Amino acid dipepetide frequency for Torque teno midi virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.167AlaAla: 9.167 ± 2.67
0.0AlaCys: 0.0 ± 0.0
6.112AlaAsp: 6.112 ± 2.55
0.0AlaGlu: 0.0 ± 0.0
2.292AlaPhe: 2.292 ± 0.809
4.584AlaGly: 4.584 ± 1.335
4.584AlaHis: 4.584 ± 1.335
1.528AlaIle: 1.528 ± 0.931
4.584AlaLys: 4.584 ± 1.25
5.348AlaLeu: 5.348 ± 1.928
0.0AlaMet: 0.0 ± 0.0
0.764AlaAsn: 0.764 ± 0.831
2.292AlaPro: 2.292 ± 0.809
1.528AlaGln: 1.528 ± 0.614
0.0AlaArg: 0.0 ± 0.0
9.167AlaSer: 9.167 ± 1.274
3.056AlaThr: 3.056 ± 1.351
2.292AlaVal: 2.292 ± 1.699
0.0AlaTrp: 0.0 ± 0.0
0.0AlaTyr: 0.0 ± 0.0
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.764CysCys: 0.764 ± 0.465
2.292CysAsp: 2.292 ± 1.699
0.764CysGlu: 0.764 ± 0.465
0.764CysPhe: 0.764 ± 0.465
0.0CysGly: 0.0 ± 0.0
0.764CysHis: 0.764 ± 0.465
0.764CysIle: 0.764 ± 0.747
1.528CysLys: 1.528 ± 0.931
3.056CysLeu: 3.056 ± 1.275
1.528CysMet: 1.528 ± 0.614
2.292CysAsn: 2.292 ± 1.699
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.764CysArg: 0.764 ± 0.465
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.764CysTyr: 0.764 ± 0.465
0.0CysXaa: 0.0 ± 0.0
Asp
3.056AspAla: 3.056 ± 1.275
0.0AspCys: 0.0 ± 0.0
0.0AspAsp: 0.0 ± 0.0
3.056AspGlu: 3.056 ± 1.275
9.167AspPhe: 9.167 ± 3.825
6.875AspGly: 6.875 ± 3.676
0.0AspHis: 0.0 ± 0.0
3.82AspIle: 3.82 ± 2.326
2.292AspLys: 2.292 ± 1.396
5.348AspLeu: 5.348 ± 2.967
0.0AspMet: 0.0 ± 0.0
3.056AspAsn: 3.056 ± 1.275
2.292AspPro: 2.292 ± 0.733
0.764AspGln: 0.764 ± 0.465
3.056AspArg: 3.056 ± 1.275
7.639AspSer: 7.639 ± 1.788
4.584AspThr: 4.584 ± 0.637
3.056AspVal: 3.056 ± 1.861
0.0AspTrp: 0.0 ± 0.0
0.0AspTyr: 0.0 ± 0.0
0.0AspXaa: 0.0 ± 0.0
Glu
0.764GluAla: 0.764 ± 0.465
0.764GluCys: 0.764 ± 0.747
6.112GluAsp: 6.112 ± 3.381
7.639GluGlu: 7.639 ± 1.788
0.0GluPhe: 0.0 ± 0.0
0.0GluGly: 0.0 ± 0.0
0.764GluHis: 0.764 ± 0.747
1.528GluIle: 1.528 ± 0.931
3.056GluLys: 3.056 ± 2.108
4.584GluLeu: 4.584 ± 2.251
0.0GluMet: 0.0 ± 0.0
3.82GluAsn: 3.82 ± 1.417
0.764GluPro: 0.764 ± 0.831
1.528GluGln: 1.528 ± 0.931
2.292GluArg: 2.292 ± 1.442
3.82GluSer: 3.82 ± 0.894
3.82GluThr: 3.82 ± 1.417
3.82GluVal: 3.82 ± 0.894
0.0GluTrp: 0.0 ± 0.0
0.764GluTyr: 0.764 ± 0.465
0.0GluXaa: 0.0 ± 0.0
Phe
2.292PheAla: 2.292 ± 1.699
0.0PheCys: 0.0 ± 0.0
0.0PheAsp: 0.0 ± 0.0
1.528PheGlu: 1.528 ± 0.676
0.764PhePhe: 0.764 ± 0.465
1.528PheGly: 1.528 ± 0.931
0.764PheHis: 0.764 ± 0.831
2.292PheIle: 2.292 ± 1.396
3.82PheLys: 3.82 ± 2.093
0.764PheLeu: 0.764 ± 0.465
0.764PheMet: 0.764 ± 0.715
0.0PheAsn: 0.0 ± 0.0
4.584PhePro: 4.584 ± 3.397
2.292PheGln: 2.292 ± 1.396
3.82PheArg: 3.82 ± 0.894
3.056PheSer: 3.056 ± 1.134
5.348PheThr: 5.348 ± 3.257
1.528PheVal: 1.528 ± 0.931
2.292PheTrp: 2.292 ± 1.396
6.875PheTyr: 6.875 ± 0.74
0.0PheXaa: 0.0 ± 0.0
Gly
3.056GlyAla: 3.056 ± 1.275
1.528GlyCys: 1.528 ± 0.931
0.0GlyAsp: 0.0 ± 0.0
3.82GlyGlu: 3.82 ± 2.5
2.292GlyPhe: 2.292 ± 0.809
7.639GlyGly: 7.639 ± 1.788
3.056GlyHis: 3.056 ± 2.184
1.528GlyIle: 1.528 ± 0.931
5.348GlyLys: 5.348 ± 0.667
3.056GlyLeu: 3.056 ± 1.275
1.528GlyMet: 1.528 ± 0.614
3.056GlyAsn: 3.056 ± 1.861
2.292GlyPro: 2.292 ± 1.396
3.056GlyGln: 3.056 ± 1.275
3.056GlyArg: 3.056 ± 1.134
0.0GlySer: 0.0 ± 0.0
1.528GlyThr: 1.528 ± 0.614
1.528GlyVal: 1.528 ± 0.614
0.764GlyTrp: 0.764 ± 0.465
0.764GlyTyr: 0.764 ± 0.465
0.0GlyXaa: 0.0 ± 0.0
His
0.764HisAla: 0.764 ± 0.465
0.0HisCys: 0.0 ± 0.0
3.056HisAsp: 3.056 ± 1.275
0.0HisGlu: 0.0 ± 0.0
0.0HisPhe: 0.0 ± 0.0
0.764HisGly: 0.764 ± 0.465
0.0HisHis: 0.0 ± 0.0
0.764HisIle: 0.764 ± 0.465
3.056HisLys: 3.056 ± 1.275
3.056HisLeu: 3.056 ± 2.184
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
4.584HisPro: 4.584 ± 1.619
1.528HisGln: 1.528 ± 0.676
2.292HisArg: 2.292 ± 0.733
2.292HisSer: 2.292 ± 0.793
1.528HisThr: 1.528 ± 0.931
2.292HisVal: 2.292 ± 0.733
0.764HisTrp: 0.764 ± 0.465
0.764HisTyr: 0.764 ± 0.465
0.0HisXaa: 0.0 ± 0.0
Ile
1.528IleAla: 1.528 ± 0.614
0.0IleCys: 0.0 ± 0.0
3.056IleAsp: 3.056 ± 1.861
1.528IleGlu: 1.528 ± 0.931
3.82IlePhe: 3.82 ± 0.894
1.528IleGly: 1.528 ± 0.931
1.528IleHis: 1.528 ± 0.931
5.348IleIle: 5.348 ± 3.257
3.82IleLys: 3.82 ± 0.755
5.348IleLeu: 5.348 ± 0.667
0.764IleMet: 0.764 ± 0.465
7.639IleAsn: 7.639 ± 1.191
3.82IlePro: 3.82 ± 1.559
0.764IleGln: 0.764 ± 0.747
3.056IleArg: 3.056 ± 1.861
4.584IleSer: 4.584 ± 1.25
4.584IleThr: 4.584 ± 1.962
0.0IleVal: 0.0 ± 0.0
4.584IleTrp: 4.584 ± 0.637
1.528IleTyr: 1.528 ± 0.931
0.0IleXaa: 0.0 ± 0.0
Lys
4.584LysAla: 4.584 ± 1.995
3.056LysCys: 3.056 ± 1.275
10.695LysAsp: 10.695 ± 6.745
3.82LysGlu: 3.82 ± 2.012
2.292LysPhe: 2.292 ± 0.809
2.292LysGly: 2.292 ± 1.396
3.056LysHis: 3.056 ± 0.581
5.348LysIle: 5.348 ± 1.528
6.112LysLys: 6.112 ± 2.456
4.584LysLeu: 4.584 ± 0.986
0.0LysMet: 0.0 ± 0.0
3.056LysAsn: 3.056 ± 2.108
7.639LysPro: 7.639 ± 1.249
5.348LysGln: 5.348 ± 2.442
8.403LysArg: 8.403 ± 3.55
0.764LysSer: 0.764 ± 0.747
1.528LysThr: 1.528 ± 1.495
1.528LysVal: 1.528 ± 0.931
1.528LysTrp: 1.528 ± 0.931
4.584LysTyr: 4.584 ± 1.335
0.0LysXaa: 0.0 ± 0.0
Leu
11.459LeuAla: 11.459 ± 7.041
2.292LeuCys: 2.292 ± 1.396
3.82LeuAsp: 3.82 ± 2.326
2.292LeuGlu: 2.292 ± 1.699
1.528LeuPhe: 1.528 ± 0.931
3.056LeuGly: 3.056 ± 1.146
2.292LeuHis: 2.292 ± 1.396
3.82LeuIle: 3.82 ± 1.559
3.82LeuLys: 3.82 ± 1.559
10.695LeuLeu: 10.695 ± 1.756
0.0LeuMet: 0.0 ± 0.0
3.82LeuAsn: 3.82 ± 1.533
5.348LeuPro: 5.348 ± 2.622
9.167LeuGln: 9.167 ± 2.429
2.292LeuArg: 2.292 ± 0.809
9.931LeuSer: 9.931 ± 2.11
0.764LeuThr: 0.764 ± 0.831
3.82LeuVal: 3.82 ± 1.533
0.0LeuTrp: 0.0 ± 0.0
0.764LeuTyr: 0.764 ± 0.465
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
0.0MetCys: 0.0 ± 0.0
0.0MetAsp: 0.0 ± 0.0
0.0MetGlu: 0.0 ± 0.0
0.764MetPhe: 0.764 ± 0.831
0.0MetGly: 0.0 ± 0.0
0.764MetHis: 0.764 ± 0.465
0.764MetIle: 0.764 ± 0.465
1.528MetLys: 1.528 ± 0.614
1.528MetLeu: 1.528 ± 0.931
0.764MetMet: 0.764 ± 0.747
0.0MetAsn: 0.0 ± 0.0
3.056MetPro: 3.056 ± 1.146
3.056MetGln: 3.056 ± 2.108
0.0MetArg: 0.0 ± 0.0
1.528MetSer: 1.528 ± 1.081
0.0MetThr: 0.0 ± 0.0
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
0.764MetTyr: 0.764 ± 0.465
0.0MetXaa: 0.0 ± 0.0
Asn
1.528AsnAla: 1.528 ± 1.663
2.292AsnCys: 2.292 ± 1.699
0.0AsnAsp: 0.0 ± 0.0
0.764AsnGlu: 0.764 ± 0.831
2.292AsnPhe: 2.292 ± 1.442
1.528AsnGly: 1.528 ± 0.931
0.0AsnHis: 0.0 ± 0.0
6.875AsnIle: 6.875 ± 0.74
2.292AsnLys: 2.292 ± 0.793
5.348AsnLeu: 5.348 ± 3.257
2.292AsnMet: 2.292 ± 0.638
1.528AsnAsn: 1.528 ± 0.614
3.82AsnPro: 3.82 ± 1.559
9.167AsnGln: 9.167 ± 3.267
1.528AsnArg: 1.528 ± 0.614
3.82AsnSer: 3.82 ± 1.34
3.82AsnThr: 3.82 ± 1.749
0.0AsnVal: 0.0 ± 0.0
3.056AsnTrp: 3.056 ± 1.275
0.764AsnTyr: 0.764 ± 0.465
0.0AsnXaa: 0.0 ± 0.0
Pro
4.584ProAla: 4.584 ± 1.619
0.764ProCys: 0.764 ± 0.465
3.056ProAsp: 3.056 ± 1.861
1.528ProGlu: 1.528 ± 0.676
4.584ProPhe: 4.584 ± 1.335
4.584ProGly: 4.584 ± 1.25
0.764ProHis: 0.764 ± 0.465
3.056ProIle: 3.056 ± 1.861
6.112ProLys: 6.112 ± 1.44
3.056ProLeu: 3.056 ± 1.134
0.0ProMet: 0.0 ± 0.0
2.292ProAsn: 2.292 ± 0.809
9.931ProPro: 9.931 ± 2.614
4.584ProGln: 4.584 ± 1.586
5.348ProArg: 5.348 ± 3.174
2.292ProSer: 2.292 ± 1.287
4.584ProThr: 4.584 ± 1.335
1.528ProVal: 1.528 ± 0.931
2.292ProTrp: 2.292 ± 0.809
5.348ProTyr: 5.348 ± 0.878
0.0ProXaa: 0.0 ± 0.0
Gln
0.764GlnAla: 0.764 ± 0.747
0.0GlnCys: 0.0 ± 0.0
0.764GlnAsp: 0.764 ± 0.465
4.584GlnGlu: 4.584 ± 2.792
2.292GlnPhe: 2.292 ± 1.396
0.764GlnGly: 0.764 ± 0.465
3.056GlnHis: 3.056 ± 1.134
7.639GlnIle: 7.639 ± 3.339
6.112GlnLys: 6.112 ± 3.312
6.112GlnLeu: 6.112 ± 3.107
1.528GlnMet: 1.528 ± 0.931
5.348GlnAsn: 5.348 ± 1.856
4.584GlnPro: 4.584 ± 1.995
9.167GlnGln: 9.167 ± 4.73
3.056GlnArg: 3.056 ± 1.275
0.764GlnSer: 0.764 ± 0.831
4.584GlnThr: 4.584 ± 1.586
0.764GlnVal: 0.764 ± 0.831
0.764GlnTrp: 0.764 ± 0.465
2.292GlnTyr: 2.292 ± 0.793
0.0GlnXaa: 0.0 ± 0.0
Arg
2.292ArgAla: 2.292 ± 1.396
0.0ArgCys: 0.0 ± 0.0
5.348ArgAsp: 5.348 ± 2.967
1.528ArgGlu: 1.528 ± 1.081
4.584ArgPhe: 4.584 ± 1.962
2.292ArgGly: 2.292 ± 0.809
1.528ArgHis: 1.528 ± 0.614
0.764ArgIle: 0.764 ± 0.465
7.639ArgLys: 7.639 ± 2.161
2.292ArgLeu: 2.292 ± 0.793
2.292ArgMet: 2.292 ± 1.04
3.82ArgAsn: 3.82 ± 1.417
0.764ArgPro: 0.764 ± 0.831
3.82ArgGln: 3.82 ± 1.669
13.751ArgArg: 13.751 ± 6.557
0.0ArgSer: 0.0 ± 0.0
8.403ArgThr: 8.403 ± 3.72
1.528ArgVal: 1.528 ± 0.931
0.764ArgTrp: 0.764 ± 0.465
1.528ArgTyr: 1.528 ± 0.931
0.0ArgXaa: 0.0 ± 0.0
Ser
5.348SerAla: 5.348 ± 0.878
0.764SerCys: 0.764 ± 0.747
2.292SerAsp: 2.292 ± 0.793
0.764SerGlu: 0.764 ± 0.465
2.292SerPhe: 2.292 ± 1.396
5.348SerGly: 5.348 ± 3.755
2.292SerHis: 2.292 ± 1.699
6.112SerIle: 6.112 ± 1.501
9.167SerLys: 9.167 ± 3.171
3.056SerLeu: 3.056 ± 1.861
0.764SerMet: 0.764 ± 0.627
2.292SerAsn: 2.292 ± 1.287
3.056SerPro: 3.056 ± 1.351
3.056SerGln: 3.056 ± 1.275
3.82SerArg: 3.82 ± 2.5
7.639SerSer: 7.639 ± 6.725
3.82SerThr: 3.82 ± 1.34
0.764SerVal: 0.764 ± 0.465
0.0SerTrp: 0.0 ± 0.0
5.348SerTyr: 5.348 ± 0.667
0.0SerXaa: 0.0 ± 0.0
Thr
3.82ThrAla: 3.82 ± 1.417
0.764ThrCys: 0.764 ± 0.465
7.639ThrAsp: 7.639 ± 1.788
3.82ThrGlu: 3.82 ± 1.749
2.292ThrPhe: 2.292 ± 1.396
3.82ThrGly: 3.82 ± 1.533
2.292ThrHis: 2.292 ± 0.809
6.112ThrIle: 6.112 ± 0.725
5.348ThrLys: 5.348 ± 1.57
2.292ThrLeu: 2.292 ± 0.809
0.0ThrMet: 0.0 ± 0.0
2.292ThrAsn: 2.292 ± 0.809
5.348ThrPro: 5.348 ± 0.878
1.528ThrGln: 1.528 ± 0.614
4.584ThrArg: 4.584 ± 1.335
4.584ThrSer: 4.584 ± 2.573
3.82ThrThr: 3.82 ± 1.195
1.528ThrVal: 1.528 ± 0.931
0.764ThrTrp: 0.764 ± 0.465
1.528ThrTyr: 1.528 ± 0.614
0.0ThrXaa: 0.0 ± 0.0
Val
1.528ValAla: 1.528 ± 0.931
0.764ValCys: 0.764 ± 0.465
0.764ValAsp: 0.764 ± 0.747
6.112ValGlu: 6.112 ± 3.381
0.0ValPhe: 0.0 ± 0.0
0.764ValGly: 0.764 ± 0.465
0.0ValHis: 0.0 ± 0.0
0.764ValIle: 0.764 ± 0.465
1.528ValLys: 1.528 ± 0.931
2.292ValLeu: 2.292 ± 1.396
0.0ValMet: 0.0 ± 0.0
1.528ValAsn: 1.528 ± 0.676
1.528ValPro: 1.528 ± 0.931
2.292ValGln: 2.292 ± 0.809
2.292ValArg: 2.292 ± 1.396
2.292ValSer: 2.292 ± 0.793
2.292ValThr: 2.292 ± 1.396
0.764ValVal: 0.764 ± 0.465
0.0ValTrp: 0.0 ± 0.0
0.764ValTyr: 0.764 ± 0.465
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
2.292TrpCys: 2.292 ± 1.699
1.528TrpAsp: 1.528 ± 0.931
0.764TrpGlu: 0.764 ± 0.465
0.764TrpPhe: 0.764 ± 0.465
1.528TrpGly: 1.528 ± 0.931
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
5.348TrpLeu: 5.348 ± 0.968
0.764TrpMet: 0.764 ± 0.465
0.0TrpAsn: 0.0 ± 0.0
2.292TrpPro: 2.292 ± 1.396
0.764TrpGln: 0.764 ± 0.465
0.0TrpArg: 0.0 ± 0.0
0.764TrpSer: 0.764 ± 0.465
0.764TrpThr: 0.764 ± 0.465
0.0TrpVal: 0.0 ± 0.0
1.528TrpTrp: 1.528 ± 0.931
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.764TyrAla: 0.764 ± 0.465
0.0TyrCys: 0.0 ± 0.0
1.528TyrAsp: 1.528 ± 0.931
1.528TyrGlu: 1.528 ± 0.931
1.528TyrPhe: 1.528 ± 0.931
0.0TyrGly: 0.0 ± 0.0
0.0TyrHis: 0.0 ± 0.0
0.0TyrIle: 0.0 ± 0.0
3.056TyrLys: 3.056 ± 2.108
3.82TyrLeu: 3.82 ± 1.533
0.764TyrMet: 0.764 ± 0.747
6.875TyrAsn: 6.875 ± 1.35
2.292TyrPro: 2.292 ± 0.809
1.528TyrGln: 1.528 ± 0.931
1.528TyrArg: 1.528 ± 0.931
3.056TyrSer: 3.056 ± 1.146
5.348TyrThr: 5.348 ± 2.967
1.528TyrVal: 1.528 ± 0.931
0.0TyrTrp: 0.0 ± 0.0
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1310 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski