Amino acid dipepetide frequency for Methylocystis sp. (strain SC2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.738AlaAla: 18.738 ± 0.199	1.239AlaCys: 1.239 ± 0.039	6.673AlaAsp: 6.673 ± 0.078	7.802AlaGlu: 7.802 ± 0.087	5.033AlaPhe: 5.033 ± 0.067	9.755AlaGly: 9.755 ± 0.1	2.669AlaHis: 2.669 ± 0.05	6.627AlaIle: 6.627 ± 0.077	4.685AlaLys: 4.685 ± 0.064	15.116AlaLeu: 15.116 ± 0.138	3.199AlaMet: 3.199 ± 0.048	3.127AlaAsn: 3.127 ± 0.061	7.837AlaPro: 7.837 ± 0.103	4.723AlaGln: 4.723 ± 0.067	11.278AlaArg: 11.278 ± 0.134	7.028AlaSer: 7.028 ± 0.09	6.26AlaThr: 6.26 ± 0.07	7.873AlaVal: 7.873 ± 0.096	1.489AlaTrp: 1.489 ± 0.038	2.771AlaTyr: 2.771 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	1.476CysAla: 1.476 ± 0.039	0.163CysCys: 0.163 ± 0.012	0.595CysAsp: 0.595 ± 0.021	0.573CysGlu: 0.573 ± 0.019	0.36CysPhe: 0.36 ± 0.017	1.037CysGly: 1.037 ± 0.031	0.27CysHis: 0.27 ± 0.02	0.359CysIle: 0.359 ± 0.018	0.239CysLys: 0.239 ± 0.015	0.781CysLeu: 0.781 ± 0.026	0.177CysMet: 0.177 ± 0.012	0.232CysAsn: 0.232 ± 0.015	0.54CysPro: 0.54 ± 0.023	0.231CysGln: 0.231 ± 0.013	0.7CysArg: 0.7 ± 0.026	0.514CysSer: 0.514 ± 0.024	0.307CysThr: 0.307 ± 0.017	0.819CysVal: 0.819 ± 0.023	0.126CysTrp: 0.126 ± 0.01	0.214CysTyr: 0.214 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.072AspAla: 8.072 ± 0.097	0.581AspCys: 0.581 ± 0.023	3.254AspAsp: 3.254 ± 0.054	3.584AspGlu: 3.584 ± 0.059	2.369AspPhe: 2.369 ± 0.049	4.833AspGly: 4.833 ± 0.082	1.167AspHis: 1.167 ± 0.034	2.808AspIle: 2.808 ± 0.051	1.828AspLys: 1.828 ± 0.042	5.669AspLeu: 5.669 ± 0.073	1.201AspMet: 1.201 ± 0.03	1.204AspAsn: 1.204 ± 0.032	3.329AspPro: 3.329 ± 0.056	1.503AspGln: 1.503 ± 0.037	4.142AspArg: 4.142 ± 0.061	2.396AspSer: 2.396 ± 0.05	1.88AspThr: 1.88 ± 0.045	4.265AspVal: 4.265 ± 0.065	0.974AspTrp: 0.974 ± 0.027	1.541AspTyr: 1.541 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	8.15GluAla: 8.15 ± 0.114	0.443GluCys: 0.443 ± 0.022	2.759GluAsp: 2.759 ± 0.052	3.412GluGlu: 3.412 ± 0.067	1.997GluPhe: 1.997 ± 0.041	4.243GluGly: 4.243 ± 0.063	1.225GluHis: 1.225 ± 0.033	3.632GluIle: 3.632 ± 0.055	2.59GluLys: 2.59 ± 0.05	5.457GluLeu: 5.457 ± 0.071	1.422GluMet: 1.422 ± 0.034	1.706GluAsn: 1.706 ± 0.04	2.665GluPro: 2.665 ± 0.054	2.014GluGln: 2.014 ± 0.041	5.766GluArg: 5.766 ± 0.085	2.991GluSer: 2.991 ± 0.055	3.685GluThr: 3.685 ± 0.058	3.203GluVal: 3.203 ± 0.062	0.742GluTrp: 0.742 ± 0.028	0.958GluTyr: 0.958 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	5.223PheAla: 5.223 ± 0.075	0.488PheCys: 0.488 ± 0.021	2.872PheAsp: 2.872 ± 0.054	2.424PheGlu: 2.424 ± 0.051	1.634PhePhe: 1.634 ± 0.042	3.65PheGly: 3.65 ± 0.054	0.799PheHis: 0.799 ± 0.023	1.79PheIle: 1.79 ± 0.04	1.121PheLys: 1.121 ± 0.031	3.678PheLeu: 3.678 ± 0.062	0.756PheMet: 0.756 ± 0.027	1.069PheAsn: 1.069 ± 0.032	1.644PhePro: 1.644 ± 0.038	0.973PheGln: 0.973 ± 0.023	2.432PheArg: 2.432 ± 0.043	2.463PheSer: 2.463 ± 0.053	1.879PheThr: 1.879 ± 0.039	3.036PheVal: 3.036 ± 0.047	0.577PheTrp: 0.577 ± 0.024	0.988PheTyr: 0.988 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	11.427GlyAla: 11.427 ± 0.12	0.884GlyCys: 0.884 ± 0.029	4.574GlyAsp: 4.574 ± 0.073	4.886GlyGlu: 4.886 ± 0.075	3.681GlyPhe: 3.681 ± 0.059	7.122GlyGly: 7.122 ± 0.144	1.668GlyHis: 1.668 ± 0.044	2.726GlyIle: 2.726 ± 0.052	3.184GlyLys: 3.184 ± 0.061	8.08GlyLeu: 8.08 ± 0.086	1.826GlyMet: 1.826 ± 0.046	1.628GlyAsn: 1.628 ± 0.048	3.396GlyPro: 3.396 ± 0.059	2.33GlyGln: 2.33 ± 0.044	6.235GlyArg: 6.235 ± 0.07	3.918GlySer: 3.918 ± 0.075	2.774GlyThr: 2.774 ± 0.059	7.276GlyVal: 7.276 ± 0.091	1.292GlyTrp: 1.292 ± 0.046	2.115GlyTyr: 2.115 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.443HisAla: 2.443 ± 0.044	0.266HisCys: 0.266 ± 0.016	1.204HisAsp: 1.204 ± 0.033	1.154HisGlu: 1.154 ± 0.03	0.878HisPhe: 0.878 ± 0.026	1.898HisGly: 1.898 ± 0.048	0.544HisHis: 0.544 ± 0.028	0.978HisIle: 0.978 ± 0.031	0.525HisLys: 0.525 ± 0.02	1.917HisLeu: 1.917 ± 0.04	0.474HisMet: 0.474 ± 0.019	0.478HisAsn: 0.478 ± 0.019	1.289HisPro: 1.289 ± 0.034	0.506HisGln: 0.506 ± 0.021	1.436HisArg: 1.436 ± 0.036	1.018HisSer: 1.018 ± 0.036	0.711HisThr: 0.711 ± 0.024	1.524HisVal: 1.524 ± 0.038	0.327HisTrp: 0.327 ± 0.016	0.568HisTyr: 0.568 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.356IleAla: 7.356 ± 0.073	0.535IleCys: 0.535 ± 0.019	3.733IleAsp: 3.733 ± 0.054	3.8IleGlu: 3.8 ± 0.053	1.868IlePhe: 1.868 ± 0.047	4.673IleGly: 4.673 ± 0.067	0.935IleHis: 0.935 ± 0.029	2.072IleIle: 2.072 ± 0.048	1.372IleLys: 1.372 ± 0.035	3.956IleLeu: 3.956 ± 0.053	0.88IleMet: 0.88 ± 0.025	1.238IleAsn: 1.238 ± 0.034	2.071IlePro: 2.071 ± 0.044	1.095IleGln: 1.095 ± 0.034	2.899IleArg: 2.899 ± 0.052	2.747IleSer: 2.747 ± 0.054	1.969IleThr: 1.969 ± 0.048	4.456IleVal: 4.456 ± 0.071	0.536IleTrp: 0.536 ± 0.02	1.133IleTyr: 1.133 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.149LysAla: 4.149 ± 0.076	0.238LysCys: 0.238 ± 0.015	1.802LysAsp: 1.802 ± 0.038	1.853LysGlu: 1.853 ± 0.044	1.129LysPhe: 1.129 ± 0.033	2.731LysGly: 2.731 ± 0.047	0.616LysHis: 0.616 ± 0.023	2.067LysIle: 2.067 ± 0.046	1.535LysLys: 1.535 ± 0.043	3.391LysLeu: 3.391 ± 0.052	0.817LysMet: 0.817 ± 0.025	1.039LysAsn: 1.039 ± 0.032	2.118LysPro: 2.118 ± 0.049	1.016LysGln: 1.016 ± 0.029	2.784LysArg: 2.784 ± 0.048	2.09LysSer: 2.09 ± 0.045	2.092LysThr: 2.092 ± 0.049	2.069LysVal: 2.069 ± 0.043	0.379LysTrp: 0.379 ± 0.018	0.631LysTyr: 0.631 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	14.464LeuAla: 14.464 ± 0.147	0.952LeuCys: 0.952 ± 0.031	5.987LeuAsp: 5.987 ± 0.067	5.447LeuGlu: 5.447 ± 0.068	3.845LeuPhe: 3.845 ± 0.067	7.66LeuGly: 7.66 ± 0.079	1.852LeuHis: 1.852 ± 0.044	4.941LeuIle: 4.941 ± 0.064	3.374LeuLys: 3.374 ± 0.051	9.448LeuLeu: 9.448 ± 0.107	2.063LeuMet: 2.063 ± 0.042	2.491LeuAsn: 2.491 ± 0.055	5.203LeuPro: 5.203 ± 0.073	2.551LeuGln: 2.551 ± 0.048	7.707LeuArg: 7.707 ± 0.092	6.459LeuSer: 6.459 ± 0.07	5.296LeuThr: 5.296 ± 0.07	6.796LeuVal: 6.796 ± 0.086	1.188LeuTrp: 1.188 ± 0.037	2.133LeuTyr: 2.133 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.64MetAla: 2.64 ± 0.054	0.177MetCys: 0.177 ± 0.013	0.931MetAsp: 0.931 ± 0.027	1.082MetGlu: 1.082 ± 0.03	0.709MetPhe: 0.709 ± 0.025	1.506MetGly: 1.506 ± 0.037	0.414MetHis: 0.414 ± 0.019	1.181MetIle: 1.181 ± 0.033	0.912MetLys: 0.912 ± 0.03	2.166MetLeu: 2.166 ± 0.046	0.523MetMet: 0.523 ± 0.026	0.731MetAsn: 0.731 ± 0.024	1.154MetPro: 1.154 ± 0.027	0.725MetGln: 0.725 ± 0.025	2.057MetArg: 2.057 ± 0.04	1.698MetSer: 1.698 ± 0.036	1.634MetThr: 1.634 ± 0.034	1.162MetVal: 1.162 ± 0.035	0.196MetTrp: 0.196 ± 0.014	0.275MetTyr: 0.275 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.348AsnAla: 3.348 ± 0.064	0.285AsnCys: 0.285 ± 0.019	1.388AsnAsp: 1.388 ± 0.033	1.377AsnGlu: 1.377 ± 0.038	1.105AsnPhe: 1.105 ± 0.031	2.212AsnGly: 2.212 ± 0.074	0.531AsnHis: 0.531 ± 0.024	1.303AsnIle: 1.303 ± 0.036	0.742AsnLys: 0.742 ± 0.028	2.439AsnLeu: 2.439 ± 0.047	0.547AsnMet: 0.547 ± 0.021	0.65AsnAsn: 0.65 ± 0.032	1.604AsnPro: 1.604 ± 0.042	0.662AsnGln: 0.662 ± 0.023	1.746AsnArg: 1.746 ± 0.037	1.237AsnSer: 1.237 ± 0.038	0.95AsnThr: 0.95 ± 0.03	2.041AsnVal: 2.041 ± 0.043	0.452AsnTrp: 0.452 ± 0.024	0.692AsnTyr: 0.692 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	6.408ProAla: 6.408 ± 0.089	0.432ProCys: 0.432 ± 0.017	3.32ProAsp: 3.32 ± 0.062	3.429ProGlu: 3.429 ± 0.053	2.085ProPhe: 2.085 ± 0.045	4.234ProGly: 4.234 ± 0.068	1.154ProHis: 1.154 ± 0.03	2.589ProIle: 2.589 ± 0.05	1.897ProLys: 1.897 ± 0.038	5.026ProLeu: 5.026 ± 0.074	1.123ProMet: 1.123 ± 0.027	1.416ProAsn: 1.416 ± 0.031	3.338ProPro: 3.338 ± 0.074	1.873ProGln: 1.873 ± 0.043	3.57ProArg: 3.57 ± 0.062	3.036ProSer: 3.036 ± 0.055	2.627ProThr: 2.627 ± 0.052	3.472ProVal: 3.472 ± 0.058	0.697ProTrp: 0.697 ± 0.026	1.176ProTyr: 1.176 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.915GlnAla: 3.915 ± 0.062	0.249GlnCys: 0.249 ± 0.017	1.343GlnAsp: 1.343 ± 0.035	1.658GlnGlu: 1.658 ± 0.037	1.081GlnPhe: 1.081 ± 0.03	2.226GlnGly: 2.226 ± 0.045	0.599GlnHis: 0.599 ± 0.023	1.763GlnIle: 1.763 ± 0.036	1.117GlnLys: 1.117 ± 0.03	2.737GlnLeu: 2.737 ± 0.05	0.729GlnMet: 0.729 ± 0.024	0.888GlnAsn: 0.888 ± 0.034	1.614GlnPro: 1.614 ± 0.037	1.028GlnGln: 1.028 ± 0.035	2.507GlnArg: 2.507 ± 0.049	1.829GlnSer: 1.829 ± 0.046	1.604GlnThr: 1.604 ± 0.043	1.68GlnVal: 1.68 ± 0.043	0.408GlnTrp: 0.408 ± 0.018	0.571GlnTyr: 0.571 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	10.077ArgAla: 10.077 ± 0.129	0.655ArgCys: 0.655 ± 0.024	4.545ArgAsp: 4.545 ± 0.067	4.889ArgGlu: 4.889 ± 0.071	3.305ArgPhe: 3.305 ± 0.059	5.429ArgGly: 5.429 ± 0.069	1.673ArgHis: 1.673 ± 0.036	4.03ArgIle: 4.03 ± 0.054	2.561ArgLys: 2.561 ± 0.048	8.793ArgLeu: 8.793 ± 0.114	1.753ArgMet: 1.753 ± 0.037	1.994ArgAsn: 1.994 ± 0.035	3.886ArgPro: 3.886 ± 0.06	2.437ArgGln: 2.437 ± 0.048	7.321ArgArg: 7.321 ± 0.091	4.159ArgSer: 4.159 ± 0.062	3.003ArgThr: 3.003 ± 0.05	5.06ArgVal: 5.06 ± 0.068	1.11ArgTrp: 1.11 ± 0.032	1.851ArgTyr: 1.851 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	7.098SerAla: 7.098 ± 0.082	0.616SerCys: 0.616 ± 0.023	3.006SerAsp: 3.006 ± 0.047	3.056SerGlu: 3.056 ± 0.057	2.44SerPhe: 2.44 ± 0.048	5.247SerGly: 5.247 ± 0.085	1.092SerHis: 1.092 ± 0.033	2.684SerIle: 2.684 ± 0.054	1.777SerLys: 1.777 ± 0.047	5.586SerLeu: 5.586 ± 0.072	1.178SerMet: 1.178 ± 0.034	1.364SerAsn: 1.364 ± 0.033	3.087SerPro: 3.087 ± 0.053	1.623SerGln: 1.623 ± 0.039	4.201SerArg: 4.201 ± 0.061	3.023SerSer: 3.023 ± 0.061	2.492SerThr: 2.492 ± 0.056	3.901SerVal: 3.901 ± 0.058	0.742SerTrp: 0.742 ± 0.023	1.284SerTyr: 1.284 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.267ThrAla: 5.267 ± 0.065	0.409ThrCys: 0.409 ± 0.018	2.19ThrAsp: 2.19 ± 0.051	2.076ThrGlu: 2.076 ± 0.044	1.734ThrPhe: 1.734 ± 0.038	4.031ThrGly: 4.031 ± 0.066	0.991ThrHis: 0.991 ± 0.03	2.712ThrIle: 2.712 ± 0.053	1.542ThrLys: 1.542 ± 0.038	5.61ThrLeu: 5.61 ± 0.072	0.955ThrMet: 0.955 ± 0.031	1.178ThrAsn: 1.178 ± 0.036	3.569ThrPro: 3.569 ± 0.067	1.502ThrGln: 1.502 ± 0.036	3.551ThrArg: 3.551 ± 0.055	2.627ThrSer: 2.627 ± 0.062	2.527ThrThr: 2.527 ± 0.082	3.193ThrVal: 3.193 ± 0.069	0.522ThrTrp: 0.522 ± 0.02	1.009ThrTyr: 1.009 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	9.74ValAla: 9.74 ± 0.116	0.698ValCys: 0.698 ± 0.024	4.362ValAsp: 4.362 ± 0.055	4.722ValGlu: 4.722 ± 0.08	2.707ValPhe: 2.707 ± 0.052	5.497ValGly: 5.497 ± 0.085	1.246ValHis: 1.246 ± 0.035	3.569ValIle: 3.569 ± 0.054	2.461ValLys: 2.461 ± 0.054	6.169ValLeu: 6.169 ± 0.068	1.504ValMet: 1.504 ± 0.036	1.925ValAsn: 1.925 ± 0.039	2.783ValPro: 2.783 ± 0.059	1.718ValGln: 1.718 ± 0.038	4.636ValArg: 4.636 ± 0.065	4.222ValSer: 4.222 ± 0.063	3.871ValThr: 3.871 ± 0.064	5.657ValVal: 5.657 ± 0.084	0.897ValTrp: 0.897 ± 0.029	1.506ValTyr: 1.506 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.233TrpAla: 1.233 ± 0.032	0.127TrpCys: 0.127 ± 0.01	0.595TrpAsp: 0.595 ± 0.024	0.558TrpGlu: 0.558 ± 0.024	0.523TrpPhe: 0.523 ± 0.02	0.927TrpGly: 0.927 ± 0.036	0.262TrpHis: 0.262 ± 0.015	0.662TrpIle: 0.662 ± 0.026	0.453TrpLys: 0.453 ± 0.022	1.59TrpLeu: 1.59 ± 0.042	0.352TrpMet: 0.352 ± 0.02	0.398TrpAsn: 0.398 ± 0.021	0.739TrpPro: 0.739 ± 0.026	0.379TrpGln: 0.379 ± 0.017	1.715TrpArg: 1.715 ± 0.038	0.884TrpSer: 0.884 ± 0.026	0.776TrpThr: 0.776 ± 0.022	0.633TrpVal: 0.633 ± 0.025	0.224TrpTrp: 0.224 ± 0.016	0.248TrpTyr: 0.248 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.698TyrAla: 2.698 ± 0.041	0.276TyrCys: 0.276 ± 0.014	1.469TyrAsp: 1.469 ± 0.037	1.277TyrGlu: 1.277 ± 0.035	1.014TyrPhe: 1.014 ± 0.03	2.112TyrGly: 2.112 ± 0.044	0.428TyrHis: 0.428 ± 0.02	0.83TyrIle: 0.83 ± 0.029	0.633TyrLys: 0.633 ± 0.023	2.244TyrLeu: 2.244 ± 0.042	0.391TyrMet: 0.391 ± 0.019	0.555TyrAsn: 0.555 ± 0.024	1.039TyrPro: 1.039 ± 0.029	0.657TyrGln: 0.657 ± 0.025	1.847TyrArg: 1.847 ± 0.04	1.16TyrSer: 1.16 ± 0.031	0.855TyrThr: 0.855 ± 0.028	1.776TyrVal: 1.776 ± 0.036	0.402TyrTrp: 0.402 ± 0.019	0.623TyrTyr: 0.623 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4040 proteins (1212217 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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