Amino acid dipepetide frequency for Salmonella phage 34

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.108AlaAla: 10.108 ± 1.199
1.095AlaCys: 1.095 ± 0.321
5.812AlaAsp: 5.812 ± 0.692
6.991AlaGlu: 6.991 ± 0.853
3.454AlaPhe: 3.454 ± 0.487
6.486AlaGly: 6.486 ± 0.862
1.348AlaHis: 1.348 ± 0.347
6.149AlaIle: 6.149 ± 0.713
5.475AlaLys: 5.475 ± 0.75
6.57AlaLeu: 6.57 ± 0.892
4.043AlaMet: 4.043 ± 0.559
6.149AlaAsn: 6.149 ± 0.794
2.358AlaPro: 2.358 ± 0.425
3.201AlaGln: 3.201 ± 0.668
5.475AlaArg: 5.475 ± 0.687
4.549AlaSer: 4.549 ± 0.62
5.644AlaThr: 5.644 ± 0.824
5.222AlaVal: 5.222 ± 0.588
1.516AlaTrp: 1.516 ± 0.332
2.948AlaTyr: 2.948 ± 0.442
0.0AlaXaa: 0.0 ± 0.0
Cys
0.927CysAla: 0.927 ± 0.302
0.253CysCys: 0.253 ± 0.147
0.337CysAsp: 0.337 ± 0.164
0.674CysGlu: 0.674 ± 0.245
0.59CysPhe: 0.59 ± 0.266
1.095CysGly: 1.095 ± 0.332
0.505CysHis: 0.505 ± 0.25
0.421CysIle: 0.421 ± 0.211
0.927CysLys: 0.927 ± 0.3
0.674CysLeu: 0.674 ± 0.242
0.421CysMet: 0.421 ± 0.192
0.674CysAsn: 0.674 ± 0.254
0.421CysPro: 0.421 ± 0.17
0.505CysGln: 0.505 ± 0.2
1.432CysArg: 1.432 ± 0.371
1.011CysSer: 1.011 ± 0.324
0.337CysThr: 0.337 ± 0.213
1.095CysVal: 1.095 ± 0.318
0.168CysTrp: 0.168 ± 0.115
0.505CysTyr: 0.505 ± 0.193
0.0CysXaa: 0.0 ± 0.0
Asp
7.749AspAla: 7.749 ± 0.886
1.095AspCys: 1.095 ± 0.336
3.875AspAsp: 3.875 ± 0.701
3.79AspGlu: 3.79 ± 0.591
2.106AspPhe: 2.106 ± 0.497
4.38AspGly: 4.38 ± 0.582
0.927AspHis: 0.927 ± 0.306
4.127AspIle: 4.127 ± 0.616
3.369AspLys: 3.369 ± 0.597
4.549AspLeu: 4.549 ± 0.64
1.853AspMet: 1.853 ± 0.405
2.19AspAsn: 2.19 ± 0.388
1.769AspPro: 1.769 ± 0.395
1.011AspGln: 1.011 ± 0.26
1.937AspArg: 1.937 ± 0.361
3.285AspSer: 3.285 ± 0.57
2.106AspThr: 2.106 ± 0.415
4.549AspVal: 4.549 ± 0.659
0.758AspTrp: 0.758 ± 0.291
3.454AspTyr: 3.454 ± 0.456
0.0AspXaa: 0.0 ± 0.0
Glu
5.728GluAla: 5.728 ± 0.653
1.348GluCys: 1.348 ± 0.316
3.538GluAsp: 3.538 ± 0.578
5.138GluGlu: 5.138 ± 0.837
2.022GluPhe: 2.022 ± 0.488
3.875GluGly: 3.875 ± 0.474
1.263GluHis: 1.263 ± 0.332
3.706GluIle: 3.706 ± 0.554
4.38GluLys: 4.38 ± 0.595
6.57GluLeu: 6.57 ± 0.678
2.106GluMet: 2.106 ± 0.424
3.285GluAsn: 3.285 ± 0.495
2.274GluPro: 2.274 ± 0.46
3.454GluGln: 3.454 ± 0.581
4.464GluArg: 4.464 ± 0.76
3.538GluSer: 3.538 ± 0.517
2.695GluThr: 2.695 ± 0.522
2.864GluVal: 2.864 ± 0.471
1.769GluTrp: 1.769 ± 0.348
1.685GluTyr: 1.685 ± 0.357
0.0GluXaa: 0.0 ± 0.0
Phe
3.032PheAla: 3.032 ± 0.471
0.758PheCys: 0.758 ± 0.243
2.274PheAsp: 2.274 ± 0.506
1.6PheGlu: 1.6 ± 0.338
1.179PhePhe: 1.179 ± 0.382
2.358PheGly: 2.358 ± 0.438
0.59PheHis: 0.59 ± 0.222
2.864PheIle: 2.864 ± 0.491
1.853PheLys: 1.853 ± 0.445
2.022PheLeu: 2.022 ± 0.477
0.927PheMet: 0.927 ± 0.23
2.358PheAsn: 2.358 ± 0.434
1.432PhePro: 1.432 ± 0.324
1.179PheGln: 1.179 ± 0.401
1.516PheArg: 1.516 ± 0.42
2.358PheSer: 2.358 ± 0.479
2.274PheThr: 2.274 ± 0.414
1.348PheVal: 1.348 ± 0.305
0.59PheTrp: 0.59 ± 0.229
1.095PheTyr: 1.095 ± 0.33
0.0PheXaa: 0.0 ± 0.0
Gly
5.475GlyAla: 5.475 ± 0.969
0.59GlyCys: 0.59 ± 0.174
3.538GlyAsp: 3.538 ± 0.484
4.043GlyGlu: 4.043 ± 0.586
2.527GlyPhe: 2.527 ± 0.534
5.138GlyGly: 5.138 ± 1.016
0.842GlyHis: 0.842 ± 0.285
4.127GlyIle: 4.127 ± 0.634
5.307GlyLys: 5.307 ± 0.648
5.475GlyLeu: 5.475 ± 0.675
2.948GlyMet: 2.948 ± 0.504
3.538GlyAsn: 3.538 ± 0.51
1.095GlyPro: 1.095 ± 0.32
3.79GlyGln: 3.79 ± 0.746
4.717GlyArg: 4.717 ± 0.684
3.875GlySer: 3.875 ± 0.657
3.622GlyThr: 3.622 ± 0.564
5.475GlyVal: 5.475 ± 0.601
1.516GlyTrp: 1.516 ± 0.347
2.022GlyTyr: 2.022 ± 0.417
0.0GlyXaa: 0.0 ± 0.0
His
1.179HisAla: 1.179 ± 0.308
0.253HisCys: 0.253 ± 0.132
1.179HisAsp: 1.179 ± 0.321
1.516HisGlu: 1.516 ± 0.335
1.095HisPhe: 1.095 ± 0.323
1.011HisGly: 1.011 ± 0.317
0.337HisHis: 0.337 ± 0.157
0.927HisIle: 0.927 ± 0.228
1.263HisLys: 1.263 ± 0.396
1.516HisLeu: 1.516 ± 0.412
0.674HisMet: 0.674 ± 0.208
0.421HisAsn: 0.421 ± 0.18
0.758HisPro: 0.758 ± 0.253
0.842HisGln: 0.842 ± 0.27
0.758HisArg: 0.758 ± 0.307
0.927HisSer: 0.927 ± 0.31
0.505HisThr: 0.505 ± 0.201
0.674HisVal: 0.674 ± 0.233
0.253HisTrp: 0.253 ± 0.139
0.59HisTyr: 0.59 ± 0.218
0.0HisXaa: 0.0 ± 0.0
Ile
6.654IleAla: 6.654 ± 0.7
0.505IleCys: 0.505 ± 0.187
3.538IleAsp: 3.538 ± 0.52
3.875IleGlu: 3.875 ± 0.599
2.274IlePhe: 2.274 ± 0.512
5.307IleGly: 5.307 ± 0.818
1.348IleHis: 1.348 ± 0.347
4.38IleIle: 4.38 ± 0.795
2.695IleLys: 2.695 ± 0.401
3.201IleLeu: 3.201 ± 0.632
1.263IleMet: 1.263 ± 0.385
3.201IleAsn: 3.201 ± 0.549
3.032IlePro: 3.032 ± 0.514
1.853IleGln: 1.853 ± 0.4
3.285IleArg: 3.285 ± 0.438
4.633IleSer: 4.633 ± 0.689
4.885IleThr: 4.885 ± 0.514
3.201IleVal: 3.201 ± 0.497
0.505IleTrp: 0.505 ± 0.188
2.274IleTyr: 2.274 ± 0.325
0.0IleXaa: 0.0 ± 0.0
Lys
5.475LysAla: 5.475 ± 0.692
0.927LysCys: 0.927 ± 0.268
3.538LysAsp: 3.538 ± 0.586
4.717LysGlu: 4.717 ± 0.66
2.022LysPhe: 2.022 ± 0.45
3.79LysGly: 3.79 ± 0.537
0.758LysHis: 0.758 ± 0.237
3.285LysIle: 3.285 ± 0.634
5.054LysLys: 5.054 ± 0.792
6.402LysLeu: 6.402 ± 0.792
1.6LysMet: 1.6 ± 0.419
2.443LysAsn: 2.443 ± 0.502
4.127LysPro: 4.127 ± 0.626
2.864LysGln: 2.864 ± 0.632
4.043LysArg: 4.043 ± 0.559
3.706LysSer: 3.706 ± 0.596
3.538LysThr: 3.538 ± 0.532
3.032LysVal: 3.032 ± 0.531
0.253LysTrp: 0.253 ± 0.14
2.19LysTyr: 2.19 ± 0.493
0.0LysXaa: 0.0 ± 0.0
Leu
7.244LeuAla: 7.244 ± 0.783
0.59LeuCys: 0.59 ± 0.256
3.875LeuAsp: 3.875 ± 0.608
4.97LeuGlu: 4.97 ± 0.634
2.695LeuPhe: 2.695 ± 0.523
4.717LeuGly: 4.717 ± 0.769
1.179LeuHis: 1.179 ± 0.313
5.138LeuIle: 5.138 ± 0.737
6.233LeuLys: 6.233 ± 0.707
7.328LeuLeu: 7.328 ± 0.837
2.527LeuMet: 2.527 ± 0.436
4.464LeuAsn: 4.464 ± 0.586
2.695LeuPro: 2.695 ± 0.491
2.948LeuGln: 2.948 ± 0.514
4.296LeuArg: 4.296 ± 0.661
5.896LeuSer: 5.896 ± 0.594
4.717LeuThr: 4.717 ± 0.501
4.212LeuVal: 4.212 ± 0.491
1.011LeuTrp: 1.011 ± 0.319
2.443LeuTyr: 2.443 ± 0.414
0.0LeuXaa: 0.0 ± 0.0
Met
3.201MetAla: 3.201 ± 0.53
0.337MetCys: 0.337 ± 0.172
1.263MetAsp: 1.263 ± 0.385
1.516MetGlu: 1.516 ± 0.359
0.421MetPhe: 0.421 ± 0.185
2.022MetGly: 2.022 ± 0.322
0.084MetHis: 0.084 ± 0.085
1.769MetIle: 1.769 ± 0.34
2.864MetLys: 2.864 ± 0.472
2.527MetLeu: 2.527 ± 0.464
1.011MetMet: 1.011 ± 0.249
1.263MetAsn: 1.263 ± 0.296
1.263MetPro: 1.263 ± 0.338
2.022MetGln: 2.022 ± 0.408
2.443MetArg: 2.443 ± 0.41
2.864MetSer: 2.864 ± 0.475
2.106MetThr: 2.106 ± 0.437
1.937MetVal: 1.937 ± 0.37
0.084MetTrp: 0.084 ± 0.081
1.095MetTyr: 1.095 ± 0.326
0.0MetXaa: 0.0 ± 0.0
Asn
5.307AsnAla: 5.307 ± 0.791
0.337AsnCys: 0.337 ± 0.168
2.358AsnAsp: 2.358 ± 0.515
2.274AsnGlu: 2.274 ± 0.393
0.758AsnPhe: 0.758 ± 0.247
4.801AsnGly: 4.801 ± 0.573
1.095AsnHis: 1.095 ± 0.349
2.948AsnIle: 2.948 ± 0.511
2.527AsnLys: 2.527 ± 0.484
3.285AsnLeu: 3.285 ± 0.533
1.685AsnMet: 1.685 ± 0.347
2.358AsnAsn: 2.358 ± 0.476
2.611AsnPro: 2.611 ± 0.471
2.78AsnGln: 2.78 ± 0.507
2.443AsnArg: 2.443 ± 0.501
3.622AsnSer: 3.622 ± 0.482
2.611AsnThr: 2.611 ± 0.462
2.443AsnVal: 2.443 ± 0.697
0.59AsnTrp: 0.59 ± 0.242
1.6AsnTyr: 1.6 ± 0.375
0.0AsnXaa: 0.0 ± 0.0
Pro
2.864ProAla: 2.864 ± 0.415
0.168ProCys: 0.168 ± 0.113
3.285ProAsp: 3.285 ± 0.441
4.97ProGlu: 4.97 ± 0.604
1.263ProPhe: 1.263 ± 0.287
1.853ProGly: 1.853 ± 0.441
0.674ProHis: 0.674 ± 0.234
2.358ProIle: 2.358 ± 0.363
2.358ProLys: 2.358 ± 0.419
3.285ProLeu: 3.285 ± 0.608
1.348ProMet: 1.348 ± 0.35
1.6ProAsn: 1.6 ± 0.349
1.348ProPro: 1.348 ± 0.356
1.6ProGln: 1.6 ± 0.31
1.6ProArg: 1.6 ± 0.334
2.274ProSer: 2.274 ± 0.338
1.937ProThr: 1.937 ± 0.338
3.032ProVal: 3.032 ± 0.509
0.168ProTrp: 0.168 ± 0.108
1.011ProTyr: 1.011 ± 0.32
0.0ProXaa: 0.0 ± 0.0
Gln
3.201GlnAla: 3.201 ± 0.535
0.421GlnCys: 0.421 ± 0.19
2.611GlnAsp: 2.611 ± 0.5
2.527GlnGlu: 2.527 ± 0.412
1.095GlnPhe: 1.095 ± 0.32
2.695GlnGly: 2.695 ± 0.618
1.011GlnHis: 1.011 ± 0.293
3.032GlnIle: 3.032 ± 0.555
1.769GlnLys: 1.769 ± 0.358
3.79GlnLeu: 3.79 ± 0.527
1.516GlnMet: 1.516 ± 0.311
2.274GlnAsn: 2.274 ± 0.739
1.685GlnPro: 1.685 ± 0.358
3.454GlnGln: 3.454 ± 0.893
3.201GlnArg: 3.201 ± 0.512
3.454GlnSer: 3.454 ± 0.573
1.432GlnThr: 1.432 ± 0.333
2.274GlnVal: 2.274 ± 0.536
0.927GlnTrp: 0.927 ± 0.25
2.022GlnTyr: 2.022 ± 0.406
0.0GlnXaa: 0.0 ± 0.0
Arg
4.633ArgAla: 4.633 ± 0.467
0.758ArgCys: 0.758 ± 0.281
3.875ArgAsp: 3.875 ± 0.593
3.959ArgGlu: 3.959 ± 0.575
1.516ArgPhe: 1.516 ± 0.34
3.454ArgGly: 3.454 ± 0.517
1.432ArgHis: 1.432 ± 0.299
3.454ArgIle: 3.454 ± 0.551
4.043ArgLys: 4.043 ± 0.72
4.717ArgLeu: 4.717 ± 0.607
2.695ArgMet: 2.695 ± 0.43
2.527ArgAsn: 2.527 ± 0.635
2.022ArgPro: 2.022 ± 0.5
2.78ArgGln: 2.78 ± 0.453
3.706ArgArg: 3.706 ± 0.802
3.622ArgSer: 3.622 ± 0.469
1.769ArgThr: 1.769 ± 0.348
3.622ArgVal: 3.622 ± 0.505
0.927ArgTrp: 0.927 ± 0.283
2.106ArgTyr: 2.106 ± 0.493
0.0ArgXaa: 0.0 ± 0.0
Ser
5.728SerAla: 5.728 ± 0.728
1.095SerCys: 1.095 ± 0.364
3.454SerAsp: 3.454 ± 0.552
3.959SerGlu: 3.959 ± 0.622
2.358SerPhe: 2.358 ± 0.51
5.812SerGly: 5.812 ± 0.848
1.179SerHis: 1.179 ± 0.33
3.959SerIle: 3.959 ± 0.646
3.369SerLys: 3.369 ± 0.465
5.644SerLeu: 5.644 ± 0.692
1.769SerMet: 1.769 ± 0.332
2.527SerAsn: 2.527 ± 0.35
3.201SerPro: 3.201 ± 0.482
2.864SerGln: 2.864 ± 0.52
3.369SerArg: 3.369 ± 0.488
3.369SerSer: 3.369 ± 0.627
2.611SerThr: 2.611 ± 0.539
3.875SerVal: 3.875 ± 0.551
0.927SerTrp: 0.927 ± 0.276
2.19SerTyr: 2.19 ± 0.448
0.0SerXaa: 0.0 ± 0.0
Thr
5.644ThrAla: 5.644 ± 0.704
0.59ThrCys: 0.59 ± 0.224
2.695ThrAsp: 2.695 ± 0.428
2.695ThrGlu: 2.695 ± 0.502
1.937ThrPhe: 1.937 ± 0.423
4.212ThrGly: 4.212 ± 0.661
0.674ThrHis: 0.674 ± 0.202
3.285ThrIle: 3.285 ± 0.46
3.79ThrLys: 3.79 ± 0.701
3.285ThrLeu: 3.285 ± 0.605
1.011ThrMet: 1.011 ± 0.287
1.937ThrAsn: 1.937 ± 0.433
2.78ThrPro: 2.78 ± 0.449
2.443ThrGln: 2.443 ± 0.39
2.527ThrArg: 2.527 ± 0.495
3.117ThrSer: 3.117 ± 0.481
2.527ThrThr: 2.527 ± 0.47
3.032ThrVal: 3.032 ± 0.369
0.758ThrTrp: 0.758 ± 0.246
1.685ThrTyr: 1.685 ± 0.391
0.0ThrXaa: 0.0 ± 0.0
Val
6.317ValAla: 6.317 ± 0.561
0.758ValCys: 0.758 ± 0.252
3.706ValAsp: 3.706 ± 0.55
4.212ValGlu: 4.212 ± 0.493
2.274ValPhe: 2.274 ± 0.396
3.538ValGly: 3.538 ± 0.647
0.337ValHis: 0.337 ± 0.186
3.117ValIle: 3.117 ± 0.658
3.79ValLys: 3.79 ± 0.565
5.054ValLeu: 5.054 ± 0.697
1.263ValMet: 1.263 ± 0.395
3.032ValAsn: 3.032 ± 0.535
2.022ValPro: 2.022 ± 0.463
2.022ValGln: 2.022 ± 0.39
3.117ValArg: 3.117 ± 0.474
4.212ValSer: 4.212 ± 0.663
3.285ValThr: 3.285 ± 0.539
4.633ValVal: 4.633 ± 0.544
0.758ValTrp: 0.758 ± 0.272
1.853ValTyr: 1.853 ± 0.507
0.0ValXaa: 0.0 ± 0.0
Trp
1.095TrpAla: 1.095 ± 0.292
0.337TrpCys: 0.337 ± 0.183
0.842TrpAsp: 0.842 ± 0.294
0.758TrpGlu: 0.758 ± 0.28
0.505TrpPhe: 0.505 ± 0.203
0.927TrpGly: 0.927 ± 0.282
0.337TrpHis: 0.337 ± 0.168
0.59TrpIle: 0.59 ± 0.223
1.348TrpLys: 1.348 ± 0.364
1.179TrpLeu: 1.179 ± 0.396
0.758TrpMet: 0.758 ± 0.222
0.421TrpAsn: 0.421 ± 0.18
0.505TrpPro: 0.505 ± 0.185
0.842TrpGln: 0.842 ± 0.233
0.758TrpArg: 0.758 ± 0.232
0.674TrpSer: 0.674 ± 0.191
0.505TrpThr: 0.505 ± 0.205
1.011TrpVal: 1.011 ± 0.282
0.253TrpTrp: 0.253 ± 0.131
0.421TrpTyr: 0.421 ± 0.186
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.032TyrAla: 3.032 ± 0.541
0.758TyrCys: 0.758 ± 0.244
3.285TyrAsp: 3.285 ± 0.706
1.516TyrGlu: 1.516 ± 0.39
1.516TyrPhe: 1.516 ± 0.31
2.19TyrGly: 2.19 ± 0.576
0.758TyrHis: 0.758 ± 0.338
2.358TyrIle: 2.358 ± 0.532
1.348TyrLys: 1.348 ± 0.318
2.106TyrLeu: 2.106 ± 0.399
0.59TyrMet: 0.59 ± 0.216
1.769TyrAsn: 1.769 ± 0.457
1.6TyrPro: 1.6 ± 0.421
1.937TyrGln: 1.937 ± 0.44
2.527TyrArg: 2.527 ± 0.425
2.274TyrSer: 2.274 ± 0.54
1.516TyrThr: 1.516 ± 0.253
1.769TyrVal: 1.769 ± 0.429
0.337TyrTrp: 0.337 ± 0.157
1.095TyrTyr: 1.095 ± 0.351
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 78 proteins (11873 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski