Amino acid dipepetide frequency for Hymenobacter roseosalivarius DSM 11622

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.217AlaAla: 12.217 ± 0.132	0.807AlaCys: 0.807 ± 0.025	5.442AlaAsp: 5.442 ± 0.061	5.69AlaGlu: 5.69 ± 0.069	3.78AlaPhe: 3.78 ± 0.056	8.075AlaGly: 8.075 ± 0.095	1.937AlaHis: 1.937 ± 0.046	4.329AlaIle: 4.329 ± 0.065	3.678AlaLys: 3.678 ± 0.06	10.651AlaLeu: 10.651 ± 0.112	1.848AlaMet: 1.848 ± 0.041	3.284AlaAsn: 3.284 ± 0.05	5.175AlaPro: 5.175 ± 0.081	4.837AlaGln: 4.837 ± 0.072	5.688AlaArg: 5.688 ± 0.073	5.254AlaSer: 5.254 ± 0.069	6.447AlaThr: 6.447 ± 0.086	6.929AlaVal: 6.929 ± 0.078	1.167AlaTrp: 1.167 ± 0.03	3.093AlaTyr: 3.093 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.638CysAla: 0.638 ± 0.024	0.145CysCys: 0.145 ± 0.012	0.384CysAsp: 0.384 ± 0.017	0.377CysGlu: 0.377 ± 0.02	0.321CysPhe: 0.321 ± 0.017	0.658CysGly: 0.658 ± 0.025	0.204CysHis: 0.204 ± 0.015	0.343CysIle: 0.343 ± 0.015	0.202CysLys: 0.202 ± 0.013	0.788CysLeu: 0.788 ± 0.023	0.142CysMet: 0.142 ± 0.011	0.252CysAsn: 0.252 ± 0.013	0.458CysPro: 0.458 ± 0.024	0.316CysGln: 0.316 ± 0.015	0.444CysArg: 0.444 ± 0.018	0.474CysSer: 0.474 ± 0.017	0.431CysThr: 0.431 ± 0.017	0.494CysVal: 0.494 ± 0.019	0.104CysTrp: 0.104 ± 0.007	0.256CysTyr: 0.256 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.657AspAla: 4.657 ± 0.059	0.349AspCys: 0.349 ± 0.016	2.217AspAsp: 2.217 ± 0.05	3.14AspGlu: 3.14 ± 0.053	2.597AspPhe: 2.597 ± 0.043	3.567AspGly: 3.567 ± 0.053	0.884AspHis: 0.884 ± 0.024	2.567AspIle: 2.567 ± 0.044	2.365AspLys: 2.365 ± 0.049	5.115AspLeu: 5.115 ± 0.059	0.942AspMet: 0.942 ± 0.031	2.013AspAsn: 2.013 ± 0.043	2.431AspPro: 2.431 ± 0.042	2.086AspGln: 2.086 ± 0.039	2.616AspArg: 2.616 ± 0.042	2.573AspSer: 2.573 ± 0.041	2.664AspThr: 2.664 ± 0.049	3.53AspVal: 3.53 ± 0.053	0.7AspTrp: 0.7 ± 0.023	2.12AspTyr: 2.12 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	5.57GluAla: 5.57 ± 0.076	0.327GluCys: 0.327 ± 0.016	2.228GluAsp: 2.228 ± 0.041	3.421GluGlu: 3.421 ± 0.065	2.145GluPhe: 2.145 ± 0.039	3.397GluGly: 3.397 ± 0.048	1.17GluHis: 1.17 ± 0.028	2.737GluIle: 2.737 ± 0.049	2.945GluLys: 2.945 ± 0.058	6.245GluLeu: 6.245 ± 0.085	1.337GluMet: 1.337 ± 0.034	2.158GluAsn: 2.158 ± 0.048	2.275GluPro: 2.275 ± 0.041	3.084GluGln: 3.084 ± 0.058	3.372GluArg: 3.372 ± 0.06	2.502GluSer: 2.502 ± 0.037	2.812GluThr: 2.812 ± 0.047	4.079GluVal: 4.079 ± 0.063	0.668GluTrp: 0.668 ± 0.022	1.814GluTyr: 1.814 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.776PheAla: 3.776 ± 0.049	0.367PheCys: 0.367 ± 0.017	2.525PheAsp: 2.525 ± 0.045	2.256PheGlu: 2.256 ± 0.041	2.007PhePhe: 2.007 ± 0.045	3.379PheGly: 3.379 ± 0.048	0.776PheHis: 0.776 ± 0.028	1.932PheIle: 1.932 ± 0.042	1.582PheLys: 1.582 ± 0.036	4.223PheLeu: 4.223 ± 0.063	0.794PheMet: 0.794 ± 0.023	1.748PheAsn: 1.748 ± 0.039	1.803PhePro: 1.803 ± 0.037	1.594PheGln: 1.594 ± 0.039	2.539PheArg: 2.539 ± 0.045	2.787PheSer: 2.787 ± 0.046	2.839PheThr: 2.839 ± 0.048	2.94PheVal: 2.94 ± 0.043	0.559PheTrp: 0.559 ± 0.021	1.605PheTyr: 1.605 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	6.309GlyAla: 6.309 ± 0.077	0.65GlyCys: 0.65 ± 0.026	3.046GlyAsp: 3.046 ± 0.052	3.631GlyGlu: 3.631 ± 0.048	3.393GlyPhe: 3.393 ± 0.058	6.182GlyGly: 6.182 ± 0.091	1.547GlyHis: 1.547 ± 0.034	4.105GlyIle: 4.105 ± 0.058	3.637GlyLys: 3.637 ± 0.054	8.113GlyLeu: 8.113 ± 0.097	1.52GlyMet: 1.52 ± 0.035	2.761GlyAsn: 2.761 ± 0.054	2.816GlyPro: 2.816 ± 0.049	3.832GlyGln: 3.832 ± 0.057	4.432GlyArg: 4.432 ± 0.064	4.423GlySer: 4.423 ± 0.071	4.758GlyThr: 4.758 ± 0.089	5.141GlyVal: 5.141 ± 0.063	0.989GlyTrp: 0.989 ± 0.028	2.819GlyTyr: 2.819 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.698HisAla: 1.698 ± 0.035	0.206HisCys: 0.206 ± 0.013	1.023HisAsp: 1.023 ± 0.029	1.093HisGlu: 1.093 ± 0.031	1.043HisPhe: 1.043 ± 0.025	1.489HisGly: 1.489 ± 0.031	0.585HisHis: 0.585 ± 0.026	0.962HisIle: 0.962 ± 0.027	0.668HisLys: 0.668 ± 0.023	2.415HisLeu: 2.415 ± 0.045	0.347HisMet: 0.347 ± 0.014	0.706HisAsn: 0.706 ± 0.02	1.256HisPro: 1.256 ± 0.029	0.957HisGln: 0.957 ± 0.032	1.189HisArg: 1.189 ± 0.035	1.04HisSer: 1.04 ± 0.026	1.149HisThr: 1.149 ± 0.03	1.221HisVal: 1.221 ± 0.03	0.291HisTrp: 0.291 ± 0.014	0.887HisTyr: 0.887 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	4.474IleAla: 4.474 ± 0.06	0.422IleCys: 0.422 ± 0.018	2.676IleAsp: 2.676 ± 0.051	2.745IleGlu: 2.745 ± 0.054	1.866IlePhe: 1.866 ± 0.039	3.822IleGly: 3.822 ± 0.065	0.868IleHis: 0.868 ± 0.027	2.633IleIle: 2.633 ± 0.047	2.113IleLys: 2.113 ± 0.045	4.345IleLeu: 4.345 ± 0.063	0.856IleMet: 0.856 ± 0.027	2.051IleAsn: 2.051 ± 0.044	2.382IlePro: 2.382 ± 0.041	1.846IleGln: 1.846 ± 0.039	2.921IleArg: 2.921 ± 0.047	3.099IleSer: 3.099 ± 0.043	3.261IleThr: 3.261 ± 0.048	3.288IleVal: 3.288 ± 0.056	0.517IleTrp: 0.517 ± 0.021	1.55IleTyr: 1.55 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	4.146LysAla: 4.146 ± 0.072	0.221LysCys: 0.221 ± 0.015	2.105LysAsp: 2.105 ± 0.048	2.505LysGlu: 2.505 ± 0.05	1.4LysPhe: 1.4 ± 0.034	2.817LysGly: 2.817 ± 0.049	0.79LysHis: 0.79 ± 0.025	2.217LysIle: 2.217 ± 0.042	2.538LysLys: 2.538 ± 0.057	4.365LysLeu: 4.365 ± 0.062	1.194LysMet: 1.194 ± 0.037	1.777LysAsn: 1.777 ± 0.04	2.202LysPro: 2.202 ± 0.044	2.031LysGln: 2.031 ± 0.035	2.214LysArg: 2.214 ± 0.039	2.255LysSer: 2.255 ± 0.045	2.507LysThr: 2.507 ± 0.044	2.917LysVal: 2.917 ± 0.049	0.431LysTrp: 0.431 ± 0.018	1.407LysTyr: 1.407 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	11.056LeuAla: 11.056 ± 0.106	0.762LeuCys: 0.762 ± 0.026	5.423LeuAsp: 5.423 ± 0.055	5.209LeuGlu: 5.209 ± 0.065	4.296LeuPhe: 4.296 ± 0.063	7.865LeuGly: 7.865 ± 0.089	2.286LeuHis: 2.286 ± 0.044	4.788LeuIle: 4.788 ± 0.08	4.225LeuLys: 4.225 ± 0.061	13.376LeuLeu: 13.376 ± 0.144	2.0LeuMet: 2.0 ± 0.042	4.335LeuAsn: 4.335 ± 0.066	6.202LeuPro: 6.202 ± 0.084	4.305LeuGln: 4.305 ± 0.06	7.591LeuArg: 7.591 ± 0.09	6.537LeuSer: 6.537 ± 0.085	7.407LeuThr: 7.407 ± 0.083	7.465LeuVal: 7.465 ± 0.071	1.058LeuTrp: 1.058 ± 0.032	3.309LeuTyr: 3.309 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	1.977MetAla: 1.977 ± 0.043	0.117MetCys: 0.117 ± 0.008	0.786MetAsp: 0.786 ± 0.027	0.974MetGlu: 0.974 ± 0.03	0.596MetPhe: 0.596 ± 0.023	1.397MetGly: 1.397 ± 0.037	0.438MetHis: 0.438 ± 0.018	0.849MetIle: 0.849 ± 0.025	1.145MetLys: 1.145 ± 0.034	2.188MetLeu: 2.188 ± 0.043	0.496MetMet: 0.496 ± 0.021	0.794MetAsn: 0.794 ± 0.019	1.274MetPro: 1.274 ± 0.031	0.969MetGln: 0.969 ± 0.026	1.313MetArg: 1.313 ± 0.032	1.175MetSer: 1.175 ± 0.031	1.172MetThr: 1.172 ± 0.031	1.3MetVal: 1.3 ± 0.034	0.168MetTrp: 0.168 ± 0.012	0.49MetTyr: 0.49 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.433AsnAla: 3.433 ± 0.056	0.276AsnCys: 0.276 ± 0.015	1.806AsnAsp: 1.806 ± 0.037	1.965AsnGlu: 1.965 ± 0.045	1.729AsnPhe: 1.729 ± 0.039	2.995AsnGly: 2.995 ± 0.056	0.69AsnHis: 0.69 ± 0.025	1.931AsnIle: 1.931 ± 0.046	1.619AsnLys: 1.619 ± 0.039	4.022AsnLeu: 4.022 ± 0.055	0.748AsnMet: 0.748 ± 0.026	1.638AsnAsn: 1.638 ± 0.046	2.545AsnPro: 2.545 ± 0.053	1.814AsnGln: 1.814 ± 0.037	2.216AsnArg: 2.216 ± 0.042	2.189AsnSer: 2.189 ± 0.045	2.321AsnThr: 2.321 ± 0.049	2.616AsnVal: 2.616 ± 0.049	0.482AsnTrp: 0.482 ± 0.018	1.491AsnTyr: 1.491 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	6.48ProAla: 6.48 ± 0.08	0.255ProCys: 0.255 ± 0.012	3.237ProAsp: 3.237 ± 0.054	3.355ProGlu: 3.355 ± 0.05	1.915ProPhe: 1.915 ± 0.038	3.811ProGly: 3.811 ± 0.051	0.981ProHis: 0.981 ± 0.026	2.227ProIle: 2.227 ± 0.041	1.836ProLys: 1.836 ± 0.046	4.941ProLeu: 4.941 ± 0.07	0.846ProMet: 0.846 ± 0.028	2.051ProAsn: 2.051 ± 0.044	2.402ProPro: 2.402 ± 0.056	2.166ProGln: 2.166 ± 0.04	2.503ProArg: 2.503 ± 0.044	2.643ProSer: 2.643 ± 0.05	3.496ProThr: 3.496 ± 0.056	4.081ProVal: 4.081 ± 0.066	0.541ProTrp: 0.541 ± 0.019	1.573ProTyr: 1.573 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.962GlnAla: 4.962 ± 0.074	0.233GlnCys: 0.233 ± 0.013	1.863GlnAsp: 1.863 ± 0.038	2.534GlnGlu: 2.534 ± 0.046	1.749GlnPhe: 1.749 ± 0.036	2.749GlnGly: 2.749 ± 0.041	1.126GlnHis: 1.126 ± 0.033	2.045GlnIle: 2.045 ± 0.042	1.93GlnLys: 1.93 ± 0.04	5.487GlnLeu: 5.487 ± 0.066	0.957GlnMet: 0.957 ± 0.024	1.807GlnAsn: 1.807 ± 0.039	2.771GlnPro: 2.771 ± 0.045	3.188GlnGln: 3.188 ± 0.062	3.256GlnArg: 3.256 ± 0.05	2.082GlnSer: 2.082 ± 0.038	2.584GlnThr: 2.584 ± 0.044	3.521GlnVal: 3.521 ± 0.049	0.556GlnTrp: 0.556 ± 0.022	1.52GlnTyr: 1.52 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	5.335ArgAla: 5.335 ± 0.072	0.39ArgCys: 0.39 ± 0.017	2.762ArgAsp: 2.762 ± 0.054	3.474ArgGlu: 3.474 ± 0.057	2.799ArgPhe: 2.799 ± 0.048	3.731ArgGly: 3.731 ± 0.059	1.405ArgHis: 1.405 ± 0.033	3.051ArgIle: 3.051 ± 0.047	2.412ArgLys: 2.412 ± 0.032	7.136ArgLeu: 7.136 ± 0.088	1.265ArgMet: 1.265 ± 0.031	2.264ArgAsn: 2.264 ± 0.047	3.114ArgPro: 3.114 ± 0.053	3.556ArgGln: 3.556 ± 0.059	4.42ArgArg: 4.42 ± 0.062	2.78ArgSer: 2.78 ± 0.049	3.583ArgThr: 3.583 ± 0.049	4.252ArgVal: 4.252 ± 0.059	0.86ArgTrp: 0.86 ± 0.03	2.475ArgTyr: 2.475 ± 0.043	0.001ArgXaa: 0.001 ± 0.001
Ser	5.348SerAla: 5.348 ± 0.056	0.518SerCys: 0.518 ± 0.02	2.493SerAsp: 2.493 ± 0.041	2.63SerGlu: 2.63 ± 0.041	2.79SerPhe: 2.79 ± 0.054	4.531SerGly: 4.531 ± 0.071	0.994SerHis: 0.994 ± 0.025	2.839SerIle: 2.839 ± 0.053	2.226SerLys: 2.226 ± 0.041	6.072SerLeu: 6.072 ± 0.068	1.063SerMet: 1.063 ± 0.03	2.091SerAsn: 2.091 ± 0.046	2.897SerPro: 2.897 ± 0.051	2.139SerGln: 2.139 ± 0.04	3.291SerArg: 3.291 ± 0.05	3.597SerSer: 3.597 ± 0.059	3.526SerThr: 3.526 ± 0.06	3.958SerVal: 3.958 ± 0.055	0.752SerTrp: 0.752 ± 0.023	2.07SerTyr: 2.07 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	6.398ThrAla: 6.398 ± 0.089	0.406ThrCys: 0.406 ± 0.018	3.372ThrAsp: 3.372 ± 0.047	3.119ThrGlu: 3.119 ± 0.051	2.499ThrPhe: 2.499 ± 0.049	5.072ThrGly: 5.072 ± 0.079	1.172ThrHis: 1.172 ± 0.03	3.135ThrIle: 3.135 ± 0.048	2.27ThrLys: 2.27 ± 0.042	6.59ThrLeu: 6.59 ± 0.067	1.046ThrMet: 1.046 ± 0.026	2.329ThrAsn: 2.329 ± 0.05	3.718ThrPro: 3.718 ± 0.053	2.439ThrGln: 2.439 ± 0.042	3.159ThrArg: 3.159 ± 0.05	3.546ThrSer: 3.546 ± 0.063	4.165ThrThr: 4.165 ± 0.082	4.576ThrVal: 4.576 ± 0.072	0.72ThrTrp: 0.72 ± 0.026	2.232ThrTyr: 2.232 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	7.692ValAla: 7.692 ± 0.078	0.554ValCys: 0.554 ± 0.02	3.251ValAsp: 3.251 ± 0.056	3.805ValGlu: 3.805 ± 0.055	2.866ValPhe: 2.866 ± 0.048	5.19ValGly: 5.19 ± 0.069	1.236ValHis: 1.236 ± 0.03	3.266ValIle: 3.266 ± 0.054	2.817ValLys: 2.817 ± 0.054	7.989ValLeu: 7.989 ± 0.081	1.354ValMet: 1.354 ± 0.036	2.547ValAsn: 2.547 ± 0.055	3.597ValPro: 3.597 ± 0.053	3.037ValGln: 3.037 ± 0.044	4.768ValArg: 4.768 ± 0.057	4.252ValSer: 4.252 ± 0.061	4.105ValThr: 4.105 ± 0.066	5.673ValVal: 5.673 ± 0.072	0.777ValTrp: 0.777 ± 0.026	2.244ValTyr: 2.244 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.002TrpAla: 1.002 ± 0.027	0.103TrpCys: 0.103 ± 0.009	0.522TrpAsp: 0.522 ± 0.02	0.602TrpGlu: 0.602 ± 0.02	0.524TrpPhe: 0.524 ± 0.022	0.8TrpGly: 0.8 ± 0.028	0.322TrpHis: 0.322 ± 0.016	0.45TrpIle: 0.45 ± 0.019	0.473TrpLys: 0.473 ± 0.022	1.663TrpLeu: 1.663 ± 0.04	0.266TrpMet: 0.266 ± 0.015	0.47TrpAsn: 0.47 ± 0.019	0.505TrpPro: 0.505 ± 0.021	0.797TrpGln: 0.797 ± 0.023	0.836TrpArg: 0.836 ± 0.024	0.621TrpSer: 0.621 ± 0.024	0.624TrpThr: 0.624 ± 0.023	0.81TrpVal: 0.81 ± 0.028	0.222TrpTrp: 0.222 ± 0.015	0.403TrpTyr: 0.403 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.159TyrAla: 3.159 ± 0.05	0.322TyrCys: 0.322 ± 0.016	1.972TyrAsp: 1.972 ± 0.041	1.763TyrGlu: 1.763 ± 0.039	1.718TyrPhe: 1.718 ± 0.032	2.579TyrGly: 2.579 ± 0.043	0.812TyrHis: 0.812 ± 0.024	1.33TyrIle: 1.33 ± 0.032	1.36TyrLys: 1.36 ± 0.035	3.773TyrLeu: 3.773 ± 0.058	0.595TyrMet: 0.595 ± 0.021	1.447TyrAsn: 1.447 ± 0.035	1.515TyrPro: 1.515 ± 0.034	1.926TyrGln: 1.926 ± 0.04	2.297TyrArg: 2.297 ± 0.042	1.995TyrSer: 1.995 ± 0.041	2.11TyrThr: 2.11 ± 0.041	2.233TyrVal: 2.233 ± 0.04	0.453TyrTrp: 0.453 ± 0.017	1.533TyrTyr: 1.533 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4391 proteins (1404893 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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