArg: 2.071 ± 0.382
4.058IleSer: 4.058 ± 0.506
3.147IleThr: 3.147 ± 0.457
2.982IleVal: 2.982 ± 0.746
0.745IleTrp: 0.745 ± 0.234
1.905IleTyr: 1.905 ± 0.434
0.0IleXaa: 0.0 ± 0.0
Lys
5.632LysAla: 5.632 ± 0.573
0.911LysCys: 0.911 ± 0.324
3.644LysAsp: 3.644 ± 0.718
4.555LysGlu: 4.555 ± 0.678
1.656LysPhe: 1.656 ± 0.332
3.644LysGly: 3.644 ± 0.551
1.16LysHis: 1.16 ± 0.4
3.644LysIle: 3.644 ± 0.593
3.644LysLys: 3.644 ± 0.565
3.147LysLeu: 3.147 ± 0.522
1.822LysMet: 1.822 ± 0.42
1.988LysAsn: 1.988 ± 0.414
3.313LysPro: 3.313 ± 0.564
1.325LysGln: 1.325 ± 0.515
3.064LysArg: 3.064 ± 0.467
3.893LysSer: 3.893 ± 0.469
2.485LysThr: 2.485 ± 0.506
3.147LysVal: 3.147 ± 0.465
1.16LysTrp: 1.16 ± 0.293
1.905LysTyr: 1.905 ± 0.404
0.0LysXaa: 0.0 ± 0.0
Leu
7.206LeuAla: 7.206 ± 1.092
0.911LeuCys: 0.911 ± 0.346
3.727LeuAsp: 3.727 ± 0.516
4.887LeuGlu: 4.887 ± 0.928
2.236LeuPhe: 2.236 ± 0.474
5.632LeuGly: 5.632 ± 0.798
0.663LeuHis: 0.663 ± 0.243
4.804LeuIle: 4.804 ± 0.637
4.224LeuLys: 4.224 ± 0.833
3.479LeuLeu: 3.479 ± 0.535
1.656LeuMet: 1.656 ± 0.372
4.224LeuAsn: 4.224 ± 0.501
4.058LeuPro: 4.058 ± 0.666
3.81LeuGln: 3.81 ± 0.771
4.472LeuArg: 4.472 ± 0.724
5.963LeuSer: 5.963 ± 0.568
4.804LeuThr: 4.804 ± 0.598
5.052LeuVal: 5.052 ± 0.519
1.077LeuTrp: 1.077 ± 0.311
1.656LeuTyr: 1.656 ± 0.31
0.0LeuXaa: 0.0 ± 0.0
Met
2.816MetAla: 2.816 ± 0.422
0.414MetCys: 0.414 ± 0.136
1.16MetAsp: 1.16 ± 0.259
1.325MetGlu: 1.325 ± 0.342
0.497MetPhe: 0.497 ± 0.207
2.65MetGly: 2.65 ± 0.452
0.414MetHis: 0.414 ± 0.206
0.911MetIle: 0.911 ± 0.3
1.822MetLys: 1.822 ± 0.428
2.319MetLeu: 2.319 ± 0.355
1.077MetMet: 1.077 ± 0.317
0.911MetAsn: 0.911 ± 0.263
1.242MetPro: 1.242 ± 0.24
1.491MetGln: 1.491 ± 0.351
1.905MetArg: 1.905 ± 0.331
2.402MetSer: 2.402 ± 0.367
1.905MetThr: 1.905 ± 0.362
1.408MetVal: 1.408 ± 0.381
0.663MetTrp: 0.663 ± 0.229
0.994MetTyr: 0.994 ± 0.269
0.0MetXaa: 0.0 ± 0.0
Asn
4.887AsnAla: 4.887 ± 0.695
0.166AsnCys: 0.166 ± 0.117
2.568AsnAsp: 2.568 ± 0.428
2.236AsnGlu: 2.236 ± 0.343
1.16AsnPhe: 1.16 ± 0.305
3.893AsnGly: 3.893 ± 0.768
0.828AsnHis: 0.828 ± 0.286
2.568AsnIle: 2.568 ± 0.391
1.656AsnLys: 1.656 ± 0.317
3.313AsnLeu: 3.313 ± 0.513
1.822AsnMet: 1.822 ± 0.33
2.568AsnAsn: 2.568 ± 0.645
3.396AsnPro: 3.396 ± 0.566
2.071AsnGln: 2.071 ± 0.525
2.899AsnArg: 2.899 ± 0.454
2.153AsnSer: 2.153 ± 0.415
2.899AsnThr: 2.899 ± 0.467
2.153AsnVal: 2.153 ± 0.54
1.408AsnTrp: 1.408 ± 0.33
1.491AsnTyr: 1.491 ± 0.253
0.0AsnXaa: 0.0 ± 0.0
Pro
4.307ProAla: 4.307 ± 0.687
0.663ProCys: 0.663 ± 0.211
3.561ProAsp: 3.561 ± 0.419
4.555ProGlu: 4.555 ± 0.653
2.733ProPhe: 2.733 ± 0.345
2.899ProGly: 2.899 ± 0.586
0.828ProHis: 0.828 ± 0.2
2.071ProIle: 2.071 ± 0.443
2.153ProLys: 2.153 ± 0.463
2.485ProLeu: 2.485 ± 0.471
1.077ProMet: 1.077 ± 0.297
2.236ProAsn: 2.236 ± 0.375
1.905ProPro: 1.905 ± 0.43
2.236ProGln: 2.236 ± 0.506
1.822ProArg: 1.822 ± 0.361
3.313ProSer: 3.313 ± 0.542
2.982ProThr: 2.982 ± 0.489
3.81ProVal: 3.81 ± 0.397
0.414ProTrp: 0.414 ± 0.21
1.905ProTyr: 1.905 ± 0.292
0.0ProXaa: 0.0 ± 0.0
Gln
5.715GlnAla: 5.715 ± 0.766
0.414GlnCys: 0.414 ± 0.157
2.568GlnAsp: 2.568 ± 0.392
3.147GlnGlu: 3.147 ± 0.627
1.325GlnPhe: 1.325 ± 0.302
3.644GlnGly: 3.644 ± 0.621
0.663GlnHis: 0.663 ± 0.265
2.153GlnIle: 2.153 ± 0.414
1.905GlnLys: 1.905 ± 0.382
3.644GlnLeu: 3.644 ± 0.562
1.408GlnMet: 1.408 ± 0.359
1.988GlnAsn: 1.988 ± 0.391
2.236GlnPro: 2.236 ± 0.554
3.396GlnGln: 3.396 ± 0.917
2.071GlnArg: 2.071 ± 0.476
3.561GlnSer: 3.561 ± 0.72
2.236GlnThr: 2.236 ± 0.424
2.236GlnVal: 2.236 ± 0.537
0.414GlnTrp: 0.414 ± 0.165
0.745GlnTyr: 0.745 ± 0.247
0.0GlnXaa: 0.0 ± 0.0
Arg
4.472ArgAla: 4.472 ± 0.468
0.745ArgCys: 0.745 ± 0.234
3.147ArgAsp: 3.147 ± 0.464
5.135ArgGlu: 5.135 ± 0.624
0.911ArgPhe: 0.911 ± 0.222
3.561ArgGly: 3.561 ± 0.435
0.497ArgHis: 0.497 ± 0.216
3.561ArgIle: 3.561 ± 0.691
4.058ArgLys: 4.058 ± 0.569
4.224ArgLeu: 4.224 ± 0.504
1.491ArgMet: 1.491 ± 0.325
2.982ArgAsn: 2.982 ± 0.427
2.402ArgPro: 2.402 ± 0.434
2.899ArgGln: 2.899 ± 0.581
3.479ArgArg: 3.479 ± 0.532
2.816ArgSer: 2.816 ± 0.493
2.319ArgThr: 2.319 ± 0.39
4.141ArgVal: 4.141 ± 0.527
0.911ArgTrp: 0.911 ± 0.239
1.822ArgTyr: 1.822 ± 0.344
0.0ArgXaa: 0.0 ± 0.0
Ser
6.543SerAla: 6.543 ± 0.708
0.248SerCys: 0.248 ± 0.142
2.899SerAsp: 2.899 ± 0.484
4.472SerGlu: 4.472 ± 0.771
1.822SerPhe: 1.822 ± 0.446
6.129SerGly: 6.129 ± 0.836
1.242SerHis: 1.242 ± 0.316
3.147SerIle: 3.147 ± 0.574
3.644SerLys: 3.644 ± 0.543
5.715SerLeu: 5.715 ± 0.642
2.153SerMet: 2.153 ± 0.373
3.313SerAsn: 3.313 ± 0.578
3.396SerPro: 3.396 ± 0.911
3.313SerGln: 3.313 ± 0.617
3.644SerArg: 3.644 ± 0.643
4.804SerSer: 4.804 ± 0.59
3.064SerThr: 3.064 ± 0.641
4.39SerVal: 4.39 ± 0.574
0.663SerTrp: 0.663 ± 0.203
2.402SerTyr: 2.402 ± 0.483
0.0SerXaa: 0.0 ± 0.0
Thr
4.969ThrAla: 4.969 ± 0.541
0.331ThrCys: 0.331 ± 0.248
2.402ThrAsp: 2.402 ± 0.468
3.064ThrGlu: 3.064 ± 0.631
1.325ThrPhe: 1.325 ± 0.365
5.963ThrGly: 5.963 ± 1.031
1.077ThrHis: 1.077 ± 0.341
3.147ThrIle: 3.147 ± 0.596
3.147ThrLys: 3.147 ± 0.555
4.141ThrLeu: 4.141 ± 0.603
1.16ThrMet: 1.16 ± 0.286
1.822ThrAsn: 1.822 ± 0.352
4.307ThrPro: 4.307 ± 0.685
1.574ThrGln: 1.574 ± 0.357
1.988ThrArg: 1.988 ± 0.493
3.479ThrSer: 3.479 ± 0.609
3.396ThrThr: 3.396 ± 0.624
3.147ThrVal: 3.147 ± 0.363
0.911ThrTrp: 0.911 ± 0.318
1.656ThrTyr: 1.656 ± 0.345
0.0ThrXaa: 0.0 ± 0.0
Val
4.804ValAla: 4.804 ± 0.669
0.828ValCys: 0.828 ± 0.234
4.638ValAsp: 4.638 ± 0.585
4.638ValGlu: 4.638 ± 0.806
2.071ValPhe: 2.071 ± 0.491
4.638ValGly: 4.638 ± 0.657
0.994ValHis: 0.994 ± 0.357
3.81ValIle: 3.81 ± 0.471
3.727ValLys: 3.727 ± 0.49
3.561ValLeu: 3.561 ± 0.484
1.905ValMet: 1.905 ± 0.348
2.816ValAsn: 2.816 ± 0.457
2.485ValPro: 2.485 ± 0.366
1.905ValGln: 1.905 ± 0.403
3.064ValArg: 3.064 ± 0.615
4.804ValSer: 4.804 ± 0.54
4.058ValThr: 4.058 ± 0.673
3.064ValVal: 3.064 ± 0.573
1.077ValTrp: 1.077 ± 0.383
2.485ValTyr: 2.485 ± 0.402
0.0ValXaa: 0.0 ± 0.0
Trp
1.408TrpAla: 1.408 ± 0.293
0.166TrpCys: 0.166 ± 0.118
1.325TrpAsp: 1.325 ± 0.389
1.242TrpGlu: 1.242 ± 0.343
0.58TrpPhe: 0.58 ± 0.182
0.828TrpGly: 0.828 ± 0.383
0.497TrpHis: 0.497 ± 0.159
0.911TrpIle: 0.911 ± 0.287
1.077TrpLys: 1.077 ± 0.242
0.663TrpLeu: 0.663 ± 0.219
0.497TrpMet: 0.497 ± 0.242
0.663TrpAsn: 0.663 ± 0.231
0.663TrpPro: 0.663 ± 0.232
0.994TrpGln: 0.994 ± 0.253
0.994TrpArg: 0.994 ± 0.305
1.491TrpSer: 1.491 ± 0.348
0.745TrpThr: 0.745 ± 0.213
0.828TrpVal: 0.828 ± 0.227
0.083TrpTrp: 0.083 ± 0.082
0.248TrpTyr: 0.248 ± 0.133
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.313TyrAla: 3.313 ± 0.502
0.828TyrCys: 0.828 ± 0.257
1.905TyrAsp: 1.905 ± 0.394
2.153TyrGlu: 2.153 ± 0.472
1.242TyrPhe: 1.242 ± 0.296
2.319TyrGly: 2.319 ± 0.405
0.497TyrHis: 0.497 ± 0.217
1.491TyrIle: 1.491 ± 0.274
1.408TyrLys: 1.408 ± 0.354
1.905TyrLeu: 1.905 ± 0.471
0.745TyrMet: 0.745 ± 0.221
1.656TyrAsn: 1.656 ± 0.357
1.242TyrPro: 1.242 ± 0.333
1.656TyrGln: 1.656 ± 0.294
2.816TyrArg: 2.816 ± 0.405
1.574TyrSer: 1.574 ± 0.366
1.408TyrThr: 1.408 ± 0.332
1.905TyrVal: 1.905 ± 0.383
0.663TyrTrp: 0.663 ± 0.281
0.911TyrTyr: 0.911 ± 0.205
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 58 proteins (12075 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski