Amino acid dipepetide frequency for Coccidioides immitis (strain RS) (Valley fever fungus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.981AlaAla: 7.981 ± 0.06	1.041AlaCys: 1.041 ± 0.018	3.803AlaAsp: 3.803 ± 0.031	4.979AlaGlu: 4.979 ± 0.044	2.971AlaPhe: 2.971 ± 0.029	5.327AlaGly: 5.327 ± 0.042	1.708AlaHis: 1.708 ± 0.02	4.145AlaIle: 4.145 ± 0.034	4.126AlaLys: 4.126 ± 0.034	7.323AlaLeu: 7.323 ± 0.057	1.793AlaMet: 1.793 ± 0.024	2.854AlaAsn: 2.854 ± 0.028	4.474AlaPro: 4.474 ± 0.04	3.182AlaGln: 3.182 ± 0.029	4.981AlaArg: 4.981 ± 0.04	6.987AlaSer: 6.987 ± 0.048	4.799AlaThr: 4.799 ± 0.029	4.933AlaVal: 4.933 ± 0.036	0.989AlaTrp: 0.989 ± 0.016	1.917AlaTyr: 1.917 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	0.943CysAla: 0.943 ± 0.015	0.295CysCys: 0.295 ± 0.009	0.662CysAsp: 0.662 ± 0.015	0.684CysGlu: 0.684 ± 0.015	0.567CysPhe: 0.567 ± 0.013	0.955CysGly: 0.955 ± 0.015	0.381CysHis: 0.381 ± 0.01	0.728CysIle: 0.728 ± 0.014	0.577CysLys: 0.577 ± 0.012	1.36CysLeu: 1.36 ± 0.023	0.286CysMet: 0.286 ± 0.008	0.448CysAsn: 0.448 ± 0.01	0.756CysPro: 0.756 ± 0.013	0.511CysGln: 0.511 ± 0.012	0.886CysArg: 0.886 ± 0.014	1.049CysSer: 1.049 ± 0.016	0.679CysThr: 0.679 ± 0.012	0.81CysVal: 0.81 ± 0.015	0.211CysTrp: 0.211 ± 0.007	0.37CysTyr: 0.37 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.174AspAla: 4.174 ± 0.037	0.661AspCys: 0.661 ± 0.012	4.049AspAsp: 4.049 ± 0.051	4.305AspGlu: 4.305 ± 0.038	2.112AspPhe: 2.112 ± 0.026	3.826AspGly: 3.826 ± 0.034	1.244AspHis: 1.244 ± 0.021	3.314AspIle: 3.314 ± 0.03	2.394AspLys: 2.394 ± 0.027	4.895AspLeu: 4.895 ± 0.036	1.213AspMet: 1.213 ± 0.02	1.931AspAsn: 1.931 ± 0.023	3.316AspPro: 3.316 ± 0.033	1.832AspGln: 1.832 ± 0.022	3.153AspArg: 3.153 ± 0.035	4.19AspSer: 4.19 ± 0.031	2.803AspThr: 2.803 ± 0.023	3.5AspVal: 3.5 ± 0.031	0.793AspTrp: 0.793 ± 0.014	1.505AspTyr: 1.505 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	5.108GluAla: 5.108 ± 0.039	0.683GluCys: 0.683 ± 0.014	4.116GluAsp: 4.116 ± 0.038	5.592GluGlu: 5.592 ± 0.058	2.063GluPhe: 2.063 ± 0.024	3.603GluGly: 3.603 ± 0.032	1.381GluHis: 1.381 ± 0.019	3.341GluIle: 3.341 ± 0.029	3.985GluLys: 3.985 ± 0.04	5.355GluLeu: 5.355 ± 0.044	1.487GluMet: 1.487 ± 0.021	2.597GluAsn: 2.597 ± 0.025	2.962GluPro: 2.962 ± 0.035	2.529GluGln: 2.529 ± 0.03	4.214GluArg: 4.214 ± 0.038	4.63GluSer: 4.63 ± 0.039	3.368GluThr: 3.368 ± 0.029	3.407GluVal: 3.407 ± 0.031	0.874GluTrp: 0.874 ± 0.016	1.691GluTyr: 1.691 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	2.844PheAla: 2.844 ± 0.029	0.619PheCys: 0.619 ± 0.014	2.195PheAsp: 2.195 ± 0.023	2.188PheGlu: 2.188 ± 0.027	1.576PhePhe: 1.576 ± 0.024	2.699PheGly: 2.699 ± 0.03	0.939PheHis: 0.939 ± 0.016	1.832PheIle: 1.832 ± 0.024	1.583PheLys: 1.583 ± 0.022	3.529PheLeu: 3.529 ± 0.037	0.759PheMet: 0.759 ± 0.014	1.436PheAsn: 1.436 ± 0.019	2.092PhePro: 2.092 ± 0.024	1.444PheGln: 1.444 ± 0.021	2.135PheArg: 2.135 ± 0.022	3.242PheSer: 3.242 ± 0.029	2.09PheThr: 2.09 ± 0.025	2.268PheVal: 2.268 ± 0.026	0.611PheTrp: 0.611 ± 0.015	1.081PheTyr: 1.081 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	4.758GlyAla: 4.758 ± 0.035	0.883GlyCys: 0.883 ± 0.019	3.529GlyAsp: 3.529 ± 0.031	3.69GlyGlu: 3.69 ± 0.038	2.626GlyPhe: 2.626 ± 0.029	5.368GlyGly: 5.368 ± 0.062	1.605GlyHis: 1.605 ± 0.027	3.521GlyIle: 3.521 ± 0.033	3.57GlyLys: 3.57 ± 0.038	5.742GlyLeu: 5.742 ± 0.04	1.543GlyMet: 1.543 ± 0.02	2.531GlyAsn: 2.531 ± 0.026	3.25GlyPro: 3.25 ± 0.032	2.468GlyGln: 2.468 ± 0.025	4.333GlyArg: 4.333 ± 0.038	5.56GlySer: 5.56 ± 0.042	3.69GlyThr: 3.69 ± 0.033	4.088GlyVal: 4.088 ± 0.037	1.101GlyTrp: 1.101 ± 0.02	2.012GlyTyr: 2.012 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	1.826HisAla: 1.826 ± 0.02	0.364HisCys: 0.364 ± 0.01	1.259HisAsp: 1.259 ± 0.016	1.312HisGlu: 1.312 ± 0.016	0.964HisPhe: 0.964 ± 0.014	1.725HisGly: 1.725 ± 0.029	0.864HisHis: 0.864 ± 0.02	1.333HisIle: 1.333 ± 0.019	0.969HisLys: 0.969 ± 0.016	2.306HisLeu: 2.306 ± 0.025	0.489HisMet: 0.489 ± 0.01	0.874HisAsn: 0.874 ± 0.015	1.798HisPro: 1.798 ± 0.026	1.032HisGln: 1.032 ± 0.017	1.727HisArg: 1.727 ± 0.022	2.036HisSer: 2.036 ± 0.025	1.275HisThr: 1.275 ± 0.016	1.387HisVal: 1.387 ± 0.017	0.337HisTrp: 0.337 ± 0.01	0.659HisTyr: 0.659 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	4.02IleAla: 4.02 ± 0.032	0.821IleCys: 0.821 ± 0.016	2.905IleAsp: 2.905 ± 0.028	2.965IleGlu: 2.965 ± 0.029	2.108IlePhe: 2.108 ± 0.027	3.044IleGly: 3.044 ± 0.03	1.301IleHis: 1.301 ± 0.015	2.652IleIle: 2.652 ± 0.031	2.389IleLys: 2.389 ± 0.026	4.892IleLeu: 4.892 ± 0.041	1.047IleMet: 1.047 ± 0.016	1.879IleAsn: 1.879 ± 0.023	3.378IlePro: 3.378 ± 0.031	2.021IleGln: 2.021 ± 0.024	3.093IleArg: 3.093 ± 0.026	4.352IleSer: 4.352 ± 0.034	2.795IleThr: 2.795 ± 0.03	3.074IleVal: 3.074 ± 0.03	0.693IleTrp: 0.693 ± 0.014	1.446IleTyr: 1.446 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	4.239LysAla: 4.239 ± 0.039	0.588LysCys: 0.588 ± 0.014	2.876LysAsp: 2.876 ± 0.029	3.671LysGlu: 3.671 ± 0.043	1.602LysPhe: 1.602 ± 0.019	3.067LysGly: 3.067 ± 0.033	1.194LysHis: 1.194 ± 0.017	2.518LysIle: 2.518 ± 0.029	3.732LysLys: 3.732 ± 0.06	4.391LysLeu: 4.391 ± 0.037	1.091LysMet: 1.091 ± 0.017	1.903LysAsn: 1.903 ± 0.023	2.925LysPro: 2.925 ± 0.032	2.085LysGln: 2.085 ± 0.025	3.874LysArg: 3.874 ± 0.036	3.812LysSer: 3.812 ± 0.039	2.739LysThr: 2.739 ± 0.027	2.857LysVal: 2.857 ± 0.03	0.669LysTrp: 0.669 ± 0.013	1.469LysTyr: 1.469 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	7.33LeuAla: 7.33 ± 0.051	1.291LeuCys: 1.291 ± 0.02	5.13LeuAsp: 5.13 ± 0.039	5.734LeuGlu: 5.734 ± 0.047	3.375LeuPhe: 3.375 ± 0.034	5.685LeuGly: 5.685 ± 0.041	2.354LeuHis: 2.354 ± 0.027	4.07LeuIle: 4.07 ± 0.038	4.534LeuLys: 4.534 ± 0.035	8.468LeuLeu: 8.468 ± 0.064	1.746LeuMet: 1.746 ± 0.019	3.352LeuAsn: 3.352 ± 0.03	5.562LeuPro: 5.562 ± 0.045	3.918LeuGln: 3.918 ± 0.031	6.12LeuArg: 6.12 ± 0.04	7.784LeuSer: 7.784 ± 0.05	4.575LeuThr: 4.575 ± 0.033	5.216LeuVal: 5.216 ± 0.038	1.139LeuTrp: 1.139 ± 0.019	2.317LeuTyr: 2.317 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.179MetAla: 2.179 ± 0.025	0.247MetCys: 0.247 ± 0.008	1.217MetAsp: 1.217 ± 0.016	1.397MetGlu: 1.397 ± 0.018	0.709MetPhe: 0.709 ± 0.015	1.419MetGly: 1.419 ± 0.019	0.486MetHis: 0.486 ± 0.012	1.031MetIle: 1.031 ± 0.019	1.113MetLys: 1.113 ± 0.018	1.823MetLeu: 1.823 ± 0.021	0.548MetMet: 0.548 ± 0.014	0.82MetAsn: 0.82 ± 0.014	1.209MetPro: 1.209 ± 0.018	0.828MetGln: 0.828 ± 0.016	1.275MetArg: 1.275 ± 0.02	1.804MetSer: 1.804 ± 0.02	1.217MetThr: 1.217 ± 0.017	1.284MetVal: 1.284 ± 0.018	0.258MetTrp: 0.258 ± 0.008	0.5MetTyr: 0.5 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.012AsnAla: 3.012 ± 0.028	0.502AsnCys: 0.502 ± 0.012	1.972AsnAsp: 1.972 ± 0.021	2.143AsnGlu: 2.143 ± 0.023	1.396AsnPhe: 1.396 ± 0.019	2.889AsnGly: 2.889 ± 0.033	0.917AsnHis: 0.917 ± 0.015	2.24AsnIle: 2.24 ± 0.024	1.72AsnLys: 1.72 ± 0.022	3.366AsnLeu: 3.366 ± 0.027	0.855AsnMet: 0.855 ± 0.018	1.6AsnAsn: 1.6 ± 0.025	2.646AsnPro: 2.646 ± 0.027	1.415AsnGln: 1.415 ± 0.022	2.192AsnArg: 2.192 ± 0.022	2.904AsnSer: 2.904 ± 0.031	2.13AsnThr: 2.13 ± 0.025	2.297AsnVal: 2.297 ± 0.021	0.538AsnTrp: 0.538 ± 0.012	1.021AsnTyr: 1.021 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	4.997ProAla: 4.997 ± 0.043	0.634ProCys: 0.634 ± 0.013	3.142ProAsp: 3.142 ± 0.03	3.961ProGlu: 3.961 ± 0.035	2.175ProPhe: 2.175 ± 0.023	3.96ProGly: 3.96 ± 0.037	1.45ProHis: 1.45 ± 0.021	2.672ProIle: 2.672 ± 0.029	2.862ProLys: 2.862 ± 0.029	4.909ProLeu: 4.909 ± 0.039	1.074ProMet: 1.074 ± 0.016	2.34ProAsn: 2.34 ± 0.027	5.76ProPro: 5.76 ± 0.092	2.563ProGln: 2.563 ± 0.034	3.682ProArg: 3.682 ± 0.038	6.476ProSer: 6.476 ± 0.055	3.979ProThr: 3.979 ± 0.038	3.606ProVal: 3.606 ± 0.036	0.719ProTrp: 0.719 ± 0.014	1.537ProTyr: 1.537 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.265GlnAla: 3.265 ± 0.032	0.486GlnCys: 0.486 ± 0.012	1.988GlnAsp: 1.988 ± 0.022	2.479GlnGlu: 2.479 ± 0.028	1.35GlnPhe: 1.35 ± 0.019	2.4GlnGly: 2.4 ± 0.022	1.113GlnHis: 1.113 ± 0.016	1.934GlnIle: 1.934 ± 0.022	2.195GlnLys: 2.195 ± 0.025	3.499GlnLeu: 3.499 ± 0.033	0.886GlnMet: 0.886 ± 0.016	1.701GlnAsn: 1.701 ± 0.021	2.728GlnPro: 2.728 ± 0.038	2.378GlnGln: 2.378 ± 0.041	2.825GlnArg: 2.825 ± 0.03	3.317GlnSer: 3.317 ± 0.032	2.205GlnThr: 2.205 ± 0.022	2.064GlnVal: 2.064 ± 0.023	0.497GlnTrp: 0.497 ± 0.012	1.095GlnTyr: 1.095 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.811ArgAla: 4.811 ± 0.033	0.843ArgCys: 0.843 ± 0.017	3.491ArgAsp: 3.491 ± 0.034	4.218ArgGlu: 4.218 ± 0.039	2.265ArgPhe: 2.265 ± 0.027	3.954ArgGly: 3.954 ± 0.042	1.71ArgHis: 1.71 ± 0.022	3.196ArgIle: 3.196 ± 0.03	3.825ArgLys: 3.825 ± 0.033	5.758ArgLeu: 5.758 ± 0.043	1.41ArgMet: 1.41 ± 0.02	2.482ArgAsn: 2.482 ± 0.026	3.86ArgPro: 3.86 ± 0.036	2.774ArgGln: 2.774 ± 0.028	5.801ArgArg: 5.801 ± 0.049	5.409ArgSer: 5.409 ± 0.048	3.459ArgThr: 3.459 ± 0.031	3.519ArgVal: 3.519 ± 0.03	0.94ArgTrp: 0.94 ± 0.014	1.721ArgTyr: 1.721 ± 0.023	0.0ArgXaa: 0.0 ± 0.0
Ser	6.554SerAla: 6.554 ± 0.044	0.962SerCys: 0.962 ± 0.017	4.201SerAsp: 4.201 ± 0.035	4.43SerGlu: 4.43 ± 0.037	3.145SerPhe: 3.145 ± 0.03	5.582SerGly: 5.582 ± 0.044	2.145SerHis: 2.145 ± 0.024	4.206SerIle: 4.206 ± 0.036	4.128SerLys: 4.128 ± 0.039	7.718SerLeu: 7.718 ± 0.052	1.791SerMet: 1.791 ± 0.02	3.163SerAsn: 3.163 ± 0.033	5.939SerPro: 5.939 ± 0.058	3.561SerGln: 3.561 ± 0.038	5.748SerArg: 5.748 ± 0.046	9.439SerSer: 9.439 ± 0.088	5.616SerThr: 5.616 ± 0.053	4.567SerVal: 4.567 ± 0.036	1.051SerTrp: 1.051 ± 0.016	2.025SerTyr: 2.025 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	4.635ThrAla: 4.635 ± 0.037	0.747ThrCys: 0.747 ± 0.013	2.713ThrAsp: 2.713 ± 0.023	3.089ThrGlu: 3.089 ± 0.026	2.139ThrPhe: 2.139 ± 0.023	3.959ThrGly: 3.959 ± 0.034	1.297ThrHis: 1.297 ± 0.017	2.99ThrIle: 2.99 ± 0.029	2.686ThrLys: 2.686 ± 0.03	5.061ThrLeu: 5.061 ± 0.039	1.154ThrMet: 1.154 ± 0.017	1.998ThrAsn: 1.998 ± 0.02	4.223ThrPro: 4.223 ± 0.045	2.004ThrGln: 2.004 ± 0.025	3.271ThrArg: 3.271 ± 0.031	5.234ThrSer: 5.234 ± 0.046	3.805ThrThr: 3.805 ± 0.038	3.446ThrVal: 3.446 ± 0.03	0.751ThrTrp: 0.751 ± 0.014	1.444ThrTyr: 1.444 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	4.691ValAla: 4.691 ± 0.031	0.843ValCys: 0.843 ± 0.018	3.574ValAsp: 3.574 ± 0.032	3.822ValGlu: 3.822 ± 0.031	2.319ValPhe: 2.319 ± 0.027	3.679ValGly: 3.679 ± 0.035	1.36ValHis: 1.36 ± 0.018	2.936ValIle: 2.936 ± 0.029	2.992ValLys: 2.992 ± 0.029	5.375ValLeu: 5.375 ± 0.038	1.242ValMet: 1.242 ± 0.015	2.207ValAsn: 2.207 ± 0.025	3.535ValPro: 3.535 ± 0.03	2.264ValGln: 2.264 ± 0.026	3.486ValArg: 3.486 ± 0.03	4.694ValSer: 4.694 ± 0.036	3.214ValThr: 3.214 ± 0.033	3.914ValVal: 3.914 ± 0.038	0.799ValTrp: 0.799 ± 0.016	1.598ValTyr: 1.598 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.035TrpAla: 1.035 ± 0.017	0.211TrpCys: 0.211 ± 0.007	0.84TrpAsp: 0.84 ± 0.016	0.834TrpGlu: 0.834 ± 0.015	0.505TrpPhe: 0.505 ± 0.012	0.822TrpGly: 0.822 ± 0.015	0.333TrpHis: 0.333 ± 0.009	0.734TrpIle: 0.734 ± 0.013	0.797TrpLys: 0.797 ± 0.012	1.279TrpLeu: 1.279 ± 0.017	0.359TrpMet: 0.359 ± 0.01	0.621TrpAsn: 0.621 ± 0.014	0.589TrpPro: 0.589 ± 0.014	0.528TrpGln: 0.528 ± 0.011	0.966TrpArg: 0.966 ± 0.015	0.978TrpSer: 0.978 ± 0.018	0.778TrpThr: 0.778 ± 0.014	0.787TrpVal: 0.787 ± 0.014	0.254TrpTrp: 0.254 ± 0.008	0.369TrpTyr: 0.369 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.91TyrAla: 1.91 ± 0.024	0.438TyrCys: 0.438 ± 0.012	1.55TyrAsp: 1.55 ± 0.02	1.491TyrGlu: 1.491 ± 0.02	1.194TyrPhe: 1.194 ± 0.019	1.905TyrGly: 1.905 ± 0.024	0.751TyrHis: 0.751 ± 0.013	1.481TyrIle: 1.481 ± 0.02	1.125TyrLys: 1.125 ± 0.017	2.648TyrLeu: 2.648 ± 0.03	0.589TyrMet: 0.589 ± 0.012	1.021TyrAsn: 1.021 ± 0.014	1.498TyrPro: 1.498 ± 0.02	1.07TyrGln: 1.07 ± 0.02	1.684TyrArg: 1.684 ± 0.021	2.072TyrSer: 2.072 ± 0.023	1.432TyrThr: 1.432 ± 0.022	1.522TyrVal: 1.522 ± 0.021	0.393TyrTrp: 0.393 ± 0.011	0.868TyrTyr: 0.868 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9712 proteins (4213409 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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