Amino acid dipepetide frequency for Strigops habroptila (Kakapo)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.214AlaAla: 7.214 ± 0.044	1.372AlaCys: 1.372 ± 0.013	3.052AlaAsp: 3.052 ± 0.015	4.851AlaGlu: 4.851 ± 0.027	2.53AlaPhe: 2.53 ± 0.013	4.627AlaGly: 4.627 ± 0.025	1.396AlaHis: 1.396 ± 0.011	2.903AlaIle: 2.903 ± 0.013	3.536AlaLys: 3.536 ± 0.022	6.872AlaLeu: 6.872 ± 0.03	1.602AlaMet: 1.602 ± 0.011	2.195AlaAsn: 2.195 ± 0.013	3.636AlaPro: 3.636 ± 0.027	2.938AlaGln: 2.938 ± 0.021	3.34AlaArg: 3.34 ± 0.018	5.324AlaSer: 5.324 ± 0.024	3.437AlaThr: 3.437 ± 0.019	4.976AlaVal: 4.976 ± 0.017	0.763AlaTrp: 0.763 ± 0.007	1.547AlaTyr: 1.547 ± 0.01	0.0AlaXaa: 0.0 ± 0.0
Cys	1.269CysAla: 1.269 ± 0.011	0.667CysCys: 0.667 ± 0.009	1.101CysAsp: 1.101 ± 0.013	1.34CysGlu: 1.34 ± 0.015	0.924CysPhe: 0.924 ± 0.007	1.548CysGly: 1.548 ± 0.015	0.667CysHis: 0.667 ± 0.009	1.147CysIle: 1.147 ± 0.013	1.243CysLys: 1.243 ± 0.012	2.219CysLeu: 2.219 ± 0.015	0.463CysMet: 0.463 ± 0.006	0.898CysAsn: 0.898 ± 0.01	1.354CysPro: 1.354 ± 0.015	1.107CysGln: 1.107 ± 0.015	1.316CysArg: 1.316 ± 0.012	2.074CysSer: 2.074 ± 0.015	1.213CysThr: 1.213 ± 0.012	1.344CysVal: 1.344 ± 0.012	0.298CysTrp: 0.298 ± 0.004	0.637CysTyr: 0.637 ± 0.006	0.0CysXaa: 0.0 ± 0.0
Asp	2.942AspAla: 2.942 ± 0.016	1.121AspCys: 1.121 ± 0.013	2.759AspAsp: 2.759 ± 0.016	3.67AspGlu: 3.67 ± 0.021	2.171AspPhe: 2.171 ± 0.014	3.438AspGly: 3.438 ± 0.021	1.136AspHis: 1.136 ± 0.009	2.824AspIle: 2.824 ± 0.016	2.674AspLys: 2.674 ± 0.017	4.92AspLeu: 4.92 ± 0.023	1.168AspMet: 1.168 ± 0.01	1.904AspAsn: 1.904 ± 0.014	2.785AspPro: 2.785 ± 0.018	1.842AspGln: 1.842 ± 0.015	2.381AspArg: 2.381 ± 0.015	4.134AspSer: 4.134 ± 0.022	2.609AspThr: 2.609 ± 0.014	3.181AspVal: 3.181 ± 0.019	0.642AspTrp: 0.642 ± 0.007	1.597AspTyr: 1.597 ± 0.011	0.0AspXaa: 0.0 ± 0.0
Glu	4.817GluAla: 4.817 ± 0.028	1.343GluCys: 1.343 ± 0.018	4.42GluAsp: 4.42 ± 0.022	7.74GluGlu: 7.74 ± 0.05	2.071GluPhe: 2.071 ± 0.012	4.013GluGly: 4.013 ± 0.018	1.568GluHis: 1.568 ± 0.013	3.374GluIle: 3.374 ± 0.017	5.401GluLys: 5.401 ± 0.035	6.488GluLeu: 6.488 ± 0.038	1.795GluMet: 1.795 ± 0.012	3.276GluAsn: 3.276 ± 0.017	2.833GluPro: 2.833 ± 0.016	3.257GluGln: 3.257 ± 0.022	3.926GluArg: 3.926 ± 0.023	4.455GluSer: 4.455 ± 0.02	3.49GluThr: 3.49 ± 0.028	4.244GluVal: 4.244 ± 0.02	0.729GluTrp: 0.729 ± 0.007	1.737GluTyr: 1.737 ± 0.012	0.0GluXaa: 0.0 ± 0.0
Phe	2.117PheAla: 2.117 ± 0.011	0.955PheCys: 0.955 ± 0.007	1.783PheAsp: 1.783 ± 0.011	2.055PheGlu: 2.055 ± 0.012	1.688PhePhe: 1.688 ± 0.016	2.228PheGly: 2.228 ± 0.018	1.051PheHis: 1.051 ± 0.008	1.992PheIle: 1.992 ± 0.015	1.869PheLys: 1.869 ± 0.013	4.083PheLeu: 4.083 ± 0.023	0.792PheMet: 0.792 ± 0.008	1.455PheAsn: 1.455 ± 0.011	1.957PhePro: 1.957 ± 0.014	1.79PheGln: 1.79 ± 0.012	1.876PheArg: 1.876 ± 0.014	3.38PheSer: 3.38 ± 0.019	2.113PheThr: 2.113 ± 0.014	2.277PheVal: 2.277 ± 0.014	0.494PheTrp: 0.494 ± 0.006	1.258PheTyr: 1.258 ± 0.01	0.0PheXaa: 0.0 ± 0.0
Gly	4.178GlyAla: 4.178 ± 0.027	1.343GlyCys: 1.343 ± 0.013	3.144GlyAsp: 3.144 ± 0.031	3.883GlyGlu: 3.883 ± 0.019	2.416GlyPhe: 2.416 ± 0.019	4.841GlyGly: 4.841 ± 0.038	1.611GlyHis: 1.611 ± 0.013	2.953GlyIle: 2.953 ± 0.017	3.795GlyLys: 3.795 ± 0.021	5.287GlyLeu: 5.287 ± 0.024	1.414GlyMet: 1.414 ± 0.011	2.533GlyAsn: 2.533 ± 0.017	3.093GlyPro: 3.093 ± 0.03	2.608GlyGln: 2.608 ± 0.016	3.6GlyArg: 3.6 ± 0.018	5.594GlySer: 5.594 ± 0.041	3.604GlyThr: 3.604 ± 0.021	3.464GlyVal: 3.464 ± 0.02	0.848GlyTrp: 0.848 ± 0.009	1.9GlyTyr: 1.9 ± 0.015	0.0GlyXaa: 0.0 ± 0.0
His	1.364HisAla: 1.364 ± 0.01	0.742HisCys: 0.742 ± 0.009	0.941HisAsp: 0.941 ± 0.008	1.35HisGlu: 1.35 ± 0.011	1.052HisPhe: 1.052 ± 0.008	1.59HisGly: 1.59 ± 0.012	0.918HisHis: 0.918 ± 0.011	1.323HisIle: 1.323 ± 0.008	1.305HisLys: 1.305 ± 0.01	2.751HisLeu: 2.751 ± 0.015	0.602HisMet: 0.602 ± 0.006	0.972HisAsn: 0.972 ± 0.008	1.615HisPro: 1.615 ± 0.013	1.179HisGln: 1.179 ± 0.009	1.517HisArg: 1.517 ± 0.011	2.221HisSer: 2.221 ± 0.014	1.297HisThr: 1.297 ± 0.01	1.51HisVal: 1.51 ± 0.011	0.343HisTrp: 0.343 ± 0.005	0.844HisTyr: 0.844 ± 0.007	0.0HisXaa: 0.0 ± 0.0
Ile	2.89IleAla: 2.89 ± 0.013	1.172IleCys: 1.172 ± 0.011	2.309IleAsp: 2.309 ± 0.015	2.816IleGlu: 2.816 ± 0.015	2.019IlePhe: 2.019 ± 0.014	2.411IleGly: 2.411 ± 0.015	1.294IleHis: 1.294 ± 0.009	2.612IleIle: 2.612 ± 0.015	2.855IleLys: 2.855 ± 0.015	4.75IleLeu: 4.75 ± 0.022	1.045IleMet: 1.045 ± 0.008	2.105IleAsn: 2.105 ± 0.014	2.714IlePro: 2.714 ± 0.016	2.411IleGln: 2.411 ± 0.017	2.454IleArg: 2.454 ± 0.013	3.956IleSer: 3.956 ± 0.019	2.763IleThr: 2.763 ± 0.017	2.76IleVal: 2.76 ± 0.017	0.547IleTrp: 0.547 ± 0.006	1.531IleTyr: 1.531 ± 0.012	0.0IleXaa: 0.0 ± 0.0
Lys	3.95LysAla: 3.95 ± 0.021	1.181LysCys: 1.181 ± 0.012	3.288LysAsp: 3.288 ± 0.019	5.235LysGlu: 5.235 ± 0.032	1.774LysPhe: 1.774 ± 0.013	3.249LysGly: 3.249 ± 0.022	1.491LysHis: 1.491 ± 0.011	2.964LysIle: 2.964 ± 0.017	4.819LysLys: 4.819 ± 0.03	5.479LysLeu: 5.479 ± 0.027	1.479LysMet: 1.479 ± 0.01	2.557LysAsn: 2.557 ± 0.013	2.963LysPro: 2.963 ± 0.02	2.869LysGln: 2.869 ± 0.021	3.341LysArg: 3.341 ± 0.02	4.031LysSer: 4.031 ± 0.022	3.22LysThr: 3.22 ± 0.017	3.568LysVal: 3.568 ± 0.02	0.648LysTrp: 0.648 ± 0.006	1.72LysTyr: 1.72 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	6.412LeuAla: 6.412 ± 0.028	2.254LeuCys: 2.254 ± 0.016	4.738LeuAsp: 4.738 ± 0.019	7.095LeuGlu: 7.095 ± 0.036	3.543LeuPhe: 3.543 ± 0.022	5.337LeuGly: 5.337 ± 0.024	2.747LeuHis: 2.747 ± 0.016	4.121LeuIle: 4.121 ± 0.02	6.043LeuLys: 6.043 ± 0.032	10.58LeuLeu: 10.58 ± 0.047	2.062LeuMet: 2.062 ± 0.012	3.781LeuAsn: 3.781 ± 0.016	5.622LeuPro: 5.622 ± 0.024	5.772LeuGln: 5.772 ± 0.03	5.542LeuArg: 5.542 ± 0.025	7.915LeuSer: 7.915 ± 0.027	4.959LeuThr: 4.959 ± 0.019	5.402LeuVal: 5.402 ± 0.024	1.138LeuTrp: 1.138 ± 0.009	2.7LeuTyr: 2.7 ± 0.015	0.0LeuXaa: 0.0 ± 0.0
Met	1.805MetAla: 1.805 ± 0.013	0.437MetCys: 0.437 ± 0.006	1.319MetAsp: 1.319 ± 0.009	1.944MetGlu: 1.944 ± 0.012	0.824MetPhe: 0.824 ± 0.008	1.32MetGly: 1.32 ± 0.012	0.523MetHis: 0.523 ± 0.006	0.926MetIle: 0.926 ± 0.008	1.547MetLys: 1.547 ± 0.011	2.075MetLeu: 2.075 ± 0.011	0.601MetMet: 0.601 ± 0.008	0.969MetAsn: 0.969 ± 0.007	1.082MetPro: 1.082 ± 0.011	1.06MetGln: 1.06 ± 0.009	1.071MetArg: 1.071 ± 0.009	1.627MetSer: 1.627 ± 0.011	1.097MetThr: 1.097 ± 0.008	1.447MetVal: 1.447 ± 0.01	0.26MetTrp: 0.26 ± 0.004	0.633MetTyr: 0.633 ± 0.007	0.0MetXaa: 0.0 ± 0.0
Asn	2.277AsnAla: 2.277 ± 0.015	0.966AsnCys: 0.966 ± 0.011	1.681AsnAsp: 1.681 ± 0.014	2.429AsnGlu: 2.429 ± 0.015	1.543AsnPhe: 1.543 ± 0.012	2.759AsnGly: 2.759 ± 0.021	0.962AsnHis: 0.962 ± 0.008	2.38AsnIle: 2.38 ± 0.014	2.408AsnLys: 2.408 ± 0.014	3.929AsnLeu: 3.929 ± 0.019	1.0AsnMet: 1.0 ± 0.008	1.739AsnAsn: 1.739 ± 0.013	2.23AsnPro: 2.23 ± 0.013	1.704AsnGln: 1.704 ± 0.013	1.945AsnArg: 1.945 ± 0.012	3.356AsnSer: 3.356 ± 0.018	2.2AsnThr: 2.2 ± 0.012	2.373AsnVal: 2.373 ± 0.016	0.485AsnTrp: 0.485 ± 0.006	1.218AsnTyr: 1.218 ± 0.01	0.0AsnXaa: 0.0 ± 0.0
Pro	4.489ProAla: 4.489 ± 0.028	1.184ProCys: 1.184 ± 0.013	2.654ProAsp: 2.654 ± 0.016	3.953ProGlu: 3.953 ± 0.023	1.882ProPhe: 1.882 ± 0.014	4.23ProGly: 4.23 ± 0.033	1.376ProHis: 1.376 ± 0.012	1.944ProIle: 1.944 ± 0.014	2.673ProLys: 2.673 ± 0.021	4.934ProLeu: 4.934 ± 0.023	1.004ProMet: 1.004 ± 0.01	1.88ProAsn: 1.88 ± 0.012	5.227ProPro: 5.227 ± 0.047	2.539ProGln: 2.539 ± 0.02	2.841ProArg: 2.841 ± 0.018	5.178ProSer: 5.178 ± 0.028	2.738ProThr: 2.738 ± 0.02	3.785ProVal: 3.785 ± 0.02	0.611ProTrp: 0.611 ± 0.007	1.401ProTyr: 1.401 ± 0.012	0.0ProXaa: 0.0 ± 0.0
Gln	3.238GlnAla: 3.238 ± 0.022	1.024GlnCys: 1.024 ± 0.011	2.279GlnAsp: 2.279 ± 0.016	3.708GlnGlu: 3.708 ± 0.03	1.427GlnPhe: 1.427 ± 0.009	2.552GlnGly: 2.552 ± 0.016	1.379GlnHis: 1.379 ± 0.011	2.144GlnIle: 2.144 ± 0.012	3.007GlnLys: 3.007 ± 0.021	4.735GlnLeu: 4.735 ± 0.023	1.15GlnMet: 1.15 ± 0.008	1.977GlnAsn: 1.977 ± 0.014	2.585GlnPro: 2.585 ± 0.025	3.125GlnGln: 3.125 ± 0.036	2.812GlnArg: 2.812 ± 0.016	3.231GlnSer: 3.231 ± 0.022	2.298GlnThr: 2.298 ± 0.015	2.743GlnVal: 2.743 ± 0.016	0.559GlnTrp: 0.559 ± 0.007	1.273GlnTyr: 1.273 ± 0.009	0.0GlnXaa: 0.0 ± 0.0
Arg	3.553ArgAla: 3.553 ± 0.021	1.28ArgCys: 1.28 ± 0.016	2.721ArgAsp: 2.721 ± 0.025	3.715ArgGlu: 3.715 ± 0.022	1.857ArgPhe: 1.857 ± 0.012	3.297ArgGly: 3.297 ± 0.018	1.468ArgHis: 1.468 ± 0.011	2.501ArgIle: 2.501 ± 0.015	3.577ArgLys: 3.577 ± 0.019	5.123ArgLeu: 5.123 ± 0.022	1.216ArgMet: 1.216 ± 0.01	2.169ArgAsn: 2.169 ± 0.012	2.72ArgPro: 2.72 ± 0.017	2.579ArgGln: 2.579 ± 0.016	4.153ArgArg: 4.153 ± 0.024	4.176ArgSer: 4.176 ± 0.027	2.736ArgThr: 2.736 ± 0.014	3.0ArgVal: 3.0 ± 0.015	0.701ArgTrp: 0.701 ± 0.006	1.568ArgTyr: 1.568 ± 0.012	0.0ArgXaa: 0.0 ± 0.0
Ser	5.348SerAla: 5.348 ± 0.022	1.917SerCys: 1.917 ± 0.017	3.999SerAsp: 3.999 ± 0.023	5.089SerGlu: 5.089 ± 0.026	3.081SerPhe: 3.081 ± 0.014	5.29SerGly: 5.29 ± 0.066	2.039SerHis: 2.039 ± 0.014	3.57SerIle: 3.57 ± 0.018	4.274SerLys: 4.274 ± 0.023	8.021SerLeu: 8.021 ± 0.027	1.696SerMet: 1.696 ± 0.011	2.96SerAsn: 2.96 ± 0.019	5.552SerPro: 5.552 ± 0.034	3.662SerGln: 3.662 ± 0.02	4.239SerArg: 4.239 ± 0.025	9.427SerSer: 9.427 ± 0.057	4.61SerThr: 4.61 ± 0.026	5.066SerVal: 5.066 ± 0.022	1.002SerTrp: 1.002 ± 0.009	2.156SerTyr: 2.156 ± 0.014	0.0SerXaa: 0.0 ± 0.0
Thr	3.891ThrAla: 3.891 ± 0.017	1.356ThrCys: 1.356 ± 0.018	2.684ThrAsp: 2.684 ± 0.014	3.638ThrGlu: 3.638 ± 0.02	2.116ThrPhe: 2.116 ± 0.014	3.568ThrGly: 3.568 ± 0.02	1.193ThrHis: 1.193 ± 0.01	2.52ThrIle: 2.52 ± 0.015	2.727ThrLys: 2.727 ± 0.014	5.129ThrLeu: 5.129 ± 0.022	1.126ThrMet: 1.126 ± 0.009	1.9ThrAsn: 1.9 ± 0.01	3.211ThrPro: 3.211 ± 0.022	2.146ThrGln: 2.146 ± 0.013	2.34ThrArg: 2.34 ± 0.014	4.655ThrSer: 4.655 ± 0.025	3.024ThrThr: 3.024 ± 0.024	3.993ThrVal: 3.993 ± 0.019	0.673ThrTrp: 0.673 ± 0.007	1.507ThrTyr: 1.507 ± 0.01	0.0ThrXaa: 0.0 ± 0.0
Val	4.155ValAla: 4.155 ± 0.016	1.513ValCys: 1.513 ± 0.013	2.945ValAsp: 2.945 ± 0.019	3.922ValGlu: 3.922 ± 0.019	2.548ValPhe: 2.548 ± 0.017	3.311ValGly: 3.311 ± 0.017	1.523ValHis: 1.523 ± 0.01	3.059ValIle: 3.059 ± 0.018	3.631ValLys: 3.631 ± 0.019	6.384ValLeu: 6.384 ± 0.027	1.379ValMet: 1.379 ± 0.011	2.502ValAsn: 2.502 ± 0.017	3.573ValPro: 3.573 ± 0.018	2.818ValGln: 2.818 ± 0.016	3.032ValArg: 3.032 ± 0.014	4.988ValSer: 4.988 ± 0.021	3.754ValThr: 3.754 ± 0.019	4.102ValVal: 4.102 ± 0.019	0.722ValTrp: 0.722 ± 0.007	1.717ValTyr: 1.717 ± 0.013	0.0ValXaa: 0.0 ± 0.0
Trp	0.721TrpAla: 0.721 ± 0.007	0.265TrpCys: 0.265 ± 0.004	0.665TrpAsp: 0.665 ± 0.008	0.77TrpGlu: 0.77 ± 0.007	0.44TrpPhe: 0.44 ± 0.005	0.735TrpGly: 0.735 ± 0.01	0.33TrpHis: 0.33 ± 0.005	0.61TrpIle: 0.61 ± 0.007	0.823TrpLys: 0.823 ± 0.007	1.233TrpLeu: 1.233 ± 0.011	0.33TrpMet: 0.33 ± 0.005	0.564TrpAsn: 0.564 ± 0.008	0.474TrpPro: 0.474 ± 0.006	0.557TrpGln: 0.557 ± 0.006	0.712TrpArg: 0.712 ± 0.007	0.914TrpSer: 0.914 ± 0.01	0.653TrpThr: 0.653 ± 0.008	0.71TrpVal: 0.71 ± 0.007	0.21TrpTrp: 0.21 ± 0.004	0.354TrpTyr: 0.354 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.482TyrAla: 1.482 ± 0.01	0.739TyrCys: 0.739 ± 0.008	1.412TyrAsp: 1.412 ± 0.012	1.775TyrGlu: 1.775 ± 0.011	1.307TyrPhe: 1.307 ± 0.011	1.764TyrGly: 1.764 ± 0.014	0.763TyrHis: 0.763 ± 0.008	1.55TyrIle: 1.55 ± 0.011	1.62TyrLys: 1.62 ± 0.015	2.773TyrLeu: 2.773 ± 0.016	0.641TyrMet: 0.641 ± 0.007	1.248TyrAsn: 1.248 ± 0.01	1.295TyrPro: 1.295 ± 0.01	1.281TyrGln: 1.281 ± 0.01	1.671TyrArg: 1.671 ± 0.013	2.365TyrSer: 2.365 ± 0.013	1.584TyrThr: 1.584 ± 0.013	1.633TyrVal: 1.633 ± 0.011	0.395TyrTrp: 0.395 ± 0.007	1.037TyrTyr: 1.037 ± 0.009	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.015XaaXaa: 0.015 ± 0.009

Statistics based on 24357 proteins (16680854 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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