Amino acid dipepetide frequency for Achromobacter phage vB_AxyS_19-32_Axy06

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.747AlaAla: 8.747 ± 0.912
0.578AlaCys: 0.578 ± 0.198
5.06AlaAsp: 5.06 ± 0.662
7.373AlaGlu: 7.373 ± 0.946
3.325AlaPhe: 3.325 ± 0.521
7.518AlaGly: 7.518 ± 0.892
1.59AlaHis: 1.59 ± 0.377
5.205AlaIle: 5.205 ± 0.67
4.915AlaLys: 4.915 ± 0.741
7.662AlaLeu: 7.662 ± 0.779
3.108AlaMet: 3.108 ± 0.438
3.542AlaAsn: 3.542 ± 0.462
3.687AlaPro: 3.687 ± 0.769
4.193AlaGln: 4.193 ± 0.645
5.421AlaArg: 5.421 ± 0.646
5.566AlaSer: 5.566 ± 0.814
6.217AlaThr: 6.217 ± 0.743
6.795AlaVal: 6.795 ± 0.682
2.024AlaTrp: 2.024 ± 0.385
2.53AlaTyr: 2.53 ± 0.415
0.0AlaXaa: 0.0 ± 0.0
Cys
0.723CysAla: 0.723 ± 0.269
0.145CysCys: 0.145 ± 0.119
0.361CysAsp: 0.361 ± 0.163
0.651CysGlu: 0.651 ± 0.256
0.434CysPhe: 0.434 ± 0.175
0.506CysGly: 0.506 ± 0.221
0.145CysHis: 0.145 ± 0.093
0.289CysIle: 0.289 ± 0.132
0.434CysLys: 0.434 ± 0.184
0.578CysLeu: 0.578 ± 0.193
0.361CysMet: 0.361 ± 0.154
0.506CysAsn: 0.506 ± 0.191
0.651CysPro: 0.651 ± 0.276
0.072CysGln: 0.072 ± 0.084
0.651CysArg: 0.651 ± 0.236
0.434CysSer: 0.434 ± 0.202
0.217CysThr: 0.217 ± 0.122
0.578CysVal: 0.578 ± 0.164
0.361CysTrp: 0.361 ± 0.16
0.361CysTyr: 0.361 ± 0.177
0.0CysXaa: 0.0 ± 0.0
Asp
5.277AspAla: 5.277 ± 0.532
0.361AspCys: 0.361 ± 0.129
3.976AspAsp: 3.976 ± 0.784
3.687AspGlu: 3.687 ± 0.576
2.675AspPhe: 2.675 ± 0.521
5.349AspGly: 5.349 ± 0.785
0.723AspHis: 0.723 ± 0.193
2.747AspIle: 2.747 ± 0.432
3.253AspLys: 3.253 ± 0.587
5.494AspLeu: 5.494 ± 0.664
2.241AspMet: 2.241 ± 0.449
2.602AspAsn: 2.602 ± 0.37
2.675AspPro: 2.675 ± 0.477
1.663AspGln: 1.663 ± 0.466
1.807AspArg: 1.807 ± 0.425
2.964AspSer: 2.964 ± 0.455
2.602AspThr: 2.602 ± 0.392
4.265AspVal: 4.265 ± 0.861
0.867AspTrp: 0.867 ± 0.24
2.241AspTyr: 2.241 ± 0.439
0.0AspXaa: 0.0 ± 0.0
Glu
7.229GluAla: 7.229 ± 0.867
0.723GluCys: 0.723 ± 0.321
3.687GluAsp: 3.687 ± 0.54
5.205GluGlu: 5.205 ± 0.754
2.096GluPhe: 2.096 ± 0.411
3.47GluGly: 3.47 ± 0.686
0.723GluHis: 0.723 ± 0.257
2.747GluIle: 2.747 ± 0.46
3.903GluLys: 3.903 ± 0.605
6.795GluLeu: 6.795 ± 0.623
2.096GluMet: 2.096 ± 0.431
2.169GluAsn: 2.169 ± 0.545
3.108GluPro: 3.108 ± 0.457
3.831GluGln: 3.831 ± 0.66
3.976GluArg: 3.976 ± 0.546
2.747GluSer: 2.747 ± 0.435
2.964GluThr: 2.964 ± 0.434
4.915GluVal: 4.915 ± 0.595
1.446GluTrp: 1.446 ± 0.335
2.169GluTyr: 2.169 ± 0.554
0.0GluXaa: 0.0 ± 0.0
Phe
2.891PheAla: 2.891 ± 0.469
0.434PheCys: 0.434 ± 0.141
2.819PheAsp: 2.819 ± 0.421
2.602PheGlu: 2.602 ± 0.443
0.94PhePhe: 0.94 ± 0.248
3.181PheGly: 3.181 ± 0.52
0.434PheHis: 0.434 ± 0.173
1.807PheIle: 1.807 ± 0.392
2.096PheLys: 2.096 ± 0.431
2.241PheLeu: 2.241 ± 0.505
1.373PheMet: 1.373 ± 0.327
0.94PheAsn: 0.94 ± 0.287
2.169PhePro: 2.169 ± 0.367
1.157PheGln: 1.157 ± 0.319
2.313PheArg: 2.313 ± 0.405
2.602PheSer: 2.602 ± 0.516
1.735PheThr: 1.735 ± 0.43
2.675PheVal: 2.675 ± 0.475
0.651PheTrp: 0.651 ± 0.22
1.373PheTyr: 1.373 ± 0.298
0.0PheXaa: 0.0 ± 0.0
Gly
6.433GlyAla: 6.433 ± 0.827
0.217GlyCys: 0.217 ± 0.117
4.409GlyAsp: 4.409 ± 0.53
3.759GlyGlu: 3.759 ± 0.593
3.253GlyPhe: 3.253 ± 0.508
6.939GlyGly: 6.939 ± 1.053
0.506GlyHis: 0.506 ± 0.27
4.843GlyIle: 4.843 ± 0.476
4.843GlyLys: 4.843 ± 0.707
6.65GlyLeu: 6.65 ± 0.595
2.096GlyMet: 2.096 ± 0.41
3.976GlyAsn: 3.976 ± 0.77
3.397GlyPro: 3.397 ± 0.67
2.964GlyGln: 2.964 ± 0.511
3.903GlyArg: 3.903 ± 0.566
5.494GlySer: 5.494 ± 0.944
3.903GlyThr: 3.903 ± 0.553
5.638GlyVal: 5.638 ± 0.926
1.663GlyTrp: 1.663 ± 0.344
2.602GlyTyr: 2.602 ± 0.432
0.072GlyXaa: 0.072 ± 0.079
His
1.518HisAla: 1.518 ± 0.333
0.361HisCys: 0.361 ± 0.164
0.578HisAsp: 0.578 ± 0.168
0.94HisGlu: 0.94 ± 0.275
0.651HisPhe: 0.651 ± 0.236
1.084HisGly: 1.084 ± 0.37
0.289HisHis: 0.289 ± 0.208
1.084HisIle: 1.084 ± 0.304
0.723HisLys: 0.723 ± 0.209
1.446HisLeu: 1.446 ± 0.378
0.361HisMet: 0.361 ± 0.16
0.94HisAsn: 0.94 ± 0.31
1.084HisPro: 1.084 ± 0.254
0.434HisGln: 0.434 ± 0.167
1.229HisArg: 1.229 ± 0.291
1.084HisSer: 1.084 ± 0.303
0.578HisThr: 0.578 ± 0.177
1.373HisVal: 1.373 ± 0.306
0.072HisTrp: 0.072 ± 0.077
0.651HisTyr: 0.651 ± 0.208
0.0HisXaa: 0.0 ± 0.0
Ile
5.06IleAla: 5.06 ± 0.677
0.578IleCys: 0.578 ± 0.283
3.903IleAsp: 3.903 ± 0.654
3.542IleGlu: 3.542 ± 0.578
0.867IlePhe: 0.867 ± 0.251
3.542IleGly: 3.542 ± 0.522
1.373IleHis: 1.373 ± 0.343
2.024IleIle: 2.024 ± 0.419
2.675IleLys: 2.675 ± 0.425
2.964IleLeu: 2.964 ± 0.505
0.795IleMet: 0.795 ± 0.231
2.819IleAsn: 2.819 ± 0.533
2.385IlePro: 2.385 ± 0.396
1.735IleGln: 1.735 ± 0.359
3.397IleArg: 3.397 ± 0.578
3.325IleSer: 3.325 ± 0.635
2.819IleThr: 2.819 ± 0.474
4.048IleVal: 4.048 ± 0.414
0.94IleTrp: 0.94 ± 0.274
1.663IleTyr: 1.663 ± 0.426
0.0IleXaa: 0.0 ± 0.0
Lys
5.855LysAla: 5.855 ± 0.801
0.361LysCys: 0.361 ± 0.184
2.458LysAsp: 2.458 ± 0.55
3.47LysGlu: 3.47 ± 0.537
2.385LysPhe: 2.385 ± 0.508
4.699LysGly: 4.699 ± 0.572
1.084LysHis: 1.084 ± 0.319
2.964LysIle: 2.964 ± 0.493
3.325LysLys: 3.325 ± 0.591
4.193LysLeu: 4.193 ± 0.571
1.301LysMet: 1.301 ± 0.305
1.373LysAsn: 1.373 ± 0.312
2.458LysPro: 2.458 ± 0.522
2.458LysGln: 2.458 ± 0.432
2.964LysArg: 2.964 ± 0.555
2.819LysSer: 2.819 ± 0.366
3.108LysThr: 3.108 ± 0.44
3.903LysVal: 3.903 ± 0.655
1.084LysTrp: 1.084 ± 0.3
1.518LysTyr: 1.518 ± 0.403
0.0LysXaa: 0.0 ± 0.0
Leu
8.963LeuAla: 8.963 ± 0.827
0.94LeuCys: 0.94 ± 0.223
4.265LeuAsp: 4.265 ± 0.526
6.144LeuGlu: 6.144 ± 0.783
2.169LeuPhe: 2.169 ± 0.458
5.349LeuGly: 5.349 ± 0.554
1.157LeuHis: 1.157 ± 0.265
3.181LeuIle: 3.181 ± 0.439
4.409LeuLys: 4.409 ± 0.68
6.072LeuLeu: 6.072 ± 0.663
2.313LeuMet: 2.313 ± 0.5
3.614LeuAsn: 3.614 ± 0.583
5.638LeuPro: 5.638 ± 0.73
4.554LeuGln: 4.554 ± 0.574
5.205LeuArg: 5.205 ± 0.693
4.988LeuSer: 4.988 ± 0.497
5.494LeuThr: 5.494 ± 0.751
4.265LeuVal: 4.265 ± 0.623
1.012LeuTrp: 1.012 ± 0.287
2.313LeuTyr: 2.313 ± 0.453
0.0LeuXaa: 0.0 ± 0.0
Met
2.964MetAla: 2.964 ± 0.482
0.217MetCys: 0.217 ± 0.133
1.663MetAsp: 1.663 ± 0.346
1.59MetGlu: 1.59 ± 0.345
1.157MetPhe: 1.157 ± 0.331
1.663MetGly: 1.663 ± 0.281
0.723MetHis: 0.723 ± 0.289
1.446MetIle: 1.446 ± 0.308
1.518MetLys: 1.518 ± 0.347
2.675MetLeu: 2.675 ± 0.512
0.578MetMet: 0.578 ± 0.186
1.518MetAsn: 1.518 ± 0.324
1.735MetPro: 1.735 ± 0.27
1.301MetGln: 1.301 ± 0.327
1.373MetArg: 1.373 ± 0.296
2.096MetSer: 2.096 ± 0.409
2.096MetThr: 2.096 ± 0.508
1.952MetVal: 1.952 ± 0.363
0.072MetTrp: 0.072 ± 0.071
0.651MetTyr: 0.651 ± 0.208
0.0MetXaa: 0.0 ± 0.0
Asn
4.265AsnAla: 4.265 ± 0.423
0.578AsnCys: 0.578 ± 0.19
1.807AsnAsp: 1.807 ± 0.428
2.385AsnGlu: 2.385 ± 0.385
1.879AsnPhe: 1.879 ± 0.395
4.409AsnGly: 4.409 ± 0.719
0.217AsnHis: 0.217 ± 0.126
2.169AsnIle: 2.169 ± 0.389
1.735AsnLys: 1.735 ± 0.4
3.903AsnLeu: 3.903 ± 0.597
1.084AsnMet: 1.084 ± 0.224
1.735AsnAsn: 1.735 ± 0.391
2.747AsnPro: 2.747 ± 0.525
1.446AsnGln: 1.446 ± 0.468
1.663AsnArg: 1.663 ± 0.384
2.096AsnSer: 2.096 ± 0.491
2.385AsnThr: 2.385 ± 0.616
2.241AsnVal: 2.241 ± 0.433
1.229AsnTrp: 1.229 ± 0.22
1.157AsnTyr: 1.157 ± 0.326
0.0AsnXaa: 0.0 ± 0.0
Pro
4.988ProAla: 4.988 ± 0.7
0.145ProCys: 0.145 ± 0.11
3.253ProAsp: 3.253 ± 0.565
3.687ProGlu: 3.687 ± 0.641
1.663ProPhe: 1.663 ± 0.445
4.988ProGly: 4.988 ± 0.84
0.94ProHis: 0.94 ± 0.227
2.602ProIle: 2.602 ± 0.523
3.325ProLys: 3.325 ± 0.554
2.964ProLeu: 2.964 ± 0.343
1.157ProMet: 1.157 ± 0.299
2.385ProAsn: 2.385 ± 0.404
1.952ProPro: 1.952 ± 0.36
2.313ProGln: 2.313 ± 0.347
2.602ProArg: 2.602 ± 0.471
3.181ProSer: 3.181 ± 0.447
3.542ProThr: 3.542 ± 0.517
3.614ProVal: 3.614 ± 0.496
0.578ProTrp: 0.578 ± 0.201
0.94ProTyr: 0.94 ± 0.218
0.0ProXaa: 0.0 ± 0.0
Gln
4.699GlnAla: 4.699 ± 0.552
0.361GlnCys: 0.361 ± 0.194
1.879GlnAsp: 1.879 ± 0.387
2.891GlnGlu: 2.891 ± 0.556
2.313GlnPhe: 2.313 ± 0.473
3.108GlnGly: 3.108 ± 0.442
0.723GlnHis: 0.723 ± 0.34
1.807GlnIle: 1.807 ± 0.387
1.663GlnLys: 1.663 ± 0.465
3.687GlnLeu: 3.687 ± 0.443
1.518GlnMet: 1.518 ± 0.339
1.59GlnAsn: 1.59 ± 0.406
1.663GlnPro: 1.663 ± 0.258
1.807GlnGln: 1.807 ± 0.472
2.819GlnArg: 2.819 ± 0.4
2.241GlnSer: 2.241 ± 0.408
2.169GlnThr: 2.169 ± 0.422
3.47GlnVal: 3.47 ± 0.533
0.723GlnTrp: 0.723 ± 0.215
1.229GlnTyr: 1.229 ± 0.314
0.0GlnXaa: 0.0 ± 0.0
Arg
5.711ArgAla: 5.711 ± 0.67
0.145ArgCys: 0.145 ± 0.095
3.325ArgAsp: 3.325 ± 0.628
3.542ArgGlu: 3.542 ± 0.555
1.735ArgPhe: 1.735 ± 0.501
3.831ArgGly: 3.831 ± 0.657
1.157ArgHis: 1.157 ± 0.355
2.891ArgIle: 2.891 ± 0.418
3.759ArgLys: 3.759 ± 0.549
4.988ArgLeu: 4.988 ± 0.685
2.747ArgMet: 2.747 ± 0.415
2.169ArgAsn: 2.169 ± 0.343
3.108ArgPro: 3.108 ± 0.532
2.024ArgGln: 2.024 ± 0.341
4.482ArgArg: 4.482 ± 0.519
2.747ArgSer: 2.747 ± 0.465
3.253ArgThr: 3.253 ± 0.514
4.482ArgVal: 4.482 ± 0.44
1.012ArgTrp: 1.012 ± 0.264
1.735ArgTyr: 1.735 ± 0.414
0.0ArgXaa: 0.0 ± 0.0
Ser
4.915SerAla: 4.915 ± 0.695
0.578SerCys: 0.578 ± 0.18
4.193SerAsp: 4.193 ± 0.573
3.325SerGlu: 3.325 ± 0.551
2.096SerPhe: 2.096 ± 0.477
4.482SerGly: 4.482 ± 0.614
1.084SerHis: 1.084 ± 0.278
3.181SerIle: 3.181 ± 0.501
2.53SerLys: 2.53 ± 0.443
4.409SerLeu: 4.409 ± 0.588
1.518SerMet: 1.518 ± 0.324
2.53SerAsn: 2.53 ± 0.503
2.096SerPro: 2.096 ± 0.526
2.241SerGln: 2.241 ± 0.452
3.759SerArg: 3.759 ± 0.532
2.964SerSer: 2.964 ± 0.679
3.614SerThr: 3.614 ± 0.609
4.409SerVal: 4.409 ± 0.69
1.084SerTrp: 1.084 ± 0.294
1.735SerTyr: 1.735 ± 0.379
0.0SerXaa: 0.0 ± 0.0
Thr
5.566ThrAla: 5.566 ± 1.108
0.434ThrCys: 0.434 ± 0.197
2.53ThrAsp: 2.53 ± 0.459
3.47ThrGlu: 3.47 ± 0.532
2.169ThrPhe: 2.169 ± 0.36
4.265ThrGly: 4.265 ± 0.517
1.084ThrHis: 1.084 ± 0.318
2.964ThrIle: 2.964 ± 0.414
2.458ThrLys: 2.458 ± 0.483
5.638ThrLeu: 5.638 ± 0.697
1.012ThrMet: 1.012 ± 0.269
2.241ThrAsn: 2.241 ± 0.538
3.47ThrPro: 3.47 ± 0.494
2.458ThrGln: 2.458 ± 0.47
2.675ThrArg: 2.675 ± 0.43
3.036ThrSer: 3.036 ± 0.568
3.687ThrThr: 3.687 ± 0.658
3.831ThrVal: 3.831 ± 0.449
1.59ThrTrp: 1.59 ± 0.361
2.096ThrTyr: 2.096 ± 0.411
0.0ThrXaa: 0.0 ± 0.0
Val
5.566ValAla: 5.566 ± 0.692
0.361ValCys: 0.361 ± 0.227
4.482ValAsp: 4.482 ± 0.58
4.554ValGlu: 4.554 ± 0.508
2.747ValPhe: 2.747 ± 0.469
5.494ValGly: 5.494 ± 0.607
1.446ValHis: 1.446 ± 0.347
3.542ValIle: 3.542 ± 0.574
3.976ValLys: 3.976 ± 0.651
6.072ValLeu: 6.072 ± 0.803
1.663ValMet: 1.663 ± 0.292
2.53ValAsn: 2.53 ± 0.56
4.265ValPro: 4.265 ± 0.702
3.47ValGln: 3.47 ± 0.495
4.771ValArg: 4.771 ± 0.767
3.325ValSer: 3.325 ± 0.452
3.976ValThr: 3.976 ± 0.429
4.409ValVal: 4.409 ± 0.776
1.446ValTrp: 1.446 ± 0.301
2.313ValTyr: 2.313 ± 0.385
0.0ValXaa: 0.0 ± 0.0
Trp
1.446TrpAla: 1.446 ± 0.334
0.434TrpCys: 0.434 ± 0.188
1.012TrpAsp: 1.012 ± 0.258
1.229TrpGlu: 1.229 ± 0.327
0.94TrpPhe: 0.94 ± 0.298
1.446TrpGly: 1.446 ± 0.325
0.289TrpHis: 0.289 ± 0.189
1.157TrpIle: 1.157 ± 0.345
0.867TrpLys: 0.867 ± 0.258
1.084TrpLeu: 1.084 ± 0.359
0.361TrpMet: 0.361 ± 0.154
0.578TrpAsn: 0.578 ± 0.223
0.94TrpPro: 0.94 ± 0.252
0.506TrpGln: 0.506 ± 0.181
1.157TrpArg: 1.157 ± 0.24
1.735TrpSer: 1.735 ± 0.358
0.795TrpThr: 0.795 ± 0.226
1.446TrpVal: 1.446 ± 0.296
0.434TrpTrp: 0.434 ± 0.168
1.084TrpTyr: 1.084 ± 0.394
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.241TyrAla: 2.241 ± 0.409
0.506TyrCys: 0.506 ± 0.214
1.807TyrAsp: 1.807 ± 0.347
1.952TyrGlu: 1.952 ± 0.361
0.94TyrPhe: 0.94 ± 0.273
2.241TyrGly: 2.241 ± 0.428
0.795TyrHis: 0.795 ± 0.268
1.807TyrIle: 1.807 ± 0.401
1.446TyrLys: 1.446 ± 0.447
2.53TyrLeu: 2.53 ± 0.466
1.229TyrMet: 1.229 ± 0.289
1.373TyrAsn: 1.373 ± 0.294
1.59TyrPro: 1.59 ± 0.357
1.735TyrGln: 1.735 ± 0.471
2.602TyrArg: 2.602 ± 0.518
1.301TyrSer: 1.301 ± 0.308
1.518TyrThr: 1.518 ± 0.284
2.096TyrVal: 2.096 ± 0.423
0.651TyrTrp: 0.651 ± 0.232
0.94TyrTyr: 0.94 ± 0.209
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.072XaaArg: 0.072 ± 0.079
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 55 proteins (13835 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski