Amino acid dipepetide frequency for Leucobacter triazinivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.361AlaAla: 21.361 ± 0.251	0.811AlaCys: 0.811 ± 0.03	7.712AlaAsp: 7.712 ± 0.103	9.856AlaGlu: 9.856 ± 0.127	3.725AlaPhe: 3.725 ± 0.069	12.761AlaGly: 12.761 ± 0.136	2.65AlaHis: 2.65 ± 0.056	5.961AlaIle: 5.961 ± 0.083	2.639AlaLys: 2.639 ± 0.066	14.413AlaLeu: 14.413 ± 0.165	2.606AlaMet: 2.606 ± 0.046	2.16AlaAsn: 2.16 ± 0.058	6.947AlaPro: 6.947 ± 0.099	4.236AlaGln: 4.236 ± 0.076	9.912AlaArg: 9.912 ± 0.13	7.099AlaSer: 7.099 ± 0.088	6.491AlaThr: 6.491 ± 0.085	11.167AlaVal: 11.167 ± 0.141	1.759AlaTrp: 1.759 ± 0.045	2.423AlaTyr: 2.423 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.778CysAla: 0.778 ± 0.034	0.051CysCys: 0.051 ± 0.007	0.348CysAsp: 0.348 ± 0.018	0.342CysGlu: 0.342 ± 0.02	0.192CysPhe: 0.192 ± 0.013	0.672CysGly: 0.672 ± 0.027	0.119CysHis: 0.119 ± 0.011	0.235CysIle: 0.235 ± 0.015	0.058CysLys: 0.058 ± 0.007	0.434CysLeu: 0.434 ± 0.021	0.087CysMet: 0.087 ± 0.009	0.106CysAsn: 0.106 ± 0.01	0.266CysPro: 0.266 ± 0.019	0.116CysGln: 0.116 ± 0.01	0.39CysArg: 0.39 ± 0.022	0.381CysSer: 0.381 ± 0.022	0.378CysThr: 0.378 ± 0.02	0.466CysVal: 0.466 ± 0.022	0.067CysTrp: 0.067 ± 0.008	0.107CysTyr: 0.107 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.61AspAla: 8.61 ± 0.11	0.264AspCys: 0.264 ± 0.016	3.579AspAsp: 3.579 ± 0.077	4.331AspGlu: 4.331 ± 0.071	1.718AspPhe: 1.718 ± 0.041	5.753AspGly: 5.753 ± 0.113	1.139AspHis: 1.139 ± 0.034	2.055AspIle: 2.055 ± 0.051	0.74AspLys: 0.74 ± 0.03	5.748AspLeu: 5.748 ± 0.087	0.796AspMet: 0.796 ± 0.027	0.757AspAsn: 0.757 ± 0.026	4.895AspPro: 4.895 ± 0.076	1.418AspGln: 1.418 ± 0.044	4.874AspArg: 4.874 ± 0.08	2.46AspSer: 2.46 ± 0.052	2.798AspThr: 2.798 ± 0.062	4.471AspVal: 4.471 ± 0.065	0.891AspTrp: 0.891 ± 0.031	1.253AspTyr: 1.253 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	8.183GluAla: 8.183 ± 0.122	0.314GluCys: 0.314 ± 0.019	2.88GluAsp: 2.88 ± 0.06	3.669GluGlu: 3.669 ± 0.069	1.949GluPhe: 1.949 ± 0.046	4.343GluGly: 4.343 ± 0.075	1.799GluHis: 1.799 ± 0.048	3.112GluIle: 3.112 ± 0.064	1.21GluLys: 1.21 ± 0.042	7.523GluLeu: 7.523 ± 0.101	1.17GluMet: 1.17 ± 0.036	1.291GluAsn: 1.291 ± 0.034	3.173GluPro: 3.173 ± 0.066	2.926GluGln: 2.926 ± 0.065	6.464GluArg: 6.464 ± 0.094	3.177GluSer: 3.177 ± 0.051	3.464GluThr: 3.464 ± 0.069	4.902GluVal: 4.902 ± 0.068	0.943GluTrp: 0.943 ± 0.031	1.208GluTyr: 1.208 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.37PheAla: 4.37 ± 0.07	0.195PheCys: 0.195 ± 0.013	2.294PheAsp: 2.294 ± 0.048	2.001PheGlu: 2.001 ± 0.05	1.094PhePhe: 1.094 ± 0.036	3.394PheGly: 3.394 ± 0.06	0.515PheHis: 0.515 ± 0.02	1.238PheIle: 1.238 ± 0.043	0.417PheLys: 0.417 ± 0.021	2.602PheLeu: 2.602 ± 0.051	0.522PheMet: 0.522 ± 0.025	0.584PheAsn: 0.584 ± 0.027	1.44PhePro: 1.44 ± 0.036	0.72PheGln: 0.72 ± 0.029	1.812PheArg: 1.812 ± 0.043	1.908PheSer: 1.908 ± 0.043	2.033PheThr: 2.033 ± 0.049	2.737PheVal: 2.737 ± 0.058	0.473PheTrp: 0.473 ± 0.024	0.549PheTyr: 0.549 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	12.223GlyAla: 12.223 ± 0.145	0.594GlyCys: 0.594 ± 0.024	5.16GlyAsp: 5.16 ± 0.106	5.628GlyGlu: 5.628 ± 0.075	3.284GlyPhe: 3.284 ± 0.067	8.022GlyGly: 8.022 ± 0.132	1.697GlyHis: 1.697 ± 0.045	4.958GlyIle: 4.958 ± 0.072	1.895GlyLys: 1.895 ± 0.051	8.837GlyLeu: 8.837 ± 0.113	1.959GlyMet: 1.959 ± 0.055	1.594GlyAsn: 1.594 ± 0.04	3.921GlyPro: 3.921 ± 0.067	2.337GlyGln: 2.337 ± 0.057	6.548GlyArg: 6.548 ± 0.084	5.974GlySer: 5.974 ± 0.092	5.109GlyThr: 5.109 ± 0.093	7.932GlyVal: 7.932 ± 0.09	1.559GlyTrp: 1.559 ± 0.039	2.119GlyTyr: 2.119 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.543HisAla: 2.543 ± 0.05	0.136HisCys: 0.136 ± 0.012	1.282HisAsp: 1.282 ± 0.033	1.345HisGlu: 1.345 ± 0.035	0.559HisPhe: 0.559 ± 0.023	2.048HisGly: 2.048 ± 0.052	0.525HisHis: 0.525 ± 0.024	0.685HisIle: 0.685 ± 0.029	0.255HisLys: 0.255 ± 0.015	2.144HisLeu: 2.144 ± 0.048	0.29HisMet: 0.29 ± 0.015	0.323HisAsn: 0.323 ± 0.016	1.559HisPro: 1.559 ± 0.043	0.543HisGln: 0.543 ± 0.025	1.775HisArg: 1.775 ± 0.048	0.979HisSer: 0.979 ± 0.034	1.042HisThr: 1.042 ± 0.036	1.467HisVal: 1.467 ± 0.04	0.304HisTrp: 0.304 ± 0.019	0.43HisTyr: 0.43 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.245IleAla: 7.245 ± 0.101	0.271IleCys: 0.271 ± 0.017	3.407IleAsp: 3.407 ± 0.057	3.242IleGlu: 3.242 ± 0.057	1.119IlePhe: 1.119 ± 0.039	4.704IleGly: 4.704 ± 0.077	0.685IleHis: 0.685 ± 0.027	1.784IleIle: 1.784 ± 0.05	0.717IleLys: 0.717 ± 0.031	3.832IleLeu: 3.832 ± 0.066	0.675IleMet: 0.675 ± 0.026	0.845IleAsn: 0.845 ± 0.033	2.471IlePro: 2.471 ± 0.05	0.916IleGln: 0.916 ± 0.031	2.847IleArg: 2.847 ± 0.049	2.477IleSer: 2.477 ± 0.05	2.767IleThr: 2.767 ± 0.057	4.45IleVal: 4.45 ± 0.07	0.484IleTrp: 0.484 ± 0.023	0.689IleTyr: 0.689 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	1.856LysAla: 1.856 ± 0.052	0.07LysCys: 0.07 ± 0.008	0.879LysAsp: 0.879 ± 0.035	0.822LysGlu: 0.822 ± 0.033	0.469LysPhe: 0.469 ± 0.022	1.251LysGly: 1.251 ± 0.041	0.469LysHis: 0.469 ± 0.024	0.922LysIle: 0.922 ± 0.035	0.701LysLys: 0.701 ± 0.038	1.825LysLeu: 1.825 ± 0.048	0.352LysMet: 0.352 ± 0.02	0.531LysAsn: 0.531 ± 0.024	1.083LysPro: 1.083 ± 0.038	0.73LysGln: 0.73 ± 0.028	1.645LysArg: 1.645 ± 0.05	1.096LysSer: 1.096 ± 0.037	1.172LysThr: 1.172 ± 0.042	1.365LysVal: 1.365 ± 0.041	0.271LysTrp: 0.271 ± 0.017	0.387LysTyr: 0.387 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	14.66LeuAla: 14.66 ± 0.156	0.54LeuCys: 0.54 ± 0.024	6.686LeuAsp: 6.686 ± 0.084	5.65LeuGlu: 5.65 ± 0.081	2.854LeuPhe: 2.854 ± 0.063	9.713LeuGly: 9.713 ± 0.116	1.907LeuHis: 1.907 ± 0.043	4.631LeuIle: 4.631 ± 0.08	1.564LeuLys: 1.564 ± 0.047	10.873LeuLeu: 10.873 ± 0.18	1.752LeuMet: 1.752 ± 0.043	1.781LeuAsn: 1.781 ± 0.045	5.484LeuPro: 5.484 ± 0.078	2.719LeuGln: 2.719 ± 0.059	7.829LeuArg: 7.829 ± 0.118	5.897LeuSer: 5.897 ± 0.081	5.799LeuThr: 5.799 ± 0.071	9.022LeuVal: 9.022 ± 0.115	1.211LeuTrp: 1.211 ± 0.033	1.523LeuTyr: 1.523 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	1.85MetAla: 1.85 ± 0.053	0.089MetCys: 0.089 ± 0.01	0.809MetAsp: 0.809 ± 0.034	0.705MetGlu: 0.705 ± 0.029	0.485MetPhe: 0.485 ± 0.022	1.359MetGly: 1.359 ± 0.038	0.401MetHis: 0.401 ± 0.022	0.943MetIle: 0.943 ± 0.035	0.393MetLys: 0.393 ± 0.022	2.076MetLeu: 2.076 ± 0.047	0.339MetMet: 0.339 ± 0.021	0.541MetAsn: 0.541 ± 0.022	1.092MetPro: 1.092 ± 0.035	0.619MetGln: 0.619 ± 0.024	1.541MetArg: 1.541 ± 0.04	1.521MetSer: 1.521 ± 0.036	1.473MetThr: 1.473 ± 0.039	1.281MetVal: 1.281 ± 0.035	0.21MetTrp: 0.21 ± 0.015	0.305MetTyr: 0.305 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.384AsnAla: 2.384 ± 0.061	0.118AsnCys: 0.118 ± 0.01	1.039AsnAsp: 1.039 ± 0.033	1.034AsnGlu: 1.034 ± 0.036	0.618AsnPhe: 0.618 ± 0.026	1.826AsnGly: 1.826 ± 0.053	0.347AsnHis: 0.347 ± 0.018	0.763AsnIle: 0.763 ± 0.031	0.339AsnLys: 0.339 ± 0.022	1.741AsnLeu: 1.741 ± 0.044	0.308AsnMet: 0.308 ± 0.019	0.41AsnAsn: 0.41 ± 0.019	1.475AsnPro: 1.475 ± 0.04	0.533AsnGln: 0.533 ± 0.027	1.36AsnArg: 1.36 ± 0.038	0.95AsnSer: 0.95 ± 0.031	1.102AsnThr: 1.102 ± 0.04	1.455AsnVal: 1.455 ± 0.041	0.31AsnTrp: 0.31 ± 0.019	0.436AsnTyr: 0.436 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	7.282ProAla: 7.282 ± 0.122	0.2ProCys: 0.2 ± 0.015	3.57ProAsp: 3.57 ± 0.076	4.872ProGlu: 4.872 ± 0.071	1.631ProPhe: 1.631 ± 0.045	5.69ProGly: 5.69 ± 0.089	1.149ProHis: 1.149 ± 0.042	2.173ProIle: 2.173 ± 0.052	0.99ProLys: 0.99 ± 0.035	4.923ProLeu: 4.923 ± 0.069	0.877ProMet: 0.877 ± 0.026	1.068ProAsn: 1.068 ± 0.033	2.298ProPro: 2.298 ± 0.064	1.653ProGln: 1.653 ± 0.041	3.585ProArg: 3.585 ± 0.071	3.07ProSer: 3.07 ± 0.056	2.706ProThr: 2.706 ± 0.053	4.888ProVal: 4.888 ± 0.083	0.759ProTrp: 0.759 ± 0.034	0.986ProTyr: 0.986 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.558GlnAla: 3.558 ± 0.063	0.146GlnCys: 0.146 ± 0.012	1.285GlnAsp: 1.285 ± 0.041	1.573GlnGlu: 1.573 ± 0.044	0.853GlnPhe: 0.853 ± 0.032	2.198GlnGly: 2.198 ± 0.053	0.77GlnHis: 0.77 ± 0.033	1.433GlnIle: 1.433 ± 0.042	0.627GlnLys: 0.627 ± 0.024	3.464GlnLeu: 3.464 ± 0.069	0.556GlnMet: 0.556 ± 0.023	0.632GlnAsn: 0.632 ± 0.025	1.615GlnPro: 1.615 ± 0.046	1.503GlnGln: 1.503 ± 0.05	2.794GlnArg: 2.794 ± 0.055	1.555GlnSer: 1.555 ± 0.039	1.497GlnThr: 1.497 ± 0.042	2.223GlnVal: 2.223 ± 0.044	0.408GlnTrp: 0.408 ± 0.017	0.589GlnTyr: 0.589 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	10.016ArgAla: 10.016 ± 0.146	0.4ArgCys: 0.4 ± 0.022	4.408ArgAsp: 4.408 ± 0.077	5.179ArgGlu: 5.179 ± 0.088	2.645ArgPhe: 2.645 ± 0.06	6.103ArgGly: 6.103 ± 0.089	1.573ArgHis: 1.573 ± 0.045	4.195ArgIle: 4.195 ± 0.063	1.433ArgLys: 1.433 ± 0.045	7.761ArgLeu: 7.761 ± 0.104	1.582ArgMet: 1.582 ± 0.038	1.349ArgAsn: 1.349 ± 0.035	3.889ArgPro: 3.889 ± 0.075	2.021ArgGln: 2.021 ± 0.05	6.885ArgArg: 6.885 ± 0.112	4.566ArgSer: 4.566 ± 0.073	4.281ArgThr: 4.281 ± 0.071	6.423ArgVal: 6.423 ± 0.089	1.148ArgTrp: 1.148 ± 0.031	1.637ArgTyr: 1.637 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	7.37SerAla: 7.37 ± 0.092	0.329SerCys: 0.329 ± 0.02	3.145SerAsp: 3.145 ± 0.057	3.376SerGlu: 3.376 ± 0.063	1.917SerPhe: 1.917 ± 0.044	6.36SerGly: 6.36 ± 0.093	1.041SerHis: 1.041 ± 0.037	2.523SerIle: 2.523 ± 0.045	1.008SerLys: 1.008 ± 0.033	5.337SerLeu: 5.337 ± 0.076	1.167SerMet: 1.167 ± 0.035	1.08SerAsn: 1.08 ± 0.038	3.032SerPro: 3.032 ± 0.055	1.438SerGln: 1.438 ± 0.039	4.093SerArg: 4.093 ± 0.068	3.4SerSer: 3.4 ± 0.072	3.367SerThr: 3.367 ± 0.063	4.529SerVal: 4.529 ± 0.069	0.894SerTrp: 0.894 ± 0.035	1.156SerTyr: 1.156 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	7.392ThrAla: 7.392 ± 0.105	0.274ThrCys: 0.274 ± 0.018	3.009ThrAsp: 3.009 ± 0.06	3.192ThrGlu: 3.192 ± 0.064	1.603ThrPhe: 1.603 ± 0.043	5.7ThrGly: 5.7 ± 0.091	1.106ThrHis: 1.106 ± 0.035	2.613ThrIle: 2.613 ± 0.056	0.99ThrLys: 0.99 ± 0.033	5.581ThrLeu: 5.581 ± 0.078	0.939ThrMet: 0.939 ± 0.032	1.02ThrAsn: 1.02 ± 0.038	3.593ThrPro: 3.593 ± 0.071	1.372ThrGln: 1.372 ± 0.034	3.967ThrArg: 3.967 ± 0.065	3.079ThrSer: 3.079 ± 0.052	3.138ThrThr: 3.138 ± 0.072	5.315ThrVal: 5.315 ± 0.09	0.727ThrTrp: 0.727 ± 0.028	0.925ThrTyr: 0.925 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	11.012ValAla: 11.012 ± 0.13	0.536ValCys: 0.536 ± 0.02	5.089ValAsp: 5.089 ± 0.069	5.066ValGlu: 5.066 ± 0.079	2.955ValPhe: 2.955 ± 0.058	6.598ValGly: 6.598 ± 0.094	1.684ValHis: 1.684 ± 0.036	4.065ValIle: 4.065 ± 0.059	1.365ValLys: 1.365 ± 0.041	9.381ValLeu: 9.381 ± 0.131	1.462ValMet: 1.462 ± 0.039	1.714ValAsn: 1.714 ± 0.049	4.483ValPro: 4.483 ± 0.08	2.369ValGln: 2.369 ± 0.049	6.176ValArg: 6.176 ± 0.09	5.124ValSer: 5.124 ± 0.072	5.025ValThr: 5.025 ± 0.081	7.734ValVal: 7.734 ± 0.1	1.112ValTrp: 1.112 ± 0.034	1.516ValTyr: 1.516 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.594TrpAla: 1.594 ± 0.043	0.115TrpCys: 0.115 ± 0.011	0.697TrpAsp: 0.697 ± 0.026	0.724TrpGlu: 0.724 ± 0.025	0.554TrpPhe: 0.554 ± 0.023	1.056TrpGly: 1.056 ± 0.031	0.334TrpHis: 0.334 ± 0.017	0.726TrpIle: 0.726 ± 0.027	0.274TrpLys: 0.274 ± 0.016	1.572TrpLeu: 1.572 ± 0.045	0.311TrpMet: 0.311 ± 0.017	0.379TrpAsn: 0.379 ± 0.021	0.657TrpPro: 0.657 ± 0.027	0.532TrpGln: 0.532 ± 0.023	1.26TrpArg: 1.26 ± 0.038	0.858TrpSer: 0.858 ± 0.031	0.753TrpThr: 0.753 ± 0.03	1.158TrpVal: 1.158 ± 0.036	0.356TrpTrp: 0.356 ± 0.02	0.266TrpTyr: 0.266 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.405TyrAla: 2.405 ± 0.049	0.142TyrCys: 0.142 ± 0.012	1.271TyrAsp: 1.271 ± 0.035	1.093TyrGlu: 1.093 ± 0.038	0.675TyrPhe: 0.675 ± 0.028	1.799TyrGly: 1.799 ± 0.039	0.322TyrHis: 0.322 ± 0.018	0.612TyrIle: 0.612 ± 0.027	0.281TyrLys: 0.281 ± 0.016	2.031TyrLeu: 2.031 ± 0.048	0.281TyrMet: 0.281 ± 0.018	0.381TyrAsn: 0.381 ± 0.022	0.996TyrPro: 0.996 ± 0.031	0.578TyrGln: 0.578 ± 0.025	1.737TyrArg: 1.737 ± 0.042	0.991TyrSer: 0.991 ± 0.031	1.14TyrThr: 1.14 ± 0.038	1.479TyrVal: 1.479 ± 0.033	0.287TyrTrp: 0.287 ± 0.019	0.406TyrTyr: 0.406 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2978 proteins (1009833 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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