Amino acid dipepetide frequency for Streptococcus satellite phage Javan468

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.496AlaAla: 2.496 ± 0.887
1.427AlaCys: 1.427 ± 0.635
2.496AlaAsp: 2.496 ± 0.541
4.993AlaGlu: 4.993 ± 1.888
2.14AlaPhe: 2.14 ± 0.757
3.21AlaGly: 3.21 ± 1.044
0.357AlaHis: 0.357 ± 0.413
6.419AlaIle: 6.419 ± 1.433
4.993AlaLys: 4.993 ± 1.021
3.923AlaLeu: 3.923 ± 1.343
1.427AlaMet: 1.427 ± 0.854
2.496AlaAsn: 2.496 ± 1.189
1.427AlaPro: 1.427 ± 0.803
2.496AlaGln: 2.496 ± 0.939
2.496AlaArg: 2.496 ± 0.968
2.853AlaSer: 2.853 ± 0.96
3.21AlaThr: 3.21 ± 1.356
3.923AlaVal: 3.923 ± 1.04
0.713AlaTrp: 0.713 ± 0.553
1.783AlaTyr: 1.783 ± 0.57
0.0AlaXaa: 0.0 ± 0.0
Cys
0.357CysAla: 0.357 ± 0.297
0.0CysCys: 0.0 ± 0.0
0.357CysAsp: 0.357 ± 0.442
0.357CysGlu: 0.357 ± 0.343
0.0CysPhe: 0.0 ± 0.0
0.357CysGly: 0.357 ± 0.38
0.357CysHis: 0.357 ± 0.31
0.0CysIle: 0.0 ± 0.0
0.357CysLys: 0.357 ± 0.442
0.0CysLeu: 0.0 ± 0.0
0.357CysMet: 0.357 ± 0.329
0.713CysAsn: 0.713 ± 0.415
0.713CysPro: 0.713 ± 0.426
1.07CysGln: 1.07 ± 0.638
0.357CysArg: 0.357 ± 0.297
0.0CysSer: 0.0 ± 0.0
0.357CysThr: 0.357 ± 0.352
0.357CysVal: 0.357 ± 0.38
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.853AspAla: 2.853 ± 1.062
0.357AspCys: 0.357 ± 0.38
4.636AspAsp: 4.636 ± 1.291
4.636AspGlu: 4.636 ± 1.309
2.853AspPhe: 2.853 ± 0.956
2.496AspGly: 2.496 ± 0.874
0.0AspHis: 0.0 ± 0.0
4.993AspIle: 4.993 ± 1.217
8.203AspLys: 8.203 ± 1.44
4.993AspLeu: 4.993 ± 0.968
2.14AspMet: 2.14 ± 0.88
4.28AspAsn: 4.28 ± 0.852
0.357AspPro: 0.357 ± 0.31
1.07AspGln: 1.07 ± 0.659
1.427AspArg: 1.427 ± 0.632
3.923AspSer: 3.923 ± 0.826
1.783AspThr: 1.783 ± 0.82
3.923AspVal: 3.923 ± 0.845
1.07AspTrp: 1.07 ± 0.458
3.21AspTyr: 3.21 ± 0.907
0.0AspXaa: 0.0 ± 0.0
Glu
4.28GluAla: 4.28 ± 0.858
0.0GluCys: 0.0 ± 0.0
3.21GluAsp: 3.21 ± 1.529
4.993GluGlu: 4.993 ± 1.59
4.28GluPhe: 4.28 ± 1.445
3.923GluGly: 3.923 ± 0.979
1.783GluHis: 1.783 ± 0.706
7.133GluIle: 7.133 ± 1.632
7.846GluLys: 7.846 ± 2.384
13.195GluLeu: 13.195 ± 2.678
5.35GluMet: 5.35 ± 1.368
5.35GluAsn: 5.35 ± 1.077
2.496GluPro: 2.496 ± 1.078
5.706GluGln: 5.706 ± 1.307
3.21GluArg: 3.21 ± 1.184
2.853GluSer: 2.853 ± 1.233
5.706GluThr: 5.706 ± 1.347
4.28GluVal: 4.28 ± 1.148
1.07GluTrp: 1.07 ± 0.702
1.07GluTyr: 1.07 ± 0.565
0.0GluXaa: 0.0 ± 0.0
Phe
2.14PheAla: 2.14 ± 0.799
0.0PheCys: 0.0 ± 0.0
2.14PheAsp: 2.14 ± 0.845
3.923PheGlu: 3.923 ± 1.077
1.783PhePhe: 1.783 ± 0.764
1.783PheGly: 1.783 ± 0.603
0.713PheHis: 0.713 ± 0.442
3.21PheIle: 3.21 ± 1.199
3.923PheLys: 3.923 ± 1.141
2.853PheLeu: 2.853 ± 0.818
1.427PheMet: 1.427 ± 0.7
1.427PheAsn: 1.427 ± 0.813
1.427PhePro: 1.427 ± 0.697
0.713PheGln: 0.713 ± 0.522
0.357PheArg: 0.357 ± 0.297
2.853PheSer: 2.853 ± 0.908
1.783PheThr: 1.783 ± 0.583
1.783PheVal: 1.783 ± 0.908
0.0PheTrp: 0.0 ± 0.0
1.07PheTyr: 1.07 ± 0.686
0.0PheXaa: 0.0 ± 0.0
Gly
1.427GlyAla: 1.427 ± 0.788
0.357GlyCys: 0.357 ± 0.297
2.14GlyAsp: 2.14 ± 0.848
3.923GlyGlu: 3.923 ± 0.875
1.07GlyPhe: 1.07 ± 0.5
1.07GlyGly: 1.07 ± 0.466
0.713GlyHis: 0.713 ± 0.382
3.923GlyIle: 3.923 ± 1.48
5.35GlyLys: 5.35 ± 1.463
4.993GlyLeu: 4.993 ± 1.209
0.713GlyMet: 0.713 ± 0.406
4.636GlyAsn: 4.636 ± 1.47
0.713GlyPro: 0.713 ± 0.62
2.14GlyGln: 2.14 ± 0.733
0.713GlyArg: 0.713 ± 0.473
1.07GlySer: 1.07 ± 0.612
2.496GlyThr: 2.496 ± 0.74
4.993GlyVal: 4.993 ± 1.254
0.713GlyTrp: 0.713 ± 0.686
3.21GlyTyr: 3.21 ± 0.849
0.0GlyXaa: 0.0 ± 0.0
His
0.357HisAla: 0.357 ± 0.38
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
2.853HisGlu: 2.853 ± 0.927
1.427HisPhe: 1.427 ± 0.533
1.783HisGly: 1.783 ± 0.693
1.07HisHis: 1.07 ± 0.602
0.713HisIle: 0.713 ± 0.406
1.07HisLys: 1.07 ± 0.531
1.427HisLeu: 1.427 ± 0.532
0.713HisMet: 0.713 ± 0.5
1.07HisAsn: 1.07 ± 0.59
0.0HisPro: 0.0 ± 0.0
0.713HisGln: 0.713 ± 0.567
0.357HisArg: 0.357 ± 0.393
0.713HisSer: 0.713 ± 0.46
1.783HisThr: 1.783 ± 0.908
0.357HisVal: 0.357 ± 0.343
0.0HisTrp: 0.0 ± 0.0
0.713HisTyr: 0.713 ± 0.599
0.0HisXaa: 0.0 ± 0.0
Ile
3.566IleAla: 3.566 ± 1.423
0.0IleCys: 0.0 ± 0.0
6.776IleAsp: 6.776 ± 1.327
7.133IleGlu: 7.133 ± 1.499
3.21IlePhe: 3.21 ± 1.115
3.566IleGly: 3.566 ± 1.142
0.713IleHis: 0.713 ± 0.54
4.636IleIle: 4.636 ± 1.085
8.203IleLys: 8.203 ± 2.382
7.133IleLeu: 7.133 ± 1.393
2.14IleMet: 2.14 ± 0.91
5.706IleAsn: 5.706 ± 1.411
2.496IlePro: 2.496 ± 0.877
1.783IleGln: 1.783 ± 0.547
3.21IleArg: 3.21 ± 1.108
4.636IleSer: 4.636 ± 1.525
5.35IleThr: 5.35 ± 1.217
3.923IleVal: 3.923 ± 1.056
1.427IleTrp: 1.427 ± 0.804
1.783IleTyr: 1.783 ± 0.767
0.0IleXaa: 0.0 ± 0.0
Lys
6.419LysAla: 6.419 ± 1.782
0.357LysCys: 0.357 ± 0.38
3.923LysAsp: 3.923 ± 1.202
11.056LysGlu: 11.056 ± 2.07
0.713LysPhe: 0.713 ± 0.511
5.706LysGly: 5.706 ± 1.797
2.14LysHis: 2.14 ± 0.724
4.993LysIle: 4.993 ± 1.153
9.272LysLys: 9.272 ± 2.616
8.203LysLeu: 8.203 ± 1.659
3.21LysMet: 3.21 ± 1.057
7.846LysAsn: 7.846 ± 1.303
2.14LysPro: 2.14 ± 0.664
5.35LysGln: 5.35 ± 1.117
3.566LysArg: 3.566 ± 1.259
5.706LysSer: 5.706 ± 1.94
5.706LysThr: 5.706 ± 1.824
6.776LysVal: 6.776 ± 1.897
1.427LysTrp: 1.427 ± 0.832
4.28LysTyr: 4.28 ± 1.023
0.0LysXaa: 0.0 ± 0.0
Leu
6.063LeuAla: 6.063 ± 1.643
0.713LeuCys: 0.713 ± 0.485
10.342LeuAsp: 10.342 ± 1.71
9.986LeuGlu: 9.986 ± 2.367
3.21LeuPhe: 3.21 ± 0.85
5.35LeuGly: 5.35 ± 1.794
1.07LeuHis: 1.07 ± 0.567
6.776LeuIle: 6.776 ± 1.69
8.559LeuLys: 8.559 ± 2.076
9.629LeuLeu: 9.629 ± 1.767
2.14LeuMet: 2.14 ± 0.978
6.776LeuAsn: 6.776 ± 1.22
1.07LeuPro: 1.07 ± 0.694
2.496LeuGln: 2.496 ± 0.836
3.566LeuArg: 3.566 ± 1.182
4.636LeuSer: 4.636 ± 1.129
4.636LeuThr: 4.636 ± 1.181
4.636LeuVal: 4.636 ± 1.211
0.357LeuTrp: 0.357 ± 0.393
4.993LeuTyr: 4.993 ± 0.931
0.0LeuXaa: 0.0 ± 0.0
Met
2.853MetAla: 2.853 ± 1.081
0.0MetCys: 0.0 ± 0.0
2.853MetAsp: 2.853 ± 1.348
2.496MetGlu: 2.496 ± 0.83
0.357MetPhe: 0.357 ± 0.393
0.357MetGly: 0.357 ± 0.393
1.07MetHis: 1.07 ± 0.672
1.427MetIle: 1.427 ± 0.596
3.21MetLys: 3.21 ± 1.514
3.21MetLeu: 3.21 ± 0.989
2.14MetMet: 2.14 ± 0.908
2.496MetAsn: 2.496 ± 0.772
1.07MetPro: 1.07 ± 0.606
0.713MetGln: 0.713 ± 0.426
1.783MetArg: 1.783 ± 0.738
1.783MetSer: 1.783 ± 0.948
2.853MetThr: 2.853 ± 0.96
0.713MetVal: 0.713 ± 0.5
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
6.063AsnAla: 6.063 ± 1.273
0.357AsnCys: 0.357 ± 0.442
2.853AsnAsp: 2.853 ± 1.029
4.636AsnGlu: 4.636 ± 1.397
1.427AsnPhe: 1.427 ± 0.735
5.35AsnGly: 5.35 ± 1.132
1.427AsnHis: 1.427 ± 0.667
2.853AsnIle: 2.853 ± 0.822
5.706AsnLys: 5.706 ± 1.448
4.28AsnLeu: 4.28 ± 0.995
1.783AsnMet: 1.783 ± 0.757
1.783AsnAsn: 1.783 ± 0.883
1.783AsnPro: 1.783 ± 0.582
2.496AsnGln: 2.496 ± 0.835
2.14AsnArg: 2.14 ± 0.822
3.21AsnSer: 3.21 ± 1.017
4.28AsnThr: 4.28 ± 1.278
3.566AsnVal: 3.566 ± 1.088
1.427AsnTrp: 1.427 ± 0.741
3.21AsnTyr: 3.21 ± 0.95
0.0AsnXaa: 0.0 ± 0.0
Pro
1.07ProAla: 1.07 ± 0.533
0.0ProCys: 0.0 ± 0.0
0.357ProAsp: 0.357 ± 0.42
1.427ProGlu: 1.427 ± 0.53
1.427ProPhe: 1.427 ± 0.597
0.0ProGly: 0.0 ± 0.0
0.357ProHis: 0.357 ± 0.31
2.853ProIle: 2.853 ± 0.76
3.923ProLys: 3.923 ± 1.419
2.14ProLeu: 2.14 ± 0.73
0.0ProMet: 0.0 ± 0.0
1.783ProAsn: 1.783 ± 0.651
0.713ProPro: 0.713 ± 0.622
1.07ProGln: 1.07 ± 0.609
0.713ProArg: 0.713 ± 0.491
1.07ProSer: 1.07 ± 0.539
2.496ProThr: 2.496 ± 1.228
2.14ProVal: 2.14 ± 0.742
0.357ProTrp: 0.357 ± 0.31
1.427ProTyr: 1.427 ± 0.639
0.0ProXaa: 0.0 ± 0.0
Gln
2.14GlnAla: 2.14 ± 0.679
0.713GlnCys: 0.713 ± 0.505
2.853GlnAsp: 2.853 ± 1.09
2.14GlnGlu: 2.14 ± 0.866
0.713GlnPhe: 0.713 ± 0.442
1.427GlnGly: 1.427 ± 0.672
1.07GlnHis: 1.07 ± 0.651
4.28GlnIle: 4.28 ± 1.197
6.063GlnLys: 6.063 ± 1.465
4.636GlnLeu: 4.636 ± 1.329
0.713GlnMet: 0.713 ± 0.508
1.07GlnAsn: 1.07 ± 0.776
1.427GlnPro: 1.427 ± 0.621
4.636GlnGln: 4.636 ± 1.561
2.14GlnArg: 2.14 ± 0.743
3.923GlnSer: 3.923 ± 0.948
0.713GlnThr: 0.713 ± 0.468
3.923GlnVal: 3.923 ± 0.913
0.0GlnTrp: 0.0 ± 0.0
1.07GlnTyr: 1.07 ± 0.611
0.0GlnXaa: 0.0 ± 0.0
Arg
1.427ArgAla: 1.427 ± 0.762
0.0ArgCys: 0.0 ± 0.0
1.427ArgAsp: 1.427 ± 0.674
4.636ArgGlu: 4.636 ± 1.632
0.713ArgPhe: 0.713 ± 0.485
1.427ArgGly: 1.427 ± 0.692
0.713ArgHis: 0.713 ± 0.406
4.28ArgIle: 4.28 ± 1.267
3.566ArgLys: 3.566 ± 1.243
3.21ArgLeu: 3.21 ± 0.776
1.783ArgMet: 1.783 ± 0.927
1.427ArgAsn: 1.427 ± 0.718
0.357ArgPro: 0.357 ± 0.378
2.496ArgGln: 2.496 ± 0.949
0.0ArgArg: 0.0 ± 0.0
2.14ArgSer: 2.14 ± 0.892
2.496ArgThr: 2.496 ± 1.006
2.496ArgVal: 2.496 ± 0.743
0.357ArgTrp: 0.357 ± 0.38
1.427ArgTyr: 1.427 ± 0.554
0.0ArgXaa: 0.0 ± 0.0
Ser
1.783SerAla: 1.783 ± 0.701
0.713SerCys: 0.713 ± 0.473
6.419SerAsp: 6.419 ± 1.707
3.923SerGlu: 3.923 ± 0.998
2.496SerPhe: 2.496 ± 1.178
1.07SerGly: 1.07 ± 0.689
0.357SerHis: 0.357 ± 0.38
3.566SerIle: 3.566 ± 1.571
6.419SerLys: 6.419 ± 1.682
4.636SerLeu: 4.636 ± 1.133
0.713SerMet: 0.713 ± 0.378
4.28SerAsn: 4.28 ± 1.036
1.783SerPro: 1.783 ± 0.826
2.496SerGln: 2.496 ± 1.178
1.783SerArg: 1.783 ± 0.755
3.566SerSer: 3.566 ± 1.08
1.783SerThr: 1.783 ± 1.043
4.28SerVal: 4.28 ± 1.591
0.357SerTrp: 0.357 ± 0.297
2.14SerTyr: 2.14 ± 0.637
0.0SerXaa: 0.0 ± 0.0
Thr
3.566ThrAla: 3.566 ± 1.278
0.357ThrCys: 0.357 ± 0.31
2.496ThrAsp: 2.496 ± 0.988
5.706ThrGlu: 5.706 ± 1.372
1.427ThrPhe: 1.427 ± 0.726
3.566ThrGly: 3.566 ± 1.08
1.07ThrHis: 1.07 ± 0.442
4.636ThrIle: 4.636 ± 1.064
2.14ThrLys: 2.14 ± 0.957
6.776ThrLeu: 6.776 ± 1.103
0.713ThrMet: 0.713 ± 0.473
3.21ThrAsn: 3.21 ± 1.218
2.14ThrPro: 2.14 ± 0.781
2.853ThrGln: 2.853 ± 1.19
2.14ThrArg: 2.14 ± 0.679
2.14ThrSer: 2.14 ± 0.734
3.21ThrThr: 3.21 ± 1.521
4.993ThrVal: 4.993 ± 1.51
0.357ThrTrp: 0.357 ± 0.522
1.427ThrTyr: 1.427 ± 0.705
0.0ThrXaa: 0.0 ± 0.0
Val
3.566ValAla: 3.566 ± 1.288
0.0ValCys: 0.0 ± 0.0
2.14ValAsp: 2.14 ± 0.881
4.28ValGlu: 4.28 ± 2.093
2.496ValPhe: 2.496 ± 1.214
1.783ValGly: 1.783 ± 0.703
0.713ValHis: 0.713 ± 0.442
7.133ValIle: 7.133 ± 1.459
3.566ValLys: 3.566 ± 1.188
6.063ValLeu: 6.063 ± 1.238
2.14ValMet: 2.14 ± 0.963
2.496ValAsn: 2.496 ± 0.957
2.496ValPro: 2.496 ± 0.754
2.853ValGln: 2.853 ± 0.884
3.566ValArg: 3.566 ± 0.95
4.993ValSer: 4.993 ± 1.254
2.853ValThr: 2.853 ± 0.874
2.853ValVal: 2.853 ± 0.857
0.357ValTrp: 0.357 ± 0.297
4.636ValTyr: 4.636 ± 1.486
0.0ValXaa: 0.0 ± 0.0
Trp
0.713TrpAla: 0.713 ± 0.473
0.357TrpCys: 0.357 ± 0.344
1.07TrpAsp: 1.07 ± 0.691
1.427TrpGlu: 1.427 ± 0.544
0.357TrpPhe: 0.357 ± 0.393
0.0TrpGly: 0.0 ± 0.0
0.357TrpHis: 0.357 ± 0.297
0.357TrpIle: 0.357 ± 0.31
1.07TrpLys: 1.07 ± 0.585
1.07TrpLeu: 1.07 ± 0.744
0.713TrpMet: 0.713 ± 0.617
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.713TrpGln: 0.713 ± 0.415
1.07TrpArg: 1.07 ± 0.918
0.357TrpSer: 0.357 ± 0.297
0.357TrpThr: 0.357 ± 0.38
0.0TrpVal: 0.0 ± 0.0
0.357TrpTrp: 0.357 ± 0.297
0.357TrpTyr: 0.357 ± 0.393
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.14TyrAla: 2.14 ± 1.269
0.357TyrCys: 0.357 ± 0.343
1.07TyrAsp: 1.07 ± 0.629
3.21TyrGlu: 3.21 ± 1.165
3.21TyrPhe: 3.21 ± 1.038
2.14TyrGly: 2.14 ± 0.837
1.07TyrHis: 1.07 ± 0.566
3.21TyrIle: 3.21 ± 1.278
5.35TyrLys: 5.35 ± 1.159
4.636TyrLeu: 4.636 ± 1.653
0.713TyrMet: 0.713 ± 0.516
1.783TyrAsn: 1.783 ± 1.036
0.713TyrPro: 0.713 ± 0.4
1.783TyrGln: 1.783 ± 0.834
1.783TyrArg: 1.783 ± 0.731
2.14TyrSer: 2.14 ± 1.128
1.07TyrThr: 1.07 ± 0.53
1.07TyrVal: 1.07 ± 0.572
0.357TyrTrp: 0.357 ± 0.297
1.427TyrTyr: 1.427 ± 0.684
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 19 proteins (2805 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski