Amino acid dipepetide frequency for Erythrobacter neustonensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.415AlaAla: 22.415 ± 0.305	1.185AlaCys: 1.185 ± 0.044	7.859AlaAsp: 7.859 ± 0.093	8.245AlaGlu: 8.245 ± 0.118	4.581AlaPhe: 4.581 ± 0.065	12.699AlaGly: 12.699 ± 0.129	2.568AlaHis: 2.568 ± 0.052	6.929AlaIle: 6.929 ± 0.085	4.136AlaLys: 4.136 ± 0.084	15.186AlaLeu: 15.186 ± 0.176	4.191AlaMet: 4.191 ± 0.066	3.305AlaAsn: 3.305 ± 0.063	7.389AlaPro: 7.389 ± 0.118	5.104AlaGln: 5.104 ± 0.079	10.908AlaArg: 10.908 ± 0.169	6.835AlaSer: 6.835 ± 0.094	6.256AlaThr: 6.256 ± 0.075	9.145AlaVal: 9.145 ± 0.099	1.617AlaTrp: 1.617 ± 0.039	2.632AlaTyr: 2.632 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	1.094CysAla: 1.094 ± 0.035	0.089CysCys: 0.089 ± 0.009	0.595CysAsp: 0.595 ± 0.027	0.453CysGlu: 0.453 ± 0.023	0.258CysPhe: 0.258 ± 0.018	0.878CysGly: 0.878 ± 0.034	0.208CysHis: 0.208 ± 0.015	0.346CysIle: 0.346 ± 0.02	0.186CysLys: 0.186 ± 0.015	0.719CysLeu: 0.719 ± 0.029	0.127CysMet: 0.127 ± 0.012	0.23CysAsn: 0.23 ± 0.019	0.434CysPro: 0.434 ± 0.02	0.186CysGln: 0.186 ± 0.015	0.499CysArg: 0.499 ± 0.026	0.389CysSer: 0.389 ± 0.021	0.413CysThr: 0.413 ± 0.021	0.541CysVal: 0.541 ± 0.025	0.098CysTrp: 0.098 ± 0.011	0.163CysTyr: 0.163 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	8.075AspAla: 8.075 ± 0.109	0.518AspCys: 0.518 ± 0.024	3.273AspAsp: 3.273 ± 0.067	3.482AspGlu: 3.482 ± 0.08	2.314AspPhe: 2.314 ± 0.053	5.342AspGly: 5.342 ± 0.082	1.238AspHis: 1.238 ± 0.036	2.956AspIle: 2.956 ± 0.056	1.706AspLys: 1.706 ± 0.046	5.703AspLeu: 5.703 ± 0.081	1.375AspMet: 1.375 ± 0.046	1.465AspAsn: 1.465 ± 0.041	3.871AspPro: 3.871 ± 0.069	1.661AspGln: 1.661 ± 0.04	4.197AspArg: 4.197 ± 0.08	2.229AspSer: 2.229 ± 0.05	2.898AspThr: 2.898 ± 0.058	3.829AspVal: 3.829 ± 0.062	1.1AspTrp: 1.1 ± 0.034	1.533AspTyr: 1.533 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	8.46GluAla: 8.46 ± 0.107	0.377GluCys: 0.377 ± 0.021	3.091GluAsp: 3.091 ± 0.066	3.151GluGlu: 3.151 ± 0.084	1.682GluPhe: 1.682 ± 0.045	4.791GluGly: 4.791 ± 0.085	1.073GluHis: 1.073 ± 0.041	2.85GluIle: 2.85 ± 0.065	1.935GluLys: 1.935 ± 0.052	5.121GluLeu: 5.121 ± 0.071	1.445GluMet: 1.445 ± 0.044	1.469GluAsn: 1.469 ± 0.037	2.467GluPro: 2.467 ± 0.053	2.021GluGln: 2.021 ± 0.051	4.594GluArg: 4.594 ± 0.08	2.157GluSer: 2.157 ± 0.047	3.193GluThr: 3.193 ± 0.051	3.842GluVal: 3.842 ± 0.077	0.846GluTrp: 0.846 ± 0.034	1.073GluTyr: 1.073 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	5.612PheAla: 5.612 ± 0.08	0.32PheCys: 0.32 ± 0.019	2.719PheAsp: 2.719 ± 0.058	2.054PheGlu: 2.054 ± 0.051	1.333PhePhe: 1.333 ± 0.04	3.724PheGly: 3.724 ± 0.075	0.658PheHis: 0.658 ± 0.024	1.471PheIle: 1.471 ± 0.041	0.892PheLys: 0.892 ± 0.032	2.914PheLeu: 2.914 ± 0.052	0.776PheMet: 0.776 ± 0.03	1.042PheAsn: 1.042 ± 0.034	1.494PhePro: 1.494 ± 0.043	0.857PheGln: 0.857 ± 0.029	2.09PheArg: 2.09 ± 0.054	1.852PheSer: 1.852 ± 0.037	2.072PheThr: 2.072 ± 0.054	2.606PheVal: 2.606 ± 0.057	0.532PheTrp: 0.532 ± 0.022	0.894PheTyr: 0.894 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	10.989GlyAla: 10.989 ± 0.117	0.81GlyCys: 0.81 ± 0.029	4.999GlyAsp: 4.999 ± 0.077	5.393GlyGlu: 5.393 ± 0.081	3.78GlyPhe: 3.78 ± 0.067	8.244GlyGly: 8.244 ± 0.138	1.81GlyHis: 1.81 ± 0.046	4.612GlyIle: 4.612 ± 0.087	3.395GlyLys: 3.395 ± 0.062	8.852GlyLeu: 8.852 ± 0.108	2.465GlyMet: 2.465 ± 0.052	2.339GlyAsn: 2.339 ± 0.056	3.596GlyPro: 3.596 ± 0.07	3.036GlyGln: 3.036 ± 0.059	5.951GlyArg: 5.951 ± 0.081	4.653GlySer: 4.653 ± 0.082	5.324GlyThr: 5.324 ± 0.1	6.162GlyVal: 6.162 ± 0.087	1.607GlyTrp: 1.607 ± 0.045	2.177GlyTyr: 2.177 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	2.594HisAla: 2.594 ± 0.053	0.25HisCys: 0.25 ± 0.017	1.217HisAsp: 1.217 ± 0.044	0.97HisGlu: 0.97 ± 0.035	0.78HisPhe: 0.78 ± 0.032	1.854HisGly: 1.854 ± 0.048	0.571HisHis: 0.571 ± 0.025	0.878HisIle: 0.878 ± 0.032	0.476HisLys: 0.476 ± 0.022	1.753HisLeu: 1.753 ± 0.043	0.43HisMet: 0.43 ± 0.02	0.453HisAsn: 0.453 ± 0.026	1.298HisPro: 1.298 ± 0.044	0.522HisGln: 0.522 ± 0.024	1.336HisArg: 1.336 ± 0.046	0.885HisSer: 0.885 ± 0.035	0.812HisThr: 0.812 ± 0.03	1.266HisVal: 1.266 ± 0.037	0.336HisTrp: 0.336 ± 0.018	0.509HisTyr: 0.509 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	8.828IleAla: 8.828 ± 0.094	0.442IleCys: 0.442 ± 0.022	3.73IleAsp: 3.73 ± 0.071	3.454IleGlu: 3.454 ± 0.062	1.503IlePhe: 1.503 ± 0.04	5.013IleGly: 5.013 ± 0.071	0.858IleHis: 0.858 ± 0.033	2.134IleIle: 2.134 ± 0.055	1.225IleLys: 1.225 ± 0.039	3.566IleLeu: 3.566 ± 0.076	0.897IleMet: 0.897 ± 0.032	1.361IleAsn: 1.361 ± 0.036	2.176IlePro: 2.176 ± 0.06	0.972IleGln: 0.972 ± 0.034	3.03IleArg: 3.03 ± 0.059	2.316IleSer: 2.316 ± 0.05	2.876IleThr: 2.876 ± 0.062	3.788IleVal: 3.788 ± 0.072	0.555IleTrp: 0.555 ± 0.025	0.96IleTyr: 0.96 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.04LysAla: 4.04 ± 0.076	0.159LysCys: 0.159 ± 0.012	1.551LysAsp: 1.551 ± 0.048	1.17LysGlu: 1.17 ± 0.039	0.811LysPhe: 0.811 ± 0.031	2.619LysGly: 2.619 ± 0.058	0.566LysHis: 0.566 ± 0.023	1.369LysIle: 1.369 ± 0.05	1.074LysLys: 1.074 ± 0.046	3.052LysLeu: 3.052 ± 0.06	0.712LysMet: 0.712 ± 0.033	0.691LysAsn: 0.691 ± 0.027	1.808LysPro: 1.808 ± 0.053	0.894LysGln: 0.894 ± 0.029	2.128LysArg: 2.128 ± 0.057	1.42LysSer: 1.42 ± 0.047	1.522LysThr: 1.522 ± 0.041	2.252LysVal: 2.252 ± 0.057	0.327LysTrp: 0.327 ± 0.022	0.571LysTyr: 0.571 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	16.172LeuAla: 16.172 ± 0.188	0.762LeuCys: 0.762 ± 0.03	5.871LeuAsp: 5.871 ± 0.095	4.962LeuGlu: 4.962 ± 0.078	3.352LeuPhe: 3.352 ± 0.063	8.707LeuGly: 8.707 ± 0.112	1.661LeuHis: 1.661 ± 0.042	4.7LeuIle: 4.7 ± 0.089	2.756LeuLys: 2.756 ± 0.058	9.184LeuLeu: 9.184 ± 0.136	2.188LeuMet: 2.188 ± 0.047	2.181LeuAsn: 2.181 ± 0.055	5.662LeuPro: 5.662 ± 0.085	2.407LeuGln: 2.407 ± 0.053	6.788LeuArg: 6.788 ± 0.092	5.393LeuSer: 5.393 ± 0.08	5.807LeuThr: 5.807 ± 0.077	7.469LeuVal: 7.469 ± 0.103	1.181LeuTrp: 1.181 ± 0.043	1.799LeuTyr: 1.799 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.348MetAla: 3.348 ± 0.065	0.177MetCys: 0.177 ± 0.014	1.075MetAsp: 1.075 ± 0.036	1.014MetGlu: 1.014 ± 0.034	0.679MetPhe: 0.679 ± 0.024	1.97MetGly: 1.97 ± 0.048	0.441MetHis: 0.441 ± 0.021	1.387MetIle: 1.387 ± 0.041	0.902MetLys: 0.902 ± 0.032	2.824MetLeu: 2.824 ± 0.057	0.687MetMet: 0.687 ± 0.03	0.743MetAsn: 0.743 ± 0.027	1.504MetPro: 1.504 ± 0.041	0.78MetGln: 0.78 ± 0.03	1.822MetArg: 1.822 ± 0.045	1.268MetSer: 1.268 ± 0.036	1.69MetThr: 1.69 ± 0.041	1.773MetVal: 1.773 ± 0.046	0.254MetTrp: 0.254 ± 0.017	0.262MetTyr: 0.262 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.443AsnAla: 3.443 ± 0.07	0.224AsnCys: 0.224 ± 0.018	1.375AsnAsp: 1.375 ± 0.042	1.128AsnGlu: 1.128 ± 0.036	0.964AsnPhe: 0.964 ± 0.033	2.274AsnGly: 2.274 ± 0.054	0.474AsnHis: 0.474 ± 0.022	1.343AsnIle: 1.343 ± 0.04	0.564AsnLys: 0.564 ± 0.028	2.52AsnLeu: 2.52 ± 0.055	0.509AsnMet: 0.509 ± 0.023	0.611AsnAsn: 0.611 ± 0.028	1.877AsnPro: 1.877 ± 0.051	0.682AsnGln: 0.682 ± 0.026	1.791AsnArg: 1.791 ± 0.042	1.126AsnSer: 1.126 ± 0.041	1.175AsnThr: 1.175 ± 0.04	1.786AsnVal: 1.786 ± 0.047	0.362AsnTrp: 0.362 ± 0.02	0.652AsnTyr: 0.652 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	8.011ProAla: 8.011 ± 0.127	0.336ProCys: 0.336 ± 0.018	3.77ProAsp: 3.77 ± 0.06	3.686ProGlu: 3.686 ± 0.065	1.932ProPhe: 1.932 ± 0.047	4.931ProGly: 4.931 ± 0.08	1.044ProHis: 1.044 ± 0.035	2.216ProIle: 2.216 ± 0.046	1.398ProLys: 1.398 ± 0.041	5.12ProLeu: 5.12 ± 0.081	1.143ProMet: 1.143 ± 0.038	1.049ProAsn: 1.049 ± 0.038	2.665ProPro: 2.665 ± 0.075	1.966ProGln: 1.966 ± 0.05	3.231ProArg: 3.231 ± 0.06	2.45ProSer: 2.45 ± 0.054	2.329ProThr: 2.329 ± 0.05	4.31ProVal: 4.31 ± 0.068	0.642ProTrp: 0.642 ± 0.031	1.038ProTyr: 1.038 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.141GlnAla: 4.141 ± 0.07	0.206GlnCys: 0.206 ± 0.015	1.407GlnAsp: 1.407 ± 0.04	1.2GlnGlu: 1.2 ± 0.04	1.209GlnPhe: 1.209 ± 0.043	2.657GlnGly: 2.657 ± 0.049	0.596GlnHis: 0.596 ± 0.028	1.811GlnIle: 1.811 ± 0.042	0.809GlnLys: 0.809 ± 0.034	3.114GlnLeu: 3.114 ± 0.071	0.865GlnMet: 0.865 ± 0.029	0.746GlnAsn: 0.746 ± 0.029	1.803GlnPro: 1.803 ± 0.048	1.125GlnGln: 1.125 ± 0.038	2.522GlnArg: 2.522 ± 0.055	1.658GlnSer: 1.658 ± 0.045	1.664GlnThr: 1.664 ± 0.048	2.334GlnVal: 2.334 ± 0.058	0.486GlnTrp: 0.486 ± 0.023	0.623GlnTyr: 0.623 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	9.273ArgAla: 9.273 ± 0.128	0.427ArgCys: 0.427 ± 0.023	4.097ArgAsp: 4.097 ± 0.072	4.318ArgGlu: 4.318 ± 0.08	3.018ArgPhe: 3.018 ± 0.054	5.17ArgGly: 5.17 ± 0.074	1.487ArgHis: 1.487 ± 0.045	4.05ArgIle: 4.05 ± 0.069	2.05ArgLys: 2.05 ± 0.057	7.858ArgLeu: 7.858 ± 0.112	1.999ArgMet: 1.999 ± 0.05	1.75ArgAsn: 1.75 ± 0.045	3.389ArgPro: 3.389 ± 0.072	2.344ArgGln: 2.344 ± 0.057	5.301ArgArg: 5.301 ± 0.101	3.527ArgSer: 3.527 ± 0.07	3.437ArgThr: 3.437 ± 0.065	4.816ArgVal: 4.816 ± 0.073	1.152ArgTrp: 1.152 ± 0.044	1.7ArgTyr: 1.7 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.53SerAla: 6.53 ± 0.092	0.327SerCys: 0.327 ± 0.019	3.014SerAsp: 3.014 ± 0.06	2.628SerGlu: 2.628 ± 0.059	1.988SerPhe: 1.988 ± 0.049	5.325SerGly: 5.325 ± 0.09	0.943SerHis: 0.943 ± 0.035	2.25SerIle: 2.25 ± 0.057	1.177SerLys: 1.177 ± 0.041	4.925SerLeu: 4.925 ± 0.083	1.067SerMet: 1.067 ± 0.039	1.217SerAsn: 1.217 ± 0.038	2.691SerPro: 2.691 ± 0.055	1.559SerGln: 1.559 ± 0.044	3.274SerArg: 3.274 ± 0.064	2.355SerSer: 2.355 ± 0.058	2.28SerThr: 2.28 ± 0.049	3.347SerVal: 3.347 ± 0.058	0.681SerTrp: 0.681 ± 0.025	1.087SerTyr: 1.087 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.971ThrAla: 6.971 ± 0.092	0.406ThrCys: 0.406 ± 0.025	2.87ThrAsp: 2.87 ± 0.069	2.459ThrGlu: 2.459 ± 0.051	1.908ThrPhe: 1.908 ± 0.053	5.546ThrGly: 5.546 ± 0.084	0.954ThrHis: 0.954 ± 0.033	2.873ThrIle: 2.873 ± 0.063	1.216ThrLys: 1.216 ± 0.041	5.749ThrLeu: 5.749 ± 0.087	1.129ThrMet: 1.129 ± 0.034	1.288ThrAsn: 1.288 ± 0.046	3.41ThrPro: 3.41 ± 0.068	1.486ThrGln: 1.486 ± 0.044	3.77ThrArg: 3.77 ± 0.059	2.501ThrSer: 2.501 ± 0.052	2.652ThrThr: 2.652 ± 0.063	3.854ThrVal: 3.854 ± 0.07	0.614ThrTrp: 0.614 ± 0.028	1.202ThrTyr: 1.202 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	9.159ValAla: 9.159 ± 0.109	0.547ValCys: 0.547 ± 0.024	4.024ValAsp: 4.024 ± 0.061	4.15ValGlu: 4.15 ± 0.079	2.459ValPhe: 2.459 ± 0.053	5.392ValGly: 5.392 ± 0.089	1.242ValHis: 1.242 ± 0.036	4.071ValIle: 4.071 ± 0.066	1.957ValLys: 1.957 ± 0.051	7.071ValLeu: 7.071 ± 0.108	1.87ValMet: 1.87 ± 0.05	1.907ValAsn: 1.907 ± 0.049	4.031ValPro: 4.031 ± 0.061	2.01ValGln: 2.01 ± 0.047	4.92ValArg: 4.92 ± 0.072	3.783ValSer: 3.783 ± 0.066	4.681ValThr: 4.681 ± 0.072	5.228ValVal: 5.228 ± 0.089	0.947ValTrp: 0.947 ± 0.035	1.187ValTyr: 1.187 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.398TrpAla: 1.398 ± 0.042	0.114TrpCys: 0.114 ± 0.01	0.743TrpAsp: 0.743 ± 0.029	0.642TrpGlu: 0.642 ± 0.028	0.562TrpPhe: 0.562 ± 0.025	1.019TrpGly: 1.019 ± 0.029	0.345TrpHis: 0.345 ± 0.017	0.627TrpIle: 0.627 ± 0.026	0.401TrpLys: 0.401 ± 0.02	1.707TrpLeu: 1.707 ± 0.044	0.323TrpMet: 0.323 ± 0.022	0.442TrpAsn: 0.442 ± 0.019	0.673TrpPro: 0.673 ± 0.03	0.712TrpGln: 0.712 ± 0.03	1.271TrpArg: 1.271 ± 0.039	0.806TrpSer: 0.806 ± 0.033	0.709TrpThr: 0.709 ± 0.03	0.875TrpVal: 0.875 ± 0.031	0.242TrpTrp: 0.242 ± 0.017	0.277TrpTyr: 0.277 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.629TyrAla: 2.629 ± 0.058	0.229TyrCys: 0.229 ± 0.016	1.486TyrAsp: 1.486 ± 0.045	1.079TyrGlu: 1.079 ± 0.036	0.8TyrPhe: 0.8 ± 0.033	2.038TyrGly: 2.038 ± 0.051	0.455TyrHis: 0.455 ± 0.021	0.815TyrIle: 0.815 ± 0.032	0.479TyrLys: 0.479 ± 0.025	2.064TyrLeu: 2.064 ± 0.056	0.397TyrMet: 0.397 ± 0.023	0.59TyrAsn: 0.59 ± 0.023	1.028TyrPro: 1.028 ± 0.035	0.651TyrGln: 0.651 ± 0.029	1.742TyrArg: 1.742 ± 0.047	1.062TyrSer: 1.062 ± 0.032	1.07TyrThr: 1.07 ± 0.036	1.413TyrVal: 1.413 ± 0.044	0.309TyrTrp: 0.309 ± 0.02	0.514TyrTyr: 0.514 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2792 proteins (918342 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---